Flemoxin Solutab

Flemoxin soluteab is a medicinal preparation, a broad-spectrum antibiotic.

Active component of the drug is amoxicillin, it has antibacterial action. Used for various inflammatory and infectious processes of the upper and lower respiratory tract, gastrointestinal tract, urogenital system, soft tissues.

The duration of antibiotic therapy for mild and moderate infections is about 5-7 days, and in cases of infections provoked by Streptococcus pyogenes - 10 days. The disappearance of clinical manifestations of the disease is by no means a signal for immediate withdrawal of the drug: it should be taken 2 more days. If the use of flemoxin is accompanied by severe diarrhea, it can be assumed that there is pseudomembranous colitis. In such cases, the drug is subject to cancellation.

Clinical and pharmacological group

Antibiotic of a group of semisynthetic penicillins of a wide spectrum of action.

Terms of sale from pharmacies

Can buyby prescription.

Price

In pharmacies in Moscow, the average cost of the drug Flemoxin Solutab is:

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Flemoxin Solutab tablets 125 mg - 230-270 rub.
Flemoxin Solutab tablets 250 mg - 300-330 rub.
Flemoxin Solutab tablets 500 mg - 370-410 rub.
Flemoxin Solutab tablets 1000 mg - 520-550 rub.

Composition and form of release

Tablets Flemoxin Solutaba dispersible:

125, 250, 500 or 1000 mg package No. 20 (blisters of 5 pcs., 4 blisters in the package);
125 mg package number 14 (7 pcs. Blisters, 2 blisters per pack).

The dispersible (water-soluble) tablets include amoxicillin in the form of amoxicillin trihydrate (Amoxicillin trihydrate), cellulose microcrystalline and dispersible, vanillin, crospovidone, flavorings (lemon and mandarin), magnesium stearate, saccharin.

Tablets are oval, white or white with a yellowish tint of color, with a dividing risk on one side, and a numeric designation (231, 232, 234 and 236) and the manufacturer's logo on the other.

Pharmacological effect

Amoxicillin is a semisynthetic β-lactam antibiotic of the penicillin group with a broad spectrum of antimicrobial activity.

Bactericidal properties of the drug are due to the ability to suppress transpeptidase, disrupt the production of peptidoglycan (the supporting protein of the cell walls) during the periods of division and growth, to provoke the lysis of microorganisms.

It is active against Gram (+) aerobes, including Staphylococcus spp. (except for penicillinase-producing strains) and Streptococcus spp. (including Str.pneumoniae and faecalis); Gram (-) aerobes (gonococci, meningococci, intestinal and hemophilic sticks, proteus mirabilis; individual strains of Klebsiella, Shigella and Salmonella, and also in relation to H. pylori.

It is ineffective against P.rettgeri and vulgaris proteolytic strains (indolpositive), serratus, pseudomonas, enterobacteria, morganella morgani. Resistant to the effects of amoxicillin mycoplasma, rickettsia and viruses.

A feature of the dosage form is that the tablets are readily dispersible in water to form a dispersion. Thanks to this, the drug is absorbed quickly and completely (more than 93% of the dose taken) from the digestive canal. Eating does not affect the absorption of the substance. TCmax - within the range of 60 to 120 minutes. With the use of dispersible tablets, the plasma concentration of amoxicillin is higher than when insoluble forms of the drug are administered. The active substance is resistant to acids.

Indications for use

Tablets Flemoxin Solutab are intended for the treatment of diseases caused by microorganisms sensitive to Amoxicillin:

infections of the musculoskeletal system, including osteomyelitis;
infectious diseases of the skin and soft tissues - pyoderma, streptoderma, furuncles, carbuncles, erysipelas;
infectious diseases of the urinary tract and kidneys - urethritis, pyelonephritis, cystitis, interstitial nephritis;
inflammatory diseases of female genital organs - adnexitis, salpingitis, cervicitis, endocervicitis, septic complications after abortion or childbirth, endometritis;
diseases of respiratory system of inflammatory and infectious nature - complicated sinusitis, sinusitis, tonsillitis, tonsillitis, pharyngitis, bronchitis, tracheitis, hospital pneumonia.

Contraindications

The use of Flemoxin Solutaba is contraindicated in patients with a syndrome of intolerance to the components of the drug and other beta-lactam antibiotics, including other carbapenems, cephalosporins and penicillins.

