Enterofuryl

Enterofuril is a modern intestinal antiseptic sulfanilamide with a wide spectrum of action.

Is a derivative of nitrofuran. It is widely used for acute intestinal infections, accompanied by diarrhea. The active substance is nifuroxazide, which is active against many pathogenic microorganisms.

Depending on the dosage of the drug, a different therapeutic effect can be achieved. So, Enterofuril in low and medium doses is able to have bacteriostatic effect, and in high doses - bactericidal. At application antiseptic does not break the balance of useful microflora and does not cause a dysbacteriosis.

Enterofuril is safe, well tolerated, available in convenient dosage forms, which facilitate its use in infants.

Clinical and pharmacological group

Intestinal antiseptic. Antidiarrhoeal drug.

Terms of sale from pharmacies

Can buywithout a doctor's prescription.

Price

How much does the Enterofuril suspension in pharmacies cost? The average price is at the level of400 rubles.

Composition and form of release

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The manufacturer proposes to buy Enterofuril in capsules or in the form of a suspension.

Capsules are produced in a dosage of 200 and 100 mg. The first - 10 pieces in a blister, the second - for 8. Tablets oblong, yellow. Contain a powder of the same color, which is friable, compressed or with the contents of compressed elements;
Suspension leaves the factory in a bottle of dark glass, a volume of 90 ml. In the carton box is an instruction for use and a measuring spoon with graduation. On the neck - the autopsy control. The substance is thick, yellow, with the aroma of a banana.

Both the capsules and the suspension have a bright yellow color, which is due to nifuroxazide, and not to the dyes. The liquid form is sold ready-made, it does not need to be diluted with water, which is very convenient. Since the drug, mainly children's, the bottle is closed with a lid with protection from children: to open it, you need to apply force, pressing down to the click.

Both forms of enterofuril are acceptable for adults, while a child under 7 years of age is not prescribed capsules because of their size. But a competent pediatrician will be able to calculate the dose of dry matter from the capsule, which a small person could take if it is impossible to purchase a suspension. Please note that in liquid form the drug is absorbed more quickly, therefore for the removal of acute manifestations in adults it is permissible to begin therapy with this form of medication.

Pharmacological effect

The agent has a high degree of safety, efficiency and has a minimal amount of side effects. The drug is based on nifuroxazide - a substance related to the number of derivatives of 5-nitrofuran. This drug is a broad-spectrum bactericidal action. When ingested into the intestine, the active substance penetrates into the bacteria and hinders their vital activity. In low and medium concentrations, the substance has a bacteriostatic effect, disrupting the synthesis of enzyme dehydrogenase in microorganisms. Due to this, the synthesis of certain proteins stops, and the microbes stop multiplying. In a high concentration, the substance destroys the bacterial cell membranes, and they perish. Also, the substance has the ability to suppress the production of toxins by bacteria and stimulate the activity of phagocytes - special cells of the immune system that fight infection.

A positive feature of the remedy is that it acts extremely selectively, attacking only harmful microorganisms, and does not affect the beneficial microflora. This drug favorably differs from many antibiotics, which are performed in the intestine by total terror, destroying all bacteria - both good and bad. But saprophyte intestinal microflora plays an important role in the process of digestion. As a result, it is necessary to reconstruct it with difficulty, taking probiotics.

The list of microorganisms that are affected by Enterofuril is quite impressive. Among them there are both gram-positive and gram-negative bacteria:

Clostridia;
Klebsiella;
Enterobacteria;
Campylobacteria;
Staphylococci;
Streptococci;
Salmonella;
Shigella;
Intestinal sticks;
Cholera vibrios;
Bacteria of the genus Edwardsiella;
Citrobacter;
Yersinia enterocolitis.

And practice shows that bacteria are unable to develop resistance to the drug.

Enterofuril has several indications for use. The main one is the treatment of gastrointestinal infections accompanied by diarrhea. The drug can also be used in the case of chronic gastrointestinal lesions of bacterial etiology of unknown genesis. Another advantage of Enterofuril - it practically does not penetrate into the blood and carries out its activity exclusively in the intestine. The medicine is excreted from the body together with the feces.

This feature directly results in several more advantages of the tool. First, the drug does not penetrate the placental barrier, nor does it enter the mother's milk. Secondly, Enterofuril is suitable for use in children in the treatment of intestinal infections and dysbacteriosis. Children under the age of 1 month should not take Enterofuril. It is undesirable to give the drug to children under 7 years of age in a capsule form. In this case, there is a special suspension for children.

