Tsifran ST

Tsifran ST is a combined antibacterial drug combining two antimicrobial agents - ciprofloxacin and tinidazole.

The drug is effective against strains of microorganisms possessing acquired resistance to other antibiotics, including sulfonamides, nitrofurans. Due to its high efficiency and wide spectrum of action, Cyflane CT is used in the treatment of mixed infections (amebic and bacterial nature of the disease, a combination of anaerobic and aerobic flora, etc.).

The active substances are well absorbed in the gastrointestinal tract. Maximum concentrations (Сmах) of each component are reached within 1-2 hours.

Clinical and pharmacological group

Combined drug with bactericidal, antibacterial action of a wide spectrum.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Tsifran ST in pharmacies? The average price is at the level of350 rubles.

Composition and form of release

Medicinal form of the release Citrane CT - coated tablets: tablets 250 mg + 300 mg - yellow, oval; pills forte 500 mg + 600 mg - yellow, oval, on one side with a dividing line (in a cardboard bundle of 1, 2 or 10 blisters for 10 pcs.).

instagram viewer

Active substances in the composition of 1 tablet:

ciprofloxacin 250 or 500 mg (as monohydrate hydrochloride);
tinidazole BP-300 or 600 mg.

Auxiliary components:

core: sodium lauryl sulfate, sodium starch glycolate, microcrystalline cellulose, anhydrous colloidal silicon, magnesium stearate;
components of the outer layer of granules: sodium starch glycolate, purified talc, sodium lauryl sulfate, microcrystalline cellulose, anhydrous colloidal silicon, magnesium stearate;
shell: yellow Opadry, purified water.

Pharmacological effect

It is a combined antibiotic. The properties of Cyfran CT are determined by two main components: tinidazole and ciprofloxacin.

The first actively works against anaerobic microorganisms, for example, Clostridium difficile (Gram-positive bacteria of the genus Clostridium), Clostridium perfringens (anaerobic spore-forming bacteria of the genus clostridium), peptostreptococci and peptococci (gram-positive non-spore forming bacteria from the family Peptostreptococcaceae), bacteroides (genus Gram-negative anaerobic rod-shaped bacteria of the family Bacteroidaceae. They all contribute to the multiplication of pathogenic bacteria in an oxygen-free environment. For example, in the abdominal cavity, in the lungs.

Ciprofloxacin is an antibiotic. Effective in combating a wide range of gram-positive and gram-negative aerobic bacteria, such as E. coli, Klebsiella - the causative agent of pneumonia, typhoid fever and other varieties of salmonella. Proteus mirabilis, Proteus vulgaris, Yersinia enterocolitis, Pseudomonas aeruginosa, Shigella Flexner, Shigella Sonne, Duchess's stick, Hemophilus rod, Gonococcus, pneumonia, Vibrio cholerae, Bacteroides fragilis, Staphylococcus aureus, including methicillin, epidermal staphylococcus, pneumococcus, chlamydia, mycoplasma, Legionella and Koch's stick are also susceptible to ciprofloxacin.

Thanks to the action of its two main components, it works well in the treatment of mixed infections, the causative agents of which are the above-mentioned bacteria. Effective in the treatment of gastrointestinal infections (diarrhea, dysentery, etc.).

Both active substances pass the absorption process in the digestive tract. At most in a couple of hours, their concentration in the blood sets in. The half-life of tinidazole lasts up to 14 hours. It actively passes into the cerebrospinal fluid in a volume equivalent to its content in the blood, after which the process of reverse absorption into the kidneys begins. It is exported to bile in the volume of less than half of the clusters in the plasma. About a quarter of the total dose goes with urine. Metabolites are equal to 12% of the intake and go also through the urinary system. An insignificant part of tinidazole is excreted with feces.

Ciprofloxacin is rapidly absorbed in the body. Approximately 70% of the total bioavailability. If the drug was taken with food, the absorption decreases by an average of 30%.

Rapidly spreads in the liquid medium and body tissues. Penetrates the organs of the urinary system. Approximately half of the total volume is absorbed by the liver. The remaining part comes out of the body in its original form in the composition of urine. The rest - with feces. Half-life lasts a little more than four hours. In elderly patients and patients with renal insufficiency, this time may be longer.

Indications for use

What helps? Tsifran ST is used for the purpose of etiotropic therapy, that is, the goal of treatment is the elimination of bacteria and the suppression of the inflammatory process.

