Sirdalud: Instructions for use

Sirdalud

Composition

Depending on the form of release, 1 tablet of Sirdalud contains 4 mg or 2 mgtizanidine. Also, the composition contains auxiliary substances:

• MCC;
• lactose monohydrate;
• stearic acid;
• Silicon dioxide anhydrouscolloidal.

Form of issue

The package contains 30 tablets of 2 and 4 mg, the blister itself contains 10 tablets, and the package contains 3 blisters.

Tablets of 2 mg: white, flat, round, on one side of the line, on the other - the code "OZ".

Tablets of 4 mg: white, flat, round, on one side the inscription "RL on the other - crossing lines.

pharmachologic effect

It is a central muscle relaxant.

Pharmacodynamics and pharmacokinetics

Tizanidine is a relaxant of skeletal musculature, the main place of its action is the spinal cord.

This drug reduces the increased muscle tone of the skeleton, relieves spasm, increases the force of arbitrary contractions.

Tizanidine is absorbed fairly quickly and virtually completely. The largest indicator of the concentration level of the drug in plasma can be observed about an hour after its adoption. The substance is excreted by the kidneys.

Indications for the use of Sirdaluda

From what tablets Sirdalud? Indications for use are as follows:

• muscular spasm, which is associated with diseases of the spine (these includelumbarandcervical syndromes), or which appeared after the intervention of the surgeon;
• spasticity of the muscles of the skeletonin manifestationneurological diseases (multiple sclerosis, myelopathy chronic, cerebral palsy, degenerative diseases of the spinal cord).

Contraindications

This medication has a number of known contraindications:

• individual intolerance of the component present in the preparation;
• significant violations of the liver;
• children and teenagers under 18 years of age.

With special care, it is necessary to take the drug to patients older than 65 years, as well as patients with impaired renal function.

Side effects

Side effects of Sirdalud include:

As a result of the sharp termination of the adoption of Sirdalud after a long period of treatment,tachycardia, increased pressure, which can lead to a violation of the blood circulation of the brain, so the dose should be reduced gradually, until it is completely canceled.

As a result of clinical studies, the following undesirable phenomena were detected, the frequency of which was not revealed:

• confusion, hallucinations, vertigo;
• blurred vision;
• liver failure, hepatitis;
• withdrawal syndrome, asthenia.

Instructions for the use of Sirdalud (Method and dosage)

The medicine is taken orally, the dose is determined based on the individual characteristics of the human body. To minimize the risk of side effects, you should start with a dose of 1 tablet (2 mg) or half a tablet (4 mg) 3 times a day.

Whensevere muscle spasmsTablets of 2 mg or 4 mg are prescribed 3 times a day. In especially severe cases, you can take an additional 2 mg or 4 mg dose before bed.

When developingspasticity of skeletal muscles, which can be caused by neurological diseases, the initial dose is 6 mg per day, taken in 3 divided doses.

Do not take a dose above 36 mg per day.

Persons over 65 years of ageit is recommended to start taking the drug with a minimal dose, incrementally increasing it to the optimal size, which will allow for effective therapy and minimal side effects.

Patientswith impaired renal functionbegin treatment is necessary with a dose of 2 mg per day at a time. Dose is increased gradually, in small steps, taking into account the effectiveness and tolerability of the drug.

Instructions for use of Sirdalud MR

The preparation is a capsule containing 6 mgtizanidine. The initial dose of Sirdalud is 1 capsule per day.

Gradually, the dose can be increased by 6 mg at intervals of 3 to 7 days. For the majority of patients, the optimal dose is 12 mg per day.

In rare cases, the dose can be increased to 24 mg (4 capsules) per day.

The injections of this drug can be prescribed exclusively by a doctor.

Overdose

Overdosage with the drug Sirdalud Tinazidine may be expressed as follows:

• lowering of blood pressure;
• vomiting, nausea;
• drowsiness, dizziness, anxiety, miosis;
• coma, breathing disorder.

Treatment: multiple admissionactivated carbonandforced diuresisaccelerate the removal of the drug from the body. After excretion, symptomatic treatment is performed.

Interaction

Simultaneous drug consumption withinhibitors of cytochrome CYP1A2leads to an increase in the level of tizanidine in the plasma, which in turn leads to the appearance of symptoms of an overdose. Simultaneous consumption of Sirdaluda withinductors CYP1A2leads to a decrease in the level of tizanidine, which causes a decrease in the medicinal properties of the drug.

