Spazgan

Spazgan is a combined preparation that has analgesic, antispasmodic, antipyretic, m-cholinoblock and direct myotropic (smooth muscle) action.

It is mainly used for relief of pain syndrome of mild or moderate severity with smooth muscle spasms of internal organs. The "core" of the drug is triumvirate of pharmacologically active substances: a non-narcotic analgesic agent metamizole sodium (more known as analgin), myotropic antispasmodic pituopenone and m-holinoblokator fenpiverinia bromide.

Spazgan is produced in two forms of release - tablets for oral administration and injection for injection.

Clinical and pharmacological group

Combined analgesic and antispasmodic.

Terms of sale from pharmacies

Can buywithout a doctor's prescription.

Price

How much does Spazgan cost in pharmacies? The average price is at the level of120 rubles.

Composition and form of release

Medicinal forms of Spazgan:

  • Tablets (10 pcs. Each) in contour cell packs, in a carton pack of 2 or 10 packs);
  • Solution for intramuscular and intravenous administration (5 ml in ampoules, 5 ampoules in plastic outline packages, in a cardboard pack of 1 or 5 packs, 5 ml in ampoules, 5 ampoules in a cardboard bundle).
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Active substances of the preparation:

  • Metamizole sodium: in 1 tablet - 500 mg, in 1 ml of solution - 500 mg;
  • Pitofenone hydrochloride: in 1 tablet - 5 mg; in 1 ml of solution - 2 mg;
  • Fenpiverinia bromide: 1 tablet - 0.1 mg, in 1 ml of the solution - 0.02 mg.

pharmachologic effect

Spazgan is a combined medication, which contains three active components, each of which has a definite effect on the cause and symptomatology of the pain syndrome.

  • Metamizole is a non-narcotic analgesic that allows you to relax the smooth muscles, inhibit the synthesis of prostaglandins, block m-receptors of acetylcholine, reduce fever and inflammation.
  • Pitophenone hydrochloride is a myotropic antispasmodic that has a direct effect on muscle tissue, relieves spasms, a sensation of pain.
  • Fenpiverinia bromide - holinoblokator with analgesic and relaxing effect, accelerates the therapeutic effect of the drug.

In a complex the components of the drug anesthetize the foci of inflammation, relieve spasms and irritation of nerve endings.

After taking the drug, its active ingredients quickly penetrate into the digestive tract, after which they penetrate the bloodstream. The effect after taking the drug is observed after 10 to 12 minutes and remains for 3 to 4 hours. The process of metabolism of the drug occurs in the liver, excreted in the urine, bile, calves.

Indications for use

What helps? Spasgun is shown when:

  • moderately or mildly expressed pain syndrome as a result of a spasm of smooth muscles of the internal organs,
  • painful menstruation (algodismenorrhea),
  • painful syndrome of a spastic character along the bowel,
  • symptomatic therapy for neuralgia, myalgia, pain in the joints.

As an adjuvant, the drug is used to reduce the pain syndrome after diagnostic, surgical interventions. If necessary, Spazgan is prescribed to eliminate hyperthermia (elevated body temperature) with infectious and inflammatory diseases.

Contraindications

Absolute:

  • Tachyarrhythmias.
  • Granulocytopenia.
  • Hyperplasia of the prostate with a tendency to urinary retention.
  • Intestinal obstruction, megalocone.
  • Inhibition of bone marrow hematopoiesis.
  • Unstable angina.
  • Stable angina.
  • Chronic heart failure stage of decompensation.
  • Closed-angle form of glaucoma.
  • Deficiency of glucose-6-phosphate dehydrogenase.
  • Hypersensitivity to pyrazolone derivatives (tribuzone, butadione), auxiliary components.
  • Severe disorders of the hepatic and renal function.
  • Lactation period.
  • Pregnancy (especially the first trimester, the last 6 weeks).
  • Child age is up to six years.

With caution apply the drug Spazgan to patients with liver / kidney dysfunction, with bronchospasm, a tendency to arterial hypotension (the indicator of systolic pressure below 100 mm Hg), individual hypersensitivity to non-steroidal anti-inflammatory drugs, non-narcotic analgesics.

Intended use for pregnancy and lactation

Tablets or injection solutions are not used during pregnancy and lactation. Its use increases the risk of early termination of pregnancy and premature birth in the late trimester.

With lactation, the drug can be used only if, for the period of taking the drug, the baby is transferred to artificial mixtures.

Dosage and route of administration

As indicated in the instructions for the use of Spazgan tablets are taken orally, preferably after eating.

The dose and the period of treatment are assigned by the attending physician on the basis of clinical indications taking into account the age of the patient.

Recommended dosing:

  • patients older than 14 years: 1-2 pcs. 3-4 times a day for not more than 5 days. The daily dose should not exceed 8 pcs .;
  • adolescents 12-14 years: 1-1.5 pcs. not more than 4 times a day;
  • children 8-11 years: 1 pc. not more than 4 times a day.

Side effect

Against the background of the use of tablets and Spazgan solution, dry mouth, allergic reactions, malignant exudative erythema (including Stevens-Johnson syndrome), burning sensations in the mouth epigastric region, headache, dizziness, tachycardia, lowering arterial pressure, cyanosis, urine staining in red, toxic epidermal necrolysis (Lyell's syndrome).

