Non-steroidal anti-inflammatory drugs and pain medications

Anti-inflammatory and analgesic preparations

Among all medicines sold by pharmacists, the greatest demand is for painkillers. Such medications are able to relieve spasm. They eliminate the production of prostaglandins - the causative agents of unpleasant sensations.

Also, the drugs have a pronounced anti-inflammatory effect. Especially often, consumers use nonsteroidal painkillers. You can buy them without a special recipe.

The task of such means is to reduce the temperature, stop the pain and inflammation. Painkillers are also used for osteochondrosis, trauma and (only some) after surgical interventions.

Let us consider in more detail what medicines are and what are their features.

Acetylsalicylic acid: a proven tool for adults

This drug, used as an analgesic, belongs to the group of non-steroidal anti-inflammatory drugs. The active substance here is acetylsalicylic acid.

This component has a pronounced analgesic and antipyretic effect, it dilutes the blood. Also, the drug has a slight anti-inflammatory effect.

Indications for use are fever and various types of pain, heart attack, stroke, ischemia, arterial diseases and heart valve pathologies.

Do not take medicine for certain diseases of the heart, blood vessels and blood. Renal and hepatic insufficiency, ulcer and erosion of the digestive tract is an excuse to refuse to use painkillers with acetylsalicylic acid.

Medicines, which contain the described substance, have the following names:

• "Aspicor".
• "Aspirin".
• CardiAsK.
• «Упсарин УПСА» and many others.

In recent years, these drugs are practically not used to treat rheumatism, arthritis, pericarditis.

Metamizole sodium, or analgin

The drug, used as an analgesic, can have sodium metamizole as the main substance. This compound is a derivative of pyrazolone, it also belongs to the NSAID group.

The medication is able to provide analgesic, anti-inflammatory and antipyretic effects. It is often metamizole sodium used in the composition of the lytic mixture with white fever.

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It is prescribed for rheumatism, arthralgia, pain of a different nature, inflammation, myocardial infarction and thrombosis.

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This drug, used as an analgesic, is used for tumors, injuries, insect bites, in the postoperative period.

It is contraindicated to use medicines based on metamizol sodium in the inhibition of hematopoietic function, hepatic and renal failure, anemia, future mothers and lactating women. The medicine is produced in the form of tablets and a solution for injections. Trade names that you can meet:

• "Analgin".
• "Spasdolzin".
• The Baralgin.

During treatment with sodium metamizole, urine can be colored red.

Ibuprofen: proven active ingredient

Painkillers for children are often required for dental, headache, injuries, otitis, sprains and bruises. Medicines for children are needed in the period after vaccinations, to stop the signs of viral and bacterial infection.

The most popular among all formulations is a medicament based on ibuprofen. This NSAID is able to inhibit COX 1 and COX 2. The drug reduces vascular permeability, which removes inflammation.

Medication after ingestion works almost instantly. He removes the stiffness of movements, eliminates the edema, stops painful sensations of a different nature.

Compositions are produced in the form of suspensions, suppositories, tablets and injections. Trade names of preparations:

• Nurofen.
• "Advil".
• "Moment".
• "Faspik" and so on.

Take these drugs is not recommended for ulcerative lesions of the stomach, hypersensitivity, certain pathologies of blood and severe kidney failure. To children of younger age (from three months) medicines in the form of a suspension and suppositories are appointed.

Ketorolac: a strong anesthetic

It represents the anti-inflammatory and analgesic medications "Ketorol" and its structural analogues. They contain the active substance ketorolok.

It has a strong analgesic effect and has a pronounced anti-inflammatory effect.

Such medications are worse than the previous ones cope with high body temperature, but are still characterized as antipyretic.

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Appointed analgesics based on ketorolac in pain syndrome of different origin: trauma, dental and headache, migraine, arthrosis and arthritis, dislocations, postoperative period, oncological diseases and so Further.

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The active substance has the following denominations:

• Ketorol.
• "Ketanov".
• Ketorolac.
• "Ketalgin."

Compositions are issued in the form of injections, tablets, external agents and eye drops.

It is inadmissible to use drugs with high sensitivity, somatic diseases, heart and liver failure, diabetes, during pregnancy and lactation.

You can not combine these medications with corticosteroid drugs and anticoagulants. There is no proven safety in using antipyretics in children under 16 years of age.

Paracetamol and its derivatives: all known drugs

Antipyretics, analgesics, often prescribed for young children, represent the active substance paracetamol.

It has long been used in medicine, including pediatrics, and has proven safety. In the absence of contraindications, it is permissible to use it even in newborn children.

Medicines based on paracetamol:

• The "Kalpol".
• "Panadol".
• "Cefekon."
• "Efferalgan" and so on.

Medicines are available in the form of suppositories, tablets and suspensions. They perfectly cope with the pain syndrome and reduce body temperature. But the compositions have no pronounced anti-inflammatory effect.

