Arthrosilen: gel, spray, injections and pills, instructions for use

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  • 1Arthrosilen - instructions for use, price and analogues of the drug
    • 1.1What is Arthrosilen
    • 1.2Composition
    • 1.3Form of issue
    • 1.4Instructions for use Arthrozilene
    • 1.5Gel
    • 1.6Puncture
    • 1.7Candles
    • 1.8Aerosol
    • 1.9Side effects
    • 1.10Contraindications
    • 1.11Analogues
    • 1.12Price Arthrosilen
  • 2Arthrosilen: reviews, instruction and analogues of Gel, Spray, Nyxes, Capsules
    • 2.1How the drug works
    • 2.2Form of the preparation
    • 2.3In what cases is the drug used
    • 2.4Who is contraindicated with the drug
    • 2.5Manifestation of side effects
    • 2.6How the drug interacts with other drugs
    • 2.7The preparation and its analogues
    • 2.8Application and dosage
  • 3Arthrosilen
    • 3.1Composition
    • 3.2Form of issue
    • 3.3pharmachologic effect
    • 3.4Pharmacodynamics and pharmacokinetics
    • 3.5Indications for use
    • 3.6Contraindications for use
    • 3.7Side effects
    • 3.8Instructions for use Arthrosilen (Method and dosage)
    • 3.9Overdose
    • 3.10Interaction
    • 3.11special instructions
    • 3.12Terms of sale
    • 3.13Storage conditions
    • 3.14Shelf life
    • instagram viewer
    • 3.15Analogues of Atrosylen
    • 3.16Alcohol and Arthrosilen
    • 3.17Reviews about Arthrosilene
    • 3.18Price Arthrosilen, where to buy
    • 3.19WER.RU
    • 3.20ZdravZona
    • 3.21IFK Pharmacy
  • 4"Artrozilen" (injections, pills, ointment): instructions for use, analogues, reviews:
    • 4.1Non-steroidal anti-inflammatory drugs
    • 4.2Composition and properties of medicament
    • 4.3When can the drug "Artrosilen" be used?
    • 4.4Contraindications
    • 4.5Dosage
    • 4.6Adverse Events
    • 4.7Drug Interactions
    • 4.8Flamax
    • 4.9Ketoprofen
    • 4.10Reviews about the means «Artrozilen» and analogues

Arthrosilen - instructions for use, price and analogues of the drug

There is a wide selection of modern medicines that have a similar mechanism of action.

Doctors can prescribe Arthrosilen - instructions for the use of the drug during treatment are in each package.

The main active ingredient is ketoprofen, the medication is available in several dosage forms. It is not recommended to use the product without consulting a doctor.

What is Arthrosilen

This drug belongs to the NSAID group - non-steroidal anti-inflammatory drugs. The drug is a derivative of propionic acid, has antipyretic, anti-inflammatory, analgesic effect.

The medicine acts on the focus, relieving pain, inflammation and lowering the temperature.

The drug has symptomatic treatment, but does not relieve the pathogenetic factors, so the drug is used only together with other medicines in the complex therapy.

The use of arthrozylene has proved effective in the treatment of articular cartilage system:

  • gout;
  • rheumatoid arthritis;
  • arthrosis.

The medication is used according to the instructions as a medicine, which eliminates the symptoms of inflammatory diseases, as a rule, the articular apparatus. When applying Arthrosilen, it is impossible to achieve changes in the pathogenetic mechanisms that underlie the disease.

Depending on the form of release of the drug, it is absorbed by the body in different ways. For example, ketoprofen from capsules is absorbed from the digestive tract, it easily overcomes histohematetic barriers, bioavailability is 80%.

The maximum concentration is reached in the interval 4-10 hours after application.

Ketoprofen lysine salt, getting into the body, is transported by protein molecules that are present in the blood. So the active substance gets into the synovia, the tissue, then metabolism (splitting) occurs with the liver.

Leave residual products along with urine. The instruction indicates that Arthrosilen affects the articular apparatus, helps to relieve temperature, pain and inflammation.

Thanks to the analgesic effect, the agent is prescribed, if necessary:

  • pain after damage to muscle fibers, synovial membranes, tendons;
  • postoperative pain;
  • soreness of nerves, vessels, fibrous connective tissues.


Any form on the substance of ketoprofen that has the main medicinal effect is based. All other components are considered to be exclusively auxiliary. The composition of different forms of release includes such components:

  1. Capsules: lysine salt (ketoprofen), carbopol, mania stearate, povidone, diethylphthalate, polymers of methacrylic, acrylic acid, titanium dioxide, talc, gelatin.
  2. Injection solution: lysine salt, sodium hydroxide, citric acid, sterile water.
  3. Suppositories according to the instructions contain: ketoprofen, semi-synthetic glycerides;
  4. The gel consists of: ketoprofen, carbopol, TEM, polysorbate, methylparaben, prepared water, lavender or flavoring nerolene.
  5. Aerosol: ketoprofen, polysorbate 80, lavender or nerolene, PVP, benzyl alcohol, PPG,

Form of issue

A doctor can prescribe one of the medicinal forms, relying on a specific case. Simultaneous application of several options is possible to achieve maximum effect. Treatment is selected individually, and the patient can get:

  • Ointment Arthrosilen for external use, the tube contains 30-50 g;
  • capsules for oral administration, in the package of 10 pieces;
  • injection solution, ampoules are sold with instructions in a cardboard pack of 6 pcs., in each 2 ml of drug substance;
  • rectal suppositories, 10 pcs .;
  • aerosol for topical external use, spray can 25 ml.

