Norfloxacin

Norfloxacin is a broad-spectrum antibiotic from the group of fluoroquinolones, which is of synthetic origin and has a pronounced bactericidal and antimicrobial effect.

By suppressing the DNA of microorganisms, destabilizes the chain, which leads to their death. It is taken orally with infections of the urinary system, the gastrointestinal tract, both acute and chronic, gonorrhea. It is used for preventive purposes in patients with granulocytopenia.

This medicine is applied topically in cases of inflammatory processes in the ear, infectious eye diseases (blepharitis, conjunctivitis, keratitis, etc.).

Clinical and pharmacological group

Antimicrobial synthetic agent of the group of fluoroquinolones of wide spectrum of action.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Norfloxacin in pharmacies? The average price is at the level of140 rubles.

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Form of issue and composition

The drug is available in the form of film-coated tablets for oral administration. Tablets are packed in blisters of 10 pieces (1-2 blisters in a cardboard bundle with the attached detailed description).

• Each tablet contains 400 mg of the active ingredient - Norfloxacin.
• Auxiliary components - mannitol, titanium dioxide, macrogol, magnesium stearate.

Pharmacological effect

Norfloxacin is an antimicrobial drug belonging to the group of fluoroquinolones. It has bactericidal action, realized by inhibiting DNA-gyrase, which provides stability and supercoiling of bacterial DNA. This causes the destabilization of the DNA chain and the death of bacteria.

Tablets of the drug are highly effective against the following pathogenic microorganisms:

• Escherichia;
• Gonococci;
• Hemofilius influenza;
• Klebsiella;
• Enterobacteria;
• Shigella;
• Chlamydia;
• Salmonella;
• Streptococci;
• Staphylococci.

Norfloxacin does not show activity with respect to obligate anaerobes.

Indications for use

The use of the drug is indicated in the treatment of infectious diseases caused by pathogens that are sensitive to Norfloxacin:

• uncomplicated gonorrhea;
• infection of the genitals (endometritis, prostatitis, cervicitis);
• infections of the digestive tract (shigellosis, salmonellosis);
• acute and chronic infections of the urinary tract (cystitis, pyelonephritis, urethritis).

The drug is effective as a preventive measure of infectious diseases in patients with granulocytopenia.

Eye and ear drops for topical use are used in the treatment of such diseases:

• dacryocystitis;
• acute inflammation of the meibomian glands;
• external, acute and chronic otitis media; infectious diseases of the eyes (keratitis, conjunctivitis, keratoconjunctivitis, blepharoconjunctivitis, blepharitis and corneal ulcer).

Norfloxacin is a preventive measure that reduces the risk of infectious complications before and after surgical intervention, removal of foreign bodies from the cornea or conjunctiva, and also after chemical damage to the eyes. For the same purpose, the drug is used for surgical interventions on the organs of hearing.

Contraindications

Absolute:

1. Age to 18 years;
2. Pregnancy and lactation;
3. Deficiency of glucose-6-phosphate dehydrogenase;
4. Tendon tendonitis and tendonitis associated with fluoroquinolones (including anamnestic data);
5. Hypersensitivity to the components of the drug.

Relative (Norfloxacin is administered with caution in the presence of the following diseases / conditions):

1. Epilepsy;
2. Convulsive syndrome;
3. Hepatic / kidney failure;
4. Myasthenia gravis.

Use in pregnancy and lactation

This antibiotic is contraindicated to use during pregnancy and breastfeeding. If there is an urgent need for treatment with this drug during breastfeeding, it is recommended that it be temporarily suspended. During the experiments, it was noted that the drug causes arthropathy in the fetus.

Dosage and route of administration

In the instructions for use, it is indicated that a single dose of Norfloxacin for ingestion is usually 1-2 tablets (400-800 mg) at a frequency of 1-2 times per day. The maximum daily dose is, g.

In uncomplicated urinary tract infections, the course of treatment is about 3 days, with complicated - about 7-10 days. In chronic processes, the course can be increased to 3 months.

The exact dose and duration of the course is prescribed by the doctor individually for each patient.

