Eye drops Kombigan: instructions for use

Glaucoma is one of the most serious consequences of increased intraocular pressure, which most often occurs in the elderly as a result of age-related changes. Conservative treatment of glaucoma can only slow down the process of complete loss of vision, but not prevent it. However, with early diagnosis and proper regular use, there are many effective tools that help preserve the functionality of the eyes for years to come. Among these drugs are the eye drops Kombigan.

Description of the preparation

The drug is a clear solution with a shade of greenish-yellow color. The drug is packed in plastic bottles, equipped with a built-in dropper, volume 3 or 5 ml.Issued in a cardboard box, provided with an official instruction.

The composition of the drug 2 active ingredients: Brimonidine tartrate in an amount of 2 mg per 1 ml of solution, timolol maleate - 5 mg / 1ml. Among the excipients are sodium hydroxide, benzalkonium chloride, etc.

Store the drug recommended for t not above + 25 ° C.A mandatory condition is the inaccessibility to direct sunlight. If the required conditions are met, the drug can maintain its properties for 1 year and 9 months.After opening, eye drops should be used within 4 weeks.

Pharmacological action and group

The drug has a combined effect and is an effective means for reducing intraocular pressure. The therapeutic effect is made up of the properties of its constituent components:

• Brimonidine tartrate. The substance is an agonist of α-2-adrenoreceptors, which are mainly presynaptic receptors. Their stimulation leads to a decrease in IOP. There is a slight systemic absorption, which does not have a strong effect on the cardiovascular and respiratory system. The substance is rapidly absorbed into the corneal tissue and reaches a maximum concentration after 2 hours. Reduction of IOP is achieved due to a decrease in the amount of produced intraocular moisture and a slight increase in its outflow;
• Timolola maleate. The substance is a blocker of β-1 and β-2-adrenergic receptors, the result of its action is a decrease in the production of aqueous humor and a slight increase in its outflow. Its action begins after 20 minutes. after instillation, reaches a maximum after 1-2 hours and lasts for a day.

Which drops are still used to treat glaucoma and reduce intraocular pressure.

The use of active substances in combination allows a significant increase in the effectiveness of the drug compared with the use of brimonidine and timolol separately. However, even with a slight systemic absorption, the overall effect on the body can be strong, so the use of this remedy should be carried out only after the appointment of a doctor.

Indications and contraindications

Assigning eye drops Combigan is recommended in cases when the effect of local blockers of β-adrenoceptors is not effective enough.

Most often the drug is in demand for the treatment of the following pathologies:

• Open angle glaucoma. As a result of increased resistance to the outflow of intraocular fluid in the drainage network of the anterior chamber angle, there is a constantly progressive increase in intraocular pressure. The danger of the disease consists in its almost asymptomatic flow in the initial stage. Increased IOP has a complex pathological effect on the eye: pressure on the fibers of the optic nerve leads to its atrophy, and squeezing blood vessels interferes with normal metabolism in the eye tissues, preventing their supply of nutrients;

• Intraocular hypertension. The term means increased pressure inside the eye without the presence of damage to the optic nerve. Pathology is subject to treatment on a mandatory basis, because a prolonged excess of the normative parameters of IOP invariably leads to glaucoma. People with hereditary predisposition, nearsightedness or who have a diagnosis of "diabetes mellitus" are the most susceptible to hypertension. There are no obvious symptoms of this condition, as a rule, does not exist and can be detected only with periodic examinations of an ophthalmologist when the reading is 21 mm Hg. Art. more than two times.

In most cases, the drug is used to treat older people at the initial stage of glaucoma and is used twice in day, one drop in each eye, preferably at the same time, so that the interval between the procedures is the same - 12 hours. When instilled, it is recommended to press the inner corner of the eye to avoid systemic penetration.

Laser basal iridectomy is an effective method of treating glaucoma.

Contraindications

The list of contraindications in Combigan is extensive, as with most potent drugs. The main contraindication is the individual intolerance of the drug components. At the first application, special care should be taken in patients with a predisposition to allergic reactions.

Other prohibited conditions for the use of the drug include:

• Hyperreactivity of the respiratory tract (incl. bronchial asthma, bronchial obstruction syndrome);
• Severe allergic rhinitis;
• Sinus bradycardia (reduction of heart rhythm);
• Atrioventricular block (acute violation of cardiac conduction);
• Cardiogenic shock (acute pancreatic insufficiency, sharp decrease in blood pressure);
• Use in the treatment of antidepressants, MAO inhibitors;
• Pregnancy and lactation;
• Children under 18 years.

Since the drug can have a significant systemic effect, it is recommended that it be used with caution in the presence of chronic somatic diseases, as well as in conditions accompanied by violations of exchange processes.

In pregnancy

For the period of bearing the child, reliable data are not available for Combigan. Clinical trials were conducted only in animals.There were no congenital malformations of the fetus, but there were phenomena of delayed fetal development with oral intake of drugs from the group of β-blockers.Therefore, if absolutely necessary, the drug can be used during pregnancy only under the supervision of a doctor. It is recommended that the condition of the newborn be monitored in the first days of life.

List of eye drops used for glaucoma

With regard to breastfeeding, the penetration of active substances into breast milk is reliably established, therefore it is recommended to interrupt feeding for the period of treatment.

To small children

The drug is used to treat the syndrome of increased IOP, which is, as a rule, the prerogative of the elderly. In addition, the medicine has a strong enough effect, and not only local character.And, consequently, and a whole string of side effects. Therefore, the age period up to 18 years for the use of Kombigan is categorically prohibited.

Possible complications caused by the drug

Adverse events with the use of the drug can be caused, both by the active substances of the drug, and by the influence of its additional components. In this case, local manifestations are most often observed:

• Photophobia, carvings, burning;
• Allergic conjunctivitis;
• Syndrome of "dry" eye, etc. allergic reactions.

Sometimes side effects can acquire a systemic character:

• Drowsiness;
• Headache;
• Increased blood pressure.

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Drops with a hemorrhage in the eye

Drops for the eyes from fatigue and redness are described in this article.

Eye drops with antibiotic http://eyesdocs.ru/medicinaoperacii/lekarstva/vybor-glaznyx-kapel-dlya-detej-s-antibakterialnym-effektom.html

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In the most rare cases, more severe manifestations are possible:

• Dizziness, loss of consciousness;
• Enhanced palpitations;
• Perversions of taste perception;
• Contact allergic dermatitis;
• Development of rhinitis.

When manifestations of a recurring or severe nature should immediately stop taking the drug and consult an ophthalmologist.

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conclusions

Eye drops Kombigan - an effective drug of combined action, successfully used in the treatment of pathologies associated with a prolonged increase in IOP. In most cases, the remedy is used when the previous therapy is ineffective.

The use of the drug should always be justified and carried out only under the supervision of an ophthalmologist, since the drug is potent and has a number of side effects, both local and systemic character.

Also read about such drugs as Ophthalmoferon and Okapin.