Indications for use

Indications for taking the drug are as follows:

chronic or acute diarrhea associated with pathogens sensitive to the spectrum of the drug;
chronic inflammatory process in the large intestine with background diarrhea;
frequent loose stools after antibiotic therapy;
infectious lesions of the gastrointestinal tract with manifestations of diarrhea;
chronic or acute intestinal disorder with an unclear cause.

As one of the components of complex treatment, medicament include in the scheme of such diseases as:

gastroenteritis: toxic, allergic, on the background of radiation therapy;
colitis, including inflammation of an erosive nature;
Crohn's disease;
enterocolitis;
pathology of the intestine against a background of vascular disorders.

According to the research, the drug is used in the treatment of chronic diseases of the gastrointestinal tract with signs of dyspeptic disorders. Against the backdrop of treatment with Enterofuril, it is important to replenish the water and electrolyte balance, because as a result of vomiting and frequent loose stool, dehydration develops.

Contraindications

Enterofuril in the form of a suspension for oral administration:

application in patients under one month of age;
application for the treatment of diarrhea caused by helminth infections;
increased sensitivity to enterofuril or its components;
use in preterm infants;
individual intolerance to Enterofuril or its components;
application of more than one week in a row.

Enterofuril in the form of capsules with different contents of the active component:

individual intolerance to Enterofuril or its components;
use in patients up to seven years of age;
application for the treatment of diarrhea caused by helminth infections;
increased sensitivity to enterofuril or its components;
application of more than one week in a row.

Use with caution: concurrent use of Enterofuril with any medicinal products containing in the composition of ethyl alcohol.

Intended use for pregnancy and lactation

Enterofuril can be used as directed by a doctor during pregnancy and breastfeeding. Since the active substance is not absorbed into the bloodstream, it can not have a negative effect on the health of the future mother and child.

Nifuroxazide does not penetrate into breast milk, so the use of the drug is allowed during lactation. The dosage of the drug and the treatment regimen is selected by the attending physician on an individual basis, taking into account the severity of the infection and the patient's condition, treatment is carried out under his supervision.

Dosage and route of administration

As indicated in the instructions for use to dispense the Enterofuril suspension, a 5-ml measuring spoon with a calibration of 2.5 ml is used.

Before use, the suspension should be well shaken.

Children agedfrom 1 to 6 months: 2.5 ml of the suspension 2-3 times / day with an interval of 8 to 12 hours.
Childrenfrom 7 months to 3 years: 2.5 ml suspension 3 times / day with an interval of 8 hours.
Children agedfrom 3 to 6 years: 5 ml of suspension 3 times / day with an interval of 8 hours.
Children agedfrom 6 to 18 years old: 5 ml of suspension 3-4 times a day at intervals of 6 to 8 hours.
Adults: 5 ml of suspension 4 times / day with an interval of 6 hours.

The duration of the course of treatment is 5-7 days, but not more than 7 days. If no improvement occurs within the first 3 days of admission, you should see a doctor.

Adverse Reactions

Enterofuril, as a rule, well tolerated and as side effects in rare cases can provoke the following symptoms:

Allergic reactions (skin rash, hives, Quincke's edema, anaphylactic shock);
Nausea;
Vomiting.

Overdose Symptoms

The active ingredient of Enterofuril suspension is not absorbed into the systemic circulation from the intestinal lumen, so the facts of drug overdose have not been recorded to date.

special instructions

In connection with the content of methyl parahydroxybenzoate, the drug may cause allergic reactions (possibly delayed).

If symptoms of hypersensitivity (dyspnea, rash, itching) appear, stop taking the drug. The use of alcohol during therapy with nifuroxazide is prohibited.

In the treatment of diarrhea concomitantly with therapy with Enterofuril, rehydration therapy is necessary. In the case of bacterial diarrhea with signs of systemic damage, you should consult a doctor to decide on the use of antibacterial drugs of systemic action.

Enterofuryl suspension contains 1000 mg of sucrose in 5 ml. Accordingly, the content of sucrose in a single dose of 2.5 ml suspension is 0.04165 XE, and in a single dose of 5 ml - 0.0833 XE.

The daily dose of sucrose is 0.0833 XE when taking 2.5 ml of suspension 2 times a day and 0.125 XE with 2.5 ml of suspension 3 times a day.

