WALZ (40, 80 and 160 mg): instructions for use

width = Vals is a medicinal product intended for the expansion of the walls of blood vessels and arteries.

It is mainly prescribed to patients for normalization and maintenance of pressure. The drug is very popular due to the positive results and the rare occurrence of side effects.

On this page you will find all information about Wals: full instructions for use with this medicine. medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Wals. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antihypertensive drug.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does WALZ cost? The average price in pharmacies is at the level of320 rubles.

Form of issue and composition

The drug is available in the form of yellow tablets (40 mg), which are covered with a film membrane. The tablets are biconvex, have an oval shape, on the one hand - engraving "V on the other hand - lateral risks. Also produced are pink tablets (80 mg, 160 mg).

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One Valza tablet contains:

Valsartan 40 mg (80 mg or 160 mg);
Lactose monohydrate - 2, 1 mg (4, 2 mg or 8, 4 mg);
Povidone K29-32 mg (, mg or 1, mg);
Cellulose microcrystalline - 18 mg (36 mg or 72 mg);
Croscarmellose sodium mg (1, mg or 2, mg);
Talcum mg (, mg or, mg);
Magnesium stearate 3 mg (, 6 mg or, 2 mg);
Silica colloidal dioxide - 0.36 mg (2 mg or 4 mg).

Tablets are packed in blisters for 7 pcs., In cardboard boxes - 4 blisters.

Pharmacological effect

At application Valz renders hypotensive effect. The drug is a specific blocker of AT1-receptors of angiotensin II, which does not inhibit the angiotensin-converting enzyme.

Improvement of the patient's condition is observed at least 2 hours after oral administration, maximum - after 4-6 hours. The therapeutic effect of Valsa persists for 1-2 days. The maximum decrease in blood pressure occurs after 2-4 weeks of regular admission. In the event of a sudden cessation of treatment with this medication, the symptoms of withdrawal syndrome are not observed. When taken orally, WALZ is absorbed well and quickly. It has low bioavailability, perfectly binds to blood proteins.

With repeated use of the drug, no changes in the kinetic parameters were noted. When taking the medication multiple times a day, an insignificant accumulation of its active substance in the body is possible. Output unchanged with bile by intestine

Indications for use

Indications for the appointment of Valza are:

Arterial hypertension.
Increased survival of patients with myocardial infarction in the acute phase (from 12 hours to 10 days) complicated by systolic dysfunction of the left ventricle and / or left ventricular failure, with stable indicators hemodynamics.
Heart failure of chronic course (II-IV functional class according to NYHA classification) - as part of complex treatment (except combination of beta-adrenoblocker + ACE inhibitor + valsartan).

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Contraindications

The use of the drug is contraindicated:

With lactose intolerance;
Patients with galactosemia;
With the syndrome of impaired absorption of glucose-galactose;
Children and teenagers under 18;
Pregnant women;
During lactation;
In the presence of hypersensitivity to valsartan or any auxiliary component of the drug;
Patients with severe renal failure (with QC up to 10 ml / min), including those on hemodialysis;
In violation of liver function, if they are caused by obstruction of the biliary tract, including cholestasis and biliary cirrhosis.

Assign Valz, but treatment is carried out with extreme caution, people who have a pathology / condition, accompanied by a decrease in the volume of circulating blood, as well as patients with:

Arterial hypotension;
Stenosis of two renal arteries or stenosis of the artery of a single kidney;
Primary hyperaldosteronism;
Hypertrophic obstructive cardiomyopathy;
Mitral / aortic stenosis;
Hyperkalemia, developed as a result of a diet that restricts sodium intake;
Hyponatremia

Application in pregnancy and lactation

At any time of the course of pregnancy, the use of Valza is categorically contraindicated.

If there is an acute need for Valza, breastfeeding should be discontinued.

Instructions for use

The instructions for use indicate that the Vals tablets are taken orally whole (not chewing). Can be taken regardless of food.