Instructions for use Arthrozilene

The liner is present in all packaging regardless of the form of release. You can find all the necessary information about the medicine, but appoint the dosage, the doctor should take a long time.

This will help avoid side effects and prevent cases that are indicated in the contraindications section. It is important to consider the compatibility of the drug with other medications that are part of the complex therapy of the disease.

For each pharmacological form, there are different application rules, which are described in the instructions below.

The use of tablets is justified for gouty, rheumatoid arthritis, mild pain syndrome, osteoarthrosis, inflammatory lesions of the periarticular tissues, spondyloarthritis.

In the body of gelatin is a round granulate, the base is white, and the lid is green. Ketoprofen in one tablet contains 320 mg, capsules are sold for 10 pcs.

Dosage of Arthrozilene, the method of use according to the instructions:

  • before and after meals 1 capsule of Arthrosilen;
  • duration of therapy is 3-4 months;
  • the maximum concentration of the drug substance occurs, after 4-10 hours, and the effect persists throughout the day.


The application of this form extends to injuries, diseases of the musculoskeletal system. The spectrum of pathologies is wide, a medicament for external use is intended.

Concentration 5%, externally has an average density, translucent, aroma - lavender. Contains 50 g of ketoprofen per 1 g of product.

The dose, the way of using Arthrozilene according to the instructions:

  • Apply a little drug to the inflamed area, gently rub it;
  • repeat the procedure three times a day;
  • the duration of the therapeutic effect is 8 hours;
  • the course of therapy is 10 days, but can be prolonged with the agreement and recommendations of the doctor.


Intramuscular or intravenous injections are used to quickly eliminate pain immediately after trauma, surgery, with acute inflammation in the muscles, bones. Pricks Arthrosilen have a short-term effect.

Externally, the solution is a colorless, transparent, but yellowish tinge. For production use glass darkened ampoules of 2 ml. Each contains ketoprofen lysine salt 160 mg.

Dose, the method of application according to the instructions of Arthrozilene:

  • for the introduction through the vein, the drug is mixed with saline and other additional components;
  • the procedure lasts about an hour and is carried out only in stationary conditions;
  • the course of therapy is 3 days;
  • intramuscular injections are carried out for 1 ampoule 2 times a day, for the elderly - 1 time daily;
  • the effect lasts 20 hours, the result is felt 30 minutes after the injection of the solution.


Suppositories are good for moderate or mild pain, gouty, rheumatoid arthritis, inflammation of the periarticular tissues, spondyloarthritis, osteoarthritis.

Outwardly they have a torpedo-shaped appearance, a homogeneous structure, a light yellow or white color. Contains 160 mg of ketoprofen per candle.

The instruction indicates the following doses and the way of using Arthrozilene:

  • for a day you need to use 2 pcs .;
  • increase in dosage is permissible up to 3 with obvious, severe symptoms;
  • the treatment regimen is designed for 5 days;
  • there is a noticeable effect in 1 hour, lasts for 22 hours.


Spray Arthrozilen (15%) is used according to the instructions for the therapy of a wide range of pathologies, damage to the joints and other parts of the musculoskeletal system.

Externally, the aerosol for external use looks like a homogeneous white foam. At 1 g of the agent is 150 mg of ketoprofen lysine salt.

According to the instructions, Arthrosilene Spray has the following dosage and application rules:

  • apply on the inflamed area and gently rub;
  • You can repeat the procedure 3 times a day;
  • the rate is 10 days;
  • the effect lasts for 8 hours.

Side effects

This drug refers to preparations of a non-steroidal anti-inflammatory group of a new generation.

Arthrosilen was created taking into account all previous mistakes of the use of ketoprofen in other medicines.

According to the instructions, the following side effects of the medicament are possible (with the exception of aerosol or gel):

  • changes in the CNS;
  • disorders of the digestive tract;
  • change in liver function;
  • violation of the breathing process;
  • reaction to the skin;
  • changes in the work of the organs of perception;
  • allergy, angioedema;
  • changes in the processes of hematopoiesis;
  • malfunction of the genitourinary system.

In addition to the above reactions, a burning sensation, severity in the area of ​​application, itching, exacerbation of hemorrhoids may appear. Sometimes aerosol Arthrosilen can cause photosensitization, allergic manifestations.

If any side effects are found, immediately consult a doctor. Possible negative reactions do not cause the refusal of the medication and Arthrosilen found wide application in medical practice.

This drug has a greater speed of action, efficacy than its predecessors.


For each form of release there are prohibitions, for example, aerosol or gel should not be used for skin lesions, eczema, dermatosis.

Special attention should be paid to people over 60 years of age, to female women in the 1-2 trimester.

To the general contraindications of Arthrosilen in all forms of release according to the instruction is the following:

  • colitis, ulcers;
  • hypersensitivity to components;
  • Crohn's disease;
  • asthma, which is provoked by NSAIDs;
  • peptic ulcerative lesions;
  • hemophilia, other blood clotting disorders;
  • chronic gastric ulcer in the stage of exacerbation;
  • chronic kidney failure;
  • diverticular disease;
  • lactation.


In the absence of medication Arthrosilen, the patient can order or buy in the online store funds with a convergence mechanism of action. One such option is Ketonal. In comparison with Arthrosilen it has a low price, it is widely distributed.

According to the instructions, it is indicated that with an overdose it causes abdominal pain, vomiting, nausea, kidney failure and respiratory depression. All forms of the medicament contain ketoprofen, available in capsules, ampoules (injection solution), gel, tablets.

Another similar in the field of application with Arthrosilene is Oki. An Italian remedy that is available in the form of rectal suppositories, a solution for topical use, granules for solution preparation (ingestion).


