How to take Dopegit tablets at elevated pressure

Dopegit - a stimulant of central alpha2-adrenoreceptors, a drug that has an antihypertensive effect.

On this page you will find all information about Dopegit: the full instruction on the application for this medicine, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Dopegit. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

The stimulator of central alpha2-adrenergic receptors. Antihypertensive drug.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Dopegit? The average price in pharmacies is at the level of220 rubles.

Form of issue and composition

The drug is produced in the form of white or grayish-white round flat tablets containing:

250 mg of methyldopa (in the form of methyldopa sesquihydrate);
Excipients: ethyl cellulose, corn starch, magnesium stearate, stearic acid, sodium carboxymethyl starch and talc.

50 tablets are sold. in bottles of brown glass, in a cardboard box.

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Pharmacological effect

Dopegine is an antihypertensive medication of the central effect. When taking the pill inside, the sympathetic tone decreases due to stimulation of the central inhibitory presynaptic alpha 2 receptors. Under the influence of the drug, the activity of renin of the blood plasma decreases and the OPSS decreases.

The active substance of the drug inhibits the production of norepinephrine, reduces the concentration of serotonin and adrenaline in the tissues. Methyldopa does not directly affect the heart muscle, it does not provoke the development of tachycardia, as is usually the case with the use of antihypertensive drugs. With regular administration of the drug in patients, blood pressure values decrease, both in a calm state, and with insignificant physical exertion.

After taking the pill inside, the active active component of the drug is absorbed by the mucous membranes into the systemic blood stream. The maximum therapeutic effect develops 6 hours after taking the drug and remains for 12-24 hours.

Indications for use

Dopegit is prescribed for the treatment of moderate and mild hypertension (including arterial hypertension in pregnant women - the drug of choice).

Contraindications

According to the instructions, Dopegit is not used in the following cases:

Pheochromocytoma;
Hemolytic anemia;
Depression;
Cirrhosis of the liver, acute hepatitis;
Concomitant treatment with MAO inhibitors;
Diseases of the liver in the anamnesis;
Children up to three years;
Acute myocardial infarction;
Hypersensitivity to methyldopa or auxiliary components of the drug.

Dopegit is prescribed with caution when:

Diencephalic syndrome;
Old age;
Children over three years of age;
Renal insufficiency.

Application in pregnancy and lactation

According to the results of clinical studies, it was found that Dopegit during pregnancy in 2-3 trimesters does not lead to complications. However, strictly controlled studies of the influence of the drug in the third trimester were not carried out, so the possibility his admission should be decided with a doctor who can correlate the benefits to the mother and child and the perceived risks.

In a study of the health status of children whose mothers took Dopegit during pregnancy after the 26th week, no undesirable effects were identified.

The active substance of the drug is excreted in breast milk, so Dopegit is prescribed only for lactation after a careful assessment of the possible benefits for the mother and the existing risk for the child's health.

Instructions for use

The instructions for use indicate that Dopegit tablets are taken orally before or after meals. The dosage regimen is set individually.

The recommended initial dose for adults in the first 2 days of therapy is 250 mg 2-3 times / day. Then the dose can be gradually increased or decreased (depending on the degree of BP reduction). The duration of intervals between increasing and decreasing the dose of the drug should be at least 2 days. Since 2-3 days after the start of therapy, as well as with a subsequent increase in the dose may be observed the sedative side effect of the drug, it is recommended first to increase the evening dose of the drug.
The standard maintenance dose is 0.5-2 g / day. This dose is divided into 2-4 admission. The maximum daily dose of the drug should not exceed 3 g. In cases when against the background of taking the drug at a dose of 2 g / day, there is not enough effective reduction in blood pressure, it is recommended to combine Dopegit with other antihypertensive drugs. After 2-3 months of therapy, tolerance to methyldopa may develop. Effective reduction in blood pressure can be achieved by increasing the dose of the drug or concomitant use of diuretics. 48 hours after the termination of therapy with Dopegit, the blood pressure usually returns to the baseline level. "Ricochet effect" is not observed.
The drug can be administered to patients who are already receiving therapy with other antihypertensive drugs, subject to a gradual withdrawal of these drugs. In such cases, the initial dose of Dopegit should not exceed 500 mg / day. The dose is increased as needed, with intervals of at least 2 days.

When using the drug in addition to the previously prescribed antihypertensive therapy, in order to guarantee a smooth transition, it may be necessary to adjust the doses of antihypertensive drugs.

Children over 3 years:

For children, the initial dose of the drug is 10 mg / kg body weight / day. The daily dose is divided into 2-4 admission. If necessary, the dose can be gradually increased until the desired effect is achieved. Between the increase in the dose of the drug should be observed interval of at least 2 days. The maximum daily dose of Dopegit is 65 mg / kg body weight / day, but not more than 3 g / day.