Diseases / conditions in which the drug is administered with caution:

Infectious mononucleosis;
lymphocytic leukemia;
diseases of the gastrointestinal tract in the anamnesis (in particular colitis associated with the use of antibacterial agents);
kidney failure;
allergic reactions, including polyvalent hypersensitivity to xenobiotics (including in the anamnesis);
pregnancy;
the period of breastfeeding.

Intended use for pregnancy and lactation

The use of Flemoxin Solutab during pregnancy and lactation is possible if the expected The benefit of therapy for the mother exceeds the risk of side effects in the fetus and the infant.

In small amounts, amoxicillin is excreted in breast milk, which can lead to the development of sensitization in the infant.

Dosage and route of administration

As indicated in the instructions for use Flemoxin Solutab should be taken orally before, at the same time or after eating.

Flemoxin Solutab can be swallowed whole, chewed or divided into parts and washed down with a glass of water, or diluted in water of 20 or 100 ml volume before the formation of a syrup or suspension having a pleasant fruit taste.

The scheme of taking the drug is determined by the doctor individually. In determining it, it takes into account the severity of the condition, the age of the patient and the sensitivity of the causative agent to the action of amoxicillin.

Recommended dosage regimen for the treatment of moderate / mild diseases:

children 1-3 years: 2 times a day for 250 mg or 3 times a day for 125 mg;
children 3-10 years: 2 times a day for 375 mg or 3 times a day for 250 mg;
children from 10 years and adults: 2 times a day for 500-750 mg or 3 times a day for 375-500 mg.

The dose of Flemoxin Solute for children (incl. at the age of up to 1 year) depends on weight and is 30-60 mg / kg per day, divided into 2-3 doses.

In cases of severe infection, as well as in the treatment of hard-to-reach foci of infection (eg, otitis media in acute course), the daily dose of Flemoxin Solutaba is recommended to be divided into 3 divided doses.

In high doses, the drug is used for relapsing infections, chronic diseases and infections in severe current: children - 60 mg / kg per day, divided into 3 doses, adults - 3 times a day for 750-1000 mg.

In acute uncomplicated gonorrhea, combined therapy is carried out: Flemoxin Solutab - 3000 mg and probenecid - 1000 mg (once).

In functional renal impairment (in patients with creatinine clearance ≤ 10 ml per minute), a dose reduction of 15-50% is indicated.

Duration of the course:

infection of moderate / mild severity: 5-7 days; more prolonged use (at least 10 days) is indicated in cases of treatment of infections that are caused by Streptococcus pyogenes;
severe infection, chronic diseases: duration is determined by the clinical picture; After the disappearance of the symptoms of the disease, therapy is continued for another 48 hours.

Adverse Reactions

Side effects are manifested as:

nausea, changes in taste, diarrhea, vomiting, moderate increase in the activity of liver enzymes (sometimes), hemorrhagic and pseudomembranous colitis (extremely rare);
interstitial nephritis (extremely rare);
Hemolytic anemia, neutropenia, agranulocytosis, thrombocytopenia.

When using the drug in the form of dispersible tablets, there were no adverse events on the part of the nervous system.

The use of the drug may be accompanied by the development of hypersensitivity reactions, which are expressed as a rash (mainly specific maculopapular), multiforme exudative erythema (rarely), angioedema and anaphylactic shock (in exceptional cases).

Overdose

Flemoxin soluteab is administered at a certain dosage, however in the case of its overdose, a rinse stomach, give activated charcoal, salt laxatives, restore the water-electrolyte balance. Such events are held only in a hospital under the strict supervision of medical personnel.

special instructions

Use with caution in patients prone to allergic reactions.

Against the background of combined therapy with metronidazole, it is not recommended to drink alcohol.

Amoxicillin in combination with metronidazole is not recommended for use in patients younger than 18 years of age; should not be used for liver disease.

Compatibility with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

Amoxicillin can reduce the effectiveness of oral contraceptives.
Amoxicillin reduces the effect of drugs, in the process of metabolism which forms PABC.
Antacids, glucosamine, laxatives, aminoglycosides slow down and decrease, and ascorbic acid increases the absorption of amoxicillin.
Amoxicillin strengthens the effect of indirect anticoagulants suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index.
With the combined use of amoxicillin and clavulanic acid, the pharmacokinetics of both components do not change.
Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs reduce the tubular secretion of amoxicillin, which can be accompanied by an increase in its concentration in the blood plasma.
With the simultaneous use of amoxicillin with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) is manifested synergism; with bacteriostatic antibiotics (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonism.

