Reopoliglukin

Reopoliglyukin - a substitute for plasma and other blood components, intended for replenishment volume of circulating blood, preservation of its aggregate state and maintenance of water-electrolyte balance.

Normalize hemodynamics, increase the volume of fluid in the bloodstream. Solutions of low-molecular dextran, in addition, contribute to improving microcirculation, reduce the aggregation of blood cells, the viscosity of the blood.

Solutions of dextran containing mannitol, also have osmodiuretic effect.

Clinical and pharmacological group

Plasmo-replacing drug.

Terms of sale from pharmacies

It is possible to buy under the prescription of the doctor.

Price

How much does Reopoliglyukin cost in pharmacies? The average price is at the level of150 rubles.

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Composition and form of release

Reopoliglyukin is available in the form of a solution for infusions, which is a colorless or slightly yellow liquid (200 ml or 400 ml in vials for blood and blood substitutes, in a cardboard bundle 1 bottle, in boxes of 24 and 40 bottles - for hospitals).

The active substance is dextran (molecular weight 3, 00-40000) in isotonic sodium chloride solution (10 g in 100 ml of solution).

Characteristics of Rheopolyglucin:

• The pH of the solution is
• Theoretical osmolarity is 316 mOsm / l;
• Relative viscosity (no more,) at a temperature of 25 ° C.

pharmachologic effect

Reopoliglyukin is a preparation of low molecular weight dextran. Under its action, the liquid from the tissues passes into the bloodstream, the viscosity of the blood decreases, which helps restore its current in the capillaries. It also helps to reduce the aggregation of blood cells (erythrocytes). The increase in the volume of blood plasma is most noticeable within an hour and a half after the administration of Reopoliglyukin.

Reopoliglyukin is involved in the stimulation of diuresis, preventing the reverse absorption of water in the renal tubules. As a result, toxins and poisons are eliminated (the detoxification effect of the drug).

It is excreted from the body by the kidneys. About 70% of the active substance is excreted on the first day after the administration (mostly unchanged, part of it decomposes to glucose). The half-life is 6 hours.

Indications for use

What helps? Reopoliglyukin is used:

1. For the prevention and treatment of shock (surgical, traumatic, burn);
2. When there is a violation of capillary blood flow;
3. For detoxification with peritonitis, burns, pancreatitis, etc .;
4. To improve local circulation in plastic and vascular surgery;
5. During cardiac surgery performed using an artificial circulation device (for addition to a perfusion fluid);
6. For the prevention and treatment of thrombophlebitis, thrombosis, endarteritis;
7. With diseases of the optic nerve and retina, inflammatory processes of the choroid and cornea.

Contraindications

Application of the solution for intravenous administration Reopoliglyukin is contraindicated in various pathological and physiological conditions of the body, which include:

1. Allergy to dextrans, including those transferred in the past, intolerance to any of the components of the drug.
2. Any body condition in which large volumes of fluid can not be injected.
3. A pathological decrease in the number of platelets in a unit of blood volume (thrombocytopenia).
4. The pathology of the kidneys, accompanied by a marked decrease in their functional activity up to the cessation of urine production (anuria).

Before applying Rheopolyglucin solution, you should make sure that there are no contraindications.

Intended use for pregnancy and lactation

There are no data on the safety of the use of Reopoliglyukin in these periods.

Dosage and route of administration

As indicated in the instructions for use Reopoliglyukin injected intravenously drip. The dose of the drug is determined individually and depends on the patient's condition and clinical situation.

Recommended doses and duration of therapy:

• Prevention and treatment of violations of capillary blood flow associated with various types of shock: 400-1000 ml (for 30-60 minutes) once or twice a day;
• Operations on the heart and blood vessels: before the operation - 10 ml / kg, during surgery - 400-500 ml, after the operation - 10 ml / kg per injection for 5-6 days;
• Detoxification: single dose - 500-1200 ml (for children - 5-10 ml / kg) for 60-90 minutes. In the first day, if necessary, another 500 ml of Reopoliglyukin (children in the same doses) are poured. In the following days, the daily dose is 500 ml for adults and 5-10 ml / kg for children. It is expedient to simultaneously introduce crystalloid solutions (Ringer-acetate, Ringer, etc.) in amounts capable of normalizing the water-electrolyte balance. This is especially important after surgical interventions and in the treatment of patients with dehydration;
• Operations with artificial circulation: the drug is added to the blood to fill the oxygenator pump (at the rate of 10-20 ml of solution per 1 kg of body weight). The concentration of the drug in the perfusion solution is no more than 3%. After the operation, Reopoliglyukin is used in the same doses as in shock conditions;
• Ophthalmic diseases: the drug is used for 10 ml by electrophoresis. The procedure is carried out once a day.

In children, the total dose of Reopoliglyukin should not be more than 15 ml / kg per day.

In cardiovascular surgery, the recommended doses for children, depending on their age, are as follows:

• 2-3 years - 10 ml / kg per day once (for 60 minutes);
• 4-8 years - 7-10 ml / kg once or twice a day;
• 9-13 years - 5-7 ml / kg once or twice a day;
• From 14 years and older - the adult dose.

With the purpose of detoxification in children, the drug is administered at a dose of 5-10 ml / kg for 60-90 minutes.

Side effect

When taking Reopoliglyukin, development of such side effects as an allergic reaction or arterial hypotension is possible.

Overdose

There were no cases of overdose of the drug Reopoliglyukin.

special instructions

In connection with possible allergic reactions, the first 10-20 ml of the infusion solution is recommended to be administered slowly, observing the patient's condition. Given the possibility of developing hypertension, it should be borne in mind that appropriate means for intensive care may be required.

Dextran with a molecular weight of 1000 can not be diluted or mixed with dextran solutions for infusions. Dextran with a molecular weight of 1000 can be introduced I / O via a Y-shaped branch or a rubber tube of the infusion system, provided that during the injection there is no significant dilution preparation.

Interaction with other drugs

Before combining the administration of drugs into the infusion solution, they should be checked for compatibility.

If it is necessary to use anticoagulants in parallel, it is recommended to reduce their dosage.

In the case of increased diuresis, the introduction of colloidal solutions is recommended, which will ensure the maintenance of the water-electrolyte balance.

In oliguria, Furosemide and saline solutions are introduced.

Reviews

In general, the drug has proved to be an effective and necessary tool. According to reviews, the drug is effective on indications for use, it rarely shows side effects.

Analogues

Structural analogs for the active substance:

• Hemostabil;
• Dextran 40;
• Dextran 70;
• Longasteril 40;
• Polyglukine;
• Polyglucin is dry;
• Reogluman;
• Reodex;
• Reomacrodex;
• Reopoliglyukin 40;
• Reopoliglyukin dry;
• Reopoliks.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Store in a dry place inaccessible to children at a temperature of 10-25 ° C.

Shelf life - 4 years.

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