What helps Biprol

Biprol is a drug from the group of selective beta-blockers.

It is used in the treatment of hypertension and angina pectoris. The international name of the drug is bisoprolol.

On this page you will find all information about Biprol: full instructions for use on this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Biprol. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Beta1-adrenoblocker.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Biprol? The average price in pharmacies is at the level of135 rubles.

Form of issue and composition

Round, biconvex tablets, covered with a film coat of yellow (for a dosage of 5 mg) or dark yellow (for a dosage of 10 mg) of color. On the cross-section, two layers are visible, the inner layer is white or white with a barely noticeable creamy hue of color.

• active substance: bisoprolol fumarate - 5 mg / 10 mg;
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• auxiliary substances: microcrystalline cellulose, ludypress LCE (lactose monohydrate, povidone - 3-4%), corn starch, silicon dioxide colloid (aerosil), crospovidone (clolidone CL), magnesium stearate.

Pharmacological effect

Biprol refers to selective beta1-adrenoblockers, does not possess internal sympathomimetic activity and is not endowed with membrane-stabilizing properties.

When taking this medication, the renin activity in the plasma decreases, the need for oxygen supply to the myocardium, heart rate in a different state decreases. This indicates that the drug has antihypertensive, antiarrhythmic and anti-anginal action. Low doses of Biprol are able to block β1-adrenergic receptors of the heart, lower the catecholamine-induced formation of AMP from ATP, reduce intracellular calcium flow, reduce myocardial contractility, inhibit conduction and excitability, and so on.

When the drug is prescribed in high doses, then its beta2-adrenergic blocking effect is noted. The hypotensive effect of this drug can reduce the minute volume of blood, sympathetic stimulation of peripheral vessels, reduce the activity of the renin-angiotensin-aldosterone system, helps restore sensitivity with a decrease in blood pressure and the effect on the central nervous system. During treatment of arterial hypertension initial efficiency is manifested after 2-5 days, and a stable effect - 1-2 months.

The antianginal effect of the drug reduces the need for oxygen in the myocardium, due to a decrease in heart rate and contractility, diastole lengthening and improvement of myocardial perfusion. The manifestation of an antiarrhythmic effect is associated with the elimination of arrhythmogenic factors, a decrease in the rate of spontaneous excitation, and so on.

Indications for use

What helps? In the instructions for use it is noted that "Biprol" is used in cardiological practice under the following conditions:

• arterial hypertension;
• IHD;
• cardiac insufficiency;
• violation of heart rate (tachyarrhythmia).

Contraindications

Do not use the drug:

• atrioventricular and other heart block;
• pressure drop less than 90 mm;
• marked violations of the respiratory function, accompanied by obstruction of the respiratory tract;
• period of pregnancy;
• shock cardiogenic type;
• heart failure, characterized by acute severe form, not amenable to treatment;
• infarct in acute period;
• breast-feeding;
• hypersensitivity reactions to the active ingredient or excipients of the drug;
• decrease in the heart rate is less than 50 beats per minute;
• the weakness of the sinus node;
• children.

The use of the drug is limited in persons suffering from:

• diabetes mellitus,
• thyrotoxic goiter;
• psoriasis;
• pulmonary obstructive diseases;
• severe degree of bronchial asthma;
• angina of Prinzmetal;
• functional hepatic or renal disorders;
• displacement of acid-base balance towards acids;
• manifestations of bradycardia, heart block or circulatory disorders in peripheral vessels.

Application in pregnancy and lactation

The drug may interfere with the development of the fetus, cause him a bradycardia and hypoglycemia. There is no confirmation of whether bisoprolol penetrates into breast milk.

Instructions for use

The instructions for use indicate that Biprol is taken orally, in the morning, on an empty stomach, the tablets are not chewed.

• Usually prescribed in a dose of 5 mg 1 time / day. If necessary, increase the dose to 10 mg 1 time / day. The maximum daily dose is 20 mg.

In patients with impaired renal function with QC less than 20 ml / min or with severe impairment of liver function, the maximum daily dose is 10 mg.

Side effects

According to the patients, the drug does not cause any side effects quite often.

Let us consider the main manifestations.