In this regard, paracetamol-based agents are used in various types of pain and fever. Do not use drugs for violations of the liver and kidneys, alcoholism. Tablets are contraindicated for children under 6 years.

For babies it is worth choosing candles or syrup.

Diclofenac: an effective anti-inflammatory drug

If you need anti-inflammatory and analgesic drugs, then give preference to drugs based on diclofenac. Their trade names are:

• Orthofen.
• Diclofenacol.
• Dicloran.
• Voltaren and others.

It is inadmissible to take them only in cases of hemopoiesis, in the last trimester of pregnancy and ulcerative-inflammatory diseases of the digestive tract.

In children under 6 years of age, medication is not used due to the lack of clinical studies.

Therefore, it is recommended for diseases of the joints, neurological pathologies. Practice the application and in gynecology. The medication also has anti-rheumatic and anti-aggregation effects.

Indomethacin: a substance with less popularity

Often a person needs painkillers for toothache. These include medications based on indomethacin. This substance has a pronounced analgesic effect.

It is effective in migraine, neurological and gynecological pains. Also, the medicine has a good anti-inflammatory effect. It is recommended to use the composition for diseases of joints and tissue traumas, infectious pathologies of ENT organs.

Effective will be medication for violations of the musculoskeletal system.

Contraindications to the use of medications on the basis of indomethacin can be called a stomach ulcer, bleeding, some diseases of the organs of vision, pathology of the vestibular apparatus, pregnancy and childhood. Trade names of medicines that you can meet at pharmacies:

• "Indomethacin."
• "Metindol".
• "Indotard" and others.

Means are given for ingestion, rectal administration, external use and in the form of eye drops.

Naproxen: antiaggregant with anti-inflammatory effect

Painkillers for headache and other types of it represents the active substance naprexen. This medicine removes inflammation, facilitates the patient's condition.

In a short time, the medicine will stop the pain syndrome caused by different causes. Apply the composition for dental, headache, myalgia, arthralgia, neuralgia, muscular discomfort, female periodic ailments.

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Naproxen is effective in degenerative diseases of the support apparatus. Do not use the formulation for renal and hepatic insufficiency, intolerance of the active substance.

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It is dangerous to use a medicine in children of the first year of life. Adults usually tolerate the following drugs:

• "Nalgezin".
• "Nappriksen."
• "Sanaprox".
• "Naprios" and so on.

Nimesulide and preparations based on it

If you need strong painkillers, you can give preference to drugs that include nimesulide. These medicines have the following trade names:

• "Nyz".
• "Nimesil".
• "Nimika."
• "Nemux" and so on.

Medications are non-narcotic analgesics. They quickly and permanently eliminate the pain syndrome of different localization. Also, the drug has a pronounced anti-inflammatory effect.

Medications based on nimesulide are used to eliminate febrile syndrome, when agents with ibuprofen and paracetamol are powerless. Clinical studies have shown that this drug is stronger in its action than its predecessors.

Some deviations in the work of the cardiovascular and hematopoietic system should be the reason for replacing the drug with another compound. Indication for the use of drugs is acute pain syndrome.

OXICAMES: A group of NSAIDs

Among all non-steroidal and anti-inflammatory drugs, it is possible to isolate the medicines-oxicams. They have different active substances and trade names. Here are some of them:

• lornoxicam ("Xefokam "Zornika");
• meloxicam ("Movix "Lem");
• piroxicam (Finalgel, Kalmopyrol);
• Tenoxicam ("Tenikam "Tobitil").

Medications are prescribed for relief of pain syndromes and removal of inflammatory processes.

Each drug has an antipyretic effect, the effect of which in this or that case may differ.

Before using any of these medications, you should read the instructions, since all drugs have separate use restrictions and special instructions.

Features of painkillers and anti-inflammatory formulations

Almost all painkillers are dispensed from pharmacies without medical prescription. But this does not mean that they can be taken thoughtlessly and in unlimited quantities. All painkillers have their own treatment period.

To stop the pain syndrome, they are taken no longer than five days in a row. If you need funds to reduce the temperature, it is acceptable to use them only three days. Doctors can prescribe medications for a longer period of time with the aim of removing inflammation.

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But it is necessary to monitor the functioning of vital organs and monitor the blood. Take painkillers at a certain time. Usually a gap of at least 4 hours is established.

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Some remedies can not be reused, sooner than in 6-8 hours. This information is always written with instructions, carefully read it.

Interesting information about the products presented, obtained by comparing them

You already know that all painkillers and antipyretic drugs have an anti-inflammatory effect, more or less. The conducted researches have shown, what means will be stronger.

On the analgesic effect, the active substances go in descending order:

• ketorolac;
• diclofenac;
• indomethacin;
• naproxen;
• ibuprofen.