Long-term therapy can cause a violation of the hematopoiesis system in the form of leukopenia, thrombocytopenia, agranulocytosis.

In addition, the use of the solution can cause the following side effects:

  • Possible: the risk of developing bronchospasm in prone patients;
  • rarely: usually with the appointment of high doses or prolonged therapy there is a violation of kidney function: anuria, oliguria, interstitial nephritis, proteinuria;
  • very rarely: decreased sweating, paresis of accommodation, difficulty urinating;
  • local reactions: with the / m introduction, the appearance of an infiltrate at the injection site.

Overdose

It is accompanied by the following symptoms: vomiting, convulsions, dry mouth, changes in perspiration, violation of accommodation, decrease in arterial pressure, drowsiness, confusion, functional disorders of the liver and kidneys.

Measures for treatment:

  • symptomatic therapy is prescribed;
  • rinsing of the stomach;
  • Use activated carbon.

special instructions

Before you start using the drug, read the special instructions:

  1. During the treatment with the drug is not recommended to take ethanol.
  2. Intolerance is very rare, but the threat of anaphylactic shock after IV injection is relatively higher than after taking the drug inside.
  3. In patients with atopic bronchial asthma and pollinosis, the risk of allergic reactions increases.
  4. Parenteral administration of the drug should be used only in those cases when ingestion is impossible or impaired absorption from the gastrointestinal tract.
  5. Special care should be taken when administering more than 2 ml of solution (there is a risk of a sharp decrease in blood pressure).
  6. With prolonged (more than a week) treatment, control of the peripheral blood picture and the functional state of the liver is necessary.
  7. If suspected of agranulocytosis or in the presence of thrombocytopenia should stop taking the drug.
  8. The use of the drug for the relief of acute pain in the abdomen is unacceptable until the cause of the disease is clarified.
  9. For the / m introduction, a long needle should be used.
  10. When treating children under 5 years of age and patients receiving cytotoxic drugs, the use of metamizole sodium should be done only under medical supervision.
  11. It is possible to stain urine in red by the release of a metabolite (it has no clinical significance).
  12. In / in the injection should be done slowly, in the position of the patient lying down and under the control of blood pressure, heart rate and respiratory rate.

Interaction with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

  1. Ethanol - the enhancement of the effects of ethanol.
  2. Cyclosporine - it is possible to reduce the concentration of cyclosporine in the blood.
  3. Oral hypoglycemic agents, indirect anticoagulants, GCS and indomethacin-metamizole sodium displace from the connection with proteins, these means, as a result of which an increase in the severity of their action is possible.
  4. Thiamazole and cytostatics - increased risk of developing leukopenia.
  5. Drugs with myelotoxic action: increased hematotoxic effect of the drug.
  6. Codeine, histamine H2 receptor blockers, propranolol - increase in the effect of the drug due to a slowing inactivation of metamizole sodium.
  7. The blockers of histamine H1 receptors, butyrophenones, phenothiazines, tricyclic antidepressants, amantadine and quinidine-may enhance m-cholinoblocking action.
  8. Chlorpromazine or other phenothiazine derivatives - development of severe hyperthermia is possible.
  9. Non-narcotic analgesics, tricyclic antidepressants, oral hormonal contraceptives and allopurinol - increase the toxicity of the drug.
  10. Phenylbutazone, barbiturates and other inducers of microsomal enzymes - a decrease in the efficacy of metamizole sodium.
  11. Sedative and anxiolytic drugs (tranquilizers) - an increase in the analgesic effect of metamizole sodium.
  12. Radiopaque drugs, colloidal blood substitutes and penicillin - combinations with preparations containing metamizole sodium, should not be used.
  13. The solution for injection is pharmaceutically incompatible with other drugs.

Reviews

We offer to familiarize with reviews of people who used the drug Spazgan:

  1. Anna. Spasgan with monthly take one tablet. Immediately ceases severe pain in the lower abdomen, is nausea. The price of the medication is affordable, with side effects still never encountered. However, I will immediately clarify that such an antispasmodic can eventually cause addictive effects, and then we will have to look for a new way to get rid of the pain.
  2. Olga. Perfectly helps with menstrual pain, but if you have time to take a pill, until the pain has started at full strength. If I did not have time, I just something killer like "Ketanov" will help to not use "Ketanov" and the like too serious drugs, just in time I drink my savior - "Spazgan".
  3. Irina. To me from a strong toothache this medicine did not help at all, although the dentist made an injection in the gum. The analgesic effect is weak and almost imperceptible. Therefore I had to look for a replacement - Spazmalgon helped, although the composition is almost identical. So in this case, each his anesthetic is suitable - you will not guess.

Analogues

Structural analogs for the active substance:

  • Baralgetas;
  • I took it;
  • Bralangin;
  • Maxigan;
  • Plenalgin;
  • Revalgine;
  • Spazmalgon;
  • Spazmaline.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

The expiration date of the medicinal product is indicated on the package. The solution for injections should be stored in a cool dark place for no more than 2 years. Tablets can be stored at room temperature, 3 years from the date of production.


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