The main advantage is the absence of contraindications, except for individual intolerance of the components. According to the instructions you can give children from 6 years old, the shelf life is 5 years.


The disadvantages can be attributed only to the lack of options for local use and a higher price.

Price Arthrosilen

You can buy a medicine without a prescription, you can read the application form in the instructions, but it's better to consult a doctor first.

Arthrosilen has brings improves the condition, but does not treat the underlying disease. The cost of the medication may vary depending on the region of sale.

Approximate price of the medicine:

  • solution Arthrosilen, ampoule 2 ml (6 pcs.) - from 160 rubles;
  • gel Arthrosilen 5%, 50 g - from 310 r;
  • Suppository Artrozilen, 10 pcs. - from 230 r;
  • capsules Arthrosilene, 10 pcs. - from 280 r;
  • Spray Arthrosilene, 15% 25 ml - from 390 r.

A source:

Arthrosilen: reviews, instruction and analogues of Gel, Spray, Nyxes, Capsules

Arthrosilene is a non-steroidal anti-inflammatory drug that is considered to be very effective and gentle. Unlike other similar drugs, it has a momentary effect on the inflammatory processes and quickly relieves pain.

Also, as numerous positive reviews show, this drug is attractive because its It is enough to take it once a day, which allows you to economically use the medicine during treatment.

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How the drug works

The composition of the drug includes ketoprofen lysine salt. This substance acts as the main element of the drug, it allows it to dissolve quickly and does not irritate the gastrointestinal tract.

Has a curative effect on the body throughout the day, so that the active substance does not destroy the cartilage layer of the joints.

Drug A has the following effects on the body:

  • Anesthetizes;
  • Relieves fever;
  • Stops the inflammatory process.

When using the drug, pain is reduced by suppressing the isolation of prostaglandins. Stabilizes lysosomal enzymes, which allows you to suspend the production of the destructive substance that occurs during the inflammatory process.

Including this drug doctors recommend to use in the postoperative period, if joint transplantation was performed. If you read the reviews of doctors, arthrosilene helps to speed up the recovery process after surgery and prevent calcification of bones and soft tissues.

Despite the fact that the medicine is capable of instantly affecting the body in a manner similar to narcotic analgesics, the drug is safe for health.

Also quickly removes swelling on the injured parts of the body, relieves morning stiffness and improves motor activity.

Form of the preparation

Arthrosilen is sold in pharmacies and specialized stores in various forms, it is applied rectally, and also as a preparation of internal and local exposure, which avoids the formation of side effects.

When topically applied, arthrosilene gel and aerosol spray are used, which only affect separate parts of the body, but this form does not allow the drug to be rapidly absorbed and organism.

  • Arthrosylen capsules are available in a package of 320 mg of 10 pieces. Despite a small amount, this kind of medicine has a high dose, which allows for a long-term effect on the body. For this reason, a day is enough to take one tablet during or after a meal. Duration of treatment is usually about four months, after which a break is made.
  • The medicinal preparation in the form of a gel of 5% is used as an external agent and has positive reviews. It can be purchased in pharmacies in tubes of 30 or 50 grams. For a single use, it is recommended to use not more than five grams of gel, which roughly equals the size of a large berry. The drug is rubbed up to absorb on the affected area no more than three times a day. Treatment with a gel is carried out for not more than ten days.
  • When using an ointment, it is important to apply the medicine exclusively to the skin that is not damaged. If direct sunlight hits the skin treated with ointment, photosensitivity may appear. Using the drug, you need to ensure that it does not get on the mucous membrane of the mouth and eyes.
  • Spray aerosol 15% has the smell of lavender and is used for outdoor purposes. It is available in the form of aluminum cylinders with a volume of 25 ml with a spray device aerosol. It is recommended to use not more than two grams of medicinal product, visually such amount equals one walnut. The medicine is rubbed three times a day, it can be used no more than ten days.
  • Also in the pharmacy you can buy ampoules that contain intravenous and intramuscular injection. Ampoules have a volume of 2 ml and are sold in packages of six. Usually, injections are used for short-term treatment to relieve acute pain for three days. After that, the treatment continues with the help of capsules or candles.
  • Intravenous injections are done only in the hospital. In this case, the drug can be administered as with a dropper for half an hour, or once a volume of up to 50 ml. Such injections act quickly and effectively.
  • Candles are injected rectally. They can be purchased in a package of ten. Each suppository contains 160 mg of active substance. A day usually does not use more than three candles, it is recommended that older people use no more than two suppositories. This form of the drug allows you to quickly act on the body due to instant absorption from the rectal mucosa, which is noted by many reviews.

In what cases is the drug used

The drug has a very wide application and treats numerous symptoms.

Depending on the form of release, the rate of exposure of the drug to the body is determined.

For this reason, injections and suppositories are most often prescribed to quickly relieve pain, aerosol spray and ointments are used for long-term treatment of inflammation.

The medicine has the following indications:

Suppositories and tablets eliminate mild to moderate pain after surgery, inflammation or trauma, due to which they have positive feedback.

All forms of the drug, except for injections, are used to treat the rheumatic and inflammatory process, among which osteoarthritis, spondyloarthritis, rheumatoid and gouty arthritis, affection of periarticular tissues.

The injections are used for short-term relief from acute pain after surgery, trauma or acute inflammation in the musculoskeletal system.

Who is contraindicated with the drug

Despite the sparing effects on the body and high safety, the drug is not allowed for use in some cases. When compiling a list of contraindications, all the side effects that had an earlier analogue of this drug Ketaprofen were taken into account.