If you judge by the strength of the anti-inflammatory effect, you can get the following classification:

• indomethacin;
• diclofenac;
• naproxen;
• ibuprofen.

Taking any of these medicines can cause bleeding in the gastrointestinal tract, vomiting or nausea. Also, some formulations individually cause an allergic reaction.

If during the treatment you suddenly feel worse or new symptoms of the disease appear, then you should not hesitate. Call your doctor as soon as possible.

Medicines can lubricate the clinical picture of dangerous pathological conditions. The consequences of this are very unpleasant.

Instead of concluding

From the presented article, you could learn about the drugs that are used by consumers for the purpose of anesthetizing and relieving inflammation. It is worth remembering that many medicines have exceptionally symptomatic treatment.

They facilitate the patient's condition, relieve unpleasant sensations and eliminate fever. But they do not act on the cause of the ailment. If you feel unwell, it is advisable to contact the doctors for help.

Only a qualified specialist will be able to establish the cause of your illness, after which he will appoint the right treatment. Be healthy and live without pain!

A source: http://.ru/article/284853/protivovospalitelnyie-i-boleutolyayuschie-preparatyi

What are the non-steroidal anti-inflammatory drugs used for?

Anesthetics, or non-steroidal anti-inflammatory drugs (NSAIDs, NSAIDs) are considered non-hormonal, which are aimed at eliminating various pains, including in the muscles and joints.Such drugs have side effects in the minimum amount. Let us consider in more detail what their main purpose is and under what diseases they are used.

General information about the preparations

Nonsteroid drugs are generally dispensed in a pharmacy without a prescription.

According to statistics, almost 30 million people throughout the world use drugs that have an anti-inflammatory and analgesic effect, every day.

Half of the people from this statistical figure are people of advanced age, namely, over 60 years of age.

It is worth noting that most old people suffer from many joint diseases, muscle pain, back and other other ailments, and it is simply necessary to use potent painkillers facilities. For example, painkillers for arthrosis, analgesics for pain in the back are indispensable, and also with the development of other "old" diseases, for the relief of the symptoms of which other means ineffective.

Such a drug will have anti-inflammatory, analgesic (analgesic), antipyretic effect, will help reduce the intensity of symptoms in diseases such as pain, inflammation and fever. In the last three decades, the popularity of such medicines has increased, which has made their use more common, unlike other drugs of similar effect.

All nonsteroidal drugs can be divided into 2 groups, taking into account their anti-inflammatory activity and chemical structure.

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The first group consists of the most powerful painkillers having a pronounced effect.

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The second group includes drugs that have a weak anti-inflammatory effect, which are called "non-narcotic analgesics".

New generation of NPPs

Developments in the field of medicine are moving forward every year.

Thus, the researchers developed a group of nonsteroidal drugs called "non-steroidal anti-inflammatory drugs of a new generation".

Such modern means are called selective, because they have a more sparing effect on the body, without traumatizing other healthy organs and systems.

New non-steroidal agents have better tolerability of the body than first-generation drugs, have less harm to the gastrointestinal tract and practically do not affect the process of clotting blood.

Unlike non-selective drugs, they do not affect cartilage cells of the joint and are considered chondrojetral.

Consider the list of the most common nonsteroidal pain medications:

1. Nimesulide. The medicine is used for pains in the joints, arthritis and other known diseases. The analgesic is able to anesthetize the necessary area of ​​the trunk, eliminate the inflammation process and muscle discomfort, normalize the temperature. Form of manufacture - ointment, which is applied to problem areas. When itching and redness of the skin is recommended, consult a doctor.
2. Celecoxib. The medicine will help to numb the necessary area, to remove the inflammation. They are used for such diseases as osteochondrosis and arthrosis.
3. Meloksikam (Movalis). Has analgesic, anti-inflammatory effect. Injection of the drug is the most gentle form of taking Meloxicam.
4. Xefokam. Very strong anesthetic, the effect of which is observed about 12 hours. The effect can be compared with drugs such as Morphine and Codeine (narcotic painkillers), but addictive to such a drug, according to numerous studies, was not diagnosed as well as side effects from CNS.

NPvs with neuralgia

Intercostal neuralgia is a disease that is accompanied by inflammation in the nerve fiber, thus causing tissue edema and pain.

Anti-inflammatory drugs with intercostal neuralgia will help to eliminate such an inflammatory process and the problem itself as a whole. These drugs include Diclofenac, Nimesulid, Voltaren.

The appointment of such drugs with intercostal neuralgia is performed only by a doctor.

The doctor prescribes a certain dosage, which is recommended to be observed. As a rule, with intercostal neuralgia, any drug is taken 2 times a day. The form of release of medicines can be different.

These are tablets, and rectal suppositories, injections. In each case of intercostal neuralgia, the form of the medication to be taken may be different. This will also be determined by the doctor.

