Eliwis

Elixis is an anticoagulant of direct action.

The drug is considered as an inhibitor of the coagulation factor. The composition acts selectively, and reversibly blocks the activity of the enzyme center to ensure antithrombotic activity. Eliksis actively inhibits free and bound factors. Immediately after oral administration, the active ingredient is actively absorbed in the gastrointestinal tract.

The maximum concentration of the active substance in the blood plasma is reached 3-4 hours after oral administration. The process of eating does not have a direct effect on the absorption of the active substance.

Clinical and pharmacological group

Factor Xa inhibitor, direct acting anticoagulant.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Elixis 5 mg in pharmacies? The average price is at the level of850 rubles.

Composition and form of release

The drug Elikvis is available in the form of tablets, coated with a film membrane.

In 1 tablet of apixaban 2.5 or 5 mg. Lactose, MCC, croscarmellose sodium, magnesium stearate, sodium lauryl sulfate, as auxiliary substances.
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The product is packaged in blisters of 10 and 14 (only for a dosage of 5 mg) units. In the carton pack, 1, 2, 6, 10 blisters (2.5 mg dosage) or 2, 4, 6, 10 blisters (5 mg dosage) can be contained.

Pharmacological effect

The drug belongs to the group of direct anticoagulants, selectively suppresses blood coagulation factors Xa (FXa). The antithrombotic potential of the drug does not require conditionality with antithrombin III and p-glycoprotein. The drug suppresses bound and free FXa and prothrombinase activity, which prevents the formation of thrombi and thrombin (serine protease). The active substance does not directly affect the aggregation of platelets, indirectly suppressing only the form of aggregation that is induced by thrombin.

Admission Elikvis dosage of active substance up to 10 mg provides bioavailability up to 50%. The medicine is well absorbed in the stomach and intestines. It reaches a maximum concentration 3-4 hours after ingestion. The diet does not affect the total concentration of apixaban in the blood plasma. At a dosage of more than 25 mg, the absorption of the drug slows and the bioavailability decreases. Binding to blood proteins - 87%. It is excreted mainly through the intestine; through the kidneys - about 27%.

Indications for use

The list of indications for the use of the remedy can be presented in the following form:

with the aim of preventing venous thromboembolism in patients in the period before the planned endoprosthesis replacement;
prevention of stroke in patients over the age of 75;
arterial hypertension complicated by diabetes mellitus;
cardiac ischemia;
chronic heart failure;
deep vein thrombosis;
pulmonary embolism;
relapse of DVT or PE.

Contraindications

Absolute contraindications to taking the remedy:

active bleeding;
pregnancy;
pathology of the liver, complicated by the risk of bleeding;
children and adolescents under 18;
impaired renal function;
the period of breastfeeding;
hypersensitivity to apixaban or other elements of the composition of tablets.

Relative contraindications:

exacerbations of gastrointestinal ulcers;
hemorrhagic stroke;
spinal puncture;
use of CYP3A4 inhibitors (itraconazole, ketoconazole, voriconazole);
epidural anesthesia;
thrombocytopenia;
concurrent use of NSAIDs;
bleeding disorders of congenital nature.

Intended use for pregnancy and lactation

When carrying out laboratory tests on animals, the toxic effect of the drug on the fetus was not established. The remedy is not capable of distorting the reproductive functions of a person. Information about the use during pregnancy is not complete - the composition is not recommended for admission.

A study in laboratory animals showed that the active component of the drug rapidly penetrates into breast milk. Its concentration in a given liquid is several times the permissible maximum for blood indices. Risk for an infant receiving similar milk is not established. If it is necessary to obtain a similar course of exposure during lactation, the issue of transferring the child to artificial feeding should be resolved.

Dosage and route of administration

As indicated in the instructions for use of the tablet, Elixis should be taken orally regardless of the time of meals.

Recommended dosing regimes:

period after planned arthroplasty of the knee or hip joint: 2.5 mg twice a day (the first dose is recommended 12-24 hours after surgery). The duration of therapy is 10-14 days after prosthetics of the knee joint, 32-38 days after hip replacement;
Atrial fibrillation: Elixis 5 mg 2 times a day. Reduction in the daily dose of 2 times (2.5 mg twice a day) is required for patients who combine at least two of the following factors: body weight ≤ 60 kg, age ≥ 80 years, plasma creatinine concentration ≥1.5 mg / dL (133 μmol / L);
treatment of pulmonary embolism and deep vein thrombosis: the first 7 days - 10 mg twice a day, then - 5 mg 2 times a day. The duration of treatment is at least 3 months, depends on the manifestations of the disease, the relationship between the expected benefit and the possible risk of developing a clinically significant bleeding, presence and reversibility of factors predisposing to recurrence (trauma, recent surgical intervention, prolonged immobilization, etc.);
prevention of recurrence of PE and DVT: 2.5 mg twice a day. Preventative therapy is prescribed after at least 6 months of treatment of these diseases.

