Doxycycline: instructions and reviews of people

Doxycycline is a semisynthetic broad-spectrum antibiotic that belongs to the tetracycline pharmacological group and has a bacteriostatic effect on microorganisms - inhibits the ability of microbes multiply in the body.

The antibiotic penetrates into the cells of microorganisms and blocks the synthesis of proteins there. The drug has an effect on a large number of microbes - pathogens of aerobic (requiring oxygen for development) and anaerobic (can develop without access to oxygen) infections.

On this page you will find all information about Doxycycline: the full instructions for use for this medicine medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Doxycycline. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antibiotic of the tetracycline group.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Doxycycline? The average price in pharmacies is at the level of20 rubles.

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Form of issue and composition

The agent is implemented in the form of capsules and lyophilizate, which is used to prepare a solution for infusions. Inside the capsules is a yellowish powder with white impregnations. In the contoured package - 5 tablets. Lyophilizate is contained in ampoules of 100 mg, in a cardboard box with septa there may be 5 or 10 ampoules.

1. The formulation contains capsules containing the active ingredient doxycycline (a substance in the form of doxycycline hiclate), as well as additional components: lactose monohydrate, magnesium stearate, potato starch. The capsule consists of glycerol, gelatin, propyl parahydroxybenzoate, methyl parahydroxybenzoate, sodium lauryl sulfate, additives E 104, E 110.
2. Doxycycline in ampoules (lyophilizate, used to prepare a solution for infusions), in the composition has an active component doxycycline (in the form of hydrochloride).

Dispersible tablets Doxycycline are also produced.

Pharmacological effect

The active component of Doxycycline has a bacteriostatic effect against many Gram-positive and Gram-negative microorganisms.

Penetrating into the cell, the medication acts on intracellularly located pathogens. The drug is active against most pathogens of serious infectious diseases - tularemia, plague and anthrax microbes, as well as brucella, legionella, rickettsia, cholera vibrio and causative agents of glanders. In addition, the effective administration of Doxycycline in ureaplasma and chlamydia.

Unlike other antibiotics, Doxycycline, according to the instructions, depresses the intestinal flora to a lesser degree, and is also characterized by a longer duration of therapeutic action.

Indications for use

Indications for the use of the drug are infectious-inflammatory diseases caused by microorganisms sensitive to Doxycycline:

1. Infectious diseases of the eyes.
2. Infections of ENT organs (sinusitis, tonsillitis, otitis).
3. Infections of soft tissues and skin (furunculosis, infected burns, abscesses, phlegmon, wounds).
4. Infections of the gastrointestinal tract and bile ducts (cholangitis, cholecystitis, travelers' diarrhea, bacterial dysentery, gastroenterocolitis).
5. Respiratory tract infections (tracheitis, exacerbation of chronic bronchitis, acute bronchitis, bronchopneumonia, lung abscess, severe and moderate pneumonia, empyema of the pleura).
6. Preventing malaria caused by Plasmodium falciparum, with short trips (less than 4 months) in an area where strains resistant to pyrimethamine sulfadoxine and / or chloroquine.
7. Infections of the genitourinary system (endometritis, prostatitis, cystitis, urethritis, pyelonephritis, urethro-cystitis, endocervicitis, urogenital mycoplasmosis, gonorrhea, acute orchidpididitis).
8. Yersiniosis, fever Ku, yaws, syphilis, rickettsiosis, typhus (including tick-borne recurrent, sypnoy), legionellosis, chlamydia of different localization (including proctitis and prostatitis), spotted fever of the Rocky Mountains, cholera, malaria, Lyme disease (borreliosis) I st., amoebic and bacillary dysentery, actinomycosis, Tularemia.
9. As part of the combined treatment - ornithosis, trachoma, whooping cough, leptospirosis, psittacosis, granulocyte erlichiosis, sepsis, osteomyelitis, brucellosis, peritonitis subacute septic endocarditis, prevention of postoperative purulent complications.

Additionally for capsules: acne, rickettsiosis.

