At what pressure is appointed Diroton: instructions for use

click fraud protection

Diroton has pronounced hypotensive (lowers blood pressure) and peripherally vasodilating properties.

Active substances - lisinopril, belongs to the group of angiotensin-converting enzyme inhibitors, reduces the level of angiotensin II and aldosterone in plasma. As a result, the peripheral counteraction of the vessels decreases, the minute volume increases, the heart rate does not change, the perfusion of the kidneys can increase.

On this page you will find all information about Diroton: the full instruction on the application for this medicine, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Diroton. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

ACE inhibitor.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Diroton? The average price in pharmacies is at the level of120 rubles.

Form of issue and composition

Diroton is available in the form of white tablets. On one side they have separating risk, and on the other side - engraving, which corresponds to the content of the main active ingredient of lisinopril in one tablet:

instagram viewer

  • "2.5" - 2.5 mg (flat round);
  • "5" - 5 mg (flat in the form of a disk);
  • "10" - 10 mg (biconvex quadrangular form);
  • "20" - 20 mg (biconvex pentagonal shape).
  • Auxiliary components of the composition: corn starch, magnesium stearate, mannitol, calcium hydrophosphate dihydrate, talc.

For sale, Diroton comes in blisters for 14 tablets in cardboard packs of 1, 2, 4 blisters.

Pharmacological effect

Due to the active ingredient, lisinopril, the diroton has a peripherally vasodilating and strongly pronounced antihypertensive (lowers blood pressure) properties.

In addition, as a result of the use of Diroton tablets, from which preload and pressure in the pulmonary capillaries decrease, an increase in the minute volume of blood occurs. The action occurs 60 minutes after the application of Diroton. The maximum effect is observed after six to seven hours and persists for 24 hours.

Indications for use

What helps? Diroton is used not only from pressure, but from different pathologies. From a number of pathologies, the main ones in the treatment of which the drug is used are the following:

  1. Arterial hypertension (in the form of monotherapy or in combination with other antihypertensive drugs).
  2. Chronic heart failure (as part of combination therapy to treat patients taking digitalis and / or diuretics).
  3. Diabetic nephropathy (to reduce albuminuria in patients with insulin-dependent diabetes mellitus with normal blood pressure and in patients with non-insulin-dependent diabetes mellitus with hypertension).
  4. Acute myocardial infarction (within the first 24 hours with stable hemodynamic parameters to maintain these parameters and prevention of left ventricular dysfunction and heart failure).

At what pressure do you designate?

In the recommendations for admission is not indicated, under what figures of blood pressure you need to start taking "Diroton".

Doctors say that hypertension rates are purely individual, because one patient normally has pressure is 90/70, and raising to 130/80 is dangerous for him, and the other is normal - 140/90. In connection with this differentiation, a specialist should be engaged, which in the end will determine whether there is a need to use Lysinopril.


The use of the drug Diroton instruction prohibits when:

  • hypersensitivity to lisinopril;
  • stenosis of the aortic aorta;
  • changes in biochemical parameters of blood;
  • stenosis (constriction) of the renal arteries;
  • decompensated renal failure;
  • primary aldosteronism (a tumor of the adrenal cortex with the formation of an excessive amount of aldosterone).

The use of Diroton is contraindicated in pregnancy, lactation and children under 16 years.

Application in pregnancy and lactation

The use of Diroton in pregnancy is contraindicated. Lizinopril penetrates the placental barrier. When establishing a pregnancy, the drug should be stopped as soon as possible.

Admission of ACE inhibitors in the II and III trimesters of pregnancy has an adverse effect on the fetus (possible marked decrease in blood pressure, renal failure, hyperkalemia, skull hypoplasia, intrauterine death). Data on the negative effects of the drug on the fetus in the case of application in the I trimester is not. For newborns and infants who have undergone intrauterine exposure to ACE inhibitors, it is recommended that establish careful monitoring for the timely detection of a marked decrease in blood pressure, oliguria, hyperkalemia.

There is no data on the penetration of lisinopril into breast milk. If it is necessary to prescribe the drug during lactation, breastfeeding should be discontinued.

Instructions for use

In the instructions for use it is indicated that Diroton is taken 1 time per day, washed down with a small amount of water. It is recommended to take the reception at the same time, regardless of the meal, preferably in the morning.

  1. With essential hypertension take 10 mg / day. (as a starting therapy). The maintenance dosage is 20 mg / day. The maximum daily dose is 40 mg. The maximum effect of the drug is achieved after 2-4 weeks of continuous use, which should be taken into account when the antihypertensive effect is insufficiently expressed and the desire to increase the dosage.
  2. In the absence of the effect of treatment with diroton in the maximum daily dose, it is necessary to use another drug to lower the pressure. It is necessary to cancel diuretics (if they were received by the patient) 2-3 days before lisinopril intake. If this is not possible, the starting dose of lisinopril should be reduced to 5 mg / day.
  3. Renovascular hypertension or hyper-function of the renin-angiotensin-aldosterone system: the starting dose is 2.5-5 mg / day, the maintenance dose depends on the level of blood pressure.

In the case of heart failure, a combination of lisinopril with diuretics and / or digitalis preparations is used. However, it is recommended to reduce the dose of diuretic.

With renal failure or in the case of chronic hemodialysis, the starting dose depends on the creatinine clearance. At a clearance of 30-70 ml / min - 5-10 mg / day, at 10-30 ml / min. - 2.5-5 mg / day, with a clearance of less than 10 ml / min - 2.5 mg / day. lisinopril. The maintenance dose depends on the level of blood pressure. It is necessary to monitor the functional state of the kidneys, the content of potassium and sodium in the blood serum.

