Norbaktin

Norbaktin is a synthetic antimicrobial drug with a broad spectrum of action, which has antibacterial properties, refers to the quinolone / fluoroquinolone group.

The main component, norfloxacin, is an annihilator for various aerobic bacteria. The effectiveness of the drug is achieved by destroying the DNA bonds of bacteria. Norbaktin actively fights against bacteria resistant to the main groups of antibiotics.

Highly active against most Gram-negative bacteria: Escherichia coli (E. coli), Salmonella spp. (salmonella), Shigella spp. (Shigella), Proteus spp. (Proteus), Morganella morganii, Klebsiella spp. (including Klebsiella pneumoniae), Enterobacter spp., Serratia spp., Citrobacter spp., Yersinia spp., Providencia spp., Haemophilus influenzae, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Neisseria meningitidis.

Clinical and pharmacological group

Antimicrobial synthetic agent of the group of fluoroquinolones of wide spectrum of action.

Conditions of leave from pharmacies

It is released on prescription.

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Price list

How much does Norbaktin cost in pharmacies? The average price in 2018 is at the level of360 rubles.

Form of issue and composition

Produced in the form of tablets coated with a film shell: white or almost white, oval, with bevelled edges, on one side - risk, on the other - squeezed quadrangle, in which the inscription "NBT 400" is engraved (10 pcs. in blisters or strips, 1, 2 or 3 blisters or a strip in a cardboard bundle).

Composition of 1 tablet:

Active substance: norfloxacin - 400 mg;
Additional components: sodium lauryl sulfate, silicon dioxide colloid, corn starch, magnesium stearate, croscarmellose sodium, microcrystalline cellulose, purified talc;
Sheath composition: macrogol 40, titanium dioxide, hypromellose, purified talc, purified water.

Pharmacological effect

Norbaktin has a bactericidal effect. The active ingredient Norfloxacin is an antibacterial agent belonging to the group of fluoroquinolones and acts on bacterial DNA-gyrase, which is responsible for supercoiling, which ensures the stability of bacterial DNA. Due to the destabilization of the DNA chain, the death of pathogenic microorganisms takes place.

The following bacteria are sensitive to Norbaktin:

Yersinis enterocolitica;
Citrobacter spp .;
Vibrio parahaemolyticus;
Staphylococcus epidermidis;
Chlamydia spp .;
Staphylococcus aureus;
Legionella spp .;
Klebsiella spp .;
Vibrio cholerae;
Enterobacter spp .;
Haemophilus influenzae;
Aeromonas plesiomonas;
Escherichia coli;
Shigella spp .;
Mycoplasma pneumonia;
Neisseria meningitis;
Campylobacter jejuni;
Salmonella spp .;
Neisseria gonorrhoeae;
Hafnia, Proteus spp.

Insensitive to Norbaktin are anaerobic bacteria, Ureaplasma urealyticum, and Nocardia asteroids.

The duration of the therapeutic effect is at least 12 hours.

Indications for use

The medical preparation in the form of tablets must be taken in a complete course of 7 to 10 days in such clinical pictures, it is important to consider the drug interaction, the potential risk of side effects:

infections of the digestive tract, intestinal disorders;
prevention of sepsis in neuropathy;
"Traveler's diarrhea" (other problems during gastric activity during acclimatization);
gonococcal infection of uncomplicated form, initial stage;
infection of the genitals, urinary system, for example, gonorrhea.

Typical medication is prescribed with such diagnoses of the organism:

endometritis;
salmonellosis;
prostatitis;
cervicitis;
shigellosis.

Contraindications

Because fluoroquinolones are able to accumulate in connective tissue and cartilage, destroying them, norfloxacin preparations categorically can not be taken by pregnant and lactating women, children and adolescents until they reach adulthood.

In addition, Norbaktin is contraindicated in persons with hypersensitivity, certain deficient conditions, epilepsy, atherosclerosis and impaired circulation in the vessels of the brain, insufficiency of the liver and kidneys.

Dosage and route of administration

The instructions for use indicate that Norbaktin is a drug for oral use: the tablets should be swallowed whole and washed down with plenty of liquid. To achieve the maximum therapeutic effect is possible using the drug on an empty stomach - 1 hour before or 2 hours after eating.

The dose and duration of treatment in each case is determined by the doctor depending on the indications and severity of the course of the disease.

Recommended average doses:

Acute uncomplicated gonococcal infection: 800 mg once;
Acute uncomplicated cystitis: 200-400 mg twice a day for 3-5 days;
Other acute infections of the urinary system: 400 mg twice a day for 7-10 days;
Sexually Transmitted Infections: 400-600 mg twice a day for 7 days;
Infectious diseases of the gastrointestinal tract: 400 mg 2-3 times a day for 3-5 days;
Prevention of travelers' diarrhea in epidemically unfavorable regions: 400 mg once a day, duration of therapy - if necessary, but not more than 21 days;
Recurrent and chronic recurrent infectious diseases of the urinary system: 400 mg twice a day for 4 weeks. In case of relapse, 400 mg once a day for up to 12 weeks;
Prevention of sepsis in patients with neutropenia: 400 mg 3 times a day for 8 weeks.

