What is Duzopharm assigned for: instruction and feedback

Duzopharm has an effective vasodilating effect. The drug is able to significantly improve blood circulation in peripheral vessels and the brain. This increases the minute volume of the heart.

It should be noted that the drug has virtually no effect on the frequency of cardiac contractions and blood pressure. Thanks to the preparation, the metabolism in cells is significantly improved. In this case, the absorption of oxygen and glucose by tissues becomes more effective.

On this page you will find all information about Duzopharm: the full instruction on the application for this medicine, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Duzopharm. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Peripheral vasodilator.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much are Duzopharm tablets? The average price in pharmacies is at the level of400 rubles.

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Form of issue and composition

Produced in the form of orange tablets biconvex form, which are covered with a film membrane. Blisters are in a cardboard rectangular package of three, six and nine pieces. Each contains 10 tablets.

One tablet contains 50 mg of naphthyrofuryl oxalate. Auxiliary components: magnesium stearate, lactose monohydrate, colloidal silicon dioxide, wheat starch, microcrystalline cellulose, copovidone, talc.
The film shell includes titanium dioxide, magnesium stearate, talc, macrogol 6000, dye yellow E110, copolymer of methacrylic acid and ethyl acrylate.

To the preparation "Duzopharm" the instruction indicates that the active substance is naphthydrofuryl (naftidrofuryl).

Pharmacological effect

A drug that improves cerebral and peripheral circulation. Has vasodilator effect. Reduces OPSS and increases the minute volume of the heart, without having a significant impact on heart rate and blood pressure. The vasodilating effect of Duzopharm is the result of its direct myotropic action, antagonistic to serotonin 5HT2 receptors and alpha-adrenergic blocking action.

Has m-anticholinergic action. Has a positive effect on cellular metabolism, improving the utilization of oxygen and glucose. This action of the drug is due to its ability to increase the level of ATP and inhibit the enzyme succinate dehydrogenase. Activates the utilization of glucose through the cycle of citric acid and increases the conversion of succinic acid into fumaric acid.

As a result, the resistance of cells (including the brain) to hypoxia increases. In addition, Duzopharm® reduces the increased viscosity of the blood.

Indications for use

The drug is prescribed, if necessary, to maintain normal blood circulation in the body. So, the main indications are:

The recovery period after a stroke.
Various arterial pathologies.
Problems of peripheral blood supply.
Vascular damage resulting from multiple spasms or Raynaud's syndrome.
Various brain traumas, which caused the circulatory disturbance in the brain.

Contraindications

You can not accept:

hemorrhagic stroke (acute stage);
epilepsy, increased convulsive alertness;
myocardial infarction (acute stage);
arterial hypotension;
tachyarrhythmias;
increased individual sensitivity to the drug;
age under 18 years (effectiveness and safety not established);
chronic heart failure of II-III stage (III-IV according to NYHA - functional classification of heart failure of the New York Association of Cardiology).

Carefully:

angle-closure glaucoma;
hyperplasia of the prostate.

Application in pregnancy and lactation

Data on the effects on the body of a pregnant woman is not enough, so the use of Duzopharm in this period is not recommended. When taking into account the potential risk and possible positive effects, the drug should be used with caution.

Instructions for use

The instructions for use indicate that Duzopharm is administered orally with a large amount of liquid: at least 1 cup of water.

The drug is indicated for long-term therapy. The following dosage is recommended:

In violation of peripheral circulation - taking a daily dose of 400 to 600 mg, and a single dose of 200 mg.
When cerebral circulation is disturbed, a drug in a daily dose of 300-600 mg, in 3 divided doses.

The dosage of the drug and the duration of admission are determined by the attending physician, based on the clinical condition of the patient. When using Duzopharm tablets according to the instructions for renal / hepatic insufficiency, dose adjustment is not necessary.

Side effects

When using the drug at a dosage of 300-600 mg, Duzopharm is tolerated well.

The appearance of the following undesirable reactions is rare:

Digestive system: gastric ulcer, diarrhea, increased activity of liver enzymes, decreased appetite, nausea, intestinal colic, vomiting, pain in the epigastric region;
CNS: changes in the duration and quality of sleep, headache, dizziness;
Other: in rare cases, allergic reactions are possible.

Overdose

In case of an overdose, the following symptoms are observed:

ventricular arrhythmia;
bradycardia;
increased severity of side effects;
lowering blood pressure;
anxiety.

Symptomatic treatment, as well as the appointment of sorbents and laxatives, is indicated. There is no specific antidote.

special instructions

The drug does not affect the ability of the patient to drive a car or be controlled with different mechanisms.

The active substance can enter the breast milk, so during the lactation it is necessary to exclude this drug. However, its effect on the child's body is not fully understood.

During treatment it is recommended to stop smoking and excessive consumption of alcoholic beverages.

Drug Interactions

The drug increases the antihypertensive effect of antihypertensive medications. In the case where there is a need for simultaneous use of antihypertensive drugs and Duzopharm, blood pressure indicators should be monitored frequently.

Reviews

We picked up some of the people's comments about Duzopharm:

Pauline. My mom Duzofarm was prescribed an endocrinologist, her sugar is slightly higher than normal, the doctor said that only with the help of this drug, you can avoid vascular complications. He takes 50 mg three times a day, three times a day for three months, which means that he has gone dizzy, there are no jumps in blood pressure, his legs do not swell. The doctor prescribed to drink 6 months. How many she drank different drugs, but that's such a good and fast effect as from Duzopharm was not, so will drink as an endocrinologist appointed. Thanks a lot to the doctor.
Alexandra. It is the therapeutic effect of this drug has an exceptional long-term use (about six months). If you take several months, after the drug is abolished, all the results achieved will go wrong. But the result of Duzopharm gives quickly. The noise in my ears disappeared literally in 2.5 weeks of admission. In the subsequent attacks of headache became less and less, by the end of the 2 month of admission they had completely disappeared. There was dizziness, impaired coordination and memory impairment with concentration. The first two in 3-3.5 months came back to normal, but with the latter had to fiddle the longest. Just then I interrupted the treatment, and everything returned. In the end, she was treated for 3 more months, but all the symptoms of the disease had completely passed, now they do not even bother occasionally.

As for the reviews, in most cases they are positive. Patients note that the pills relieve dizziness, act quickly and are inexpensive. The risk of side effects is small enough.