Teturam

width = The drug Teturam refers to a group of drugs used to combat alcohol dependence. Also, the medication is used to prevent the recurrence of chronic alcoholism and as a detoxification drug for nickel poisoning.

Tablets cause a conditioned reflex to the taste and smell of alcohol, which makes its use impossible. The patient is carefully examined before starting therapy. If there are no contraindications to the application, the doctor explains how to take the drug, and warns that it is dangerous to use alcohol during treatment.

The maximum therapeutic effect is noticeable 12 hours after taking the drug and lasts for 10-14 days.

Clinical and pharmacological group

Means for the treatment of alcohol dependence ..

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Teturam in pharmacies cost? The average price is at the level of220 rubles.

Composition and form of release

Teturam tablets are produced, 5, and 5 g in packages of 50 or 30 pieces, as well as a substance-powder.

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The main active substance of the drug Teturam is disulfiram.

In addition, it contains the following additional components: potato starch, povidone, impellose, colloidal silicon dioxide, stearic acid.

pharmachologic effect

Getting into the body, Teturam acts as an inhibitor of altaldehyde dehydrogenase - an enzyme that takes part in the metabolism of ethanol. As a result, the blood level of acetaldehyde increases.

This causes symptoms of intoxication:

heart rhythm disorder;
chills;
chest pain;
redness of the face;
nausea with vomiting;
general weakness;
pressure reduction;
difficulty breathing.

Because of these symptoms, drinking alcohol ceases to give a person pleasure. Gradually, he completely ceases to consume alcohol.

After taking Teturam pills inside the active substance quickly enough and almost completely absorbed into the systemic bloodstream from the intestine (bioavailability is 70-90%). It is evenly distributed in tissues, metabolized in the liver with the formation of inactive decay products, which are excreted from the body mainly with urine.

Indications for use

The remedy is used as an effective method of preventing chronic alcoholism. Teturam can be used as a drug that guarantees no relapse during the main treatment with other specific techniques. The remedy can be used by loved ones as a secret from an alcoholic, and be used consciously by a lover of booze.

The active substance of Teturam - disulfiram is the antidote of nickel, for this reason it is permissible to use the drug for detoxification during poisoning with this metal.

Contraindications

Absolute:

Malignant tumors;
Hepatic failure and kidney disease;
Diabetes;
Thyrotoxicosis;
Glaucoma;
Pregnancy;
Lactation period;
Hypersensitivity;
Bleeding from the gastrointestinal tract (GI tract), erosive lesions of the gastrointestinal mucosa, exacerbation of gastric ulcer or duodenal ulcer;
Severe emphysema of the lungs, bronchial asthma, pulmonary tuberculosis with hemoptysis;
Diseases of the cardiovascular system in the stage of decompensation (including atherosclerosis of cerebral vessels, pronounced cardiosclerosis, coronary
insufficiency, aortic aneurysm, pre- and post-infarction states, arterial hypertension II-III stages);
Neuritis of the auditory and optic nerves, polyneuropathy, neuropsychiatric diseases, epilepsy, infectious diseases of the central nervous system.

Relative (special care is required when applying):

Stomach ulcer and duodenal ulcer in remission;
Cardiovascular diseases in the stage of compensation;
Endarteritis;
Psychoses due to the administration of disulfiram in the anamnesis;
Residual effects of cerebral circulation;
Age over 60 years.

Dosage and route of administration

As indicated in the instructions for use, Teturam tablets are taken orally. The drug is administered after a full medical examination, the doctor must warn the patient about the possible consequences and complications.

Recommended dosing: according to an individual scheme, from 150 to 500 mg twice a day. Teturam-alcohol sample is carried out after 7-10 days of therapy, it consists of taking 20-30 ml of vodka (40%) after the patient after 500 mg of the drug. In the case of a weak reaction, the amount of vodka is increased by 10-20 ml. The dose of alcohol should not exceed 120 mg.

Repeated trials with correction of doses of alcohol and / or drug are carried out 1-2 days in a hospital and 3-5 days later - on an outpatient basis. Supportive therapy in a daily dose of 150-200 mg can last for 1-3 years.

Teturamalkolkolnye samples should necessarily be conducted under the supervision of a doctor, since it is impossible to predict the reaction to alcohol in each specific case. Often a person experiences severe, poorly tolerated sensations that require rapid elimination. For the relief of painful and excessive reactions in teturamalkolnyh samples used a number of drugs, most of which are administered intravenously or intramuscularly. It is because of the likelihood of such interference that the doctor must be present and observe the progress of the tetramalcoholic sample.

Side effects

Against the background of the use of Teturam, there may be side effects such as:

edema of the brain;
memory impairment;
headache;
collapse;
myocardial infarction;
skin rash;
angina pectoris;
metallic or bitter taste in the oral cavity;
insomnia;
angioedema;
arrhythmia;
anxiety and fear;
hives;
tachycardia;
dizziness;
spasm of bronchi;
convulsions;
psychoses;
gastritis;
confusion of consciousness;
optic neuritis;
hepatitis;
difficulty breathing.

