Tardiferon

Tardiferon is a medicinal preparation that effectively replenishes the iron deficiency and improves the synthesis of hemoglobin in the body.

Iron occupies the central part of the hemoglobin molecule and is responsible for stimulating hematopoiesis. Elimination of violations of hemopoiesis is carried out by replenishing the lack of iron in the body due to the active substance of the drug.

Ascorbic acid, also a part of Tardiferon, increases the digestibility of ferrous sulfate by about 4 times during its absorption in the gastrointestinal tract. Mucoproteosis improves the tolerability of the active substance of the drug.

Clinical and pharmacological group

Anti-anemic drug.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Tardiferone in pharmacies cost? The average price is at the level of300 rubles.

Composition and form of release

Tardiferone is available in the form of long-acting tablets coated with a sugar shell: biconvex, with smooth, smooth surface of white or almost white color (10 pieces in blisters, in a cardboard bundle 3 blisters).

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Composition of 1 tablet:

active substance: iron (in the form of ferrous sulfate × 11/2 H2O) - 80 mg (corresponding to 256.3 mg of ferrous sulfate × 11/2 H2O);
auxiliary components: potato starch, triethyl citrate, hydrogenated castor oil, ascorbic acid, copolymer methacrylic acid and methacrylate, magnesium stearate, anhydrous mucoproteosis, povidone, talc, magnesium trisilicate;
sugar shell: rice starch, carnauba wax, talc, sucrose, titanium dioxide, methyl methacrylate copolymer, butyl methacrylate and dimethylaminoethyl methacrylate.

pharmachologic effect

The drug Tardiferon is a complex iron of prolonged action.

The drug Tardiferon contains ferrous iron, which is part of the salt. Effectively compensates for iron deficiency in the body (in particular, with iron deficiency anemia), participates in metabolic processes, stimulates erythropoiesis. Iron ions are a part of myoglobin, hemoglobin, many enzymes. Lack of iron in the body can occur with a lack of this trace element in food, a violation of iron absorption in the gastrointestinal tract (surgical interventions of large volume, associated with resection of intestines, stomach, chronic diarrhea), with increased demand for iron (periods of active growth, pregnancy, increased physical activity), with blood loss (hemorrhagic complications of surgical interventions, peptic ulcer / duodenal ulcer, ulcerative colitis, profuse menstruation, etc.).

When conducting course therapy iron deficiency anemia there is a gradual regression of clinical symptoms of anemia (fatigue, general weakness, dryness and soreness of the skin, dizziness, tachycardia), indicators of laboratory studies. 325 mg of ferrous sulfate (II) corresponds to 0.105 g of elemental iron.

Pharmacodynamics and pharmacokinetics

Tardiferone tablets are characterized by a prolonged effect. Mucoproteosis increases the bioavailability of ferrous ions, which ensures its gradual release in the small intestine. The maximum concentration of iron is detected in the blood plasma approximately 7 hours after oral administration. The level of this substance is maintained at a consistently high level for 24 hours. Bioavailability is 5-35%.

The rate and degree of absorption of ferrous sulfate is directly determined by the presence of its own iron stores in the body. Excess iron is cumulated in the tissues in the form of ferritin, and is also excreted through the kidneys, intestines and during sweating.

Indications for use

Tardiferone is prescribed for the treatment and prevention of iron deficiency states of various etiologies, incl. with a reduction in the absorption of iron from gastrointestinal tract, pregnancy and lactation, with unbalanced and malnutrition and long bleeding.

Contraindications

Absolute:

violation of iron utilization (anemia due to lead poisoning, iron deficiency anemia);
children up to six years;
isomaltase / invertase deficiency syndrome, galactose malabsorption syndrome and glucose intolerance, fructose intolerance;
increased content of iron in the body (hemochromatosis, hemosiderosis);
acute bleeding from the gastrointestinal tract;
intestinal obstruction, esophageal stenosis and / or obstructive changes in the gastrointestinal tract;
anemia not related to iron deficiency (thalassemia, hemolytic and aplastic anemia, megaloblastic anemia due to vitamin B12 deficiency);
hypersensitivity to any of the components of the drug.

Relative (Tardifiron is used with caution):

renal or hepatic insufficiency;
peptic ulcer of the duodenum and stomach;
inflammatory bowel disease;
alcoholism.