Nvs with intervertebral hernia

Actively used painkillers for hernia spinal cord. These include Nimesulide, Ibuprofen, Aceclofenac and Diclofenac.

By blocking the production of histamine, the drugs relieve edema in the area of ​​the herniated intervertebral space, while providing anti-inflammatory and analgesic effects.

Such preparations for the treatment of hernia are produced with a different chemical structure and can be used in different forms of their release, like tablets, ointments or suspensions.

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For example, Aceclofenac and Diclofenac block the production of enzymes that contribute to the onset of inflammatory processes.

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They also help to thin the blood and remove toxic substances from it.

Hernias in the cervical and lumbar regions are most often eliminated with the help of Diclofenac, released in the form of injections, as well as Midokalma.

Together with these drugs, hernia in these departments is recommended to treat and with the use of ointments, for example, Voltaren - gel. A drug such as Diclofenac can cause a variety of side effects.

That is why when diagnosing a herniated intervertebral space, treatment with such a drug is carried out for no more than 2 weeks.

Нпвс at pains in joints

Nonsteroidal agents for joints, including diseases such as osteoarthritis and rheumatoid arthritis, have an analgesic, anti-inflammatory and antipyretic effect. Different drugs have different manifestations of such effects on the body.

It is for this reason that the doctor appoints certain medications for each patient with joint pains.

For example, in one case, the funds are suitable for long-term treatment, and in another case, such drugs are prescribed to eliminate pain and fever.

Appoints non-steroidal funds for pain in the joints only the doctor, based on the individual characteristics of the course of the disease, as well as taking into account the patient's tolerability of a drug.

Нпвс after operations

Of course, non-steroid drugs after surgery do not have a pronounced effect, unlike opioid drugs, that is, narcotic drugs. For this reason, they will not be able to eliminate severe pain right after the operation, in the early days. But in the following days they will be quite effective:

Diclofenac. You can achieve the desired effect within half an hour after taking the medicine.

Penetrating into each organ and tissue, the drug is effective for every kind of operation.

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With severe pain after the operation, Diclofenac injections are prescribed, gradually switching to a tablet form of administration.

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Nimesulide. Modern and safer means for use after the operation of different localization. The only drawback of such a drug is that there is no injectable form of release.

Rofecoxib. Use both injection and tablet form for use after the operation of different locations. There is no damage to the gastrointestinal mucosa, which makes the drug safe for use with the existing stomach ulcer.

Side effects and contraindications

If, for a long time and in the maximum dosage, to take this type of medication, it does not matter which treatment for the disease, you can come up with such side effects:

• disturbed functioning of the central nervous system (it can be frequent dizziness, the development of noise in the ears, headache);
• deviations in the functioning of the visual system;
• changes in the work of the heart and blood vessels (this can be increased heart rate, increased blood pressure, the appearance of edema);
• the occurrence of an ulcer, perforation, gastric or intestinal bleeding, dyspeptic disorders, a violation of the functioning of an organ such as the liver;
• allergic reactions (it can be erythema, urticaria, bronchial asthma, anaphylactic shock);
• the onset of renal insufficiency;
• disturbed process of urination.

The main contraindications include:

• individual intolerance to drugs with this effect;
• stomach ulcer and 12 - duodenal ulcer;
• other lesions of the digestive system;
• the disturbed functioning of organs such as the liver and kidneys.

A relative contraindication to the use of this group of drugs is pregnancy.

Thus, the use of non-steroidal agents in the 3-trimester of the provision is prohibited, when such may contribute to the development of kidney complications in the child.

Preterm birth can also occur as a result of taking medications.

In order not to cause side effects from taking non-steroidal anti-inflammatory drugs, it is necessary to follow all the doctor's recommendations for their use.

A source: http://drpozvonkov.ru/lechenie/medikomentoznoe/dlya-chego-naznachayut-nesteroidnye-protivovospalitelnye-sredstva.html

Non-steroidal anti-inflammatory drugs (NSAIDs)

Nonsteroidal anti-inflammatory drugs (NVS) - a group of drugs that have a pronounced anti-inflammatory, antipyretic and analgesic effect.

The effect of NVS is to block some enzymes that promote the formation of biologically active substances that trigger an inflammatory response.

The most dangerous side effects of NVS are exacerbation of gastric ulcer and duodenal ulcer, as well as allergy.

What are nonsteroidal anti-inflammatory drugs and how do they work?

Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs not belonging to the group of steroid hormones and possessing a pronounced anti-inflammatory effect. The list of medicines relating to this group can be found in the table at the end of the article.

Pain, inflammation and temperature are constant signs of almost all diseases.

In the human body, these three phenomena, characteristic of the disease, are controlled by a group of biologically active substances (prostaglandins) that are produced in diseased tissues.

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I act on the vessels and nerves at the wound site or in the diseased organ, prostaglandins cause swelling, redness, soreness. In the human brain, prostaglandins activate the center responsible for fever and cause fever.

