How does it feel after Anafranil: instructions for use and reviews

Anaphranil is an antidepressant that has antihistamine, anticholinergic, and antiserotonergic properties.

It is prescribed for psychomotor retardation, anxiety, depressed mood and other typical appearances of the depressive syndrome. Has a specific effect on obsessive-compulsive disorders.

On this page you will find all information about Anaphranil: the full instructions for use for this medicine medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Anaphranil. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antidepressant.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Anafranil? The average price in pharmacies is at the level of350 rublesfor pills. Solution for injection 25 mg, 10 ampoules:640-750 rubles.

Form of issue and composition

The preparation is produced in this form:

1. Anafranil 25 mg, tablets No. 10, 30. Light yellow, biconvex, round.
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2. Anafranil 75 mg, tablets. Pink, in the form of capsules, biconcave, with an engraved strip on both sides, on one side of the "C / G "G / D" - on the other. They are sold in blisters, in a cardboard box. In each blister is 10 pieces.
3. A solution for intravenous or intravenous administration of 25 mg, ampoules. Colorless, transparent. For sale in cardboard packs of 10 pieces.

Pharmacological effect

An active component of Anafranil is clomipramine, an antidepressant with a pronounced sedative and moderate analgesic effect. According to some reviews, Anafranil is characterized by its ability to relieve depression, anxiety, and disinhibition.

The drug helps with eating disorders such as bulimia, which can be accompanied by depression. Manifestations of the depressed state of the nervous system begin to subside a week after the start of treatment. Anaphranil is undesirable to prescribe to patients with narcoleptic drowsiness: in this case the medicine proves to be ineffective.

Indications for use

Application of anaphranil to adults is required when:

• Chronic pain syndromes;
• Phobias and panic attacks;
• Depressive states of various origins;
• Obsessive-compulsive syndromes;
• Dissociative disorders;
• Cataplexy accompanying narcolepsy.

Children and adolescents Anafranil is shown at:

• Obsessive-compulsive syndromes;
• Night enuresis.

Treatment of nocturnal enuresis is performed only in children older than 5 years. Preliminary it is necessary to exclude the organic causes of the disease and establish the ratio of potential benefit and risk to the child.

At present, the safety and efficacy of Anafranil in children and adolescents in the treatment of depressive conditions, phobias, panic attacks and chronic pain syndrome. Therefore, with such indications, the drug is not recommended for patients under the age of 17 years.

Contraindications

The drug is not prescribed:

• pregnant and lactating women;
• when taking MAO inhibitors (two weeks before and after), MAO-A inhibitors of reversible action;
• with allergy to tricyclic antidepressants, dibenzazepine or clomipramine groups;
• if a recent myocardial infarction occurred;
• children under 5 years;
• with the syndrome of prolongation of the QT interval.

Care should be taken:

• Persons with cardiovascular insufficiency or arrhythmia;
• with glaucoma or urinary retention;
• people who are prone to constipation, especially for bedridden or elderly people;
• with serious liver disease or hyperthyroidism;
• To old people;
• adolescents;
• with traumas of the brain;
• with epilepsy;
• when the drug is combined with antipsychotics;
• with a tumor of the adrenal medulla;
• with neuroblastoma or pheochromocytoma.

When using the drug, you should constantly monitor blood pressure, monitor intraocular pressure.

If the patient uses contact lenses, remember that the drug can reduce the intensity of tearing. This can damage the cornea.

Particular care should be taken with intravenous administration of the drug, to avoid the occurrence of anaphylactic shock.

Application in pregnancy and lactation

Instructions for use Anafranil

The instructions for use indicate that Anafranil tablets are taken with or after meals. This will prevent irritation of the mucosa. The introduction of the solution is carried out in / in, / m. Therapy is carried out by minimally effective dosages.

In elderly patients, the initial dose is 10 mg / day. Then gradually, approximately for 10 days, the daily dose of the drug is raised to the optimal level, which is 30-50 mg.

Side effects

The use of anaphranil may cause the following side effects:

• The system of hematopoiesis: agranulocytosis, leukopenia, thrombocytopenia, eosinophilia, purpura;
• Hypersensitivity reactions: systemic anaphylactoid reactions, allergic alveolitis with or without eosinophilia;
• Sensory organs: noise in the ears, a violation of taste sensations;
• Cardiovascular system: palpitations, sinus tachycardia, orthostatic hypotension, increased blood pressure, arrhythmias, minor changes in the ECG, intracardiac conduction disorders;
• Digestive system: nausea, vomiting, diarrhea, abdominal discomfort, anorexia, hepatitis, elevation of liver enzymes;
• Skin reactions: skin allergies (photosensitivity, urticaria, rashes, itching), swelling, alopecia;
• Endocrine system: a violation of potency and libido, weight gain, swelling of the mammary glands, galactorrhea, syndrome of inadequate reaction of antidiuretic hormone;
• Central and peripheral nervous systems: a feeling of fatigue, drowsiness, increased appetite, anxiety, disorientation, confusion, hallucinations, agitation, anxiety, depersonalization, manic state, tremor, headache, delirium, paresthesia, increased muscle tone, ataxia, convulsions.