The drug has absolute and relative contraindications.

Absolutely not use the medicine in the following cases:

  1. With intolerance of the components that make up the drug;
  2. At the age of up to 6 years with external application of the drug, up to 18 years with internal use of the drug;
  3. If there is a bleeding disorder;
  4. In late pregnancy;
  5. During lactation;
  6. With "aspirin asthma
  7. With exacerbation of diseases of the gastrointestinal tract;
  8. In chronic renal failure;
  9. With diverticulitis;
  10. With skin diseases.

Relative contraindications imply that the drug should be used cautiously and only after consulting a doctor. Especially this applies to medicinal forms of the drug, which can affect the entire body.

Therefore, care must be taken in the following cases:

  • Early in pregnancy;
  • In the elderly;
  • With bronchial asthma;
  • With chronic heart failure;
  • With anemia;
  • In case of dependence on substances of psychoactive effect;
  • With exacerbation of liver disease;
  • With diabetes mellitus;
  • In the case of arterial hypertension;
  • With blood diseases;
  • In case of sepsis;
  • With dehydration.

Manifestation of side effects

Despite the high safety of the drug, it has a fairly large list of side effects. As noted by numerous reviews of users and doctors, negative reactions to the drug are rare, but patients need to know what can happen when taking the drug.

For this reason, before using the drug, it is necessary not only to read reviews of users who bought this remedy, but also to consult with the attending physician, who will determine the individual dosage.

Among the side effects the producer identifies:

  1. Disturbance of the gastrointestinal tract, liquid stool, hepatitis, ulcerative lesions and other violations of the liver.
  2. Violation of the central and autonomic nervous system, psychosis, impaired vision, dizziness, excessive sweating.
  3. Allergic reaction in the form of urticaria, itching and swelling.
  4. Violation of the genitourinary system in the form of a malfunction of the menstrual cycle, pain during urination, cystitis, edema, hematuria.
  5. Violation of the cardiovascular system in the form of pressure spikes, tachycardia, pain in the chest, pallor.
  6. Violation of the hemopoietic system in the form of an increase in the spleen, purpura, leukocytosis, vasculitis, leukocytopenia, thrombocytopenia.
  7. Disturbance of the respiratory system in the form of rhinitis, swelling and spasms of the larynx, bronchospasm, laryngospasm.

How the drug interacts with other drugs

In the event that the doctor prescribes the medication, it is important to consider what medicines the patient is using at that time.

The matter is that some medicines can block efficiency or, on the contrary, strengthen its influence on an organism that can cause a toxication or other life-threatening reactions.

Arthrosilen is not recommended for use in conjunction with the following drugs:

  • Strengthening effects on the body can have ethanol, phenytoin, barbiturates, tricyclic antidepressants.
  • With the parallel use of the drug with ethanol, corticotropin may cause ulcers and bleeding in the gastrointestinal tract. It can also lead to kidney damage.
  • They can cause bleeding and generally increase the effect on the body of thrombolytic drugs, anticoagulants, cefoperazone, heparin.
  • Strengthen its negative impact on the body can estrogens, mineral corticoids, glucocorticoids.
  • The drug when used reduces the effectiveness of diuretics and antihypertensive drugs.
  • May cause an overdose of insulin and hypoglycemic drugs.
  • The drug significantly increases the concentration of lithium, verapamil, mitotrexate, nifedipine in the blood plasma.
  • Antacids and colestyramine reduce the effectiveness of Arthrosilen due to a decrease in its absorption.

The preparation and its analogues

It has numerous analogues, they release drugs, which include the same active substance - ketoprofenalysinic salt. These drugs include the well-known analogue Oka, which can be purchased in a pharmacy in the form of candles or powder for children and adults.

Also, the drug has the following taxes, which include ketoprofen:

  1. Among medicines for external use, Fastum gel, Ketoprofen Vramed, Artrum gel, Bystrum gel are isolated.
  2. Arketal Rompharm is produced in the form of solutions for injections in ampoules.
  3. Also analogue are tablets and capsules of Profenide, Ketonala Duo, Ketonala Uno.
  4. For various purposes, apply Oruvel, Fleksen, Flamax.

Despite a wide choice, numerous reviews indicate that most users choose this particular drug. According to the patients, this drug is effective, quickly helps to get rid of pain and other symptoms.

Application and dosage

Arthrosilen, the instructions for use contain detailed information on how to properly use the drug. Before using it, you should carefully read the manufacturers' instructions and carefully follow the recommendations of the doctors.

Capsules are used one at a time during or after a meal. The duration of treatment is not more than four months.

The solution in ampoules can be administered intramuscularly or intravenously once a day. Treatment is carried out for three days.

Further treatment continues with candles or capsules. Ampoules are opened neatly along the indicated line.


After the ampoule is opened, the solution is used immediately.


In order for the drug to act for a long time, intravenous administration of the drug is used. If the solution is diluted in a small volume, injected with an injection. When installing the dropper, the duration of the exposure is at least half an hour.

Rectally, the drug is administered one candle three times a day. Maximum for the day allowed to use 480 mg of the drug. Elderly, you can apply no more than two candles per day.

For external use, 5 grams of gel, 2 grams of spray are allowed. Depending on what area is damaged, the drug is rubbed into the skin until completely absorbed three times a day. Treatment can be continued for ten days.

Keep Arthrosilen in a dark place, away from children, at a temperature of no higher than 25 degrees. Shelf life of the drug is five years.

