Monural - an antibiotic for the treatment of cystitis

Monural (MONURAL, the generic international name Fosfomycin) is a broad-spectrum antibiotic.

The drug belongs to the group of uroantiseptics, the main purpose of which is the treatment and prevention of inflammatory bacterial diseases of the urinary tract. The drug has a good bactericidal effect, which is applicable to most gram-positive (enterococcus, staphylococcus) and gram-negative (cytobacteria, enterovirus, klebsiella, morganella, proteus, pseudomonas) pathogens.

Advantageous distinctive advantage of Monural from other drugs is its one-time appointment, with acute cystitis. For the course of treatment, only one sachet is enough. Such a dosage scheme relieves patients from the need to take other antibiotics for several days.

Clinical and pharmacological group

Antibiotic group of phosphonic acid derivatives. Uroantiseptic.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does the Monural cost? The average price in pharmacies is at the level of470 rubles.

Form of issue and composition

They produce Monural in the form of granules, from which a solution for oral administration is prepared: white, with a tangerine smell (in multi-layered laminated packages, in a cardboard bundle 1 package).

• The active ingredient is phosphomycin trometamol: in a package - , 54 g (including phosphomycin - 2 g) or , 31 g (including phosphomycin - 3 g).

Auxiliary components: sucrose, saccharin, orange and tangerine flavors.

Pharmacological effect

Monural is a broad-spectrum antibiotic.

The drug has a bactericidal effect, suppresses the first stage of bacterial cell wall synthesis. Monural is a structural analogue of phosphoenol pyruvate. Can enter into a competitive interaction with the enzyme N-acetyl-glucosamine-3-o-enolpyruvil-transferase. As a result, specific, selective and irreversible inhibition of this enzyme occurs, which ensures the absence cross-resistance with other classes of antibiotics and the possibility of synergism with other antibiotics.

The drug is active against most Gram-positive and Gram-negative microorganisms.

Indications for use

What helps? Monural is used in the following varieties of cystitis:

1. Acute infectious cystitis with a slight secretion of bacteria with urine (bacteriuria);
2. Chronic infectious cystitis;
3. Chronic posttraumatic cystitis with bacteriuria;
4. Cystitis in pregnancy;
5. Postoperative cystitis.

Assign Monural for cystitis 3 g (1 sachet) per day for 1-2 days (depending on the severity of the process).

Contraindications

The drug is not prescribed:

• at allergic reactions to phosphomycin or other components;
• patients with severe renal failure;
• children under five.

Use in pregnancy and lactation

In pregnancy, the appointment of Monural is carried out only on strict indications (under the condition of massive bacteriuria and the absence of effect from other therapy).

In cases where the drug is taken during lactation, breastfeeding should be abandoned.

Dosage and route of administration

In the instructions for use indicated that appoint Monural to adults 3 grams 1 time / day. The course of treatment is 1 day. If necessary (with severe or recurrent infections, the elderly) it is possible to re-take the drug at a dose of 3 g after 24 hours.

In order to prevent infection of the urinary tract with surgical intervention, transurethral diagnostic procedures, the drug is taken at a dose of 3 g for 3 hours before the intervention and 3 g at 24 hours after the first dose.

Children over the age of 5 yearsthe drug is prescribed in a dose of 2 g only once.

When the drug is prescribedpatients with renal insufficiencyshould reduce the dose and increase the interval between doses.

Before taking the granules, dissolve in 1/3 cup of water. The drug is taken 1 time / day on an empty stomach 2 hours before or after meals (preferably before going to bed), previously emptying the bladder.

Side effects

Side effects of the drug may manifest itself in the form of such reactions of the body:

1. Allergic reactions in the form of skin rashes and itching.
2. From the gastrointestinal tract - nausea, vomiting, heartburn, diarrhea. With a plentiful drink, these phenomena usually disappear.

Overdose

The risk of developing an overdose of Monural is minimal.

