Tablets Isoprinosine: instructions for use

Isoprinosine belongs to modern antiviral drugs, which have an additional pronounced immunomodulating effect.

Among all the drugs that are used in the fight against infectious pathologies of a viral origin, this drug takes a special place. It is prescribed not only for banal bronchitis or ARVI, but also for the treatment of malignant neoplasms, severe immunodeficiency states and used as a recovery therapy after severe diseases. Isoprinosine is produced by pharmaceutical companies in Portugal and Israel, so the price of the drug is quite high.

On this page you will find all information about Isoprinosine: the full instructions for use on this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Isoprinosine. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Isoprinosine? The average price in pharmacies is at the level of650 rubles.

Form of issue and composition

Isoprinosine is available in only one form, which is almost white tablets that have a slight amine odor. They differ oblong convex shape and presence of risks on one side, on which the drug can be divided into halves. One blister includes 10 tablets, and one pack can contain from 2 to 5 blisters.

• Each tablet contains 500 mg of the active ingredient inosine pranobex.
• Auxiliary substances - wheat starch, mannitol, magnesium stearate, povidone. For 10 tablets in a blister, 2, 3, 5 blisters in a cardboard package.

Such dosage forms, as suspension, powder, dragee, syrup, capsules or injections, do not have Isoprinosin.

Pharmacological effect

Isoprinosine is a synthetic derivative of purine. The active component of the drug - inosine pranobeks stimulates immunity and has a nonspecific antiviral action, blocking the multiplication of harmful viruses and alleviating the symptoms of viral diseases. Isoprinosine destroys the genetic apparatus of pathogenic microorganisms and restores the activity of lymphocytes in conditions of reduced immunity.

The drug is active against the herpes virus, measles, influenza, cytomegalovirus, poliovirus, human cell lymphoma virus. The drug increases the body's resistance to mumps, horse encephalitis, papilloma, encephalomyocarditis.

Isoprinosine, when taken orally, is absorbed from the gastrointestinal tract and reaches a maximum in the blood plasma after 1-2 hours. In this case, the drug in the body does not accumulate, undergoes metabolism and is completely excreted by the kidneys within 2 days.

Indications for use

What helps? Isoprinosine is indicated in most viral diseases, the main of which are:

1. Viral hepatitis;
2. Measles heavy current;
3. Molluscum contagiosum;
4. Stressful situations;
5. Old age;
6. Radiation therapy;
7. Treatment of influenza and other SARS;
8. Sclerosing panencephalitis (subacute);
9. Viral respiratory infections, incl. viral bronchitis;
10. Chronic infectious diseases of the urinary and respiratory systems;
11. Viral infections in patients with normal immune status and immunodeficient conditions;
12. Papillomavirus infections of mucous membranes, skin, including. papillomavirus infection of the vagina, vulva, cervix, genital warts.

In the fall and spring, when the body is particularly prone to viral infections, the doctor can recommend taking isoprinosine for prevention of those patients who often get sick during these periods.

Contraindications

Tablets of Isoprinosine are contraindicated for use in the presence of the following diseases or conditions in a person:

1. Gout;
2. Arrhythmias;
3. Pregnancy;
4. Urolithiasis disease;
5. Breastfeeding period;
6. Chronic renal failure;
7. Children under 3 years of age or body weight less than 15 kg;
8. Individual intolerance or allergic reactions to the components of the drug.

Application in pregnancy and lactation

Since the safety of the drug is not proven for the developing fetus and infant, it is not recommended for pregnant and lactating women.

Instructions for use

The instructions for use indicate that tablets of Isoprinosine are taken after meals, washed down with a small amount of water.

• The recommended daily intake for adults and children aged 3 years and over (with a body weight of 15-20 kg) is 50 mg / kg body weight in 3-4 doses (for adults - 6-8 tablets / day, for children - on 1/2 tab. for 5 kg of body weight / day).
• In severe forms of infectious diseases, the dose can be increased individually to 100 mg / kg of body weight / day, divided into 4-6 receptions. The maximum daily intake for adults is 3-4 g / day, for children - 50 mg / kg / day.

The duration of treatment for acute diseases in adults and children is usually from 5 to 14 days. Treatment should continue until the disappearance of clinical symptoms and for another 2 days already in the absence of symptoms. If necessary, the duration of treatment can be increased individually under the supervision of a doctor.

With chronic relapsing diseases in adults and children, treatment should be continued with several courses for 5-10 days with a break in admission in 8 days.

For maintenance therapy, the dose can be reduced to 500-1000 mg / day (1-2 tablets) for 30 days.

1. With papillomavirus infection, adults are prescribed 2 tab. 3 times / day, children - 1/2 tab. at 5 kg / body weight / day in 3-4 doses for 14-28 days in the form of monotherapy.
2. In herpetic infection, adults and children are prescribed a drug for 5-10 days before the symptoms disappear, in the asymptomatic period - 1 tab. 2 times / day for 30 days to reduce the number of relapses.
3. When dysplasia of the cervix, associated with the human papillomavirus, appoint 2 tab. 3 times / day for 10 days, then 2-3 similar courses are conducted with an interval of 10-14 days.
4. With recurrent genital warts, adults are prescribed 2 tab. 3 times / day, children - 1/2 tab. at 5 kg / body weight / day in 3-4 doses, either as monotherapy or in combination with surgical treatment for 14-28 days, then with a three-fold repetition of this course at intervals of 1 month.