A source:



  • The capsules contain the active ingredient:ketoprofen, presented in the form of a lysine salt. Additional ingredients: diethylphthalate, carbopol, povidone, magnesium stearate, polymers of acrylic and methacrylic acid, talc, titanium dioxide, gelatin, indigotine and quinoline yellow.
  • The injection solution also contains the active substance:ketoprofen- lysine salt. Auxiliary components: citric acid, sodium hydroxide, water sterile.
  • Suppositories Arthrosilene include in its composition an active substance:ketoprofen, in the form of a lysine salt. Auxiliary components: semi-synthetic glycerides.
  • The preparation in the form of a gel consists of an active substance:ketoprofen- Lysine salt. Additional components: polysorbate, carbopol, TEA, ethanol, flavoring nerolene or lavender, methylparaben and water prepared.
  • The aerosol contains the active substance:ketoprofen- lysine salt. Auxiliary components: nerolene or lavender, polysorbate 80, PPG, benzyl alcohol, PVP, water prepared.
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Form of issue

Arthrosilen is produced in several pharmacological forms, namely in the form of:

  • gel for external use 30-50g;
  • capsules for ingestion of 10 pieces per package;
  • injection solution in ampoules of 2 ml of 6 pieces per package;
  • rectal suppositories of 10 pieces per package;
  • external aerosol 25 ml.

pharmachologic effect

For all forms of Arthrosilen, analgesic, antipyretic and anti-inflammatory effects are characteristic.

Pharmacodynamics and pharmacokinetics

The manifestation of anti-inflammatory, analgesic and antipyretic effect is ensured by the ability of ketoprofen to inhibit COX-1 and -2, inhibit the synthesis of PG.

In addition, the drug is characterized by anti-bradykinin activity, stabilization of lysosomal membranes and inhibition of their release from the formulationEnzymes, which contribute to the destruction of tissues in cases of chronic inflammation. The release of cytokines decreases, the activity of neutrophils slows down.

The use of Arthrosilen allows you to reduce the morning stiffness, swelling of the joints, increase the volume of movements.

The lysine salt, which is part of the ketoprofen preparation, is a rapidly dissolving molecule with a neutral pH. Therefore, Arthrosilen has practically no irritating effect on the digestive tract.

External use of a spray or gel is provided by a localanti-inflammatory, antiexudativeandanalgesicEffect. This high local therapeutic effect on the affected joints, tendons, ligaments, muscles.

Treatment with the drug with articular syndrome allows you to ease pain in the joints, both in a calm state and during movement, the morning stiffness and swelling of the joints decrease.

It has been established that Arthrosilen does not exert a destructive effect on articular cartilage.

When taking capsules, the active substance is fully absorbed from the digestive tract, with bioavailability above 80%. The maximum concentration is reached after 4-10 hours from the moment of taking, depending on the dosage. In this case, the therapeutic effect persists for 4-24 hours.

Eating food can lower the concentration of matter in the body. Inside the body there is a full connectionketoprofenwith plasma proteins.

The substance is capable of penetrating the histohematological barriers into the tissue and synovial fluid, where its distribution takes place.

Metabolismketoprofen occurs in the liver, undergoing glucuronidation with the production of esters and glucuronic acid. Excretionmetabolitesis carried out in the urine and an insignificant part of the calves.


The effect of the injection solution is manifested after 20-30 minutes and lasts for 18-20 hours. The active substance is fully absorbed by binding to plasma proteins.


The drug penetrates through the histohematological barriers in the tissues and physiological fluids, evenly distributed in the body.

Metabolism occurs with the participation of liver enzymes, which are mainly excreted by the kidneys, for 24 hours.

When using the drug in the form of rectal suppositories, its effect is manifested within 45-60 minutes. The maximum concentration of the substance is directly dependent on the dosage taken.

In the body, ketoprofen is fully absorbed, binding to plasma proteins. The penetration of the substance through the histohematetic barriers was noted, being distributed in tissues and important organs.

Metabolism occurs in the liver, with the production of esters and glucuronic acid. Excretion of metabolites occurs in the urine.

The use of external means of gel and aerosol is noted by slow absorption. In this case, the action of the substance manifests itself for a short time and persists for 5-8 hours. Bioavailability is approximately 5%.

Indications for use

The main indications for the use of capsules and suppositories are:

  • inflammatory, postoperative or post-traumatic weak and moderate pain;
  • rheumatoid and goutyarthritis;
  • osteoarthritis;
  • spondyloarthritis;
  • inflammatory damage of the periarticular tissues.

The injections are prescribed for short-term treatment of acute pain syndromes accompanying:

  • diseases of the musculoskeletal system of different origin;
  • Postoperative and post-traumatic pain associated with inflammation.

Indications for the purpose of gel and aerosol are:

  • diseases of the musculoskeletal system, for example - rheumatoid and psoriaticarthritis, osteoarthritisperipheral joints or spine,ankylosing spondylitis, rheumaticdamagessoft tissues;
  • traumatic lesions of soft tissues, muscular rheumatic and non-rheumatic pain.

Contraindications for use

  • high sensitivityto the drug;
  • aspirin asthma;
  • lactation, pregnancy;
  • exacerbation of peptic ulcer of stomach and duodenum, peptic ulcer;
  • diverticulitis;
  • acute form of ulcercolitis, Crohn's disease;
  • chronicrenal insufficiency;
  • childhood;
  • hemophiliaand other disorders associated with blood clotting and so on.

Aerosol and ointment is also not recommended for:

  • wettingdermatosisOh;
  • eczema;
  • violation of the integrity of the skin.

Care should be taken when treating patients suffering from:

Side effects

The use of arthrozylene can lead to the development of abnormalities in the activity of the digestive tract, liver, nervous system, sense organs and hematopoiesis, genitourinary, cardiovascular and respiratory systems.