Overdose

Manifestations of an anaphranil overdose regrow after 4 hours after excessive use. These include:

• drowsiness, insomnia, confusion, anxiety;
• rigidity (stiffness) of muscles, ataxia, stupor;
• seizures of an epileptic nature;
• failures of intracardiac conduction, rapid rhythm.

Signs of poisoning last for four to six days. According to a number of reviews about Anafranil, a large dosage can cause vomiting, lack of urination, severe sweating. Sometimes there is a dilated pupil, dyspnea, oppression of the respiratory process.

Therapy in case of an overdose Anafranil is carried out in several ways:

• If Anafranil was taken in tablets, the patient should be washed with a stomach, then the activated charcoal should be prescribed;
• with severe poisoning with anaphranil: artificial ventilation of the lungs, cholinesterase inhibitors, anticonvulsant measures. Such methods as diuresis, hemodialysis, are considered ineffectual.

special instructions

1. Caution should be exercised if the patient has a predisposition to constipation.
2. Taking antidepressants increases the likelihood of suicidal thoughts, attempts at suicide. This should be remembered by family members and the patient's environment (guardians). Similarly, if such inclinations have not previously been observed in the patient, then the drug should be discontinued.
3. During treatment, it is possible to change the level of leukocytes, in connection with this you need to monitor blood levels.
4. In people predisposed to psychosis and older people, the drug can cause nightly delirious psychoses. After discontinuation of the medication, side effects of this kind pass.
5. Patients with panic attacks during the first days of treatment may experience deterioration, as a rule, well-being is adjusted in a week.
6. Combine the drug with electroconvulsive therapy is only in the case of careful monitoring of the patient's well-being.

At the time of prescription, the minimum number of tablets needed at the time should be indicated to avoid accidental overdose by the drug.

Drug Interactions

It should be remembered that:

1. If it is necessary to appoint fluoxetine, between taking this drug and anaphranil should take 2-3 weeks minimum.
2. It is advisable not to take diuretics during the course.
3. Anaphranil can enhance the effect of anticholinergics on the central nervous system, eyes, bladder, intestines (atropine, biperidine, antihistamines, antiparkinsonian drugs).
4. Do not administer together or immediately after the withdrawal of MAO inhibitor drugs.
5. Anaphranil inhibits the action of batanidine, guanethidine, rubber, alfamethyldopa, clonidine.
6. Before anesthesia, a specialist should be warned about the drug treatment.
7. Do not take with drugs that extend the QT interval.
8. Do not use with other drugs that inhibit the action of Anafranil (back seize serotonin and norepinephrine).
9. LS can enhance the influence of sympathomimetic drugs on CAS (epinephrine, norepinephrine, ephedrine, phenylethrin).

The drug can enhance the effects of alcohol and other CNS-oppressors.

Reviews of people about the drug Anafranil

We made a selection of reviews, in them people tell how they felt after taking Anafranil:

1. Hello everybody! I do not know if my experience will be useful, but I will share it. I take this drug for a lifetime - 25 years. 1 \ 4 for the night. It was good. But the orgasm was gone completely, it was a problem. Although depression is still a big problem. After 10 years, I refused it, there was no withdrawal syndrome, but after 1 year 3 months I stopped sharply, moved, holding on to the walls, in the head-the crap instead of the brains, where the floor, where the ceiling is not clearly, features a strong distorted. Urgently appointed him again. And then everything passed away. So, apparently, the drug is not just bad - terrible. Now such sweating that I do not leave the house. Fortunately, that's retired. Almost all the pimples are my, and this is already a whole illness. There is no life. And I'm afraid to throw it again - I do not want to repeat the situation when in general you stop being a normal living being. I do not know what to do ...
2. I pulled out the roads on the floor from the other world and these are not empty words. In its 30 years, fate presented a gift in the form of ROC. For 6 months, OCD was driven into a severe depression with all the severe consequences (insomnia-did not close eye for about 8 days and this is not an exaggeration, I realized that this is possible, then on this background thoughts about suicide). In general, I surrendered to a good doctor who prescribed me truksal and anafranil, after a month the dream was restored and anafranil I drink already 6 months... Has absolutely forgotten about by-effects of a preparation on the first month of reception, in general suffer or bear and will be to you happiness!

Reviews about Anafranil in the forums are good. The tool helps to cope with obsessive thoughts and ideas,depression, returns patients the will to live. However, the drug has a mass of side effects and it is only the doctor who is entitled to prescribe it.

Analogues

Analogues of the agent are Anafranil SR, Clominal, Clofranil and Clomipramine.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Keep out of the reach of children at a temperature not exceeding 30 ° C. Shelf life - 5 years.

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