From this article you will find out: what tablets are used for varicose veins, do they effectively eliminate the symptoms of this disease, can they completely cure varicose veins.
content of the article:
1. Flavonoids
2. Derivative routine
3. Pycnogenol
4. saponins
5. ergot derivatives
6. Synthetic materials
preparations improving microcirculation
Analgesics
Antibacterials
most effective treatments for varicose veins- surgical. Conservative drug treatment( including pills) is only of an auxiliary nature, it is aimed at eliminating the symptoms of the disease. Unfortunately, even the most effective pills for varicose veins can not cure this disease.
However, many patients with varicose veins are afraid of surgical treatment. Doctors often meet them and prescribe conservative treatment, consisting of lifestyle changes, wearing compression knitwear and drug therapy. And the medicines are given the least importance.
Most often with varicose veins appoint tablets that have phlebotonic properties, then able to increase the tone of the venous wall. These are the preparations of the following groups:
- Flavonoids( diosmin and hesperidinum).
- Derived routine.
- Pycnogenols.
- Saponins. Derived ergot.
- Synthetic substances.
In the presence of indications, doctors can also recommend taking drugs that improve microcirculation( warfarin, acetylsalicylic acid, dipyridamole, clopidogrel).In the presence of pain syndrome prescribed painkillers( ibuprofen), with infectious complications - antibiotics.
Tablets for the treatment of varicose veins are usually prescribed by general or vascular surgeons. When lesions of pelvic veins in the treatment process can also participate obstetricians-gynecologists.
Regardless of the type of varicose veins, the cause of its development is the weakening of the venous wall, so the same tablets are used for treatment. The only exception is varicose veins of the pelvis in women, who are sometimes prescribed hormonal drugs to relieve symptoms. However, it should be noted that the use of any tablets does not treat varicose veins, but only alleviates its symptoms.
1. Flavonoids
Examples of tablets from varicose of this group: Detralex, Daflon, Flebodia.
Preparations Detralex and Flebodia Flavonoids are chemical substances of plant origin. The most commonly used tablets for varicose in this group contain a combination of diosmin and hesperidin.
The most effective is the purified micronized flavonoid fraction, because due to the decrease in the particle size of the diosmin, the absorption of the preparation during oral administration is improved.
Diosmin was introduced into clinical practice in 1969.It is used to treat chronic venous insufficiency, hemorrhoids, lymphedema and varicose veins. Diosmin has anti-inflammatory, antioxidant and anti-cancer properties. In some countries of the European Union, preparations of diosmin and hesperidin are available by prescription, and in the USA they are part of the group of food additives.
Pharmacological properties of diosmin and hesperidin:
| Pharmacological indices | |
|---|---|
| Characteristics of the action | |
| Venous tone | Extend the vasoconstrictive action of norepinephrine on the venous wall, increase the tone of the veins, thereby reducing their capacity, extensibility and reducing blood stasis in the vessels. This increases the return of blood to the heart and reduces the increased venous pressure in patients with varicose veins. Suppress the increase in the number of erythrocytes, hematocrit and protein concentration in the blood caused by the vertical position. |
| Microcirculation | Suppress the increase in microvessel permeability, improve their reactivity and functional state, reduce adhesion of platelets. |
| Lymphatic drainage | Improves lymphatic drainage, increasing the frequency and intensity of contractions of lymphatic vessels and increasing the total number of functioning lymphatic capillaries. Reduce the diameter of lymphatic capillaries and reduce the pressure in them. |
Due to these properties, the combination of diosmin and hesperidin reduces the sensation of pain, tension and heaviness in the legs associated with varicose veins, and also reduces swelling.
Treatment with diosmin and hesperidin rarely causes side effects( side effects include abdominal pain, diarrhea, headaches, allergic reactions).
Preparations based on flavonoids are prescribed both as monotherapy and in combination with surgical treatment. The use of a combination of diosmin and hesperidin in the postoperative period allows to reduce swelling, pain and feeling of heaviness, improve tolerance to physical exertion and improve the quality of life.
Drugs of this group containing diosmin and hesperidin are most effective compared to other drug groups. They are most often prescribed by vascular surgeons for the treatment of varicose veins. The positive effect of bioflavonoids on the clinical picture of this disease has been proven in several scientific studies. However, even they are not able to eliminate the cosmetic defect of enlarged veins. All other tablets for the treatment of varicose veins, about which we will talk later, doctors prescribe extremely rarely.