Contraindications

Both dosage forms are contraindicated if the patient is observed:

• porphyrin disease;
• individual intolerance of Doxycycline and other tetracycline antibiotics;
• a decrease in the level of leukocytes;
• severe liver pathology.

Contraindication to the appointment of intravenous injections is:

• children under the age of 8;
• myasthenia gravis.

Capsules can not be used:

• children under 12 years of age and weighing less than 45 kg;
• with intolerance of lactase, glucose and galactose.

Application in pregnancy and lactation

Doxycycline in pregnancy is contraindicated, since the active substance penetrates the placenta and may be negative affect the development of teeth, slow down the development of the bones of the skeleton and provoke fat infiltration liver.

Do not take the drug also during breastfeeding.

Instructions for use

The instructions for use indicate that Doxycycline is taken internally. For adults and children over 12 years with a body weight of more than 45 kg, the average daily dose is 200 mg on the first day (divided into 2 divided doses - 100 mg twice a day), then 100 mg / day.

The use of Doxycycline in the form of capsules should be performed after meals, washed down with water to prevent possible irritation of the esophagus. The daily dose is taken either once every 24 hours, or twice with an interval of 12 hours:

1. With acne - 100 mg / day, the course - 6-12 weeks.
2. In chronic infections of the urinary system - 200 mg / day throughout the period of therapy.
3. In the treatment of syphilis - 300 mg / day for at least 10 days.
4. In uncomplicated infections of the urethra, cervix and rectum caused by Chlamydia trachomatis, 100 mg are prescribed twice a day for at least 7 days.
5. Treatment of leptospirosis - 100 mg orally 2 times a day for 7 days; prophylaxis of leptospirosis - 200 mg once a week during a stay in a dysfunctional area and 200 mg at the end of the trip.
6. Diarrhea "travelers" (prevention) - 200 mg on the first day of travel (for 1 dose or 100 mg twice a day), 100 mg once a day during the stay in the region (no more than 3 weeks).
7. Infections of male genital organs - 100 mg twice a day for 4 weeks. Treatment of malaria resistant to chloroquine - 200 mg / day for 7 days (in combination with shizontocidal drugs - quinine); malaria prophylaxis -100 mg once a day 1-2 days before the trip, then daily during the trip and for 4 weeks afterwards return;
8. In the treatment of gonorrhea, one of the following regimens is prescribed: acute uncomplicated urethritis - a course dose of 500 mg (1 reception - 300 mg, subsequent 2 - 100 mg at intervals of 6 hours) or 100 mg / day until complete cure (in women) or 100 mg twice a day for 7 days (in men); complicated form of gonorrhea, the course dose is 800-900 mg, which is divided into 6-7 receptions (300 mg - 1 reception, then with an interval of 6 hours for 5-6 follow-up).
9. Prevention of infections after medical abortion - 100 mg for 1 hour before abortion and 200 mg - 30 minutes after.

Maximum daily doses for adults - up to 300 mg / day or 600 mg / day for 5 days with severe gonococcal infections.

In the presence of severe hepatic insufficiency, a decrease in the daily dose of doxycycline is required, since this gradually accumulates in the body (the risk of hepatotoxic action).

Side effects

To undesirable effects of the drug Doxycycline reviews and clinical studies include:

• skin rash, swelling, itching;
• sweating, dizziness;
• nausea, vomiting, abdominal pain, anorexia;
• rarely - eosinophilia (increase in the number of eosinophils in the blood), photosensitivity (hypersensitivity to light), Quincke's edema (enlargement of part or all of the face, limbs).

With prolonged use - thrombocytopenia (reduced number of platelets), neutropenia (decrease in the number of neutrophils), hemolytic anemia (stable destruction of erythrocytes), development of intestinal dysbiosis, thrush, stable change color of teeth.

Overdose

Acute overdose Doxycycline is rare.

Symptoms: with the introduction of high doses, especially in patients with impaired liver function, the appearance of neurotoxic reactions: dizziness, nausea, vomiting, seizures, impaired consciousness due to increased intracranial pressure. Possible damage to the renal parenchyma, development of pancreatitis, an increase in other adverse reactions.