Among the list of indications for use, the following conditions are distinguished:

sexually transmitted diseases;
inflammatory processes in the pelvic cavity of a bacterial nature;
infectious processes of the digestive system;
infectious processes occurring in the upper respiratory tract;
pathology of the respiratory system, complicated by bacterial infection;
chronic pathology of the respiratory system during the period of exacerbation;
bacterial processes in the nasopharynx and other pathologies of ENT organs;
pathology of the urinary system;
inflammatory processes of the musculoskeletal system.

The drug is often used as a method of preventing the manifestation of infectious complications in the postoperative period.

Contraindications

Absolute:

combined therapy with tizanidine (associated with the probability of pronounced reduction in blood pressure and development of pronounced drowsiness);
age to 18 years;
pregnancy and the period of breastfeeding;
blood diseases, oppression of bone marrow hematopoiesis;
organic lesions of the nervous system;
acute porphyria;
lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
individual intolerance of the drug components, as well as other fluoroquinolones and imidazoles.

Relative (Tsifran ST is appointed under medical supervision):

mental illness;
marked renal / hepatic impairment;
epilepsy, epileptic syndrome;
disorders of cerebral circulation;
lesions of tendons with previous treatment with fluoroquinolones;
pronounced atherosclerosis of cerebral vessels;
heart disease (myocardial infarction, heart failure, bradycardia);
syndrome of congenital extension of the QT interval;
electrolyte imbalance, including hypokalemia, hypomagnesemia;
combined therapy with drugs that extend the QT interval, including antiarrhythmics of IA and III classes;
combined therapy with inhibitors of CYP4501A2 isoenzymes, including theophylline, methylxanthine, caffeine, duloxetine, clozapine;
elderly age.

Intended use for pregnancy and lactation

Tsifran ST is categorically contraindicated in pregnant women. If it is necessary to prescribe the drug during lactation, breast-feeding should be stopped.

Dosage and route of administration

As indicated in the instructions for use Cyflane CT is taken orally, with enough water, preferably after eating. Chew, break, or otherwise destroy the pill should not be.

Recommended adult dose of Cyfran CT:

250 mg + 300 mg: 2 times a day for 2 tablets;
500 mg + 600 mg: 2 times a day for 1 tablet.

Adverse Reactions

Against the background of taking Tsifran ST tablets, it is possible to develop unwanted reactions from various organs and systems:

Organs of the senses - impaired vision, taste, smell, tinnitus, hearing loss.
The urinary system - the appearance of crystals (crystalluria), blood (hematuria) in the urine, a violation of the process of urination of a different nature, as well as a violation of the functional state of the kidneys and the development of inflammation in them.
The blood system and red bone marrow - a decrease in the number of leukocytes (leukopenia), platelets (thrombocytopenia), erythrocytes (anemia) and a unit of blood volume.
Digestive system - decreased appetite, dryness and appearance of "metallic taste" in the mouth, nausea with periodic vomiting, diarrhea, bloating abdomen, spastic abdominal pain, jaundice, which develops against the background of a violation of the outflow of bile in the hollow structures of the hepatobiliary system.
Cardiovascular system - increased heart rate (tachycardia) with a violation of their rhythm (arrhythmia), decrease systemic arterial pressure (arterial hypotension), which can be accompanied by syncope.
Nervous system - headache, periodic dizziness, fatigue, violation of gait (ataxia) and speech (dysarthria), peripheral nerve damage (peripheral neuropathy), spasms, psychotic reactions, circulatory disturbances in the brain of varying severity, migraine can occur less often.
Allergic reactions - a rash on the skin, its itching, characteristic changes reminiscent of a nettle burn (urticaria), severe necrotic skin reactions (Stevens-Johnson syndrome, Lyell), marked swelling of the soft tissues of the face and external genitalia (angioedema Quincke), severe systemic reaction with a critical decrease in systemic arterial pressure and the development of multiple organ failure (anaphylactic shock).

The appearance of signs of the development of negative pathological reactions is the basis for stopping the use of Tsifran ST tablets and going to the doctor.

Overdose Symptoms

If after the procedure there was vomiting, dizziness, upset stomach, kidney failure, arrhythmia - this is a sure sign of an overdose. The first thing to do is to reduce the amount of the drug contained in the body, making a gastric lavage. You can cause vomiting by pressing your fingers on the root of the tongue.