Reviews

We offer you to read reviews of people who used Flemoxin Solutab:

Natalia. This antibiotic is very weak only for cramming and snot... In pneumonia, an experienced doctor will not when not appoint it. Only in injections or strong in tablet form but not always. One antibiotic drink can not always be used and, as a result, a waste of money and a result of zero. Antibiotics should be alternated in 3-5 months (so as not to repeat). Amoxicillin is included in the composition of flemoxin. before you buy a flemoxin buy one plate of amoxicillin it costs a penny put under the tongue if there is a burning sensation of sour taste means you it does not fit.
Margarita. I remember how that girlfriend told me that her friend spent her whole life squandering around the hospitals. And it all started with how her daughter discovered staphylococcus aureus. The baby was still very small and she was prescribed flemoxin solute. They were treated for about a week and how good that the drug helped. The baby was healthy. And though there were no side effects, but then for a long time they went to hospitals (and still).
Valeria. To me appointed or nominated Flemoksin soljutab at a strong angina. My throat was very sore, I was asleep, my voice was gone. The doctor prescribed rinses and this antibiotic. I liked the action of the medicine - the symptoms of the disease passed quickly enough. On the second day began to feel much better. The drug was well tolerated, no side effects were observed. I was satisfied with the action of the medicine. The product dissolves very quickly in the mouth. Passed the temperature, pain, perspiration in the throat. I took pills for five days, three times a day.

Analogues

Structural analogs for the active substance:

Amoxisar;
Amoxicillin;
Amoxicillin DS;
Amoxicillin sodium is sterile;
Amoxicillin Sandoz;
Amoxicillin-ratiopharm;
Amoxicillin trihydrate;
Amosin;
Gonoform;
Grunamox;
Danemox;
Ospamox;
Hiconcile;
EcoBall.

Before buying an analogue, consult your doctor.

Flemoxin or Amiksitsillin - which is better?

Flemoxin soluteba is a generic Amoxicillin. What is the difference between Flemoxin and the original? Amoxicillin is a semisynthetic antibiotic with a strong anti-inflammatory and bactericidal effect. It affects the cell membrane of a pathogenic microorganism and destroys it. Thus, the life of the bacterium stops. Amoxicillin is used in the treatment of respiratory diseases, urological and gynecological infections.

Flemoxin is an acid-fast antibiotic from the group of semisynthetic penicillins. It includes amoxicillin. Flemoxin also breaks the walls of the bacterial cell, stops its division and growth. The drug generic is highly active against gram-positive and gram-negative microorganisms. However, the drug is not very active in staphylococci and helicobacteria.

The main difference between Amiksitsillina and Flemoxin is their dosage form. Since the generic is released in the form of oral tablets that dissolve in the mouth, this drug does not have any negative effect on the shell of the stomach and intestines. Also, the new generation preparation Flemoxin soluteab is absorbed very quickly and completely absorbed. Within an hour, the total concentration of the active drug substance in the blood plasma can be observed.

Amiksitsillin, on the contrary, is released in conventional tablets and partially loses its bactericidal properties at the resolution in the gastrointestinal tract. That's why his generic drug has great bioavailability. It should be noted that Flemoxin Solutab costs a little more than the original.

What is better - Flemoxin or Flemoclav?

Flemoclav is a combined antibacterial preparation manufactured by Astellas Pharma in the form of dispersible tablets.

The basis of the pill is amoxicillin, but - and this is the difference between it and Flemoxin - to enhance its action in the composition The drug also includes clavulanate (or clavulanic acid), a substance that inhibits the bacterial enzymes of beta-lactamase. That is, Flemoclav is active against microorganisms sensitive to amoxicillin, and also in the strains of bacteria that produce some chromosomal and most plasmid β-lactamases.

Clavulanate inhibits beta-lactamase II, III, IV and V type, but is inactive with respect to those produced by enterobacteria, Pseudomonas aeruginosa, acinetobacteria, and sera (beta-lactamase type I).

Having high tropicity to the antibiotics of the penicillin group, clavulanate significantly expands the activity spectrum and, consequently, the use of amoxicillin.

Shelf life and storage conditions

Keep the drug in a cool dry place, out of the reach of children. The shelf life of the drug is indicated on the packaging and is 3 years from the date of manufacture.