Trigrim

Trigrim is a diuretic. It is prescribed for edema of various genesis and primary hypertension.

The main active component of the tablets Trihydrim Torasemide has a diuretic (diuretic) effect, which is realized due to the inhibition of the reverse absorption of sodium and potassium ions in the distal sections of the renal tubules.

After oral administration, the active substance is rapidly and almost completely absorbed from the digestive tract. The maximum concentration of the drug is observed after 1-2 hours after administration. Bioavailability reaches 80-91%, and with swelling it is even greater. Eating does not alter the absorption of torasemide. Up to 99% of the drug binds to blood plasma proteins.

Clinical and pharmacological group

Diuretic.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Trigrim cost 5 mg in pharmacies? The average price is at the level of300 rubles.

Composition and form of release

Medicinal form of Trigrim - tablets: round, white; 2.5 mg of biconvex form; for 5 and 10 mg - flat, with a dividing risk (10 pcs. in blisters, in a cardboard bundle of 3 blisters).

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Composition of 1 tablet:

active substance: torasemide - 2.5; 5 or 10 mg;
auxiliary components: corn starch, lactose, magnesium stearate, colloidal silicon dioxide.

pharmachologic effect

The principle of the operation of the Tri -grim tablets is explained by the combination of torasemide with the Na + / 2Cl- / K + transporter, which is located in the apical membrane of the thick segment of the ascending loop of Henle. That is why it can be said that in the human body it decreases substantially or almost completely slows down, and also reabsorption of sodium ions is prevented.

The result of this process is a decrease in the osmotic pressure of the intracellular fluid, as well as the reabsorption of water. In responses to Trigrim, it was noted that the drug, due to its antialdosterone action, which is much less pronounced than in furosemide, practically does not provoke hypokalemia, despite the high activity of its components and prolonged action.

Indications for use

Receiving of tablets Trigrim is indicated for the complex treatment of arterial hypertension (high blood pressure), the purpose of which is to reduce the volume of circulating blood.

Also, the drug is used to reduce the severity of edema of soft tissues of various locations and origin (edema caused by heart failure, liver cirrhosis, kidney or lung pathology).

Contraindications

The intake of tablets is contraindicated with several pathological and physiological states of the organism, which include:

age under 18 years (for this group of patients, efficacy / safety was not established);
pregnancy and lactation period (there is no information on the efficacy / safety of Trigrim during breastfeeding);
individual intolerance of the drug components, as well as hypersensitivity to sulfonamides;
arterial hypotension;
arrhythmia;
anuria;
Precomatitis and hepatic coma;
chronic renal failure with increasing azotemia.

Diseases / conditions in which the use of Trigrim requires caution (relative contraindications):

gout;
diabetes;
violation of water and electrolyte balance;
predisposition to the development of hyperuricemia;
cirrhosis of the liver;
violations of the hepatic function.

Intended use for pregnancy and lactation

Pregnant and lactating women do not prescribe the drug. When the baby is transferred to the mixture, Trigrim is prescribed as usual.

Dosage and route of administration

As indicated in the instructions for use, Trigrim is prescribed to adults, inside, regardless of food intake.

With primary arterial hypertension, the dose is 2.5 mg 1 time / day. If necessary, the dose can be gradually increased to 5 mg / day. According to studies, a dose of more than 5 mg / day does not lead to a further decrease in blood pressure. The maximum effect is achieved after approximately 12 weeks of continuous treatment.
With congestive heart failure prescribe a dose of 5-20 mg 1 time / day. If necessary, the daily dose can be gradually increased, doubling it, a maximum of 200 mg.
With swelling, the drug is prescribed in a dose of 5 mg 1 time / day. If necessary, the dose can be gradually increased to 20 mg 1 time / day. In some cases it is recommended to apply up to 40 mg / day.
With cirrhosis the drug is prescribed in a dose of 5-10 mg 1 time / day. If necessary, this dose can be gradually increased, doubling it, until an appropriate diuretic action is achieved. Appropriate controlled studies have not been conducted in patients with liver disease with the use of the drug at doses greater than 40 mg / day.
In chronic renal failure, the initial dose is 20 mg / day. If necessary, this dose can be gradually increased, doubling it, until the optimal diuretic effect is achieved. The maximum daily dose is 200 mg.