Patients with impaired renal function (creatinine clearance less than 20 ml / minute or serum creatinine level greater than 5 mg / 100 ml) and patients, (hemodialysis) should be prescribed at 1 full dose once a day or at ½ of the therapeutic dose 2 times a day.

Side effects

Like any other drug, Norbaktin tablets have a number of side effects:

In women, the development of candidiasis of the vagina;
From the skin - hives, the appearance of rashes, itching, redness of the skin;
From the organs of the urinary system - dysuric phenomena, the development of interstitial nephritis;
From the nervous system - dizziness, confusion, headaches, impaired sensitivity at the fingertips, anxiety, drowsiness and lethargy, fast fatigue;
From the cardiovascular system - increased heart rate, changes in blood pressure, the development of cardiac arrhythmia, vasculitis;
On the part of the digestive system - nausea, heaviness and pain in the stomach, flatulence, increased gas production, diarrhea, an increase liver, lagging of the tongue and a violation of appetite, increased activity of hepatic transaminases, in severe cases, a violation of liver function;
On the part of the blood system - a decrease in the number of platelets and leukocytes in the blood.

With the development of such side effects, drug therapy should be discontinued and seek medical attention.

Overdose

With an overdose of Norbaktin, vomiting, dizziness, drowsiness, general weakness, nausea, increased sweating, and puffiness of the face may occur. With such symptoms, gastric lavage and adequate hydration therapy with forced diuresis are required. The patient is recommended to place for several days in the hospital and conduct a survey (hemodialysis or peritoneal dialysis may be prescribed).

special instructions

It should be used with caution in patients with epilepsy, convulsive syndrome of another etiology, with severe impairment of kidney and liver function. During treatment, patients should receive a sufficient amount of fluid (under the control of diuresis).

Norfloxacin should be taken at least 2 hours before or 2 hours after ingestion of antacid agents or preparations containing iron, zinc, magnesium, calcium or sucralfate.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

Reduces the effect of nitrofurans.
With the simultaneous use of norfloxacin with cyclosporine, there is an increase in the concentration of the latter in the blood plasma.
With the simultaneous use of norfloxacin with warfarin, the anticoagulant effect of the latter is enhanced.
With the simultaneous administration of norfloxacin reduces the clearance of theophylline by 25%, so with simultaneous use should reduce the dose of theophylline.
With the simultaneous administration of norfloxacin and antacid agents or preparations containing iron, zinc, magnesium, calcium or sucralfate, decreases absorption of norfloxacin due to the formation of complexons with metal ions (the interval between their reception should be at least 4 hours).
Simultaneous administration of norfloxacin with drugs that have the potential to reduce blood pressure can cause a sharp decrease in blood pressure. In this regard, in such cases, as well as with the simultaneous introduction of barbiturates, anesthetics, it is necessary to monitor heart rate, blood pressure, ECG parameters. Simultaneous use with drugs that reduce the epileptic threshold may lead to the development of epileptiform seizures.

Reviews

We picked up some reviews of people who used the drug Norbaktin:

Margo. A couple of weeks ago, treated with acute pills cystitis. Pain with urination quickly passed, but there were problems with the stool (liquid feces). Constantly ran to the toilet, although she took the medicine on an empty stomach. When it was no longer tolerated (on the 5th day of treatment), I had to replace the drug and buy a safer Normox in the pharmacy.
Andrei. This drug was prescribed to me by my personal nephrologist who treated me and told me to drink twice a day after eating for seven days, on an empty stomach not to drink - you can put the stomach in an antibiotic. I began to observe at myself after reception mild headaches, the heart began to hurt or be ill; be sick, urine has accepted a light kind and has started to foam. At night I could not sleep for a long time, I began to worry about my lower back. I think that's what the kidneys started to know about themselves. Heavy drug for my body. The doctor said that this is a normal action of the antibiotic. They all practically harm the body and at the same time without them it is simply impossible to begin treatment.
Marina. She took the medicine for pyelonephritis for 10 days. Tablets quickly remove pain, they act gently - without side effects. In addition, the doctor prescribed probiotics, vitamins and preparations to restore immunity. I helped, so with infectious diseases of the urinary tract, I can recommend an appointment.

Analogues

Structural analogs for the active substance:

Loxon 400;
Nolycin;
Norillet;
Normax;
Noroksin;
Norfacin;
Norfloxacin;
Renor;
Sofazine;
Chibroxin;
Utibid.

Before using analogues, consult your doctor.

Storage conditions and shelf life

According to the instructions to Norbaktin, it can be used no more than 3 years from the date of release, keeping it in a room protected from moisture penetration and with an air temperature not exceeding 25 ° C.