Nasal Spray Avamis

Antiallergic drug, GCS for intranasal use, synthetic trifluorinate corticosteroid.Has a high activity for glucocorticoid receptors and a powerful anti-inflammatory effect.

Avamis, even with a single application, causes a significant improvement in the patient's well-being. Improve the effects of rhinorrhea, cleanse the nasal sinuses, reduce sneezing, itch in the nose, relieve eye symptoms such as itching, burning, lacrimation and redness of the eyes.

The improvement occurs approximately 8 hours after the first administration and is maintained for a full 24 hours after a single administration of the drug.

Clinical and pharmacological group

GCS for intranasal administration.

Conditions of leave from pharmacies

The drug is released by prescription.

Price list

How much does the Avamis Spray cost? The average price in pharmacies is at the level of600 rubles.

Form of issue and composition

Avamis is released as a suspension of white, homogeneous. Suspension is contained in bottles of dark orange glass, a volume of 30, 60 or 120 doses.

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One dose of the drug contains the active substance - micronized fluticasone furoate - 27.5 μg + auxiliary substances (cellulose, polysorbate, edetate disodium, dextrose, water).

pharmachologic effect

The effect of Avamis is due to its composition. The main substance of the spray is fluticasone furoate. It is a glucocorticosteroid, an artificially created hormone that penetrates well and quickly through the mucous membrane of the nasal cavity and affects certain receptors. As a result, mediators of inflammation, which are one of the links of an allergic reaction, are released in smaller amounts.

Thanks to this mechanism, after injecting the spray into the nasal passages, edema, itching, burning, reducing the amount of mucus to be released, eliminating nasal congestion, redness of the eyes and lacrimation are reduced. Since the active substance of Awamis remains bound to the receptors within 24 hours, there is no need to use it often, children can inject it no more often than 1 time per day.

Avamis is a topical preparation. Its active substance - fluticasone furoate - in an insignificant amount penetrates into the bloodstream and has no systemic effect. It is completely and completely eliminated from the body. Therefore, do not be afraid that the drug is hormonal. Its main action is anti-inflammatory.

What helps Avamis?

There are three main indications for taking Avramis spray:

An allergic rhinitis;
Adenoids in children;
Purulent sinusitis.

Doctors strongly recommend self-administration of the drug only with seasonal allergic rhinitis. Then it is better to start using it before the start of the season, for a week or two. Such tactics will help to survive without the usual problems a dangerous time.

In case of complications in the form of proliferation of adenoids or sinusitis, it is recommended that you discuss the medication with your doctor. Usually in such cases, Avamis is combined with other manipulations and drugs.

Contraindications

Contraindications to the use of the drug are the following conditions:

hypersensitivity to fluticasone furoate and other components of the drug.

With caution should be used in patients with severe impairment of liver function, t. the pharmacokinetics of fluticasone furoate may vary.

Pregnancy

Data on the use of fluticasone furoate in pregnancy and during breastfeeding is not enough.

Instructions for use Avaris

The instructions for use indicate that the drug Avamis is intended only for intranasal use. To achieve the maximum therapeutic effect, you must adhere to a regular scheme of application. The onset of action can be observed within 8 hours after the first administration. To achieve maximum effect, it may take several days. Care should be given to explaining to the patient the reason for the absence of an immediate effect.

Treatment of nasal and ocular symptoms of seasonal allergic rhinitis, nasal symptoms of year-round allergic rhinitis in adults and adolescents (ages 12 and older):

The recommended initial dose is 2 sprays (27.5 μg fluticasone furoate in one spray) to each nostril 1 time / day (110 μg / day).
When adequate control of symptoms is achieved, reducing the dose to 1 spray into each nostril 1 time / day (55 μg / day) can be effective for maintenance treatment.

Treatment of nasal symptoms of seasonal and year-round allergic rhinitis in children aged 2 to 11 years:

The recommended initial dose is 27.5 μg (1 spray) in each nostril 1 time / day (55 μg / day).
If there is no desired effect at a dose of 27.5 μg (1 sputtering), a dose increase up to 55 μg (2 sprays) per nostril 1 time / day (110 μg / day) is possible in each nostril 1 time / day. When an adequate control of symptoms is achieved, it is recommended to reduce the dose to 27.5 μg (1 spray) in each nostril 1 time / day (55 μg / day).

Children under 2 years of age:

There is no evidence to recommend the use of fluticasone furoate intranasally as a treatment for seasonal and allergic allergic rhinitis in children under 2 years of age.