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The action of non-steroidal anti-inflammatory drugs is to inhibit the formation of prostaglandins, which in turn will eliminate pain, inflammation and temperature. Indeed, most anti-inflammatory drugs have a pronounced analgesic and antipyretic effect.

In addition to eliminating temperature and inflammation, anti-inflammatory drugs affect the coagulability of the blood and make it more fluid, in with which they are widely used in the treatment of a number of cardiovascular diseases (atherosclerosis, angina pectoris, heart failure and etc.).

What does non-steroid means mean?

For our body, all non-steroidal anti-inflammatory drugs are foreign substances.

In the human body has its own anti-inflammatory system, which is started in case of severe injuries or stress.

The main anti-inflammatory effect in the human body carries a number of steroid hormones of the adrenal glands (glucocorticides), synthetic analogues of which are used in the manufacture of hormonal anti-inflammatory preparations.
The term "non-steroidal" means that drugs from the NSAID group do not belong to the group of steroid hormones and are devoid of a number of side effects specific for drugs from this group.

In what cases are non-steroidal anti-inflammatory drugs used?

As antipyretic agents, non-steroidal anti-inflammatory drugs are used for:

• Treatment of temperature, against a background of various diseases in children and adults

As anti-inflammatory drugs, NSAIDs are used to treat:

As an anesthetic, non-steroidal anti-inflammatory drugs are used in the treatment of:

As an angiagregant, non-steroidal anti-inflammatory drugs are used to treat:

• Ischemic heart disease, prevention of heart attack and stroke.

When should non-steroidal anti-inflammatory drugs be used?

Nonsteroidal anti-inflammatory drugs can not be used in the following cases

Side effects of non-steroidal anti-inflammatory drugs

The most dangerous side effects from using non-steroidal anti-inflammatory drugs are related to their effect on blood and gastric mucosa.

The adverse effect of non-steroidal anti-inflammatory drugs on the human body is explained by the fact, that they block the production of prostaglandins not only in the focus of inflammation, but also in healthy organs and cells blood.

Less dangerous side effects of non-steroidal anti-inflammatory drugs are associated with the possibility of developing allergies and their irritating effect on the gastrointestinal tract (nausea, vomiting, abdominal pain, bloating stomach).

Before using any of the drugs in this group, carefully read the list of contraindications and side effects.

Natural (natural) anti-inflammatory drugs

The use of non-steroidal anti-inflammatory drugs in medicine began with the discovery of such properties in some natural products.

In particular, it was noted that the extract of the bark of the willow contains a substance called salicylate, which has a strong anti-inflammatory and antipyretic effect.

Later, on the basis of salicylate, one of the most famous of the modern drugs - acetylsalicylic acid or Aspirin - was synthesized.
In folk medicine, there are certain other drugs with antipyretic and anti-inflammatory effects. Here are some of them:

• Raspberry jam and raspberry tea - reduces temperature and inflammation against the cold
• Infusion of chamomile or calendula - have a strong anti-inflammatory and antimicrobial effect when used locally

In addition to folk anti-inflammatory drugs are available and pharmacological and homeopathic medicines manufactured on the basis of natural raw materials: Revma-gel, tincture of the saber, etc.

Name of active substance	Name of the medicine
Acetylsalicylic acid	Aspirin, Aspirin Oopsa, Alka-Seltzer, Cefekon
Diclofenac	Diclofenac, Voltaren
Ketorolac	Ketorolak, Ketanov
Indomethacin	Indomethacin
ibuprofen	ibuprofen, nurofen
Naproxen	pentalginum
Oksikamy	ksefokam, piroxicam
Inhibitors of COX2	meloxicam, movalis, nise, nimesil
For external use	fasts,