Side effects

The instructions to Isoprinosin indicate that the drug can cause side effects from some body systems, namely:

1. Polyuria (urinary system);
2. Joint pain (musculoskeletal system);
3. Weakness, dizziness, headache, drowsiness or insomnia (central nervous system);
4. Increased uric acid in the blood plasma and exacerbation of gout (metabolism);
5. Nausea, pain in the epigastric region, vomiting, a temporary increase in liver transaminases and alkaline phosphatase (digestive system).

Also, the drug can cause allergic and dermatological reactions.

Overdose

There are no reliable data on clinical cases of overdose of Isoprinosine in the literature.

Good tolerability of the drug suggests that a minor overdose will not have a fundamental effect on the patient's body, but it is better to refuse personal experiments.

If the excess daily dosage of Isoprinosine is fixed more than 1.5 times, especially in a child, it is necessary to consult a doctor as soon as possible and call an ambulance.

special instructions

Before using the Isoprinosin tablets, you should read the instructions carefully. There are several special instructions that you should pay attention to, they include:

1. After taking Isoprinosine tablets for 2 weeks, it is advisable to conduct laboratory monitoring of the level of uric acid in the blood.
2. Medicines of the group of immunosuppressants can reduce the effectiveness of tablets Isoprinosin when they are used together.
3. In the case of using the drug for more than 1 month - it is necessary to monitor the parameters of the functional activity of the liver.
4. It is necessary to carry out additional control of the level of uric acid in the blood with the simultaneous use of tablets of Isoprinosine with drugs that increase its level.

The drug has no direct effect on the speed of psychomotor reactions and the ability to concentrate.

Drug Interactions

Against the background of Isoprinosin treatment, the use of xanthine oxidase inhibitors and uricosuric drugs increases the likelihood of an increase in the urinary acid concentration in the blood.

When combined with Zidovudine or Acyclovir, there is a marked increase in the therapeutic antiviral effect of the above drugs. With simultaneous administration with immunosuppressants, the effectiveness of Isoprinosine decreases.

Reviews

We picked up some feedback from people about the drug Isoprinosine:

1. Natalia. After cauterizing the genital warts, the doctor prescribed groeprosinosin 2 tablets. 3 r in d, but in the pharmacy I was given isoprinosine saying that this is the same, I already drank 4 pills and the horror started a headache and then the allergy of my eyes swelled and itched, I was not allergic in life. I will look for a replacement, it is a great pity that they did not approach the money already paid! t h be cautious, and in the instruction about pobochkah about an allergic reaction nothing is written!
2. Victor. Have appointed or nominated Iozprinosinum at gerpeticheskoj infections in a complex with ointment. The disease has gone, but I can not guarantee that it is from isoprinosine. But I can say for sure that with ARVI these pills are very helpful. Wife for 3 days of treatment got rid of the symptoms, and all treatment took only 5 days.
3. Elena. Have found out the HPV virus. Assigned isoprinosine 2 tab 3 times a day, plus candles geneferon. I read reviews about Isoprinosin and I doubt if I will throw money away. Although HPV in general is hard to cure, I've heard there are more effective drugs. In meditations for now.
4. Artem. Isoprinosine very badly affects the kidneys. After a couple of weeks of receiving from genital herpes, pain appeared in the kidney area. I went to take tests and it turned out that the sand in the kidneys went and the level of some kind of acid associated with the kidneys increased, there was nothing like this before. So I only sin on this remedy or antibiotics, which are assigned in parallel from another problem. I will not take this medicine again, as doctors will not persuade, is too young for such problems.

Most specialists state the pronounced antiviral effect of the drug. The doctors' opinions are quite unanimous: Isoprinosine does work, reducing the duration of the disease and alleviating the symptoms of infection. I would like to emphasize that isoprinosine belongs to prescription drugs. Only a competent specialist can correctly select a treatment regimen in which the dosages of medicinal substances are organically combined.

Analogues cheaper

A similar action has drugs like:

• Amiksin (628-1019 rubles);
• Viferon (160-970 rubles);
• Indinola (1160-2780 rubles);
• Acyclovir (16-198 rubles);
• Arbidola (300 rubles);
• Lavomaksa (547-1021 rubles);
• Kagocela (223-262 rubles)
• Oxolin (42-87 rubles);
• Panavir (150-1790 rubles);
• Amizona (171-389 rubles);
• Cycloferon (128-890 rubles), etc.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Shelf life of tablets Isoprinosine is 5 years from the date of their manufacture. The drug should be stored in a dry place inaccessible to children at an air temperature not exceeding + 25 ° C.

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