In case of missing the next dose, take the pill as soon as possible after the patient remembers it. In the future it is necessary to adhere to the initial scheme of therapy with taking the drug twice a day. With a temporary break in treatment, the risk of developing thrombosis increases. Patients should consider the importance of continuous anticoagulant therapy.

Transfer of the patient to Eliwis from parenteral anticoagulants and vice versa can be performed at the time of the next planned reception of the canceled remedy, without applying the next dose of the drug, which is replaced.

Transfer of a patient to Eliwis from warfarin or other vitamin K antagonists is possible if the INR value is less than 2. When transferring the patient to warfarin or other antagonists of vitamin K, Elikvis should be taken until the INR value reaches ≥ 2. This indicator must be monitored before each reception of apixaban: once it is equal to or greater than 2, Elixis is canceled.

Adverse Reactions

Common side effects:

nausea;
anemia;
bleeding during surgery.

Rarely encountered adverse reactions:

arterial hypotension;
thrombocytopenia;
hypersensitivity;
hemorrhages in the eye tissue, rectal bleeding, hemoptysis, nasal and gingival hemorrhages;
hemorrhage in the muscles;
hematuria.

Overdose Symptoms

When an overdose of Elikvis drug increases the threat of bleeding. In case of an overdose with this drug, you may consider using an enterosorbent. The specific antidote is not known.

special instructions

Throughout the course of therapy should be monitored for the development of bleeding. Also, one should constantly monitor the functioning of the nervous system.

When epidural or spinal anesthesia is performed, as well as with diagnostic puncture, there is a risk of manifestation spinal or epidural hematomas, which cause the possible development of irreversible paralysis.

Elikvis does not adversely affect psychomotor and cognitive abilities, the ability to drive vehicles and perform dangerous and complex activities.

Compatibility with other drugs

It is not recommended to combine Elikvis with alcohol.

Care should be taken when using Elixis with non-steroidal anti-inflammatory drugs as these drugs increase the likelihood of bleeding.

It is not recommended simultaneous use of drugs, the effect of which can be associated with the occurrence of serious bleeding. In particular, simultaneously with the drug Eliksvis are not used: heparin derivatives (including low molecular weight heparins), unfractionated heparin, direct inhibitors thrombin II, thrombolytic drugs, oligosaccharides, inhibiting coagulation factor Xa, thienopyridines (eg, clopidogrel), receptor antagonists to glycoproteins IIb / IIIa, dipyridamole, sulfinpyrazone, dextran, vitamin K antagonists and other anticoagulants for oral administration (oral administration).

It should be noted that unfractionated heparin is allowed to be used in doses necessary to maintain the patency of an arterial or venous catheter.

Patient Reviews

We offer you to read reviews of people who used Eliwis:

Sergei. I have diabetes, and this is one of the risks of thromboembolism. The doctor prescribed me Elixis tablets for prevention, I drank them for six months and did not notice the difference. The doctor said that I can not be afraid of the development of pathology. You need to go through the treatment every year.
Athena. The drug is very expensive, for retirees. I am 70 years old. I thought how to save - I bought 60 capsules - it counted for two months, but it turned out... there was a 2.5 mg dosage, and 5 mg x 2r was prescribed. After surgery - RF Ablation of pulmonary veins - paroxysms (AF) resumed, but doctors say that after 3 months should stabilize.
Antonina. After the endoprosthesis of the knee joint, I was prescribed Eliksis so that venous thromboembolism did not occur. I took the pill according to the instructions, did not notice anything strange during the reception. The treatment was successful, the joint began to function without problems, doctors did not reveal any complications. So the drug works!

Analogues

Substitution of the drug are medicines from the group of antithrombotic agents with the same or another active component of the formulation. Among them:

Warfarin - anticoagulant tablets based on warfarin;
Rivaroxaban - oral anticoagulant with the same substance in the composition;
Xarelto - an anticoagulant of direct action on the basis of rivaroxaban;
Dabigatran is an oral anticoagulant based on dabigatran;
Pradax - thrombin inhibitor capsules, contain dabigatran etexilate;
Edoxaban is a selective inhibitor of a coagulating factor that helps to recover after endoprosthetics.

Before buying an analogue, consult your doctor.