Older patients do not need a dose adjustment.

Side effects

Trigrim can provoke the following side effects:

from the central and peripheral nervous systems: paresthesia in the limbs, convulsions, drowsiness, general weakness, confusion, dizziness and headache;
from the cardiovascular system: lowering blood pressure, thromboembolism and circulatory disorders;
from the sense organs: noise in the ears, visual disturbances and deafness;
from the side of metabolism: violation of electrolyte balance, hypovolemia, increased blood lipids, glucose and uric acid, hypokalemia;
from the hematopoietic system: a decrease in the number of platelets, leukocytes and red blood cells;
from the urinary system: increased levels of creatinine and urea in the blood, acute retention of urine;
from the gastrointestinal tract: loss of appetite, symptoms of digestive system disorders, dry mouth, pancreatitis, increased activity of liver enzymes;
allergic reactions: photosensitivity, skin rashes and itching.

Overdose

When an overdose of the drug shows the following symptoms: increased diuresis, which is accompanied by a violation of the electrolyte balance, hypovolemia, a drop in blood pressure, confusion, drowsiness, collapse, and gastrointestinal disturbances.

For the treatment of overdose, symptomatic therapy is used, the drug is canceled or its dosage is reduced with simultaneous replenishment of lost electrolytes and liquid.

special instructions

Before you start using the drug, read the special instructions:

There is no data on the use of Trigrim in children.
If you have diabetes, you need to monitor carbohydrate metabolism.
Use with caution when gout or an increase in the concentration of uric acid.
With prolonged treatment, it is recommended to monitor electrolyte balance, glucose, uric acid, creatinine and lipids in the blood.
When hypokalemia, hyponatremia, hypovolemia or urinary disorders before the appointment of Trigrim, all these conditions are eliminated.
At the initial stage of admission, it is not recommended to drive vehicles and maintain machinery due to the possibility of dizziness.
When thrombocytopenia or oppression of bone marrow function, as well as skin rashes should be canceled drug.

Interaction with other drugs

With magnesium or potassium deficiency, the drug increases the sensitivity of the myocardium to cardiac glycosides.

Trigrim enhances the effect of antihypertensive drugs, can enhance the effects of theophylline and curare-like muscle relaxants, and in high doses - toxic action of antibiotics, aminoglycosides and cisplatin, cardiotoxic and neurotoxic effect of lithium, neurotoxic effect of cephalosporins.

With simultaneous or sequential use with angiotensin-converting enzyme inhibitors, a transient fall in the arterial pressure (it is necessary to reduce the dose of torasemide or reduce the initial dose of inhibitors of the angiotensin-converting enzyme).

With the simultaneous use of torasemide with laxatives, glucocorticoids and mineralocorticoids, potassium excretion is possible; with antidiabetic means - the effect of antidiabetics is weakened; with salicylates in high doses - the toxic effect of salicylates increases; with epinephrine and norepinephrine - their vasoconstrictive effect decreases; with colestyramine - there may be a decrease in the absorption of torasemide from the gastrointestinal tract; from probenecid and non-steroidal anti-inflammatory drugs - hypotensive and diuretic action of torasemide may decrease.

Reviews

We offer you to read reviews of people who used Trigrim:

Alexey. My doctor says that you must always monitor blood biochemistry when you take it for a long time. And so the diuretic is good
Lyudmila. All the night long I run to the toilet. Within 5 years. Already went to stenochke at night in 20-30 minutes. I did not get enough sleep. I checked myself completely. The last doctor - nephrologist canceled trigrim. It's already been 1 month - like a white light, I've been asleep all night (1-3 times) I go to the bathroom at night. Edema is absent. Less salt, fatty, spicy, salty.

In general, according to reviews about Trigrim, the drug acts almost instantly, accordingly, it has a high efficiency. Side effects are rare.