In addition, it is possible to develop various disorders of the skin and allergic reactions.

When using external drugs - gel and aerosol, photosensitization may occur.

In any case, a specialist consultation is necessary.

Instructions for use Arthrosilen (Method and dosage)

The drug is available in several pharmacological forms, intended for ingestion, rectally, parenterally and externally.

Tablets for ingestion appoint daily for 1 piece at a time or after a meal. Therapeutic course can last 3-4 months.

A solution for IM or IV is prescribed for use in an ampoule per day. As a rule, this form of the drug is used for short-term treatment for no more than 3 days in a hospital. When it is necessary to continue treatment, it is allowed to use capsules or suppositories.


Rectal suppositories are applied daily for 1 piece 2-3 times. The maximum daily dosage should not exceed 480 mg. Older patients are prescribed a daily dose of up to 2 suppositories.


Outer forms of aerosol and gel Arthrosilene instructions for use recommend applying a small amount daily 2-3 times. In this case, a single dosage of aerosol is 1-2 g. The duration of therapy is set by the attending physician, but it should not be longer than 10 days.


Cases of overdose with Arthrosylen preparations are not described.


Simultaneous application withinducers of microsomal oxidationin the field of the liver -phenytoin, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressantsincreases the production of hydroxylated active metabolites.

It has been established that Arthrosilen reduces the efficacy of someuricosuric means, enhances efficiencyanticoagulants,fibrinolytic agents, antiplatelet agents, side effectsmineralocorticoids, estrogens, andantihypertensiveanddiuretics.

Sharing withNSAIDs, GCS, corticotropin, ethanolcan cause the development of ulcers and bleeding GIT, increase the likelihood of deviations in renal function.

When used simultaneously withoral anticoagulants, thrombolytics, heparin, cefoperazone, cefamandole antiaggregantsandcefotetanethe risk of bleeding increases.

In addition, this drug increases the hypoglycemic effectinsulinand hypoglycemic agents, therefore, with simultaneous administration, dose recalculation is required.

Combination withvalproateleads to aggregation failuresplatelets, fromverapamil, nifedipine, lithium, methotrexateincreases their concentration in the plasma.

Combined reception withsantacidandcolestyraminecan reduce the absorption of arthrozylene.

special instructions

When treating with capsules, injection solution and suppositories, it is required to carry out control of peripheral blood parameters, as well as the state of liver and kidney functions.

When it is necessary to determine 17-ketosteroids, the drug is canceled before the test for 48 hours.

The use of ketoprofen often masks the symptoms of an infectious disease.

Violations of kidney and liver function require lowering of dosage and careful observation of the condition of patients.

In patients suffering frombronchial asthma, there may be an attack of bronchial asthma.


When planning pregnancy, it is recommended to refrain from the use of drugs, since it is possible to lower the probability of implantation of the egg.


Aerosol and gel Arthrosilen should be applied to the skin without damage. It is important that the drug does not get into the eyes and mucous membranes. Avoid the development of increased sensitivity or photosensitivity if you protect the skin from sunlight during the entire treatment.

Terms of sale

The preparation in the form of capsules and a solution for injections is dispensed by prescription. Ointment and spray Arthrosilen are non-prescription drugs.

Storage conditions

To store the drug is intended a dark place, protected from children, at temperatures up to 25 ° C.

Shelf life

3 years.

Analogues of Atrosylen

In modern pharmacology, many tools have been developed for such an action.

Analogs of this drug:Ketoprofen, Ketonal, Oruvel, Profenid, Knavon, Fastum, Febrofid, Actron, Flexen, Ketoprofen-Ratiopharm, Ultrafastin, Artrum, Flamax, Ketolist retard, Alremont, Asozal, Ostofen, Sinprofenand so on.

Alcohol and Arthrosilen

The simultaneous use of this drug and alcohol strengthens its effect and increases the risk of developing bleeding.

Reviews about Arthrosilene

As the reviews on gel Arthrozilen show, its effectiveness does not appear in all cases.

Messages on the forums show that this drug is often prescribed in treatmentgout.

However, the simultaneous use of capsules and gel bring relief only when the therapy is performed at the initial stage of the disease.

Nevertheless, this drug is very helpful in the treatment of traumatic pains, for example,bruises.

There are reports of how with the help of Arthrosilen, patients have eliminated inflammation of the joints.

Of course, if pain and other unwanted symptoms persist for a long time, you need to see a doctor instead of trying to choose the medication yourself.

Price Arthrosilen, where to buy

The price of suppositories for rectal use of 160 mg for 10 pieces is 220-370 rubles.

Injection solution to put injections in ampoules of 2 ml, 6 pieces per pack cost 160-190 rubles.

Tablets or capsules 320 mg of 10 pieces per pack can be bought for 270-320 rubles.

The price of gel Arthrosilene 15% varies between 270-320 rubles.

The price of the spray is 280-300 rubles.