Proper preparation of the spray, before its first use, ensures the spraying of the required dose of the drug. For this, the following actions are performed:

since this spray is a thick suspension that becomes more liquid when shaken, spray it is only after a preliminary shake (without removing the cap for 10 seconds);
remove the cap by pulling it upwards;
holding the bottle in a vertical position, point the tip away from yourself and forcefully press the button several times, after a small cloudlet comes out of the tip, the spray is ready for use.

After you prepare the spray for use, clean the nose and tilt the head forward, then insert the tip into one nostril, point it to the outer wall of the nose and spray it during inspiration. Before spraying the spray into the second nostril, exhale through the mouth.

Avoid contact with eyes when using Avamis, if this happens, wash them thoroughly with water.

In order that you do not have problems with the nebulizer, it is necessary after each application:

take a dry clean napkin and soak the tip of the spray, the inner surface of the cap;
to close the bottle, this will ensure the protection of the sprayer from contamination of various kinds (dust, mote) and prevent accidental spraying.

Do not attempt to clean the sprayer opening with sharp objects.

Side effects

Taking the drug can lead to the development of negative side reactions from various organs and body systems, they include:

Skin allergic reactions (pruritus, rash).
The development of ulcerative lesions on the mucosa of the nasal passages.
Allergic reactions of an immediate type (Quincke's edema, development of anaphylactic shock).
The occurrence of nasal bleeding (mild or moderate severity). Most often, this side effect occurs with prolonged use of the drug (more than 6 weeks).
Mental retardation in young children who have been inhaled for a long period with Avamisom. In this regard, if you need long-term therapy with this tool is recommended to regularly measure the growth of the child. In the case when the lagging begins to be recorded according to the indicated anthropometric index, the dose is either reduced to a minimally effective one, or the preparation is generally abolished.

Overdose

In a study of the bioavailability of the drug intranasally, doses were applied 24 times higher than the recommended dose for adults for more than 3 days, with no undesirable systemic reactions observed.

Drug Interactions

Fluticasone furoate is rapidly excreted by undergoing primary metabolism in the liver with the participation of the CYP3A4 isoenzyme of the cytochrome P450 system. In the study of the drug interaction of fluticasone furoate and the highly active inhibitor of the isoenzyme CYP3A4-ketoconazole, more cases of plasma concentration fluticasone furoate, the values of which were above threshold, in the group of patients receiving ketoconazole (6 of 20 patients), compared with placebo (1 of 20 patients). This small increase does not result in a statistically significant difference in the plasma cortisol content within 24 hours between the two groups.

On the basis of the theoretical data, no drug interaction of fluticasone furoate applied intranasally is assumed, according to instructions for use, with other drugs that are metabolized with the participation of cytochrome P450 isoenzymes. Therefore, no clinical studies have been conducted to study the interaction of fluticasone furoate and other drugs.

Reviews on Avamis

Reviews about the Avamis spray are good. The forums note the high effectiveness of the drug, ease of use. Drops in the nose remove the swelling of the nasal mucosa and relieve discomfort. The only thing that confuses is the relatively high cost and the fact that the drug is a hormonal drug.

Reviews for sinusitis: Despite the fact that the disease is not a direct indication for the reception of funds, it is appointed quite often. The spray for the nose well removes stuffiness and swelling, allows other substances to freely penetrate to the site of inflammation.

References when taking children: Doctors often appoint Awamis in adenoids in children, this leads to an improvement in the condition. Rarely there are cases of nasal bleeding (usually after a very long time) and ulceration of the mucous membrane.

Analogues

There are no analogues of the drug for active active substance.

Analogues of Avamis on the therapeutic effect (treatment of a common cold, allergic including): Aqua Maris, Allergoferon, Allergy, Berlikort, Vibrocil, Vividrin, Galazolin, Gistalong, Grippostad Rino, Dexamethasone, Diazolin, Vonas, Doxycycline, Dr. Thyss Nazolin, Zodak, Intal, Ketotifen, Clarisens, Claritin, Koldact, Xylometazoline, Lordestin, Morenazal, Nazivin, Nazonex, Naphthyzine, Olint, Prednisolone, Rinza, Sanorin, Suprastin, Tavegil, Pharmazoline, Fervex spray from the common cold, Cetirinax, Cetrin, Erbisol and others.

Before using analogues, consult your doctor.