Ankylosis: Species, Causes, and Treatment Ankylosis (IBC) is a disease that begins with impaired mobility (contractures) and eventually leads to complete immobility of the joints. Ankylosis of the joint is not a separate disease, but a symptom of other pathological changes. The disease affects both large and small joints (fingers and toes). Arachnoiditis: causes, symptoms, treatment Arachnoiditis is an inflammation of the arachnoid membrane of the brain or spinal cord. This pathology accounts for about 5% of the total number of organic lesions of the nervous system. As a rule, arachnoiditis is diagnosed in patients under the age of 40 (it can often be found in child). Benzidamine hydrochloride is a non-steroidal anti-inflammatory drug, an indazole derivative, without carboxyl group. Has anti-inflammatory and local anesthetic effect, antiseptic (against a wide range of microorganisms), as well as antifungal action. Acetylsalicylic acid Acetylsalicylic acid is referred to as NSAID, i.e., a group of non-steroidal anti-inflammatory drugs. Its main therapeutic effect is anesthesia, fever removal, blood thinning, by inhibiting the process of platelet aggregation. Sulfasalazine refers to agents that are used in systemic pathologies of an inflammatory nature, as well as nonspecific diseases. It has an immunosuppressive effect on the body, due to the fact that it suppresses autoimmune reactions. That is why it is used in the therapy of rheumatoid arthritis and other systemic diseases. Salicylic ointment is a very effective non-steroidal anti-inflammatory drug that is intended exclusively for topical external application. This drug is widely used in the treatment of various pathologies of skin. Xefokam - a drug from a series of non-steroidal anti-inflammatory, as well as anti-rheumatic drugs. Produced in two forms - powder and tablets. It is sold in pharmacies by prescription. Nimide is a drug from the group of classic NSAIDs (non-steroidal anti-inflammatory drugs, which has a mild anti-inflammatory effect. It is used for various inflammatory diseases with pain syndrome (inflammatory diseases of the nasopharynx, throat, ossezoperatsionnyh pain, with sports injuries. Nyz is a synthetic NSAID of a new generation related to sulfonanilides. This modern pharmacological agent makes it possible in the shortest time to relieve the pain and febrile reaction accompanying many diseases. Due to the selective inhibition of the cyclooxygenase mediator, symptoms of inflammation disappear. Candles Nurofen is an anti-inflammatory, analgesic and antipyretic. The active substance - Ibuprofen - belongs to the group of non-steroidal anti-inflammatory drugs. It is dispensed in pharmacies without a prescription. Sextafag polyvalent - pyobacteriophage, the drug acts on the specific lysis of microorganisms (staphylococci, streptococci, intestinal and pseudomonas aeruginosa). Melbek is a medicinal product that belongs to the class of NSAIDs - non-hormonal anti-inflammatory preparations. Being a selective inhibitor of COX-2, the drug has established itself as an excellent anti-inflammatory and antipyretic with effective analgesic effect. Nurofen is a medicinal product of a group of non-steroidal anti-inflammatory drugs. Has a strong analgesic property, has anti-inflammatory effect and antipyretic effect. Ozokerite refers to petroleum products, it is used as an anti-inflammatory agent in the form of compresses. Ozokerite can be bought in the form of a tile. The weight of the tiles can vary from 2 to 10 kg. It has a waxy appearance. Color - from dark shades of brown to black. But you can also find white ozocerite if it has been cleared of impurities. Refers to petroleum products, containing resin, paraffin, mineral oils and other substances. Piascladin 300 is a completely herbal preparation. It is able to regulate the metabolic processes of both cartilaginous and bone tissue of the joints of the human body, slow down their destruction, reduce pain and restore their mobility. It is also a new generation of anti-inflammatory drugs and has an analgesic effect, prevents tooth loss. Fucicort - ointment for external use, which has anti-inflammatory and antibacterial effect. Widely used in dermatology, has certain contraindications. Erbisol is a medicinal product with immunomodulatory properties. Low-molecular peptides, which are part of its composition, have a pronounced activity, which ensures the multi-duality of erbisol. Citral is a multicomponent drug that has a wide spectrum of action - anti-inflammatory, antiseptic, analgesic. For the treatment of various diseases, the recommended dosage should be clearly adhered to. Citralgin is a drug classified as anesthetic, anti-inflammatory and anti-edematous. Produced in one pharmacological form, before use, instruction is required - side effects are possible. Chymotrypsin is classified as a drug that breaks down various proteins in the body. Obtain this remedy from the organs of the digestive system of cattle.

A source: http://polismed.ru/dr-antiinflam-kw

What is it - nonsteroidal anti-inflammatory drugs, a list of NSAIDs of a new generation

Anti-inflammatory nonsteroidal drugs (NSAIDs, NSAIDs) are new generation drugs that have anti-inflammatory, antipyretic and analgesic (analgesic) effect.

Their mechanism of action is based on the blocking of certain enzymes (cyclooxygenase, COX), which are responsible for the formation of prostaglandins - chemicals that contribute to pain, fever, inflammation.

The word "non-steroidal" in the name of these drugs indicates the fact that groups are not artificial analogues of steroid hormones - the most powerful anti-inflammatory hormonal means. The most popular representatives of NSAIDs arediclofenac, ibuprofen.

Principle of work of NSAIDs

If analgesics are designed to fight pain, NSAIDs reduce two unpleasant symptoms of the disease: inflammation and pain. Many drugs of this group are considered to be nonselective inhibitors of the cyclooxygenase enzyme, which inhibit the effect of both of its isoforms (species) - COX-1 and COX-2.

Cyclooxygenase is responsible for the formation of arachidonic acid from thromboxane and prostaglandins, which in turn is obtained from the phospholipids of the cell membrane with the enzyme phospholipase A2. Among other functions, prostaglandins are regulators and mediators in the formation of inflammation.

When are NSAIDs used?

