Tioctacide BV

Tioctacid 600 T - a metabolic drug that regulates lipid and carbohydrate metabolism, has an antioxidant effect.

In addition, it has the properties of a hepatoprotector and is involved in the regulation of metabolism and energy at the cellular level

Indications for the treatment of Tioctacid are clinical manifestations in patients with diabetes mellitus, peripheral polyneuropathy. Thioctic acid protects the cell from the toxic "encroachments" of free radicals formed during metabolic processes.

Clinical and pharmacological group

A drug with an antioxidant effect regulating carbohydrate and lipid metabolism.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Tioctacide cost in pharmacies? The average price is at the level of2 000 rubles.

Composition and form of release

Tioctacide is produced in the following dosage forms:

Film-coated tablets (Thiocytase BV (rapid release)): biconvex, oblong, yellow-green (30, 60 or 100 pcs. Each). in dark glass bottles, 1 bottle in a cardboard bundle);

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The tablets covered with a cover (Tioctacid 600): biconcave, yellow with a greenish shade of color (on 30 pcs. in dark glass bottles, 1 bottle in a cardboard bundle);
Solution for intravenous administration (Tioctacid 600 T): yellowish color, transparent (24 ml in dark glass ampoules, 5 ampoules in contour cells, 1 or 2 packs in a cardboard bundle).

Composition 1 tablet Thiocacid 600:

Active substance: thioktovaya (α-lipoic) acid - 600 mg;
Auxiliary components: magnesium stearate, hydroxypropyl cellulose, low-substituted hydroxypropylcellulose, dioxide titanium, hypromellose, macrogol 6000, aluminum salt of quinoline yellow, aluminum salt of indigo carmine, talc.

Composition 1 tablet Thiocytac BV:

Active substance: thioktovaya (α-lipoic) acid - 600 mg;
Auxiliary components: low-substituted giprolose - 157 mg; giprolose - 20 mg; magnesium stearate - 24 mg;
Film coat: Macrogol 6000 - 4.7 mg; hypromellose - 15.8 mg; titanium dioxide - 4 mg; talc - 2.02 mg; aluminum lacquer based on indigocarmine - 0.16 mg; Aluminum lacquer based on dye quinoline yellow - 1.32 mg.

Composition 1 ampoule solution for intravenous administration of Thiocacid 600 T:

Active substance: thioktovaja (alpha-lipoevaja) acid - 600 mg (in the form of tioktata trometamola);
Auxiliary components: trometamol, water for injection.

pharmachologic effect

The active substance in all forms of release is thioctic (alpha-lipoic) acid. Its concentration in one ampoule or tablet is 600 mg. This is a compound of endogenous origin, which is normal for every person. Thioctic acid takes part in vital biochemical reactions and performs the role of coenzyme in the process of oxidative decarboxylation of keto acids.

At a diabetes mellitus at the person exchange products which lead to deterioration of a blood flow in nervous tissue, occurrence of sites of a hypoxia and an ischemia accumulate. This is accompanied by increased formation of free radicals, which as a result leads to damage to the peripheral nerve. Thioctic acid prevents the pathological processes described above. It helps to reduce the number of harmful metabolic products, improve blood flow inside the nervous tissue, increase the level of antioxidants and slow down destructive processes.

After the course of treatment with Tioctacid, peripheral nerve functionality is improved, which leads to restoration of sensory sensations that have been disturbed. Thioctic acid is capable of neutralizing toxic compounds that have entered the body in an exogenous way.

The technology for the production of Tioctacide tablets provides a rapid release of the active ingredient. Alpha-lipoic acid is rapidly absorbed into the blood and distributed to the tissues of the body. However, oral bioavailability is much lower. Than with intravenous administration of the drug. In addition, thioctic acid enhances the action of insulin and increases the utilization of glucose, which also helps to inhibit destructive processes in tissues in diabetes mellitus.

Thus, the drug has the following effect:

Lipid-lowering.
Hepatoprotective.
Hypocholesterolemic.
Hypoglycemic.
Neurotrophic.

Indications for use

Indications for the use of Tioctacid 600 are:

diabetic and alcoholic polyneuropathy,
hyperlipidemia,
fatty degeneration of the liver,
cirrhosis of the liver and hepatitis,
intoxication (including salts of heavy metals, pale toadstool),
treatment and prevention of coronary atherosclerosis.