Therapy: forced diuresis.

special instructions

When appointing Monural to patients with diabetes should take into account that in 1 package containing 2 g of phosphomycin, contains 2.1 g of sucrose, and in 1 packet containing 3 g of phosphomycin - 2. 213 g of sucrose.

Before you start taking Monural, tell your doctor if:

• you are allergic to any part of the medicine;
• you have ever had asthma or liver disease;
• if you are pregnant, breastfeeding or expecting to be pregnant;
• you are taking any medications, especially Cisapride (Propulside) and metoclopramide (Cerucal), as well as over-the-counter drugs, herbs, nutritional supplements and vitamins.

It should also be borne in mind that monoral can enhance diarrhea, although diarrhea in the patient is usually not an obstacle to the appointment of this drug.

Drug Interactions

With simultaneous use with metoclopramide, a decrease in the concentration of phosphomycin in serum and in urine (this combination is not recommended).

Reviews

We picked up some reviews of women who took the drug Monural for the treatment of cystitis:

1. Love. So that without relapses Monural can not cope, he as they say "here and now" removes inflammation, but it is better in a pair with Uroprofit to accept, that relapses did not happen, and it is desirable periodically prophylaxis by the same uroprofit. there are cranberries, horsetail, bearberry and vitamin c, it will strengthen the bladder. I did so - Monural + Uprophyte, then I switched to the prophylactic reception of Uprophyte, and as a result, the relapses of cystitis stopped. Now, once a year, the Uroprophy course is for maintaining the bladder, there are no relapses of cystitis, everything is OK).
2. Oksana. Many argue that treating cystitis is not recommended by antibiotics, which we usually treat other infections. After their use, strains are formed, because of which the body becomes not sensitive at all to antibiotics. To prevent this from happening, cystitis should be treated with Monural, it acts on the E. coli in the bladder and kills all the bacteria there. It always helps me quickly and quickly.
3. Anna. The first time I got myself a cystitis... I suffered a couple of days, the menstruation began... the cystitis did not seem to be) then a week later everything returned and the seizures were several times stronger and more painful, even though climbing to the wall! accepted the Monural, everything is clear according to the instructions... yes, diarrhea, unpleasant sensations, but for my happiness the pain stopped on the next day!

Analogues

Antibacterial agent for the treatment of inflammatory diseases of the genitourinary system is selected by a nephrologist or urologist. The optimal option - with intolerance of the drug Monular find structural analogues with maximum antimicrobial activity.

Effective formulations:

• Forteraz.
• Cystoral.
• Fosmicin.
• Espa-Focine.

Drugs that are similar in effect:

• Nitroxoline.
• Dioxydin.
• Zivox.
• Amisolid.
• Cubicin.
• Zeniks.
• 5-NOC.

Before using analogues, consult your doctor.

Which is better: Nolitsin or Monural?

Nolitsin is a quinolone bacterial agent with a broad spectrum of action that is used to treat infectious diseases upper and lower parts of the urinary tract (complicated or uncomplicated, taking place in acute or chronic form).

Indications for its use are pyelitis, pyelonephritis, cystitis, chronic prostatitis, associated with urological operations of an infectious disease character, neurogenic bladder, as well as nephrolithiasis caused by agents that are sensitive to Norfloxacin (the active substance of Nolicin).

The course of treatment with Norfloxacin lasts - depending on the severity of the patient's condition and the nature of the course of the disease - from 3-5 days (with uncomplicated cystitis) to several weeks (with chronic form of bacterial prostatitis).

Unlike Monural, Nolycin can not be used in pediatrics and in pregnant women.

Storage conditions and shelf life

Store for 3 years from the date of manufacture, at a temperature not exceeding 25 ° C, out of the reach of small children.

How to choose probiotics for the intestine: a list of drugs.

Effective and inexpensive cough syrups for children and adults.

Modern non-steroidal anti-inflammatory drugs.

Review of tablets from the increased pressure of the new generation.

Antiviral drugs are inexpensive and effective.