Most NSAID drugs usefor the treatment of chronic or acute inflammation, which are accompanied by pain. Anti-inflammatory non-steroid drugs have become very popular due to the effective treatment of joints.

We list the diseases in which these medicines are prescribed:

• dysmenorrhea (pain in menstruation);
• acute gout;
• postoperative pain;
• pain in the bones due to metastasis;
• intestinal obstruction;
• fever (high body temperature);
• minor pain due to trauma or inflammation of soft tissues;
• renal colic;
• back pain;
• Parkinson's disease;
• osteochondrosis;
• migraine;
• pain in the head;
• rheumatoid arthritis;
• arthrosis.

NSAIDs are not allowed to useduring erosive and ulcerative gastrointestinal lesions, especially, at the stage of exacerbation, cytopenia, expressed violations of kidney and liver, pregnancy, individual intolerance. It is necessary to be cautiously appointed to patients with asthma, and also to people who previously had negative reactions during the reception of any other NSAIDs.

Nonsteroidal anti-inflammatory drugs: a list of NSAIDs for the treatment of joints

Consider the most effective and known NSAIDs that are used to treat joints and other diseases when it is requiredantipyretic and anti-inflammatory effect:

• Ibuprofen;
• Indomethacin;
• Meloksikam;
• Naproxen;
• Celecoxib;
• Diclofenac;
• It is an ethanol;
• Ketoprofen.

Some medicines are weaker, not aggressive, some are designed for acute arthrosis, if emergency intervention is necessary to stop dangerous processes in the body.

The main advantage of the new generation of NSAIDs

Side effects are noted during prolonged use of NSAIDs (for example, during treatment of osteochondrosis) and consist of lesions of the intestinal mucosa and stomach withbleeding and ulceration. This lack of indiscriminate NSAIDs was the reason for the creation of new-generation drugs that block only COX-2 (an inflammation enzyme) and do not affect the function of COX-1 (protection enzyme).

That is, drugs of the new generation have almost no side ulcerogenic effects (damage to the mucous organs of the digestive system system) associated with prolonged use of nonselective NSAIDs, but increase the chance of thrombotic complications.

Of the minuses of the new generation of drugs can be identified only their high cost, making them inaccessible to most people.

What is the next generation of NSAIDs?

Non-steroidal anti-inflammatory drugs of the new generation work much more selectively, they are moreinhibit COX-2, with COX-1 remaining almost unaffected. This can explain the rather high effectiveness of the drug in combination with a minimum of side effects.

List of effective and popular anti-inflammatory non-steroid agentsnew generation:

• Xefokam. A drug that is based on Lornoxicam. Its characteristic feature is the fact that the drug has an increased ability to stop the painful sensation. On this indicator, it is similar to morphine, but at the same time it does not create addiction and does not have an opiate-like effect on the central nervous system.
• Movalis. It has antipyretic, well-pronounced anti-inflammatory and analgesic effect. The main advantage of this drug is that with the constant supervision of a doctor it can be used for quite a long time. It is produced by meloxicam in the form of a solution for intramuscular injections, in ointments, suppositories and tablets. Tablets of the drug are quite convenient because they have a prolonged effect, and it is enough to use one tablet throughout the day.
• Nimesulide. Successfully used for the treatment of arthritis, vertebrogenic painful sensations in the back, etc. Normalizes temperature, relieves hyperemia and inflammation. Taking the drug quickly leads to better mobility and less pain. It is also used in the form of an ointment for application to the problem area.
• Celecoxib. This drug significantly alleviates the condition of the patient with arthrosis, osteochondrosis and other diseases, effectively fights inflammation and relieves painful syndrome. Side effect on the digestive system on the part of the drug is minimal or completely absent.

In cases where long-term use of anti-inflammatory non-steroid drugs is not required, then the drugs of the old generation are used. However, sometimes this is simply a forced measure, since not all people can afford to treat these drugs themselves.

Classification of NSAIDs

By chemical origin, these drugs are with non-acidic and acidic derivatives.

Acidic preparations:

• Preparations based on indoacetic acid - sulindac, etodolac, indomethacin;
• Oksikam - meloksikam, piroxicam;
• Salicipates - diflunizal, aspirin;
• Based on propionic acid - ibuprofen, ketoprofen;
• Pyrazolidines - phenylbutazone, metamizole sodium, analgin;
• Preparations from phenylacetic acid - aceclofenac, diclofenac.

Non-acid preparations:

• Sulfonamide derivatives;
• Alkanones.

In this case, non-steroidal preparations differ in intensity and type of action - anti-inflammatory, analgesic, combined.

On the strength of the anti-inflammatory effectmedium doses of drugs are arranged in this sequence (the most powerful on top):

• Flurbiprofen;
• Indomethacin;
• Piroxicam;
• Diclofenac sodium;
• Naproxen;
• Ketoprofen;
• Aspirin;
• Amidopyrine;
• Ibuprofen.