Contraindicated application of Sirdaluda withfluvoxamine, ciprofloxacin.

The result of simultaneous application can be a significant reduction in blood pressure, which is accompanied by dizziness and drowsiness, in some cases - loss of consciousness.

It is not recommended to take medicine with antiarrhythmic drugs (such asPropafenone, mexiletine, amiodarone), some fluoroquinolones (norfloxacin, enoxacin, perfloxacin), cimetidine, ticlopidine, oral contraceptives, rofecoxib.

Application of Sirdalurda together withrifampicinreduces the content of tizanidine in plasma and, accordingly, reduces the therapeutic effect of the drug.

Treatment with the drug of smoking men may require an increase in the dose. Alcohol should be avoided, since the drug can increase the negative effect of alcohol on the central nervous system. The sedative effect of Sirdalud can enhance sleeping pills, sedatives and antihistamines.

Terms of sale

The medicine is released on prescription.

Storage conditions

Store at a temperature not exceeding 25 ° C, in a place inaccessible to children.

Shelf life

Shelf life is 3 years.

special instructions

The drug is not recommended for patients withintolerance to galactose, as well as suffering from severe forminsufficiencylactasesorglucose/ galactosemalabsorption, due to the presence of lactose in the composition.

Because one of the side effects of the drug isdrowsiness, it is highly recommended to refrain from driving a car or performing work related to machinery or machinery.

Analogues of Sirdalud

Sirdalud's analogue in form and composition isTizalud. Also by composition, the analogue is Midokalm, which is available both in film-coated tablets and as a solution for injections.

The price for analogues of Sirdalud: Tizalud costs from 55 to 72 UAH; Midokalm, depending on the form of release - from 67 to 98 UAH.

Midokalm or Sirdalud: what is better?

Sirdalud is more of a modern drug, with a dosage form that allows take it once a day, while Midokalm is more studied by doctors, has wider testimony to application. The side effects of both drugs are similar.

Reviews of Sirdalud

Comments on Sirdalurd tablets are left by patients of different ages. The average score on the forums for this medication is, a score of 5. Many patients note the occurrence of such side effects as drowsiness and fatigue. There are also reports of the effect of the drug on the liver.

Reviews of doctors about Sirdalud: the drug is used for symptomatic treatment, it helps to reduce spasms of the muscles of the skeleton.

If there is a strong manifestation of side effects or a lack of results for 3 days of taking the medication, you should contact your doctor to adjust the therapy.

The price of Sirdalud

The price for tablets of 2 mg on average is 80 UAH., The price of 4 mg is 120 UAH.

The cost of such tablets in Russia is 220 rubles, respectively. and 360 rubles.

• Online pharmacies in RussiaRussia
• Internet pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

WER.RU

• Sirdalud tablets 2 mg 30 pcs. Novartis Pharma [Novartis Pharma]
• Sirdalud tablets 4 mg 30 pcs. Novartis Pharma [Novartis Pharma]
• Sirdalud MR capsules 6 mg 30 pcs.

ZdravZona

• Sirdalud MR 6mg # 30 capsulesNotritis Pharma
• Sirdalud 2mg # 30 tabletsNitravros Pharma
• Sirdalud 4mg # 30 tabletsNitravros Pharma

IFK Pharmacy

• Sirdalud MRNovartis Pharma, Spain
• SirdaludNovartis Pharma, Germany
• SirdaludNovartis Pharma, Turkey
• SirdaludNovartis Pharma, Turkey

Pharmacy24

PaniApoteka

• Sirdalud Table. 2mg № 30Northarts
• Sirdalud Table. 2mg № 30Northarts

BIOSPHERE

NOTE! Information about medicines on the site is a reference-generalizing, collected from public sources and can not serve as a basis for making a decision about the use of medications in the course of treatment. Before using Sirdalud, be sure to consult your doctor.

A source: http://medside.ru/sirdalud

Sirdalud - official instructions for use, analogues

INSTRUCTIONS
on medical use of the drug

П №012947 / 01

Tradename:Sirdalud®

International Nonproprietary Name (INN):tizanidine

pills

1 tablet contains: active substance - tizanidine (in the form of hydrochloride) 2 mg or 4 mg; auxiliary substances: silicon dioxide colloidal anhydrous, stearic acid, microcrystalline cellulose, lactose monohydrate.

Description:
Tablets 2 mg: from white to almost white, round, flat tablets with bevelled edges, on one side is squeezed out by risk and code OZ. Tablets 4 mg: from white to almost white, round, flat tablets with bevelled edges, on one side crossed risks, on the other - the code RL.