Chronic heart failure. Assign a starting dose of 40 mg twice a day. With an insufficiently expressed effect, a phased increase in the dose to 80 mg twice a day is possible. With good tolerability, 160 mg twice daily is allowed. Correction of the dose should be carried out not more often than 1 time in 2 weeks (at such intervals it is possible to evaluate the effectiveness of each subsequent dose).
Increased survival of patients after a previous myocardial infarction. Treatment is started within 12 hours after myocardial infarction with an initial dose of 20 mg (1/2 table. 40 mg) 2 times / day, followed by an increase in the dose (40 mg, 80 mg, 160 mg 2 times / day) for several weeks, until the target dose of 160 mg 2 times / day. Reaching a dose of 80 mg 2 times / day is recommended by the end of the second week of treatment. Achievement of the maximum target dose of 160 mg 2 times / day is recommended by the end of the third month of therapy with Valz. The increase in dose depends on the tolerability of the drug during the dose selection period. In the case of development of arterial hypotension, accompanied by clinical manifestations, or renal dysfunction should consider reducing the dose. Evaluation of the condition of patients in the post-myocardial infarction period should include assessment of renal function. The maximum daily dose is 320 mg in 2 divided doses.
Arterial hypertension. It is recommended to take Valz in a starting dose of 80 mg / day. The maximum effect is achieved after 4 weeks; if after 4 weeks of therapy 80 mg / day is not enough to control hypertension, the dose is increased to 160 mg / day. Combination therapy with other antihypertensive drugs, including diuretics, is possible.

Do not prescribe more than 320 mg / day (the maximum dose should be divided into 2 doses). Perhaps the combined use of other antihypertensive drugs, including diuretics, in such cases should reduce the dose of valsartan.

In patients with mild and moderate impairment of non-biliary liver function without the effects of cholestasis, the drug should be used with caution, the daily dose should not exceed 80 mg. In patients with severe impairment of liver function (more than 9 on the Child-Pugh scale), biliary cirrhosis and cholestasis, the use of Valz is contraindicated.

Side effects

With the use of Valza a number of side effects are possible:

Often: orthostatic hypotension, postural dizziness, neutropenia, viral infections;
Sometimes: heart failure and lowering blood pressure, cough, diarrhea and abdominal pain, insomnia, fainting, decreased libido, depression, vertigo, convulsions muscle, back pain, myalgia, arthritis, hyperkalemia, sinusitis, pharyngitis, conjunctivitis, upper respiratory tract infections, edema, asthenia, epistaxis, feeling fatigue;
Rarely: vasculitis, neuralgia, dizziness, hypersensitivity, serum sickness;
Very rarely: headache, nausea, bleeding, thrombocytopenia, itching, skin rash, angioedema, arthralgia, acute renal failure, impaired renal function, rhinitis and gastroenteritis.

On the part of laboratory indicators, when using Valz, a decrease in hematocrit and hemoglobin level is possible, Hyperbilirubinemia, hypercreatininemia, increase in serum urea nitrogen concentration, an increase in hepatic activity transaminase.

Overdose

Since the therapeutic effect of the drug is to reduce blood pressure, then in patients with an overdose, their rates drop dramatically and there may be a faint or collapse. When developing an overdose, the patient is given to take activated charcoal or washed the stomach, then the treatment is symptomatic. Hemodialysis in this case is not effective.

Other symptoms of overdose may also occur:

Gastroenteritis;
Feeling of constant fatigue;
Atsenia;
Serum sickness;
Conjunctivitis;
Sinusitis, inflammatory diseases of the upper respiratory tract;
Rhinitis;
Edema, including angioedema;
Nasal bleeding.

special instructions

When treating the drug, there may be changes in the functioning of the kidneys.
Before starting treatment with Valz tablets, you need to restore the level of electrolytes and fluid. To do this, reduce the dosage of diuretics.
When treatment with Valz and chronic heart failure at the very beginning of the treatment, blood pressure may decrease, so its constant monitoring is important.
If the patient has renovascular hypertension, continuous monitoring of the creatinine and urea levels in the blood should be ensured.
During the course of treatment, the agent should carefully drive vehicles and engage in other activities that require attention and concentration.

Drug Interactions

This drug interaction is observed:

Potassium-sparing diuretics, potassium preparations, potassium-containing salts, drugs that raise the level of potassium in the blood plasma (such as heparin) increase the risk of hyperkalemia.
Other antihypertensives and diuretics increase the antihypertensive effect of valsartan.
In the treatment of arterial hypertension, valsartan had no clinically significant interaction with other concomitantly used drugs (eg, cimetidine, warfarin, digoxin, atenolol, amlodipine, glibenclamide, furosemide, indomethacin, hydrochlorothiazide).
In a joint application with ACE inhibitors, a reversible increase in the concentration of lithium in plasma and the development of toxic effects were reported.
The antihypertensive effect of the drug may be weakened when combined with NSAIDs, including. with selective inhibitors of COX-2 and acetylsalicylic acid in a dose of more than 3 g / day.