Side effects

In the instruction to Diroton it is noted that the drug can cause a number of side effects from the patient's body:

  1. Respiratory system: dry cough, dyspnea, apnea, bronchospasm;
  2. Genitourinary system: oliguria, uremia, anuria, renal failure, decreased libido and potency;
  3. Cardiovascular system: lowering blood pressure, chest pain, tachycardia, bradycardia, myocardial infarction;
  4. Skin: increased sweating, hives, photosensitivity, hair loss, itching;
  5. Circulatory system: thrombocytopenia, leukopenia, neutropenia, anemia, agranulocytosis, insignificant decreases in hematocrit and hemoglobin;
  6. Central nervous system: attention deficit disorder, mood lability, paresthesia, drowsiness, fatigue, seizures;
  7. Digestive system: vomiting, dry mouth, acute abdominal pain, diarrhea, anorexia, variance, taste disorder, hepatitis, pancreatitis, jaundice, hyperbilirubinemia.


When ingesting large doses of the drug or prolonged uncontrolled use of tablets, patients develop signs of overdose that manifest themselves with the following symptoms:

  1. Tachycardia, confusion;
  2. Dry mouth, strong thirst;
  3. Lethargy and apathy to what is happening, a decrease in reflexes.
  4. The pronounced decrease in the indices of arterial pressure, collapse, acute vascular insufficiency.

With the development of such clinical symptoms on the background of treatment with Diroton, the patient must be immediately taken to the hospital. Treatment of an overdose consists of washing the stomach, taking activated charcoal and performing symptomatic therapy if necessary.

special instructions

  1. During the period of treatment it is not recommended to drink alcoholic beverages. Ethanol enhances the hypotensive effect of the drug.
  2. Care should be taken when performing physical exercises, in hot weather (the risk of dehydration and excessive blood pressure lowering due to a decrease in BCC).
  3. Caution should be given to the drug with severe renal dysfunction, condition after kidney transplantation, bilateral stenosis of the renal arteries or stenosis of the artery of a single kidney with progressive azotemia, azotemia, renal failure.
  4. The use of the drug in recommended doses by elderly patients may be accompanied by an increase in the concentration of lisinopril in the blood. Therefore, the selection of a dose requires special attention and is carried out depending on the function of the kidneys and blood pressure of the patient.
  5. When adverse reactions from the central nervous system appear, vehicle management is not recommended, as is the performance of work associated with an increased risk.

The safety and effectiveness of the use of the pruned in children is not established. Loss of fluid and salts must be compensated before starting treatment with lisinopril. ACE inhibitors cause fetal and neonatal morbidity and mortality.

Drug Interactions

  1. Slows the excretion of lithium from the body.
  2. NSAIDs, estrogens, sympathomimetics reduce the hypotensive effect.
  3. With simultaneous application with potassium-sparing diuretics and potassium preparations, hyperkalemia is possible.
  4. Antacids and cholestyramine reduce absorption in the digestive tract.
  5. Combined use with beta-blockers, calcium channel blockers, diuretics and other antihypertensive drugs increases the severity of hypotensive action.


We picked up some of the people's comments about the drug Diroton:

  1. Varvara. I take this drug for more than two years. Very satisfied with the result - the pressure is at a normal level, sharp pressure drops stopped. Taking 1 tablet a day allows you to maintain an excellent state of health during the day. I can also note the improvement of the heart.
  2. Sasha. Not a bad drug. A pill in this group is the main one - a dry cough, but not all of them. By the way, Kapoten should also be in the house, he is taken if necessary, and Diroton is constantly.
  3. Valeria. I take the pill from the pressure every morning, as the doctor recommended. With each reception, I felt better. I did not find any side effects, it's very good. The result of taking the tablets is positive. BP pressure is normal; heart beating-norm; no headache; ears, it does not obscure. But since I have not finished the course of treatment, I continue to drink it.
  4. Irina. Diroton was discharged to my mother. With regular use, according to the doctor's recommendation, the drug is effective. But with a sharp jump in blood pressure, it does not have antihypertensive effects. Even with repeated taking or increasing dosage. We have to take other stronger drugs.

According to the reviews of doctors and patients, Diroton is coping well with the task assigned to him. Adverse reactions, despite their large number, are rare. Predominantly, patients encountered negative reactions during drug overdose. Cardiologists note that unpleasant side effects in their practice occur in the form of individual intolerance of the drug component. In such a situation, replacing the medicine becomes the solution to the problem.


Analogues of Diroton with the same active substance are drugs:

  • Vitopril;
  • Dapril;
  • Diropress;
  • Lysacard;
  • Lizinopril (Russian equivalent);
  • Lisonorm;
  • Liten;
  • Listril;
  • Sinopril;
  • Rileys-Sanovel;
  • Tenliza (the Russian analogue).

Before using analogues, consult your doctor.

Storage conditions and shelf life

Keep the drug in a dark, out of the reach of children at a temperature of +15 to 30 degrees. Diroton is fit for admission for three consecutive years after graduation.

How to choose probiotics for the intestine: a list of drugs.

Effective and inexpensive cough syrups for children and adults.

Modern non-steroidal anti-inflammatory drugs.

Review of tablets from the increased pressure of the new generation.

Antiviral drugs are inexpensive and effective.

Sign Up To Our Newsletter

Pellentesque Dui, Non Felis. Maecenas Male