Miorelaxant of central action.ATX Code:МОЗ ВХ02.

Pharmacological properties
Tizanidine is a central muscle relaxant. The main point of application of its action is in the spinal cord.

By stimulating presynaptic alpha 2 receptors, it inhibits the release of excitatory amino acids that stimulate receptors for N-methyl-D-aspartate (NMDA receptors).

As a result, the polysynaptic transmission of excitation is suppressed at the level of the intermediate neurons of the spinal cord.

Since this mechanism is responsible for the excess muscle tone, when it is suppressed, the muscle tone decreases. In addition to the muscle relaxant properties, tizanidine also has a central moderately pronounced analgesic effect.

Sirdalud is effective both in acute painful muscular spasm and in chronic spasticity of spinal and cerebral genesis. Reduces spasticity and clonic convulsions, resulting in reduced resistance to passive movements and increases the volume of active movements.

Pharmacokinetics

Suction.
Tizanidine is absorbed quickly and almost completely.

The maximum plasma concentration (C max) is reached approximately 1 hour after taking the drug.

Due to the expressed metabolism at the "first passage" through the liver, the average bioavailability is about 34%.

Distribution.
The average value of the volume of distribution during the equilibrium period with intravenous administration of the drug is 2.6 l / kg.

The binding with plasma proteins is 30%. In the dose range of 4 to 20 mg, the pharmacokinetics of tizanidine are linear.

Given the low interindividual variability of pharmacokinetic parameters (in particular, such as Cmax and area under curve "concentration-time" (AUC /), when taking tizanidine inward, it is possible to reliably predict the values ​​of its concentration in plasma. Sex does not affect the pharmacokinetic parameters of tizanidine.

Metabolism.
It was shown that tizanidine is rapidly and largely metabolized in the liver. In vitro, it was shown that tizanidine is mainly metabolized by the 1A2 isoenzyme of the cytochrome P450 system. Metabolites are inactive.

Excretion.
The average value of the half-life of tizanidine from the systemic blood flow is 2-4 hours. The drug is excreted mainly by the kidneys (approximately 70% of the dose) in the form of metabolites; the unchanged substance accounts for about 2.7%.

Peculiarities of pharmacokinetics in individual patient groups
It was found that in patients with renal insufficiency (creatinine clearance less than 25 ml / min), the mean C max was 2 times higher than this the index in healthy volunteers, and the final half-life increased to about 14 hours, as a result of which the AUC increased by an average of 6 time.

Effect of food
Simultaneous food intake does not affect the pharmacokinetics of tizanidine. Although the value of Cmax increases by 1/3, it is considered that this is not clinically relevant. There is no significant effect on absorption (AUC).

Indications for use

Painful muscular spasm:

• associated with static and functional diseases of the spine (cervical and lumbar syndromes);
• after surgical interventions, for example, about the hernia of the intervertebral disc or osteoarthrosis of the hip joint.

Spasticity of skeletal muscles in neurological diseases, for example, with multiple sclerosis, chronic myelopathy, degenerative diseases of the spinal cord, the consequences of cerebral circulation and cerebral palsy (patients over 18 years of age).

Contraindications to hypersensitivity

• Hypersensitivity to tizanidine or any other component of the drug.
• Pronounced violations of the liver.
• Simultaneous use with fluvoxamine or ciprofloxacin.

Carefully
Simultaneous use of Sirdalud with CYP1A2 inhibitors is not recommended.

Use in children
The experience of using the drug in children is limited. The use of Sirdalud in children is not recommended.

Use in renal failure and / or in elderly patients
When using Sirdalud in patients with renal insufficiency (creatinine clearance less than 25 ml / min), correction of the dosing regimen is necessary.

The experience of using Sirdalud in elderly patients is limited. Based on pharmacokinetic data, it can be assumed that in some cases, renal clearance in these patients can be significantly reduced.

Caution should be exercised when using Sirdalud in patients with renal insufficiency and elderly patients.

Application during pregnancy and lactation.

Since controlled trials of tizanidine in pregnant women have not been conducted, it should not apply during pregnancy, except in cases where the potential benefit exceeds the possible risk. Tizanidine is excreted in breast milk in small amounts, however, women who breastfeed children should not use the drug.

Dosing and Administration
The drug is prescribed inside. The dosage regimen should be selected individually.

With spasticity of skeletal muscles due to neurological diseases, the dose should be selected individually.