Side effects

The drug is well tolerated by the body, but can sometimes cause side effects. The body can have such reactions:

1. Allergic reaction: swelling, itching, skin rash, hives.
2. Digestive system: heartburn, bitterness in the mouth, decreased appetite, diarrhea, nausea, abdominal pain, vomiting.
3. Musculoskeletal system: ruptures of tendons, tendilitis, arthralgia.
4. Cardiovascular system: decreased blood pressure, tachycardia, vasculitis, arrhythmia.
5. Central nervous system: insomnia, dizziness, fainting, headache, irritability, fatigue, anxiety.
6. Urinary system: hypercreatininaemia, glomerulonephritis, urethral bleeding, dysuria, albuminuria, crystalluria, interstitial nephritis, polyuria.
7. With external application: photophobia, burning, pain, impaired vision, chemosis, conjunctival hyperemia.

Overdose

Symptoms of excessive excess dosing when taking the drug are severe drowsiness, dizziness, nausea with vomiting, the victim throws into a cold sweat, the face becomes puffy.

There is no specific antidote. As therapeutic measures, the following should be done:

• Urgently rinse the stomach;
• apply forced diuresis in combination with hydration therapy.

The patient should be supervised by medical personnel.

special instructions

Norfloxacin should be taken at least 2 hours before or 2 hours after ingestion of antacid agents or preparations containing iron, zinc, magnesium, calcium or sucralfate.

It should be used with caution in patients with epilepsy, convulsive syndrome of another etiology, with severe impairment of kidney and liver function. During treatment, patients should receive a sufficient amount of fluid (under the control of diuresis).

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Reduces the effect of nitrofurans.
2. With the simultaneous use of norfloxacin with cyclosporine, there is an increase in the concentration of the latter in the blood plasma.
3. With the simultaneous use of norfloxacin with warfarin, the anticoagulant effect of the latter is enhanced.
4. With the simultaneous administration of norfloxacin reduces the clearance of theophylline by 25%, so with simultaneous use should reduce the dose of theophylline.
5. With the simultaneous administration of norfloxacin and antacid agents or preparations containing iron, zinc, magnesium, calcium or sucralfate, the absorption of norfloxacin is reduced due to the formation of complexons with metal ions (the interval between their reception must be at least 4 h).
6. Simultaneous administration of norfloxacin with drugs that have the potential to reduce blood pressure can cause a sharp decrease in blood pressure. In this regard, in such cases, as well as with the simultaneous introduction of barbiturates, anesthetics, it is necessary to monitor heart rate, blood pressure, ECG parameters. Simultaneous use with drugs that reduce the epileptic threshold may lead to the development of epileptiform seizures.

Norfloxacin and alcohol

Drugs fluoroquinolone series are highly effective, but at the same time, and highly toxic agents. Combine them with alcohol is strictly prohibited.

Taking alcohol on the background of drug treatment can lead to the development of medical hepatitis, nephritis (up to acute renal failure) or toxic damage to the central nervous system (hallucinations, psychosis, convulsions).

Reviews

We picked up some reviews of people who used Norfloxacin:

1. Irina. I used this medicine recently as soon as I got cystitis. Saw 2 tablets 2 times a day. The course is 3 days. The result is very satisfied, because I did not take anything else. Even the probiotics forgot to drink, there was no frustration. Then she advised my mother when she also had such a problem. I advise, an effective drug!
2. Martha. While I drink norfloklatsin 2 weeks, the bacteria disappear in the urine, stop, the bacteria reappear. Probably longer it is necessary to drink. The urologist says that she did not recover.
3. Novel. A good enough antibiotic, as for me. There are contraindications, but they did not manifest themselves to me. I took it without a doctor's prescription in severe cases, when it was necessary to recover very quickly after a cold or to cure a throat with a sore throat. The drug is relatively well tolerated by the body, in rare cases there may be drowsiness. At admission I recommend to refuse works requiring higher concentration. Dysbacteriosis was not observed. If that bothers you, then you can take either cetrin or diazolin. External allergic manifestations also did not observe. At reception I recommend to adhere to the norms specified in the instruction and not to exceed them.

Analogues

Structural analogs for the active substance:

• Loxon 400;
• Nolycin;
• Norbaktin;
• Norillet;
• Normax;
• Noroksin;
• Norfacin;
• Norfloxacin Lugal;
• Renor;
• Sofazine;
• Chibroxin;
• Utibid.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Store in a dry place, out of the reach of children, at a temperature of up to 25 ° C.

Shelf life - 2 years.

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