Overdose

In case of drug overdose, neurologic complications, oppression of consciousness up to coma, cardiovascular collapse are possible. Therapy is symptomatic.

special instructions

Use with caution in patients with renal failure, liver disease, respiratory system.

Interaction with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

With concomitant use with isoniazid, there have been cases of dizziness, depression; with caffeine - reduces caffeine withdrawal from organism; with metronidazole - develops acute psychosis, confusion; with omeprazole - described the case of the development of impaired consciousness and catatonia.
With the simultaneous use of perphenazine, the development of psychotic symptoms can not be ruled out.
With simultaneous use of disulfiram inhibits metabolism and excretion of rifampicin.
With the simultaneous use of anticoagulants with coumarin derivatives (including with warfarin), anticoagulant effects increase, and the risk of bleeding increases.
Disulfiram inhibits liver enzymes, so with the simultaneous use of drugs metabolized in the liver, a violation of their metabolism is possible.
With the simultaneous use of disulfiram with tricyclic antidepressants, phenothiazine derivatives, MAO inhibitors, there is a risk of developing serious adverse reactions associated with the drug interaction.
A case of developing mania in a patient taking disulfiram and buspirone is described.
With simultaneous use, the clearance of desipramine and imipramine from the body decreases.
With simultaneous application with amitriptyline, the therapeutic effect of disulfiram may be enhanced, but it is also possible to increase the toxic effect of amitriptyline on the central nervous system.
With simultaneous use, the concentration of diazepam and chlordiazepoxide in the blood plasma increases, in some cases accompanied by dizziness. Under the influence of diazepam, a decrease in the intensity of the reaction of disulfiram-ethanol is possible. A case of increasing the toxicity of temazepam is described.
With simultaneous application with phenazone, T1 / 2 of phenazone increases; with phenytoin - are amplified effects of phenytoin due to an increase in its concentration in the blood plasma, toxic reaction.
With simultaneous application with chlorosoxazone, the concentration of chlorosoxazone in the blood plasma increases; with chlorpromazine - it is possible to increase arterial hypotension.

Reviews

We offer you to read reviews of people who used Teturam:

Eugene. If poured into the food, then you need to warn the person that he was given with food. Most people immediately refuse to take alcohol. Especially those who are already familiar with teturam. The taste of cherry in the mouth instantly recalls the consequences of the reaction alcohol - teturam.
Arkady. Earlier I often drank a lot, no exhortations helped. My wife decided to give me pills for alcoholism, I agreed, because I could not cope on my own. Began to take Teturam, after the first reception I felt a weakness, I did not like alcohol. I drank it for a year and a half, I do not drink alcoholic drinks any more.

Practicing doctors-narcologists believe that, in general, Teturam is an effective drug for the treatment of alcohol dependence, but its use requires compliance with a number of conditions. First, the consent and desire of the patient with alcoholism to receive Teturam is necessary. Secondly, it is necessary to understand the perniciousness of the disease and the desire to be cured.

In addition, doctors believe that only taking Teturam does not help to permanently cure alcoholism. Tablets will have an effect that will last for a certain period of time, but that a person again does not start drinking, will require a comprehensive treatment that includes psychotherapy. In other words, according to the doctors, Teturam's reception is provided by a certain "light period which, in the absence of complex treatment, will be interrupted by a new breakdown and drinking-bouts. After the binge, there will be a new cycle of taking the pills, etc.

Unfortunately, Teturam can be ineffective with a weak willpower in a person. In such situations, doctors recommend not taking the pill, but making a "binder" immediately.

Analogues

It is permissible to use analogues of a medicament having an identical active substance or having a similar pharmacological effect. Analogs of the drug are presented below:

Esperal;
Disulfiram;
Antabus;
Tetlong;
Alkodez;
Liveria;
Antakson;
Vivitrol;
Naltrex;
Naltrexin;
Biotredin;
Colme;
Naxon.

Before buying an analogue, consult your doctor.

Is it possible to give Teturam without the knowledge of the patient?

To give a person Teturam without his knowledge is impossible, because the drug is completely incompatible with alcohol. Accordingly, if a person secretly receiving Teturam will use alcoholic beverages, he will develop symptoms intolerance, which with a significant amount of alcohol consumed (more than 150 ml of vodka) can lead to a fatal outcome. Therefore, to give Teturam without the knowledge of the patient can not be - he must know and realize the danger to himself, if he tries to drink while taking the medication.

If on the background of taking Teturam people drink more than 50 - 80 ml of vodka, then it can develop severe disruption of the cardiovascular and respiratory systems, edema and convulsions, therefore, in such situations, the victim is urgently hospitalized in the conditions of the intensive care unit and carries out symptomatic therapy.

Teturam after alcohol

Teturam should not be taken the next day after drinking. It is necessary first to stop intoxication (for example, using Medochronal) and at least within a day to refrain from drinking alcohol. Thus, you can start taking Teturam after drinking alcohol only on days 2 - 3.