2. Derived routine
Examples of preparations: Anvenol, Venoruton, Troxevasin.
The drug Venoruton Derived routine also belong to the group of bioflavonoids. Until 1950, rutin was called vitamin P. Its derivatives have the following properties:
- Counteracts the platelet activating factor, which causes the formation of thrombi and can lead to inflammatory or allergic reactions.
- are anti-inflammatory and antioxidant substances.
- Strengthen the inner shell of blood vessels throughout the body, reducing bleeding.
Despite these useful properties, the derivative routines do not have scientifically proven efficacy in the treatment of varicose veins. Their use can reduce the pain and heaviness in the legs in some patients.
Side effects of the rutin derivatives: headaches, rash, indigestion.
3. Pycnogenols
An example of such tablets: Endothelon.
Endotelone preparation Pycnogenols are natural substances of vegetable origin, obtained from the bark of the seaside pine, grape seeds and witch hazel bark. They include procyanidins, bioflavonoids and phenolic acids, which have health-giving properties.
Pycnogenols strengthen the vascular and capillary walls, prevent the escape of fluid from the vascular bed and microblood, have anti-inflammatory properties and reduce platelet aggregation. Due to this, they can alleviate swelling, pain and a feeling of heaviness in the legs with varicose veins.
Side effects: taking pycnogenols can cause dizziness, bowel problems, headaches and mouth ulcers.
4. Saponins
Saponins are found in tablets Aescin, Escuven.
Aescin preparation Saponins are organic substances of plant origin. When varicose from saponins are most often used tablets containing escin.
Eszin is a mixture of various saponins derived from horse chestnut. It has a direct tonic effect on the veins and their valves, strengthening their structure. In addition, escin reduces the permeability of the venous and capillary wall, thereby helping to reduce swelling.
Saponins derived from horse chestnut, relax the endothelium of capillaries, increase the production of nitric oxide, reduce inflammation, which can reduce systemic blood pressure.
Improving the structural integrity of veins and their valves, escin increases venous pressure, which improves the flow of blood to the heart. It also improves the circulation of lymph. This combination of beneficial properties helps improve the condition of patients with leg varicose.
According to scientific studies, escin can reduce some of the symptoms of varicose veins, such as pain, swelling on the legs, a feeling of heaviness.
Possible side effects: nausea, heat, rashes, increased palpitations.
5. Derived ergot
An example of such agents is Vasobrail.
Drug Vasobral Ergot is a fungus parasitizing on rye, wheat and some other cereals. Derived ergot( dihydroergocryptin, dihydroergocristine) contribute to a decrease in platelet aggregation, a decrease in the permeability of the venous and capillary walls, and improve blood circulation.
For the treatment of varicose tablets containing ergot derivatives are used very rarely, their effectiveness is not proven.
6. Synthetic preparations
Synthetic substances used for the treatment of varicose veins belong to tribenozide, heptaminol and calcium dobezilate.
Tribenozide( Glivenol) reduces the permeability of the venous and capillary wall, reduces swelling, has anti-inflammatory and analgesic properties.
Heptaminol( part of the combined Ginkor FORT) increases venous tone, reduces the permeability of the vascular wall, reduces edema and pain.
Preparation Ginkor FORT Calcium dobesilate( Doxium) improves microcirculation and lymph drainage, reduces permeability of the vascular wall, reduces blood viscosity, slows platelet aggregation.
Drugs that improve microcirculation
If there is a risk of blood clots or their presence in varicose veins, doctors prescribe drugs that prevent blood clotting. These include:
- Warfarin is an anticoagulant that resists the formation of blood clots. This drug blocks the synthesis of clotting factors in the liver.
- Acetylsalicylic acid( aspirin) is an analgesic that is used in low doses to prevent platelet aggregation.
- Pentoxifylline is a drug that affects the rheological properties of the blood. It improves blood circulation, making erythrocytes more flexible.
Preparation Pentoxifylline Pain medications
Sometimes, the presence of varicose veins is accompanied by pain in the legs. In such cases, non-steroidal anti-inflammatory drugs can help. The most commonly prescribed ibuprofen or paracetamol. It should be remembered about the negative effect of these drugs on the mucosa of the gastrointestinal tract and not abuse their reception.
Preparation Ibuprofen Antibacterial drugs
Some patients with varicose veins may develop chronic venous insufficiency and trophic ulcers on the legs. When infection of these ulcers, doctors prescribe antibacterial drugs. In uncomplicated varicose veins, antibiotics are not used.
