Agapurin

Agapurin is a medicinal product from the group of purines, which improves rheological properties and microcirculation of blood.

Refers to spasmolytic and vasodilating agents. Produced in the form of long-acting tablets, white. The active substance is pentoxifylline 400 mg or 600 mg.

On this page you will find all information about Agapurin: the full instructions for use on this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Agapurin. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

A drug that improves microcirculation. Angioprotector.

Conditions of leave from pharmacies

The drug is released by prescription.

Price list

How much does Agapurin cost? The average price in pharmacies is at the level of300 rubles.

Form of release, composition and packaging

The drug Agapurin is produced in the form of tablets, 60 pieces each in glass bottles; in the form of retard tablets (SR), 20 pieces in the secondary packaging; in the form of a solution for injection, in ampoules of 5 ml of No. 5 in a box.

• 1 tablet contains 100 mg of pentoxifylline.

In addition (together with the coating): anhydrous colloidal silicon, carmelose sodium, lactose monohydrate, methylparaben, corn starch, talc, acacia gum, magnesium stearate, crystalline and powdered sucrose, titanium dioxide.

• 1 tablet of CP includes 400 mg or 600 mg of pentoxifylline.

In addition (together with the membrane): hypromellose, talc, macrogol 6000, magnesium stearate, povidone 40, sepiphilm 752 white, emulsion of dimethicone.

• 1 ml of the injection solution contains 20 mg of pentoxifylline.

In addition: water d / in, sodium chloride.

pharmachologic effect

Agapurin belongs to the purine group and has a moderate spasmolytic (ie, relaxes smooth muscle) effect. Due to this, it improves blood flow even in vessels of the smallest caliber and promotes improvement of the rheological characteristics of the blood. The pentoxifylline caused by vasodilation leads to a reduction in the overall peripheral resistance of the vessels, an increase in the impact and minute volume of the heart. There is no increase in the heart rate.

The mechanism for preventing thrombosis is associated with irreversible inhibition of phosphodiesterase, increased concentration in platelets of cAMP and the accumulation of ATP in erythrocytes. Equally important is the mechanism of Agapurin's influence on the coronary arteries. Pentoxifylline exhibits a moderate antianginal effect by expanding not only the blood vessels of the heart, but also the lungs. The drug has the ability to increase the tone of the diaphragm and intercostal muscles (respiratory musculature).

In occlusive diseases of the lower extremities (obliterating endarteritis or atherosclerosis) the drug due to spasmolytic and antiaggregant action effectively eliminates nocturnal cramps, raises the distance of walking, stops pain in calf muscles at rest.

What helps Agapurin?

The drug is prescribed for the following pathological conditions:

1. Conditions after ischemic and hemorrhagic stroke.
2. Chronic and acute impairment of cerebral circulation in the brain of ischemic etiology (cerebral atherosclerosis, among others).
3. Disturbance of blood circulation in the vessels of the eye (chronic and acute circulatory insufficiency of the vascular and reticular membranes of the eye).
4. Trophic tissue disorders caused by violation of venous or arterial microcirculation (frostbites, gangrene, varicose ulcers).
5. Inflammatory, diabetic and atherosclerotic processes accompanied by impaired peripheral circulation (obliterating endarteritis, diabetic angiopathy, "intermittent" lameness caused by atherosclerosis).
6. Dysfunction of the middle ear of vascular etiology, accompanied by deafness.
7. Angioneuropathy (Raynaud's disease, acrocyanosis, paresthesia).

Contraindications

Contraindications to the use of the drug are the following conditions:

• porphyria;
• tendency to bleeding, massive bleeding, hemorrhage to the retina;
• severe arrhythmias;
• myocardial infarction, acute hemorrhagic stroke.
• severe atherosclerosis of coronary and / or cerebral vessels;
• period of pregnancy and lactation, children under 18 years of age.

The drug is administered with caution to patients with hypotension, arrhythmia, cerebrovascular and / or cardiac atherosclerosis, impaired cardiac function, acute and chronic renal and / or hepatic insufficiency, stomach ulcers and / or duodenal ulcers. In patients who have recently undergone surgical interventions, the taking of the drug should be strictly controlled by the attending physician (it is recommended that regularly monitor the levels of hemoglobin and hematocrit), since in such patients the risk of bleeding increases.