  • Online pharmacies in RussiaRussia


  • Arthrosilen capsules 320 mg 10 pcs.
  • Arthrosilen solution 80 mg / ml 2 ml 6 pcs.
  • Arthrosylen Aerosol 15% 25 ml
  • Arthrosylen gel 5% 50 gDompe [Dompe]


  • Arthrosilen 80mg / ml solution for injections 2ml №6 ampoulesAbiogen Pharma S.p. A./Dompe S.p.
  • Arthrosilen 160mg # 10 suppositoriesInstituto de Angelie Sr. L. / Sagmel Inc.
  • Arthrosilen 320 mg №10 capsules Dompe Pharmacetici Sr. L. (ITALY)
  • Arthrosilen 160 mg 2ml №6 amp.
  • Arthrosilene 15% aerosol 25mlDompe Pharmacetici Sr. L. (ITALY)

IFK Pharmacy

  • ArthrosilenDompe Farmaceutici, Italy
  • ArthrosilenDompe Farmaceutici, Italy
  • ArthrosilenDompe Farmaceutici, Italy

NOTE! Information about medicines on the site is a reference-generalizing, collected from public sources and can not serve as a basis for making a decision about the use of medications in the course of treatment. Before using the drug Arthrosilen necessarily consult with your doctor.

A source:

"Artrozilen" (injections, pills, ointment): instructions for use, analogues, reviews:

Pain is the first signal that something is going wrong in the body. Most often this sign indicates the development of the inflammatory process.

In most cases, after diagnosis, specialists prescribe combined drugs that not only take away the pain syndrome, but also eliminate its cause. Good results are shown by non-steroidal anti-inflammatory drugs.

This group includes the drug "Artrozilen". Injections, aerosol, capsules, gel - in these forms the medicine is issued.

Non-steroidal anti-inflammatory drugs

Due to the fact that drugs from this category have a combined effect, they can be used in the complex treatment of many diseases.

You will be interested in:Teraflex tablets for the treatment of joints

With their help it is possible not only to stop the pain syndrome, but also to remove fever, to remove symptoms of general intoxication of the body.

But in most cases, non-steroidal preparations are still directed to the treatment of joint and bone disease.

Arthritis is a common name for many inflammatory processes associated with joints. To treat such pathological processes, the drug "Artrozilen" is often prescribed. With it, you can stop the spread of infection, improve the condition of the joints.

When arthritis a person feels strong discomfort, joints begin to ache and swell. Specialists often have to deal with occupational diseases. Arthritis of the hands can be diagnosed in seamstresses, hairdressers.

Problems with the joints of the spine arise from movers or builders.

Depending on the manifestations of the inflammatory process, drugs in various dosage forms can be used.


Thus, "Artrozilen" injections are used in cases of severe pain syndrome, when local treatment no longer gives a positive result. In any case, non-steroidal anti-inflammatory drugs should be prescribed by a doctor.


Self-medication often leads to complications. "Arthrosilen" in ampoules is most often used in a hospital, home therapy is unacceptable.

Composition and properties of medicament

It is worth to study carefully before applying the drug "Artrozilen" instructions for use. This is especially important for allergy sufferers who have previously experienced a reaction to a particular medication.

The composition of the medicine is the first thing to pay attention to.

The drug "Artrozilen" is available in the following dosage forms: injection, rectal suppository, gel for external use and capsules for oral administration.

In each of the options, the active ingredient is ketoprofen lysine salt. If we consider "Artrozilen" injections, then as additional elements are purified water, sodium hydroxide and citric acid.

For pain of low intensity, a preparation in the form of a gel for external use is widely used. Here, the following additional components are used: trolamine, polysorbate, lavender flavor, ethanol and purified water.

The composition of candles includes polysynthetic glycerides. Capsules are widely used, which, in addition to the active element, include the following substances: acrylic and methacrylic acid polymers, povidone, magnesium stearate.

The composition of the shell is gelatin, titanium dioxide.

The effect of the drug depends on the form of its release. The best bioavailability is the solution for injection.

Already in 5-7 minutes after the administration of the drug, the patient feels a significant improvement. For pain of low intensity, it is recommended to use capsules.

However, the effect of their use comes only after 20-30 minutes.

When can the drug "Artrosilen" be used?

Instructions for use describe the diseases in which a specialist can prescribe a drug. First of all, these are different types of arthritis (monoarthritis, polyarthritis).

Widely used in the treatment of gout, osteoporosis. As part of complex therapy, the agent can be used to treat any diseases of the musculoskeletal system.

Thus, the drug "Artrozilen" in pharmacies can be suggested for stretching or dislocations. In this case, pharmacists are more likely to recommend buying a product in the form of a gel.

However, before buying a drug, it is still better to consult an orthopedist.

"Arthrosilen" helps to normalize body temperature, perfectly removes pain, which occurs against the background of trauma. The agent can be prescribed to the patient in the postoperative period.

In surgical practice the drug is used widely enough.

Specialists in most cases prescribe medicine for patients who are in hospital due to the fact that there is a need to monitor the functionality of the liver and kidneys.


Like other medicines, the drug "Arthrosilen" has its contraindications. First of all, it must be remembered that this anti-inflammatory agent can adversely affect the liver.

In this regard, the medication in any form is not prescribed to under-age patients, women awaiting the birth of a child, and also nursing. People over 65 years of age should be treated under medical supervision.

With care, patients with alcoholic liver cirrhosis, liver failure are treated.


Women planning to conceive a child are not recommended to take "Arthrosilen" ointment. The instruction indicates that the active ingredient may adversely affect the possibility of embryo implantation in the uterus.


The drug in other dosage forms should also be taken with caution.

If lactation requires the use of a non-steroidal anti-inflammatory drug, breastfeeding should be discontinued.

When can not the "Artrosilen" remedy be prescribed yet? No injections, ointment, capsules, suppositories are taken with the following pathological processes: ulcerative colitis, bleeding disorders, diverticulitis, Crohn's disease, peptic ulcer. People with "aspirin" asthma will have to give up using the drug. This syndrome, in which narrowing of the bronchi is provoked by drugs from the group of non-steroidal anti-inflammatory drugs.