The initial daily dose should not exceed 6 mg, divided into 3 doses. The dose can be increased gradually, by 2-4 mg, at intervals of 3-4 to 7 days.

Usually, the optimal therapeutic effect is achieved at a daily dose of 12 to 24 mg divided into 3 or 4 doses at regular intervals.

Do not exceed the dose of 36 mg per day.

Use in patients with renal insufficiency
Treatment of patients with renal insufficiency (creatinine clearance less than 25 ml / min) is recommended to begin with a dose of 2 mg 1 time per day.

Increase the dose by small "steps taking into account portability and effectiveness.

If it is necessary to obtain a more pronounced effect, it is recommended first to increase the dose prescribed once a day, after which increase the multiplicity of the appointment.

Side effect
Undesired reactions are distributed according to the frequency of occurrence.

To assess the incidence of adverse reactions, the following criteria were used: very often (> 1/10); often (from> 1/100, 1/1000, 1/10000, From the side of the cardiovascular system: often - bradycardia, lowering of arterial pressure.

From the gastrointestinal tract: often - dry mouth; rarely - nausea, gastrointestinal disorders.

On the part of the liver: rarely - increased activity of hepatic transaminases, very rarely - hepatitis.

From the musculoskeletal system: rarely - muscle weakness.

Other: often - fatigue.

When taking small doses, recommended for arresting a painful muscle spasm, there were drowsiness, fatigue, dizziness, dry mouth, lowering blood pressure (BP), nausea, gastrointestinal disorders, increased hepatic activity transaminase. Typically, the above-described adverse reactions are moderately expressed and transient.

An overdose of a medicine

To date, several reports have been received of the overdose of Sirdalud, including the case when the dose taken was 400 mg. In all cases, the recovery was without any special features.

Symptoms: nausea, vomiting, decreased blood pressure, dizziness, drowsiness, miosis, restlessness, breathing disorder, coma.

Treatment. For the withdrawal of the drug from the body, it is recommended that the activated carbon is repeatedly assigned. The forced diuresis also, probably, will accelerate deducing or removing Sirdaluda. In the future, symptomatic treatment is carried out.

Interaction with other drugs and other interactions
The simultaneous use of tizanidine with fluvoxamine or ciprofloxacin, which are inhibitors of cytochrome P450 1A2, is contraindicated.

The simultaneous use of tizanidine with fluvoxamine or ciprofloxacin results in a 33-fold or 10-fold increase in the aUC of tizanidine, respectively.

The result of a combined application may be a clinically significant and prolonged decrease in blood pressure, leading to drowsiness, dizziness, inhibited psychomotor reactions.

Do not recommend the simultaneous administration of tizanidine with other inhibitors of CYP1A2 -antiaritmic drugs (amiodarone, mexiletine, propafenone), cimetidine, fluoroquinolones (enoxacin, pefloxacin, norfloxacin), rofecoxib, oral contraceptives, ticlopidine.

Simultaneous appointment of Sirdalud with antihypertensive drugs, including diuretics, can sometimes cause a decrease in blood pressure and bradycardia. Alcohol or sedatives can enhance Sirdalud's sedative effect.

Special instructions for violations
Reported cases of violations of liver function associated with tizanidine, but with a daily dose of up to 12 mg, these cases were rare.

In this regard, it is recommended to monitor functional liver function tests once a month in the first 4 months of treatment in those patients who are prescribed tizanidine at a daily dose of 12 mg and above, as well as in those cases when there are clinical signs suggesting a violation of liver function - such as unexplained nausea, anorexia, a feeling of fatigue. In the case when the levels of ALT and ACT in the serum persistently exceed the upper limit of the norm by 3 times or more, the use of Sirdalud should be discontinued.

Since the composition of tablets Sirdaluda includes lactose, it is not recommended to use the drug in patients with rare hereditary intolerance to galactose, with severe lactase deficiency or malabsorption glucose / galactose.

Influence on the ability to drive a car and work with mechanisms.

Form of issue
10 tablets in a blister pack. 3 blisters together with instructions for use in a cardboard bundle.

Storage conditionsAt a temperature of no higher than 25 ° C. The drug should be stored out of the reach of children.

List B

A source: https://medi.ru/instrukciya/sirdalud_2596/

Sirdalud - instructions for use, composition, indications, side effects, analogues and price

With headaches, pressure, fatigue, the neurologist can prescribe Sirdalud - the instruction for the use of the medication includes basic information for the patient, indicates the indications and method of administration. Tablets have an effect on muscle groups and nerve parts, shown to adults who are sick, but not children and not pregnant. Read the instructions for the use of Sirdalud.