Treatment: drug withdrawal, gastric lavage with activated charcoal, symptomatic therapy, inside appoint antacids and magnesium sulfate to prevent the absorption of doxycycline. Since tetracyclines can form chelate complexes with calcium salts, with intoxication, as counteraction, it is possible to use calcium salts.

There is no specific antidote.

Hemodialysis does not affect the half-life of serum, so it is not effective in overdose.

special instructions

1. With prolonged use of Doxycycline should periodically monitor the function of the organs of hematopoiesis and liver.
2. To avoid a locally irritating effect (gastritis, esophagitis), doxycycline is recommended in the daytime with plenty of fluids and food.
3. In overdose, especially in patients with impaired liver function, the development of neurotoxic reactions is possible: seizures, nausea, dizziness, vomiting, impaired consciousness, which is associated with increased intracranial pressure.

During treatment it is recommended to refrain from all activities that require increased attention and quick motor and mental reaction, including motor transport management.

Drug Interactions

1. Doxycycline is not taken together with other antibiotics of the tetracycline group.
2. Simultaneous administration of Doxycycline and Retinol leads to an increase in intracranial pressure.
3. Doxycycline can be combined with the appointment of Metronidazole. This combination is often used in the treatment of pelvic infections.
4. Preparations of calcium and iron reduce the absorption of Doxycycline, form with it inactive compounds (chelates), so they are not assigned simultaneously.
5. Cholestyramine, Cholestipol also reduce the absorption of Doxycycline, they should not be used simultaneously, the interval between doses should be at least 3 hours.
6. Doxycycline is not prescribed concomitantly with antibiotics of bactericidal action (cause death microorganisms), because they are antagonists of bacteriostatics, one of which is Doxycycline. Therefore, it is not prescribed simultaneously with penicillin, antibiotics of cephalosporin series.
7. Carbamazepine, barbiturates, phenytoin, Rifampicin reduce the effectiveness of Doxycycline in connection with the production of enzymes that reduce the concentration of antibiotic in the blood plasma.
8. The effectiveness of estrogen-containing contraceptives is reduced with Doxycycline; the frequency of bleeding increases. It is necessary to change the method of contraception.
9. Doxycycline is not compatible with alkaline-containing drugs (sodium bicarbonate or baking soda, antacids containing its composition of magnesium, bismuth, aluminum) and with preparations that are unstable in an acidic environment (Erythromycin, Hydrocortisone, Aminophylline).
10. Doxycycline inhibits the intestinal microflora, which leads to a decrease in the prothrombin index. In this regard, the effect of drugs that reduce blood coagulability is enhanced. These drugs include Warfarin, Phenylin, and others; Doxycycline treatment requires a correction of their dosage.

Reviews

We picked up some of the people's comments about Doxycycline:

1. Natalia. The drug, surprisingly, very well helped in the treatment of the upper respiratory tract, was very surprised by its low price and high efficiency, took it after eating and drank a day to 1.5 liters of water, so as not to suffer intestines.
2. Tatyana. Saw Doxycycline from cervicitis, in the smear there was an increased content of leukocytes. I was prescribed to drink 100 mg 3 times a day, for a week. Against the background of treatment there were no undesirable reactions. Has handed over a smear all in norm or rate. Effective and inexpensive drug, which costs only 15 rubles.
3. Anna. Antibiotic is very strong, immunity plants completely. I drank with nystatin (the doctor prescribed), then I was treated with various drugs such as linex and hilak-forte. Yes, the effect of treatment is visible and fast, but health is also great.

Analogues

The analogues of Doxycycline are:

• Doxal;
• Biocyclind;
• Abadox;
• Unidox Solutab;
• Doxipan;
• Novacycline;
• Etiodoxin;
• Cyncomycin.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Capsules should be stored away from children at a temperature of not more than 25 degrees. Shelf life of the medicine is 36 months from the date of production, at its expiration the product is recyclable.

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