Pregnancy

Take medicine for pregnant women, as well as during breastfeeding is categorically contraindicated. The safety of its reception by children is not established, although most doctors do not recommend giving medicine to patients who have not reached the age of 15-18.

Instructions for use Agapurin

The instructions for use indicate that Agapurin tablets are taken orally, without chewing, regularly at the same time, preferably after eating.

1. The drug is taken, starting with 200 mg (2 tab.) 3 times / day during the first week; with severe arterial hypotension and symptoms of irritation from the gastrointestinal tract or central nervous system, the initial dose is reduced to 100 mg (1 tab.) 3 times / day.
2. At course treatment appoint 100 mg (1 tab.) 3 times / day. The maximum daily dose of 1200 mg / day.

With insufficient renal function with a creatinine level above 400 mmol / l, doses are reduced by 30-50%.

Side effects

Taking the drug can lead to the development of negative side reactions from various organs and body systems, they include:

1. The hematopoietic system is the appearance of leukopenia or thrombocytopenia.
2. Skin: allergic reactions. There may be urticaria, rashes, itching, redness of the skin.
3. On the part of the organs of vision - impaired vision, disruption of coordination, accommodation.
4. From the side of the digestive tract, there may be a feeling of heaviness in the stomach, vomiting and vomiting, a sharp decrease in appetite, an upset stomach. Perhaps an exacerbation of cholecystitis or cholecystitis hepatitis.
5. The cardiovascular system often reacts with acute pain in the heart, arrhythmia and angina, a sharp drop in blood pressure.
6. The central nervous system can respond with sleep disorders, frequent unreasonable dizziness, increased anxiety, sudden headaches. Cramps of extremities are frequent, frequent changes of mood.

Overdose

In case of an overdose of the drug, nausea, dizziness, tachycardia, or lowering of blood pressure are possible. Symptoms including fever, hot flashes, irritation, loss of consciousness are not excluded.

In case of an overdose, stop taking the drug, rinse the stomach, take activated charcoal. In order to prevent complications in acute overdose, general and specialized medical supervision is required.

Additionally

During treatment, blood pressure should be measured regularly. Patients with impaired renal function increase the amount of medicine gradually. They need constant monitoring of the attending physician, since in case of a hemorrhage in the eye, it is immediately canceled. Also, it is not recommended to take medicine in large numbers of people with diabetes mellitus who use hypoglycemic drugs. This can cause hypoglycemia.

Patients who have recently undergone surgical operations, when using the drug should monitor the level of hematocrit and hemoglobin in the blood.

Reviews

In more than 90% of cases, reviews about Agapurin are positive. Patients receiving this drug are most often completely satisfied with its effectiveness and rarely note the development of any adverse reactions.

Also, you can often find recommendations and feedback about the use of Agapurin in bodybuilding, for the purpose of so-called pumping (tightening and expansion of muscle tissue after physical exertion). In this case, the drug is positioned as a means of the fastest set of muscle mass, which occurs due to the improvement of microcirculation in the muscles. It is worth noting that before taking Agapurin in bodybuilding should first consult with doctor, because seeming external health does not always correspond to the internal state of organs and body systems.

Analogues

By belonging to one pharmacological group and similar mechanisms of action by analogues of Agapurin are the following drugs: Arbiflex, Vazonite, Kinetal-400, Atsupentat, Dartelin, Pentohexal, Pentamon, Mellinorm, Pentylin, Pentox-400, Pentoxifylline, Pentomere, Trental, Ralofect, Radomir, Trental, Hinotal, Flexital.

Before using analogues, consult your doctor.

Terms and conditions of storage

Store Agapurin recommended in a dry, sheltered from direct sunlight and a cool place at a temperature of: 15-25 ºС - in the form of tablets, 10-25 ºС - in the form of a solution.

The shelf life of Agapurin tablets is 5 years, the solution is 3 years.

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