After these procedures, you must take intestinal sorbents and conduct symptomatic therapy. There is no specific antidote for Cyphrane CT.

special instructions

Before you start using the drug, read the special instructions:

During treatment it is not recommended to take ethanol (the risk of development of disulfiram-like reactions against the background of tinidazole, which is part of the drug).
It is recommended to avoid excessive exposure to sunlight during treatment. If photosensitisation reactions occur, discontinue use immediately.
To avoid the development of crystalluria, the recommended daily dose should not be exceeded, sufficient fluid intake and maintenance of acid urine reaction is also necessary. Causes dark staining of urine, which has no clinical significance.
Patients with epilepsy, seizures in history, vascular diseases and organic brain lesions, in communication with the threat of the development of adverse reactions from the central nervous system, the drug should be prescribed only for vital indications.
If a severe and prolonged diarrhea occurs during or after treatment, the diagnosis of pseudomembranous colitis, which requires immediate withdrawal of the drug and the appointment of appropriate treatment.
If pain occurs in the tendons or when the first signs of tendovaginitis appear, treatment should be stopped.
During the treatment should monitor the picture of peripheral blood.
During treatment, one should refrain from engaging in potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

With the use of tinidazole (imidazole derivative), it is possible (rarely) to develop generalized urticaria, edema of the face and larynx, a decrease in blood pressure, bronchospasm and dyspnea. Therefore, in patients with hypersensitivity to other imidazole derivatives, cross-sensitivity to tinidazole may also develop; development cross-allergic reaction to ciprofloxacin is also possible in patients with hypersensitivity to other fluoroquinolone derivatives. Consider the possibility of cross-allergic reactions.

Compatibility with other drugs

Tinidazole has the ability to increase the effectiveness of indirect anticoagulants. Ciprolofloxacin has the ability to reduce the intensity of the process of microsomal oxidation. Provides a decrease in the effectiveness of indirect anticoagulants. During the reception of the composition, the prothrombin index decreases in the patient. Has the ability to increase the effectiveness of other antimicrobial agents.

During the use of cephalosporin, it is necessary to control the dosage of iron-containing drugs. This need is directly related to the ability of iron to reduce the effectiveness of cephalosporin.

Patient Reviews

We offer you to get acquainted with the opinions of people who used Tsifran ST:

Marina. The dentist has appointed or nominated a preparation, since. after removal of the nerve, the tooth whines. He said that he probably chilled. Although the roentgen revealed nothing. She started to drink. Nausea, dizziness, in the mouth - horror. And salivation increased. All the time I want to eat something to somehow "hammer" an unpleasant taste in my mouth. I drink the third day. But it did not pass, the tooth whines. I do not know if I'll survive for 5 days.
Galina. Have appointed or nominated after a hysteroscopy. Mind you understand that there were no complications, it is necessary to drink, but it is something. The fact that I have a sick GASTROINTESTINAL TRACT is I know, was surveyed, but such impression, that tsitran ST beats on all organism. Without the need to advise you not to take, only a competent doctor's consultation. Hard drug.
Nastya. I met the digit for the first time. After the reception he recalled metronidazole - the same nausea, stomach aches. The doctor said to suffer. It helps, of course, well, but I would not like to face it anymore. For myself, I realized that it is better to drink this drug on an empty stomach, otherwise all food will be in the toilet.

Analogues

Structural analogs for the active substance:

Altsipro;
Afenoxin;
Basijen;
Betaciprol;
Vero-Ciprofloxacin;
Zindolin 250;
Isfipro;
Quintor;
Quipro;
Liprokhin;
Microfleks;
Oftotsipro;
PROCIPRO;
Recipro;
Siflox;
Ceprova;
Ciloxane;
Cipraz;
Ciprinol;
Ciprobay;
Ciprobide;
Ciprobrin;
Citrodox;
Ciprolake;
Tsiprolet;
Ciprolone;
Cipromed;
Cipropane;
Ciprosan;
Ciprosine;
Ciprosol;
Ciprofloxabol;
Ciprofloxacin;
Cytar;
Cifloxinal;
The figure of OD;
Tsifran ST;
Ecocylol.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Shelf life of Tsifran ST tablets is 2 years. They should be stored in the entire factory packaging, dark, dry, inaccessible to children at an air temperature of not more than + 25 ° C.