Elderly patients:

Elderly patients are prescribed a minimum initial dose, which should not exceed 250 mg / day. If necessary, the dose can be gradually increased. The duration of intervals between increasing the dose of the drug is at least 2 days. The maximum daily dose of Dopegit should not exceed 2 g.
Fainting is common in elderly patients. This may be due to increased susceptibility to the drug and pronounced atherosclerotic vascular lesions. The development of fainting can be avoided by reducing the dose of Dopegit.

Impaired renal function:

Methyldopa is excreted mainly by the kidneys, so when treating patients with impaired renal function, the dose of Dopegit should be reduced. For mild renal failure (glomerular filtration rate is 60-89 ml / min / 1.73 m2), the interval between doses of the drug should be increased to 8 hours, with renal failure of the median gravity (glomerular filtration rate - 30-59 ml / min / 1.73 m2) - up to 8-12 hours, and with severe renal failure (glomerular filtration rate - <30 ml / min / 1.73 m2) - up to 12-24 hours.
Methyldopa is removed from the body during dialysis, therefore it is recommended to use an additional dose of 250 mg to prevent the increase in blood pressure after a hemodialysis session.

Side effects

The use of Dopegit has a side effect on the patient's body at the beginning of treatment and with increasing doses, it manifests itself as general weakness, headache, retardation of psychomotor reactions, drowsiness. Then, as a rule, the condition stabilizes independently or after a dose change.

In addition, Dopegit sometimes can cause such undesirable reactions as:

Arthralgia, myalgia;
Parkinsonism, paresthesia;
Toxic epidermal necrolysis;
Hyperprolactinaemia, amenorrhea, gynecomastia;
Medication fever, vasculitis;
Pancreatitis, inflammation of the salivary glands, nausea, vomiting, colitis, diarrhea or constipation, cholestasis, jaundice;
Pericarditis, progression of angina pectoris, myocarditis, congestive heart failure.

Very often, after long-term use of Dopegit, laboratory blood tests for humoral immunity give a positive response, confirming the development of drug immune hemolytic anemia. Not often, the action of the drug causes leukopenia, thrombocytopenia, granulocytopenia.

Overdose

When the dose of Dopegit is exceeded, there is a marked decrease in blood pressure, dizziness, drowsiness, bradycardia, retardation of reactions, tremor, intestinal atony, constipation, bloating, flatulence, diarrhea, nausea and vomiting.

To eliminate symptoms, vomiting and gastric lavage are stimulated. The control of heart rate, water-electrolyte balance, bowel function, kidneys, brain function is shown. Sympatomimetics are indicated by indications.

special instructions

For the period of taking Dopegit, ethanol should be avoided.
The urine of patients taking the drug may become dark when stored.
Dopegit with infectious diseases can mask febrile syndrome.
The appearance of hemolytic anemia and a positive direct test of Coombs requires withdrawal of the drug.
When treating Dopegit, it is recommended to monitor the picture of peripheral blood and liver function.
The drug may affect the results of the determination of serum creatinine, uric acid, etc.

For the period of treatment with Dopegit, caution should be exercised when dealing with hazardous activities, which require rapid reaction and increased concentration of attention, as well as the management of vehicles.

Drug Interactions

Special care requires the simultaneous use of Dopegit with the following medicines:

Levodopa, lithium, anticoagulants, ethanol and other drugs that depress the central nervous system, haloperidol, bromocriptine: a change in the effects of these drugs and Dopegit.
Sympathomimetics, tricyclic antidepressants, phenothiazines, iron preparations for oral administration, estrogenic medicinal agents, non-steroidal anti-inflammatory drugs: a decrease in the antihypertensive effect of Dopegit.
Other antihypertensives, general anesthetics, anxiolytic drugs, beta-blockers, levodopa with carbidopa: an increase in the antihypertensive effect of Dopegit.

Dopegit with monoamine oxidase inhibitors can not be used simultaneously.

Reviews

We picked up some of the people's comments about the Dopegit drug:

Elena. Girls, dopegit really appoint or nominate during pregnancy, but it at whom pressure. I have been taking high blood pressure since 7 months. It is clear that I did not want to take it, but there is already a risk for the child and the mother herself. Total month he drank and at 8 months cesarean. They did cesarean because it increased one day very much. All individually, who it is until the end of pregnancy drinks.
Catherine. In the first trimester of pregnancy the doctor prescribed Dopegit. I read the instructions and was horrified - there are so many side effects from the heart, blood vessels, CNS. But the gynecologist said that this is the only drug that is allowed in my position. Saw a tablet from a pressure of 2 months - both I, and my doctor are positive with a positive effect.
Svetlana. The cardiologist has appointed or nominated to me after sorts or labors, the BP constantly was 140/90. Has spent on drink a course, now stably 120/80 already as 3 months. There were no side effects.

Analogues

Structural analogues of Dopegit are medicinal preparations:

Aldomet;
Dopanol;
Methyldopa.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Tablets should be stored out of the reach of children no more than 5 years from the date of manufacture, which is indicated on the packaging. The optimum storage temperature is 20 degrees.