Trombo ACC

Trombo ACC is an antiaggregant non-steroidal anti-inflammatory drug.

The main active substance of the drug is acetylsalicylic acid. It has antipyretic and anti-inflammatory effect. Also, the drug removes the pain syndrome caused by disturbances in the cardiovascular system of the body. This drug is very quickly absorbed into the blood through the digestive system, but can be metabolized in tissues.

Assign the drug in the event of heart attacks, strokes, thrombosis and after surgical consequences. The drug also participates in preventive treatment of the vascular and cardiac system.

Clinical and pharmacological group

NSAIDs. Antiaggregant.

Terms of sale from pharmacies

Can buywithout a doctor's prescription.

Price

How much does Trombo ACC cost in pharmacies? The average price of tablets is at the level of45 rubles.

Composition and form of release

Trombo ACC is available in the form of film-coated tablets of white color.

The main active substance of the drug Trombo ACC is acetylsalicylic acid.

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Auxiliary substances of Trombo ACC are microcrystalline cellulose, lactose monohydrate, colloidal silicon dioxide, potato starch.

Pharmacological effect

Acetylsalicylic acid is an ester of salicylic acid. Its mechanism of action is based on the inactivation of the enzyme COX-1, the result of which is the blocking of the synthesis of prostacyclin, prostaglandins, thromboxane. Decreased adhesion, platelet aggregation and slowed the formation of blood clots. It increases the fibrinolytic activity of plasma, reduces the concentration of coagulation factors.

The antiaggregant effect of acetylsalicylic acid is most expressed in platelets, since they can not re-synthesize COX. Antiaggregant effect appears after taking the drug in low doses and after a single dose remains for a week. This action of the drug is used for the therapy and prevention of IHD, myocardial infarction, complications of varicose veins.

The drug has anti-inflammatory, analgesic and antipyretic effects.

Indications for use

Tablets Trombo ACC are prescribed to patients as the main agent or as part of complex therapy for the treatment and prevention of the following conditions:

prevention of deep vein thrombosis;
prevention of thromboembolism after surgical interventions on vessels (coronary artery bypass grafting, stent placement in coronary arteries, angioplasty);
prevention of acute myocardial infarction (primary) for patients at risk - those with diabetes mellitus, hypercholesterolemia, hypertension, obesity;
treatment and prevention of angina attacks;
prevention of ischemic stroke with blockage of lumens of large blood vessels by atherosclerotic plaques;
prevention of cerebral circulation disorders by ischemic type.

Contraindications

The drug can not be started on its own, relying on their own feelings and well-being. The Trombo ACC tablets have a number of contraindications:

co-administration with methotrexate at a dose of 15 mg per week or more;
bronchial asthma caused by the treatment with salicylates and other non-steroidal anti-inflammatory drugs;
age is less than 18 years;
I and III trimesters of pregnancy;
lactation period;
chronic heart failure (NYHA class III-IV functional class);
hepatic insufficiency with pronounced symptoms (class B and higher on the Child-Pugh scale);
renal failure with pronounced symptoms (with creatinine clearance of 30 ml / min or less);
gastrointestinal bleeding;
lesions of the gastrointestinal tract of an erosive-ulcerative nature (in acute phase);
hemorrhagic diathesis;
glucose-galactose malabsorption, lactase deficiency and lactose intolerance;
increased sensitivity to the active substance or ancillary components of the drug, as well as other non-steroidal anti-inflammatory drugs (NSAIDs).

With care, Trombo ACC is prescribed for hepatic insufficiency (below grade B in accordance with the Child-Pugh scale), renal failure (QC greater than 30 ml / min), gastrointestinal bleeding or peptic ulcer of the stomach or duodenum (in the anamnesis), chronic diseases of the respiratory system, bronchial asthma, polyposis of the nose, hay fever, gout, allergies to medications (including antirheumatic and anti-inflammatory drugs, analgesics, NSAIDs), with the expected surgical intervention (including a minor, for example, tooth extraction), in the second trimester of pregnancy.

Intended use for pregnancy and lactation

The use of salicylates in high doses in the first 3 months of pregnancy is associated with an increased frequency of fetal development defects (split upper skies, heart defects). The use of salicylates in the first trimester of pregnancy is contraindicated.