By analgesic effectdrugs are arranged in this order:

• Ketoprofen;
• Ketorolac;
• Indomethacin;
• Diclofenac sodium;
• Amidopyrine;
• Flurbiprofen;
• Naproxen;
• Piroxicam;
• Aspirin;
• Ibuprofen.

The most commonly listed above NSAIDs arefor chronic and acute illnesses, which are accompanied by inflammation and pain.

As a rule, anti-inflammatory non-steroid drugs are used to treat joints and to relieve pain: injuries, arthrosis, arthritis, etc.

Often NSAIDs are used to anesthetize with migraines and headaches, kidney colic, postoperative pain, dysmenorrhea and the like Due to the inhibitory effect on the synthesis of prostaglandins, these drugs also have antipyretic Effect.

Dosage selection

Any new medicine for the patient should be prescribed at the beginning in the minimum dose. With normal portability in a few daysdaily dose increase.

Therapeutic doses of NSAIDs are in a wide range, with a recent trend towards an increase in single and daily doses of drugs, characterized by excellent tolerance (ibuprofen, naproxen), while maintaining the limits on the maximum dosage of indomethacin, aspirin, piroxicam, phenylbutazone. In some patients, therapeutic effect is achieved only with the use of elevated doses of NSAIDs.

Adverse Events

Prolonged use of anti-inflammatory drugsin higher doses may cause:

• Change in the work of blood vessels and heart - swelling, increased pressure, palpitations;
• Violation of urination, kidney failure;
• Violation of the CNS - disorientation, mood changes, apathy, dizziness, blurred vision, headache, tinnitus;
• Allergic reactions - hives, angio edema, erythema, anaphylactic shock, bronchial asthma, bullous dermatitis;
• Ulcer, gastritis, gastrointestinal bleeding, perforation, changes in liver function, dyspeptic disorders.

Treatment of NSAIDs must be done duringminimum possible time and minimum doses.

Pregnancy Use

It is undesirable to use preparations of the NSAID group during pregnancy, especially in the third trimester.

Although there are no directly teratogenic effects, it is believed that NSAIDs can cause renal complications in the fetus and premature closure of the arterial duct.

Also there is information about premature birth. Despite this, aspirin in combination with heparin is successfully used in women with antiphospholipid syndrome.

Description of non-steroidal anti-inflammatory drugs

Is a leaderamong non-steroidal anti-inflammatory drugs, which has a long time of action and is allowed for prolonged use.

It has a pronounced anti-inflammatory effect, which makes it possible to use it for rheumatoid arthritis, ankylosing spondylitis, osteoarthritis. Protects cartilage tissue, is not deprived of antipyretic and analgesic properties. Used for headache and toothache.

Determination of doses, options for taking (candles, injections, pills) depends on the type and severity of the ailment.

Celecoxib

The COX-2 inhibitor, which has a pronouncedanalgetic and anti-inflammatory action.

When used in therapeutic doses of a negative effect on the mucosa, the gastrointestinal tract hardly has any effect, since to COX-1 has a fairly low degree of kinship, respectively, does not cause a violation of the synthesis of constitutional prostaglandins.

Refers to the most effective non-hormonal drugs. With arthritis, it reduces the swelling of the joints, relieves pain and has a strong anti-inflammatory effect.

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When using a medical device, you need to be careful, because it has a large list of side effects.

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In pharmacology, the drug is manufactured under the names of Indovis EU, Indovazin, Indocollir, Indotard, Metindol.

Ibuprofen

Combines the ability to effectively reduce pain and temperature, relative safety, because medicines on its basis can be bought without a prescription. Ibuprofen is used as an antipyretic drug, includingand for newborns.

As an anti-inflammatory drug it is not used so often, however, the medicine is very It is also popular in rheumatology: it is used to treat osteoarthritis, rheumatoid arthritis and other diseases joints.

The most popular names are Nurofen, Ibuprom, MIG 400 and 200.

Diclofenac

Form of manufacture - capsules, tablets, gel, suppositories, solution for injections. In this preparation for the treatment of joints, both the high anti-inflammatory effect and the high analgesic activity perfectly combine.

It is produced under the names of Naklofen, Voltaren, Diklak, Orthofen, Wurdon, Diklonak P, Doleks, Olfen, Klodifen, Diclobert, etc.

Chondroprotectors - alternative drugs

Very often for the treatment of jointsuse chondroprotectors. People often do not understand the difference between chondroprotectors and NSAIDs.

The latter quickly remove pain, but at the same time have many side effects. And chondroprotectors protect cartilage tissue, but they need to be taken by courses.

In the composition of the most effective chondroprotectors there are two substances - chondroitin and glucosamine.

A source: http://artrit.guru/metody-lecheniya/medicinskie-preparaty/spisok-nesteroidnyh-protivovospalitelnyh-preparatov-novogo-pokoleniya.html