Intended use for pregnancy and lactation

The drug can be administered from 4 months of pregnancy to eliminate iron deficiency anemia. The average course of treatment is 2-3 trimester.

Studies have shown that during pregnancy and breast-feeding this drug does not have a toxic effect on the child's body. Tardiferone is also indicated as a prophylactic.

Dosage and route of administration

As indicated in the instructions for use, Tardifiron is prescribed for adults and children over 6 years of age: tablets are taken orally (without chewing). It is advisable to take the drug with water, before meals or during meals. Application for medicinal purposes: children over 6 years old - 1 tab. / Day, children older than 10 years and adults - 1-2 tablets / day.

Application for preventive purposes: pregnant women - 1 tab. / Day or every other day for the last two trimesters of pregnancy (or starting from the 4th month).

Duration of admission:

Adult patients should take the drug for a period that ensures correction of anemia and restoration of the iron reserve in the body. The dose for women is 600 mg, for men 1200 mg.

In iron deficiency anemia, the duration of admission is 3 to 6 months, depending on the degree of depletion of the iron reserve: if necessary, in the absence of adequate control of anemia, it is necessary to increase the duration of the drug intake.

Side effect

In rare cases, the following side effects occur:

from the digestive system: abdominal pain, nausea, diarrhea or constipation, vomiting;
other: allergic reactions.

Overdose

With prolonged and uncontrolled use of iron in large doses, the patients develop signs of overdose, which are expressed by the following clinical symptoms:

severe pain in the stomach;
vomiting;
the appearance of metallic taste in the mouth;
thirst and dry mouth;
nausea;
inflammation of the intestine;
constipation.

Treatment of an overdose consists in washing the stomach to a patient with 1% aqueous sodium bicarbonate solution and performing symptomatic therapy. The antidote of the drug is Deferoxamine.

special instructions

Before the beginning of therapy it is necessary to determine the content of iron and ferritin in the blood serum.

In the period of taking the drug must take into account that coffee, milk, vegetables, cereals reduce the absorption of iron.

During the period of taking the drug, a dark colouration of the stool can be observed, which is due to the excretion of non-absorbed iron and has no clinical significance, as well as a false positive benzidine test.

Due to the presence of sucrose in the formulation, it is contraindicated for its use by persons with intolerance to fructose, a syndrome of impairment absorption of glucose and galactose, or invertase / isomaltase deficiency syndrome (rare metabolic disorders).

Interaction with other drugs

Reduce iron absorption:

medicines containing carbonates, hydrogen carbonates, phosphates, oxalates;
pancreatin, pancreolipase;
antacid medicines containing salts of aluminum, calcium, magnesium, calcium preparations, etidronic acid, drugs that reduce the acidity of gastric juice (including cimetidine).

Mutually reduce absorption when combined:

tetracyclines, D-penicillamine, tea, egg yolk.

If necessary, combining with the above drugs or foods, iron preparations should be taken 1 hour before or 2 hours after they are consumed.

Increase absorbability:

ascorbic acid, ethanol (including increases the risk of toxic complications).

Iron drug in high doses reduces the absorption of zinc.

Do not administer together with other iron preparations, incl. for parenteral use, to avoid an overdose.

Reviews

We offer you to read reviews of people who used the drug:

Anastasia. Recently, I appointed a doctor to fight with mild anemia (103 indicators) as an analogue to more expensive drugs. At reception in the first day the small nausea was felt, I think, that not absolutely approaches people with infringements in organs GASTROINTESTINAL TRACT. The next day and in the subsequent body adapted. As a neutral effect, I note - staining the stool. And, so, the drug came up to me, I felt better with him, the mood was already literally in a week, on a blood test only a month later.
Natalia. A wonderful drug. The result is very satisfied. Two years could not raise hemoglobin, taking continuously expensive drugs. The doctor said that they are the most effective, and hemoglobin hardly kept for 100. Tardiferon appointed a nephrologist. Saw on 1t.2 times a day. For two months of taking hemoglobin 129!!! I felt myself a man).
Margarita. Finally, I found a drug that tolerates my stomach well. It is quite effective, hemoglobin within one and a half month of admission reached the bottom of the norm. And then I already have a whole collection of iron preparations, which I can not take because of intolerance. From "Tardiferon" my stomach does not hurt and everything is in order with digestion, the only stool was painted in dark color, I was afraid I thought the latent bleeding started, but this is the case with iron.