In the third trimester of pregnancy salicylates in high dose (more than 300 mg / day) cause inhibition of labor, premature closure of the arterial duct in the fetus, increased bleeding in the mother and fetus, and the appointment immediately before childbirth can cause intracranial hemorrhages, especially in premature infants. The use of salicylates in the III trimester of pregnancy is contraindicated.

In the second trimester of pregnancy, salicylates can only be used with strict risk and benefit estimates for the mother and fetus, preferably at doses not exceeding 150 mg / day and for a short time.

Salicylates and their metabolites are excreted in small amounts with breast milk. The accidental intake of salicylates during lactation is not accompanied by the development of adverse reactions in the child and does not require the cessation of breastfeeding. However, with prolonged use of the drug or its use in a high dose, breastfeeding should be stopped immediately.

Dosage and route of administration

As indicated in the instructions for use Thrombone ACC is preferably taken before eating, squeezed large amounts of liquid. Do not take on an empty stomach.

Primary prevention of acute myocardial infarction in the presence of risk factors: 50-100 mg / day.
Secondary prevention of myocardial infarction, angina pectoris: 50-100 mg / day.
Prevention of stroke and transient disorders of cerebral circulation: 50-100 mg / day.
Prevention of thromboembolism after surgery and invasive vascular interventions: 50-100 mg / day.
Prevention of deep vein thrombosis and thromboembolism of the pulmonary artery and its branches: 100-200 mg (2 tab.) / Day.

The drug is intended for long-term use. The duration of therapy is determined by the doctor.

Adverse Reactions

As a rule, the tablets are well tolerated by patients. Negative reactions are observed only in rare cases.

The following undesirable side effects are known when taking the drug:

digestive system: vomiting, nausea, heartburn, pain in the abdomen;
CNS: tinnitus, dizziness, hearing loss;
allergy: cardio-respiratory distress syndrome, rash, urticaria, rhinitis, itching, Quincke's edema, nasal mucus edema, bronchospasm, severe allergic
reactions, for example, anaphylactic shock;
hematopoiesis system: increased frequency of bleeding and bruising during and after operations. They can cause acute or chronic anemia with the corresponding symptoms.

In rare cases, the use of the drug can lead to gastric ulcer and duodenal ulcer, as well as transient violations of the liver with an increase in the activity of liver transaminases.

Overdose

The consequences of an overdose of thrombotic ACC are particularly serious in elderly patients and children.

In case of an overdose of mild to moderate severity (once less than 150 mg / kg) dizziness occurs, tinnitus, hearing loss, increased sweating, nausea and vomiting, headache, confusion, tachypnea, hyperventilation, respiratory alkalosis.

It shows gastric lavage, repeated intake of activated carbon, forced alkaline diuresis, restoration of water-electrolyte balance and acid-base state.

At moderate (150-300 mg / kg) and severe (more than 300 mg / kg) severity of poisoning, respiratory alkalosis with compensatory metabolic acidosis, hyperpyrexia, hyperventilation, noncardiogenic pulmonary edema, respiratory depression, asphyxia. From the cardiovascular system there is a violation of the heart rhythm, expressed hypotension, depression of cardiac activity. Also, dehydration, impaired renal function from oliguria up to the development of renal failure (hypokalemia, hypernatremia, hyponatremia) has been documented. From metabolic disorders, there is hyperglycemia, hypoglycemia, ketoacidosis. From the side of the hearing organ, noise in the ears or deafness is possible. In addition, there are gastrointestinal bleeding, hematologic disorders, prolonged prothrombin time, hypoprothrombinemia, toxic encephalopathy, suppression of CNS function.

The condition requires immediate hospitalization and emergency therapy. Gastric lavage, repeated intake of activated carbon, forced alkaline diuresis, hemodialysis, restoration of water-electrolyte balance and acid-base state, symptomatic therapy.

special instructions

Before you start using the drug, read the special instructions:

The drug should be used after the appointment of a doctor.
Overdose is especially dangerous in elderly patients.
The combination of acetylsalicylic acid with anticoagulants, thrombolytic agents and antiaggregant drugs is accompanied by an increased risk of bleeding.
Acetylsalicylic acid in low doses can provoke the development of gout in predisposed individuals (having decreased uric acid excretion).
The combination of acetylsalicylic acid with methotrexate is accompanied by an increased incidence of side effects from the hematopoiesis.
Acetylsalicylic acid in high doses has a hypoglycemic effect, which must be borne in mind when prescribing the drug patients with diabetes, receiving hypoglycemic agents for oral administration (derivatives of sulfonylureas) and insulin.
When combined appointment of GCS and salicylates should be remembered that during treatment, the level of salicylates in the blood is reduced, and after the abolition of SCS, an overdose of salicylates is possible.
The combination of acetylsalicylic acid with ibuprofen is not recommended in patients with an increased risk of cardiovascular disease, since the latter reduces the positive effect of acetylsalicylic acid on life expectancy, i.e. reduces the cardioprotective effect of acetylsalicylic acid.
Excess dose of acetylsalicylic acid is associated with a risk of gastrointestinal bleeding.
Acetylsalicylic acid can provoke bronchospasm, as well as cause attacks of bronchial asthma and other reactions of hypersensitivity. Risk factors are the presence of bronchial asthma in history, hay fever, nasal polyposis, chronic diseases respiratory system, as well as allergic reactions to other drugs (eg, skin reactions, pruritus, urticaria).
The inhibitory effect of acetylsalicylic acid on platelet aggregation persists for several days after administration, in this regard, an increased risk of bleeding during surgery or in the postoperative period. If absolute elimination of bleeding is necessary in the course of surgery, the possibility of completely abandoning the use of acetylsalicylic acid in the preoperative period.
When combined with acetylsalicylic acid and ethanol (beverages containing alcohol), the risk of damage to the mucous membrane of the gastrointestinal tract and prolonging the time of bleeding is increased.

During the treatment period, care must be taken when driving vehicles and engaging in potentially hazardous activities requiring increased concentration of attention and speed of psychomotor reactions, because the use of the drug Trombo ACC can cause dizziness.

Interaction with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

The drug weakens the activity of uricosuric medicines.
Glucocorticoids increase the degree of excretion of the drug and weaken its therapeutic activity.
The combination of acetylsalicylic acid in ethanol leads to the development of an additive effect.
Simultaneous administration of the drug with thrombolytics, anticoagulants and antiplatelet drugs increases the likelihood of various bleeding.
The combination of Trombo Ass with methotrexate, heparin, digoxin, hypoglycemic agents, indirect anticoagulants and valproic acid leads to an increase in the activity of these medicines.

Reviews

We offer you to read reviews of people who used Trombo ACC:

Catherine. Even if the medicine is prescribed to you by a doctor, I advise you to read Trombo ACC - indications for use. My doctor at the appointment of a medicine did not consider that I have a contraindication to his admission and even the presence of a threat of thromboembolism will not make me drink this remedy. To reduce the risk of thrombosis I refused to smoke, drink plenty of water and herbal decoctions.
Zinaida. The intake of these pills is quite convenient, since you only need to take it once a day, one tablet, before eating. Therefore I take before breakfast. I was prescribed a thrombol by the doctor when I saw that I had a lot of blood on the tests. And this can cause thrombosis. But now I'm more relaxed, I have been drinking two courses, and I have become much more bloody, so the tests showed. But the doctor urged now at least twice a year to drink these pills, as a preventive measure.
Alina. My elderly mother has diabetes, obesity and gout. Recently, they learned that these diseases increase the risk of thrombosis, so they started taking blood-thinning pills. Without consulting a doctor, I do not advise doing this, since not all the drugs have good compatibility (sometimes their interaction leads to deterioration). TromboAC approached us.

Analogues

Structural analogs for the active substance:

Anopyrine;
ASA cardio;
Aspicor;
Aspen;
Aspinate 300;
Aspen Cardio;
Aspirin;
Aspirin Cardio;
Acercar;
Acentene;
Acetylsalicylic acid;
Acetylsalicylic acid Cardio;
Acylpyrine;
Acsbyrin;
Bufferin;
Zorex Morning;
Cardi ASK;
Collorite;
Myristin;
Plolidol 100;
Plolidol 300;
Taspir;
Thrombogard 100;
Thrombopol;
Walsh Asalgin;
Upsarin of the UPSA;
Hack el-Payne.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Thrombo Ass should be stored in a place that is restricted from access to children's equipment, direct sunlight and moisture at room temperature (up to 25 ° C).

Shelf life - 3 years.