It should be noted that the means "Artrozilen" removes the symptoms of intoxication of the body, normalizes the patient's well-being.

Thus, signs of the presence of infection in the body may be masked.

Therefore, the drug categorically can not be used until the doctor has made an accurate diagnosis.


"Arthrosilen" injections are used in a hospital most often. For pain of moderate intensity or in the postoperative period, appoint one ampoule per day.

The drug is administered intravenously or intramuscularly, depending on the form of the disease and the localization of inflammation. In severe pain, the daily dosage can be doubled.

In this case, the doctor carefully monitors the liver of the patient.

How to use "Artrosilen" tablets? The instruction indicates that one capsule per day should be administered during or immediately after meals.


It should be taken into account that the components of the medicine can negatively affect the gastric mucosa. Therefore, therapy should never be performed on an empty stomach.


The duration of treatment is determined by the doctor, but the course should not exceed 3 months.

Candles are used for pain of moderate intensity. It is necessary to administer one suppository three times a day. For elderly patients, the norm should not exceed two times a day. Dose reduction is also recommended for violations of kidney and liver function.

Widely used is also "Arthrosilen" gel for relief of moderate joint pain.

A small amount of the drug is applied to the damaged area no more than twice a day.

If the improvement does not occur within three days, the patient is recommended to consult a doctor for additional advice.

Adverse Events

Virtually all non-steroidal anti-inflammatory drugs are excellent in relieving pain. However, many of them also lead to the development of side effects even with proper use.

What can be expected if a specialist has prescribed "Artrozilen" injections? The reviews show that the injections are painful enough, but the discomfort quickly passes after the injection.

It is often necessary to observe local allergic reactions, such as itching, burning, redness, the development of erythema.


Often develop side effects after the internal use of the drug (in the form of capsules). Patients can complain of the following unpleasant symptoms: abdominal pain, diarrhea, stomatitis.


There may be an increase in the level of bilirubin. Often you have to deal with violations of the liver and kidneys.

The patient should be informed about the development of any unpleasant symptoms to the treating doctor.

Dangerous are side effects that develop from the respiratory system. Especially often they are observed in those who are prescribed "Artrozilena" nyxes.

Experts' feedback shows that the patient can develop bronchospasm, apnea, laryngospasm.

In this regard, the medication is not recommended for use at home.

Drug Interactions

There are many drugs that can negatively affect the liver. In this regard, it is wise to select medicines for joint use with non-steroidal anti-inflammatory drugs.

To reduce the negative impact on the body together with the drug "Artrozilen not it is recommended to use medicines containing the following substances: rifampicin, phenytoin, ethanol.

It is not recommended to use barbiturates, as well as tricyclic depressants.


Against the background of simultaneous administration of the drug "Artrozilen" significantly reduces the bioavailability of many antihistamines. This should also be considered when conducting therapy.


What to do if the drugstore could not find the drug "Artrozilen". Analogues (injections, ointment, tablets) can be no less effective. However, the appointment should also be made by a doctor. It is impossible to select a substitute independently.


This drug also belongs to the category of non-steroidal anti-inflammatory drugs. They can completely replace the drug "Artrozilen." The active ingredient is also ketoprofen.

The medication is available in the form of a solution for injection, as well as in the form of capsules for internal use. In addition, the "Flamax" can be used in the first two trimesters of pregnancy if the intended benefit for the mother exceeds the potential harm for the child.

In pediatrics, the use of a drug for the treatment of children older than 15 years is allowed.

The indications of the medication is the same as "Artrozilen". The drug is used to stop the pain syndrome in arthritis and other diseases of the musculoskeletal system.

A medication can be used in the postoperative period. The drug "Flamax" can lead to the development of serious side effects, so you can not use it for self-medication.

The solution is used intravenously or intramuscularly in a hospital.


This is an inexpensive analogue of the drug "Artrozilen". The preparation is produced in the form of tablets, a gel for external use, a solution for injections.

The active ingredient, as in the previous cases, is ketoprofen lysine salt. Indications for use of the drug: pain syndrome of varying intensity, inflammatory diseases of the musculoskeletal system.

The drug is not prescribed for pregnant and lactating women, under-age patients, people with impaired liver and kidney function.


Other contraindications include: a violation of coagulation of the kidneys, duodenal ulcer, gastrointestinal bleeding, "aspirin asthma inflammatory bowel disease.


The agent "Ketoprofen" in any form can lead to the development of serious side effects.

Often after the administration of the drug in patients there is a violation of visual perception, tinnitus, headache, neuropathy, a rapid increase in blood pressure.

If you see these symptoms, you should immediately seek medical help.

Other analogs of "Artosilen" are widely used. In pharmacies, you can find such drugs as "Oki "Ketonol "Fleksen "Artrum etc.

Reviews about the means «Artrozilen» and analogues

The reviews show that the preparation "Arthrosilen" really helps quickly to cope with the pain. Painful prick is the main negative point that patients mark.

Immediately after intramuscular injection, a strong burning sensation is felt in the area of ​​exposure. Unpleasant feelings go through 3-5 minutes.

Together with this remedy quickly removes the symptoms of inflammation, reduces pain, normalizes body temperature. A good effect is shown by the analogues described.


Specialists also remind that non-steroidal anti-inflammatory drugs can not be classified as harmless drugs.


Often observed after taking the drug "Artrozilen" and its analogues, unpleasant side effects. Many complain of increased blood pressure, stomach pain.

Therefore, it is always advisable to coordinate therapy with the attending physician.

The fact that "Artrozilen" in a pharmacy can be purchased at an affordable price is also a good thing. The cost of the solution does not exceed 200 rubles.

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