Very limited experience in the use of valsartan and preparations containing lithium. In the case of lithium-containing drugs, the control of lithium concentration in blood plasma is recommended in patients receiving Valz.

WALZ and WALZ H, what's the difference?

Many patients are interested in the question: what is the difference between the drugs Valz and Wales H? Usually such an acronym stands for the manufacturer's code, but in this case everything is a bit different. The fact is that the effectiveness of the drug Valz H is much higher due to the active ingredient - hydrochlorothiazide. The decision on which drug is appropriate in each case should be taken by the attending physician.

Wals H provides an additional diuretic effect, but if this is undesirable (kidney or liver disease), it is necessary to limit the other drug.

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Reviews

We picked up some of the people's feedback on the Walsz drug:

Antonina. I am 58 years old. The pressure did not become obtrusive with 50. In the fall of 2015 took a loan, I was cut from work! The panic began. I found work for 12 hours without days off. I have a hassle in my work, let's hurry. I come home from work, everything is fine, I go to bed, I doze, I start kolbasit-the pressure increases-150 on 9, 60 by 9, 70 by 100, I start throwing everything that I have, I was helped by adelphan, now it's not there, berlipril 10. Then the ambulance. One, in a week another, the third. They ordered me to go to the doctor. The doctor said - we will make you 120 to 80 and prescribed 160, indopamide and bisoprolol. Since April I've been drinking 160 quarts, idopamide, and my biproprolol has been severely impaired. up to 60, I do not drink it, but I drink it if it is up to 100 strokes anaprilin under the tongue. Very soothes the heart. Here I drink almost a year this dosage and suddenly the pressure jump to 200, I'm shocked, how is it? She was hit by a hood. A week later, the race is a little lower. I raise the dosage, I will divide the tablet into 3 parts. So it was good. But you can not worry anyway, the movie is exciting or the children are upset, lack of sleep, immediately creeps anyway. Observe!
Nina. I have a hypertensive patient with experience, many of which have already tried on my own. At the last appointment, the doctor advised "Valz" in the morning and after dinner, one 80 mg tablet. A couple of days I took as prescribed, but the pressure dropped to 110-70, I already began to swing. I switched to one pill in the morning, everything was normal. She told the doctor, she advised to take two times, but half a tablet. Again I took as a doctor advised and again the pressure fell below what I needed. Now I drink only in the morning, on the whole tablet, the pressure is 130-90, that's what I need. So the dose should be individually selected.
Olga. Waltz was prescribed 160 once a day. The pressure before treatment with this drug reached 210/100 After intake, the pressure dropped sharply, severe headaches and pain in the heart. On the advice of the doctor, we divided the reception by 80 2 times a day. A few days later, the dose was reduced to 80 once a day. The pressure is kept low, after 2 hours after reception, the condition worsens due to low blood pressure. reach the figures of 107/80. Has tried to lower a dose to 40 once a day, sharply to cancel a preparation I am afraid, but also to accept it or him, if pressure and so low I am afraid. The attending physician is on vacation. Lowers Wales pressure well, but the condition is not very good. I accept three weeks already.

In general, the doctors' reviews of WALZE indicate that this pressure medication is an effective method of reducing elevated blood pressure. Tablets Valz 80 mg with the correct intake and dosage can reduce blood pressure, improve the overall condition of the patient. In the reviews of Valze it is also noted that with a sharp suspension of taking the drug there is no so-called withdrawal syndrome.

Analogues

Valz analogs for the active substance are:

Diovan;
Valsafors;
Tantordio;
Valsartan Zentiva;
Nortivan;
Walsakor;
Tareg.

Before using analogues, consult your doctor.

Storage conditions and shelf life

In accordance with the instruction, the WALZ must be stored out of reach of children and protected from light by a dry place, at room temperature up to 30 ° C. The shelf life of the medicine, if the recommendations are observed, is 3 years.