Contraindications

Tioctacide is contraindicated for use in the presence of the following diseases or conditions in a person:

Pregnancy;
Breast-feeding;
The age is under 18 years;
Hypersensitivity to thioktric acid or auxiliary components of the drug.

Dosage and route of administration

As indicated in the instructions for use Tioctacide BV 600 mg taken on an empty stomach inside, 0.5 hours before breakfast, swallowing whole and with enough water.

Recommended dosing: 1 pc. 1 per day.

Given the clinical feasibility, for the treatment of severe forms of polyneuropathy, the initial administration of a solution of thioctic acid for intravenous (Tioctacid 600 T) for a period of 14 to 28 days, followed by the transfer of the patient to the daily intake of the drug inside (Thiocytase BV).

Side effects

Against the background of using Tioctacide BV, patients may develop some side effects:

Immunological reactions - skin rash, itching, hives, angioedema and anaphylactic shock in severe cases;
from the side of the nervous system - headaches, taste changes at the receptor level;
on the part of the digestive system - abdominal pain, nausea and vomiting, bloating, increased gas production, diarrhea;
hypoglycemia and the appearance of characteristic clinical symptoms - rapid heart rate, hunger, increased sweating, dizziness, tremor of extremities.

If side effects occur, the patient should stop taking the pills and consult a doctor for advice.

Overdose

Symptoms: against the background of a single dose of 10-40 g of thioctic acid, it is possible to develop severe intoxication with such manifestations as generalized convulsive seizures, hypoglycemic coma, severe acid-base balance disorders, lactic acidosis, severe clotting disorders (including fatal outcome).

Treatment: if suspicion of an overdose of Tioctacid BV (a single admission of adults is more than 10 tablets, the child - more 50 mg per 1 kg of his body weight), the patient needs immediate hospitalization with the appointment of symptomatic therapy. If necessary, anticonvulsant therapy, urgent measures aimed at maintaining the functions of vital organs are used.

special instructions

Treatment of diabetic polyneuropathy should be conducted against the background of maintaining the optimal concentration of glucose in the blood.

The use of alcohol is a risk factor for the development of polyneuropathy and may reduce the effectiveness of Tioctacid BV, therefore patients should refrain from taking alcoholic beverages both during drug treatment and during periods outside of treatment.

Due to the fact that thioctic acid binds metals, and tablets Tioctacide BV take 30 minutes before breakfast, preparations containing metals should be taken at lunch or in the evening. For the same reason, during the treatment with Tioctacid BV, the use of dairy products is recommended only in the afternoon.

Interaction with other drugs

Ethanol and its metabolites weaken the action of thioctic acid.

With the simultaneous administration of thioctic acid and cisplatin, cisplatin is less effective.

Thioktic (α-lipoic) acid binds metals, so do not prescribe concurrently with preparations containing metals (for example, preparations of iron, magnesium, calcium). If Tioctacide BV is taken 30 minutes before breakfast, then preparations containing iron or magnesium can be taken in the afternoon or evening.

With the simultaneous use of thiectic acid and insulin or oral hypoglycemic drugs, their effect may be enhanced, therefore, regular monitoring of blood glucose levels is recommended, especially at the beginning of thioctic acid therapy. In some cases it is permissible to reduce the dose of hypoglycemic drugs in order to avoid the development of symptoms of hypoglycemia.

Reviews

We offer you to get acquainted with the opinions of people who used the drug Tioktatsid:

Alina. I liked the facility. And the price is quite adequate for a packing of 100 tablets, and, directly, the result - already in the first week of receiving improvements in well-being felt (appointed in connection with obesity), and then the tests were pleased with a noticeable decrease in the level of cholesterol in the blood.
Marina. I would like to share my experience, that's when my health worsened and I passed the tests, it turned out that I have increased cholesterol. Of course, the doctor immediately put me on a diet, and also recommended taking Tioctacide BV, he is on the basis of a-lipoic acid, as I explained that this drug displays harmful saturated fatty acids. And I must say that my state of health actually improved, and soon the cholesterol values came back to normal, plus the weight is normal now.
Jeanne. When I was losing weight I took Tioctacide BV, there was an initial stage of obesity, but now the situation has already leveled. The level of sugar in the blood has decreased, plus the drug accelerates the conversion of carbohydrates energy, you do not really feel hunger, and in the literal sense of the word you forget about food. And on scales, the arrow in the meantime crawls down))) I still have extra weight, but before summer I will deal with it.