Nervous system	When the medication acts, fatigue, dizziness, weakness, restlessness, sleep disorder, depression, asthenia, short-term memory loss, confusion develop.
Cardiovascular dystonia	The following reactions are noted: violation of myocardial conductivity, bradycardia, arrhythmia, orthostatic hypotension, increased symptoms of cardiovascular failure, cold extremities, increased symptoms of Raynaud.
Sense organs	Possible visual impairment, conjunctivitis, dry eyes.
Gastrointestinal tract (gastrointestinal tract)	When taking medication, vomiting, nausea, severe stool, abdominal pain, taste disorder, cholestasis (hepatic dysfunction) may occur.
Breathing system	Often, against the background of taking the medication in question, there is a difficulty in breathing, up to the development of bronchospasm.
Allergy	There are cases of occurrence of weak allergic manifestations in the form of itching, urticaria and special rashes on the skin.

Overdose

Symptoms of Biprol overdose are fainting, arrhythmia, dizziness, AV blockade, bronchospasm, severe bradycardia, chronic cardiac insufficiency, convulsions, ventricular extrasystole, difficulty breathing, marked decrease in blood pressure, cyanosis of finger nails or palms.

In such cases, gastric lavage and the appointment of symptomatic therapy are required.

special instructions

1. Before the start of treatment, it is recommended to perform a study of the function of external respiration in patients with respiratory diseases in the anamnesis.
2. When taking Biprol requires regular monitoring of patients. It should include a measurement of heart rate and blood pressure (at the beginning of treatment - every day, then every 3 to 4 months), ECG, blood glucose in diabetic patients (once every 4 to 5 months). In elderly patients it is recommended to follow the function of the kidneys (once every 4 to 5 months).
3. Patients using contact lenses should take into account that a reduction in tear fluid production is possible against the background of treatment.
4. With thyrotoxicosis, Biprol can mask certain clinical signs of thyrotoxicosis (for example, tachycardia). Sharp abolition in patients with thyrotoxicosis is contraindicated, since in this case, it is possible to increase symptoms.
5. If older bradycardia is detected in elderly patients (less than 50 beats per minute), a marked decrease in blood pressure (systolic blood pressure below 100 mm Hg. etc.), AV blockade, it is necessary to reduce the dose or stop treatment.
6. Do not abruptly interrupt treatment because of the risk of developing severe arrhythmias and myocardial infarction. Cancellation is carried out gradually, reducing the dose for 2 weeks or more (by 25% in 3-4 days).

During the treatment period, care must be taken when driving vehicles and engaging in other potentially Dangerous activities that require increased concentration and speed of psychomotor reactions

Drug Interactions

1. The joint application of "Biprol" together with diuretics critically lowers blood pressure.
2. The combination of psychotropic medications with tablets "Biprol" intensifies the inhibitory effect on the central and autonomic nervous systems.
3. "Biprol" catalyzes the effects of hypoglycemic drugs.
4. Synchronous use of a beta-blocker with non-steroids, glucocorticoids and estrogens weakens its effectiveness.
5. With simultaneous application of "Biprol" with cardiac glycosides and calcium antagonists, an increased attention to the patient due to the danger of deep bradycardia and atrioventricular blockade.
6. Taking "Biprol" or its analogs is not recommended intravenous introduction of X-ray contrasts containing iodine in order to avoid anaphylactic reactions.

Reviews

We picked up some feedback from people about the Biprol drug:

1. Kostya. In the pharmacy, I was always offered expensive foreign substitutes for the medication, they assured me that they were better. The doctor convinced me that there was no difference between the tablets. In the end, I still went through a course of treatment with Biprol, I bought it for 140 rubles. for packing. The pressure returned to normal within a couple of days. There are many side effects, but they are still avoiding me.
2. Elizabeth. A couple of months ago, I noticed that my periods are too often beating my heart, and the pressure rises to 160/100. The doctor prescribed Biprol at a dosage of 5 mg per day. In the pharmacy there were only 10 mg tablets, but I divided them in half. After 3 days the pressure stopped rising above 130/85, I feel fine.

Analogues

Synonyms of the drug are the drugs Concor, Aritel, Tirez, Bidop, Bisoprolol, Bisomor, Niperten and Coronal. Analogues of Biprol are such medicines, as:

• Atenolol-Ratiopharm;
• Metodok;
• The nebivator;
• Betak;
• Metoprolol;
• Atenolol;
• Corvitol 100;
• Serdol;
• Cordanum;
• Egilok;
• Vasocardine;
• OD-Heaven;
• Lidalok;
• Breviblock.

Before using analogues, consult your doctor.

Storage conditions and shelf life

It advises not to apply after the expiry date of the drug "Biprol" instructions for use. Analogues are affordable and can be found at any pharmacy.

Shelf life of the drug is three years from the date of manufacture. The drug should be stored in a cool dark place inaccessible to children at a temperature of no higher than +25 ° C.

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