What is Cocarboxylase: instructions for use

Kokarboksilaza - a drug that improves energy supply and tissue metabolism.

The use of the medicament makes it possible to reduce the concentration of pyruvic and lactic acid, glucose, positively affects the trophism of nerve tissues, normalizes the functionality of the cardiovascular system. If the body experiences a deficiency of this substance, the blood level of pyruvic acid rises in the blood, which can lead to the development of acidosis.

On this page you will find all information about Cocarboxylase: the full instructions for use on this medication, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already applied injections of Cocarboxylase. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Coenzyme formed in the body from thiamine.

Conditions of leave from pharmacies

It is released on prescription.

Price list

What is the cost of Cocarboxylase? The average price in pharmacies is at the level of125 rubles.

Form of issue and composition

The following dosage forms of Co-carboxylase are available:

1. Lyophilizate for the preparation of solution for intramuscular injection (in ampoules of 0.05 g, complete with a solvent - water for injection in ampoules of 2 ml, in packages of 5 sets).
2. Lyophilizate for the preparation of solution for intravenous and intramuscular administration (in ampoules of 0.025 and 0.05 g, in a set with solvent - water for injections in ampoules of 2 ml, or without it, in cartons of 10 ampoules, 5, 10 or 20 sets).
3. Powder for solution for injection (in ampoules of 0.05 grams, complete with a solvent - sodium acetate solution in ampoules of 2 ml, in packages of 3 sets).

The active substance is cocarboxylase:

• 1 ampoule with powder - 0.05 g;
• 1 ampoule with lyophilizate for intramuscular injection - 0.05 g;
• 1 ampoule with lyophilizate for intravenous and intramuscular injection - 0.025 and 0.05 g.

Pharmacological effect

Coenzyme formed in the body from thiamine. Has a metabolic action, activates tissue metabolism.

In the body it is phosphorylated to form mono-, di- and triphosphoric esters; The cocarboxylase is part of the enzymes that catalyze carboxylation and decarboxylation of keto acids, pyruvic acid, promotes the formation of acetyl-coenzyme A, which determines its participation in carbohydrate metabolism. Participation in the pentose cycle indirectly promotes the synthesis of nucleic acids, proteins and lipids. Improves the absorption of glucose, trophic nervous tissue, contributes to the normalization of the functions of the cardiovascular system.

Deficiency of cocarboxylase causes an increase in the level of pyruvic and lactic acids in the blood, which leads to acidosis and an acidotic coma.

Indications for use

What helps? Cocarboxylase is used concomitantly with other drugs in the treatment of the following diseases:

1. Chronic heart failure, postinfarction cardiosclerosis, ischemic heart disease, myocardial infarction, unstable angina;
2. Acidosis in hyperglycemic coma, metabolic acidosis, acidosis with pulmonary-cardiac and respiratory failure;
3. Renal and / or hepatic insufficiency, chronic and acute alcoholism, poisoning, intoxication with barbiturates and cardiac glycosides, infectious diseases (scarlet fever, diphtheria, paratyphoid, typhoid fever), multiple sclerosis, neuralgia, peripheral neuritis.

Also, the drug is prescribed to children during the newborn period with hypoxia, respiratory failure, perinatal hypoxic encephalopathy, sepsis, pneumonia, acidosis.

Contraindications

According to the instructions, Cocarboxylase is contraindicated in hypersensitivity.

Application in pregnancy and lactation

Cocarboxylase during pregnancy is allowed to be administered if the expected benefit for a woman significantly exceeds the potential risks for the child. If it is necessary to use the medicinal product during the lactation period, you should consult a specialist and decide on the interruption of breastfeeding of the baby.

Kokarboksilazu in pregnancy, if there are pathologies in the development of the fetus, it is strictly forbidden to appoint.

Instructions for use

The instructions for use indicate that the lyophilizate must be dissolved in water for injection before use.

Usually in the adult enter in / m or IV in a dose of 50-200 mg / day. With diabetes, the daily dose can be 0.1-1 g. The frequency and duration of the application depends on the readings.

Children - in / m, in / in (drip or jet), the newborn - sublingual. Children up to 3 months - 25 mg / day, from 4 months to 7 years - 25-50 mg / day, from 8 to 18 years - 50-100 mg / day. Duration of treatment - from 3-7 to 15 days.

Side effects

The enzyme is a well tolerated preparation, and only in rare cases can it cause side effects in the form of allergic reactions.

In addition, with intramuscular injection of the drug, hyperemia, itching and swelling may occur at the injection site.

Overdose

In case of an overdose of the drug, the severity of side effects may increase, and there may also be abnormalities in the respiratory or cardiovascular systems.

According to reviews, Cocarboxylase does not have a specific antidote. In case of an overdose, the drug should be canceled and symptomatic therapy, as well as measures to maintain the functions of the respiratory and cardiovascular systems.

Drug Interactions

Cocarboxylase increases the cardiotonic action of cardiac glycosides, and also improves their tolerability.

Reviews

We picked up some reviews of people taking the drug Cocarboxylase:

1. Maria. I had a very strong and exhausting toxicosis, the weight decreased by 6 kg, the doctor considered it necessary to write out the cocarboxylase. The drug was injected intravenously and the suffering was alleviated after ten injections. Then a healthy baby was born.
2. Victor. I was prescribed a drug after a cardiovascular disease. There were no particular changes, but the doctor said that there is a positive trend.
3. Alla. The drug kokarboksilaza wonderful, removed the noise in the ears. I received 10 injections. Thank you. I will take two courses a year. I have low blood pressure.

Analogues

According to the active ingredient and the therapeutic effect, the drug Cocarboxylase hydrochloride is similar.

Analogues for the pharmacological group (funds for the treatment of acidosis):

• Alpha D3 Teva;
• Dimephosphone;
• Kalinor;
• Quintasol;
• Sodium bicarbonate;
• Composite sodium lactate;
• Stylamine;
• Trometamol N.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Store at temperatures up to 20 ° C for up to 3 years, protect from light. Protect from children.

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