The ethanol content of the Enterofuryl suspension is 1%. The minimum single dose of the drug corresponding to 100 mg of nifuroxazide (2.5 ml of suspension) contains 0.02 g of ethanol (in terms of absolute alcohol), and the maximum The daily dose corresponding to 800 mg of nifuroxazide (5 ml of suspension 4 times a day) contains 0.16 g of ethanol (in terms of absolute alcohol).

Before the appointment of the drug, the congenital deficiency of enzymes that break down sucrose should be excluded from patients (including infants).

Compatibility with other drugs

It is not recommended simultaneous use with drugs that cause the development of disulfiram-like reactions, drugs that depress the function of the nervous system. If you are taking other medications (including OTC drugs), consult your doctor before using the drug.

Patient Reviews

We offer you to familiarize yourself with the opinions of people using Enterofuril:

Anton. Last month, I started colitis, which led to diarrhea. I could not manage on my own, so I asked the doctor what he prescribed the medicine for. I specified how many days to drink Enterofuril, and received an answer - a week. Through this time, all the symptoms went away, and I began to feel much better. My feedback on the capsules is positive.
Svetlana. This year she was lying with her son in the infectious department and she shook herself a "gift": vomiting, bellying, liquid stool. And since in our hospitals treatment of mummies is not supposed, it was necessary to get out yourself. Read the reviews on the forums about Enterofuril, the husband flew to the pharmacy. Accepted, as stated in the instructions for use. Already after two hours after the first tablet the vomiting passed, and after a day and a half I felt quite tolerable. Given the fact that I had to take care of a fevering baby, I can tell the drug only thank you very much
Yura. It is unclear why I earned a sharp diarrhea, which terribly pestered me. Appeal to the doctor gave its results - I received a prescription for Enterofuryl. According to reviews and instructions for use, I drank capsules daily. Already the first treatment eased the symptoms, and after 2 days everything went away, but I finished the course entirely for prevention.

The doctors' comments about Enterofuril are positive. It is well known that before an antimicrobial agent is prescribed, it is necessary to accurately identify the causative agent of the disease. Modern diagnostic methods allow doing this only for 3-10 days. Such procrastination in some situations can seriously affect the patient's condition.

The effectiveness of Enterofuril against most known microorganisms allows for the initiation of treatment without waiting for the results of laboratory tests. Nevertheless, most doctors emphasize the fact that the different bacteria Enterofuril acts differently. In addition, in moderate doses, it stops the growth and multiplication of bacteria, in higher doses it destroys bacterial cells. At the same time, some bacteria, disintegrating under the influence of a drug, secrete a large number dangerous to the body of toxic substances, which, penetrating into the systemic bloodstream, thereby poison it.

Therefore, appoint a doctor and select the optimal therapeutic dose for each individual patient. Self-medication can only aggravate the situation.

Analogues

Structural analogs for the active substance:

Nifuroxazide;
Ecofuril;
Ersefuril.

Before buying an analogue, consult your doctor.

Enterol or Enterofuril - which is better?

These are two different drugs that have certain common effects. Thus, Enterofuril is an antiseptic agent with a wide spectrum of action, which has a harmful effect on the pathogenic microflora, located in the lumen of the intestine.

For this reason, Enterofuril is widely used as a drug for the treatment of diarrhea of an infectious nature of origin. Violating vital functions and provoking the death of microbial cells, it effectively eliminates the cause of diarrhea.

Enterol has a disastrous effect on a narrower spectrum of microorganisms that provoke the development of diarrhea. In addition, the drug normalizes the intestinal microflora, and also increases the survival rate of lacto- and bifidobacteria. For this reason, with serious infectious diarrhea accompanied by fever, the use of Enterofuril is recommended to eliminate the cause of the development of the pathological condition.

With dysbiosis and diarrhea occurring without a rise in temperature, it is more rational to use it for treatment Enterol, which stops and symptoms of the pathological condition and normalizes the microflora in the lumen of the intestine. Enterofuril in this situation is absolutely useless.

For the prevention of dysbacteriosis, which is a consequence of taking antibiotics, you should also take Enterol, since Enterofuril only strengthens the effect and effect of the antibacterial drug.

Shelf life and storage conditions

Special requirements for the storage of Enterofuril in capsule form are not available. The preparation in the form of a suspension is recommended to store in a dry place, protected from sunlight. The optimum temperature regime is 15-30 ° C. Do not freeze the suspension.

Suspension retains its pharmacological properties for 3 years after the release date. Shelf life after opening the bottle is no more than 14 days.

Capsules may be consumed within three years after the release date.