Sirdalud Tablets

According to the pharmacological classification, the drug Sirdalud belongs to the group of central muscle relaxants.It acts on the spinal cord, which controls all the muscle parts of the body.

The action is due to the active component - tizanidine hydrochloride.

The drug is produced in the form of tablets, it has a variety of capsules with modified release, but under a different name Sirdalud MR.

In pharmacies there are only tablets Sirdalud, which are available on prescription. Detailed composition:

Format	1	2
Description	White, round, flat tablets with bevelled edges, with a risk
tizanidine hydrochloride, mg per 1 pc.	, 88	, 76
Recalculation on tizanidine, mg	2	4
Excipients	Silica colloidal anhydrous, lactose monohydrate, microcrystalline cellulose, stearic acid
Packaging	10 pieces per blister, 3 blisters per cardboard pack

Pharmacodynamics and pharmacokinetics

Tizanidine hydrochloride, entering the body, acts on the spinal cord, stimulates its presynaptic receptors, which slows down the production of excitatory amino acids that activate isoenzymes.

Due to this, on the neuronal level, suppression of the excitation transfer responsible for excess muscle tone occurs - it decreases.

In addition to the miorelaksiruyuschih properties of tizanidine, the drug has a moderately analgesic effect.

Effective medicament in relation to acute muscle spasms, accompanied by pain, impaired blood circulation.It reduces spasms, muscle tone and clonic convulsions, prevents neurological diseases.

The muscle relaxant effect depends on the concentration of the drug in the blood plasma. Tizanidine is absorbed rapidly, almost completely, the maximum concentration reaches an hour after ingestion. Bioavailability is 34%.

Eating does not affect his pharmacokinetics.

Tizanidine binds to plasma proteins by 30%, is metabolized in the liver, and has inactive metabolites. The half-life is 2-4 hours, excreted by the kidneys.

Patients with renal insufficiency experience an accelerated achievement of the maximum concentration of the active component.

The pharmacokinetics of Sirdaluda have not been studied in patients with impaired hepatic function, but probably the diseases lead to an increase in the systemic effect of the drug.

From what tablets Sirdalud

The instructions for the use of the medicinal product indicate the following indications for its use:

• Muscle painful spasms caused by diseases of the spine;
• cervical and lumbar syndromes;
• pain after surgical interventions, neurological pathologies, herniated intervertebral disc, osteoarthritis, treatment of osteochondrosis;
• spasticity of skeletal muscles in neuralgia, multiple sclerosis, chronic myelopathy, childhood Cerebral palsy, degenerative diseases of the spinal cord, the consequences of brain damage blood circulation.

According to the instructions, the drug has a narrow therapeutic index, so it needs a careful dose selection.

The medicine is taken inside, the tablets can be divided in half. The initial dose is 2 mg 3 times / day - this will minimize the risk of side effects.

Diseases need individual dosage:

1. Spasticity of skeletal muscles - 6 mg, divided into 3 times / day, the dose increases gradually by 2-4 mg, with intervals of 3-7 days. The therapeutic effect is achieved from 12-24 mg / day, divided into 3-4 doses at equal intervals of time. Do not exceed the dose of 36 mg / day.
2. Patients aged 65 years drink the minimum acceptable dose, gradually increasing it to obtain the optimal ratio of tolerability and treatment effectiveness.
3. With renal failure, the dose begins with 2 mg once a day. To obtain a pronounced effect, the dosage of Sirdalud first increases, then the multiplicity.
4. Interrupt therapy must be slow to prevent the development of increased pressure, tachycardia.

Special instructions in the manual

The instructions say that the drug Sirdalud is applied against a background of special instructions that patients should know about:

• during the intake of tablets may be observed arterial hypotension, possibly leading to loss of consciousness, collapse;
• when excess daily dose of 12 mg were cases of violations of the liver, in this regard, it is recommended to monitor the patient's liver samples every month;
• because of lactose in the composition, medicament should not be used for patients with lactase deficiency, intolerance to galactose, malabsorption of glucose and galactose;
• on the background of taking the drug may develop drowsiness, so patients should refrain from managing transport and mechanisms;
• controlled studies of the use of tizanidine in pregnant women have not been conducted, it is not known whether the substance penetrates into breast milk.

Sirdalud and alcohol

Doctors recommend that during treatment with the drug Sirdalud refrain from drinking alcohol.

Ethanol itself has a negative effect on the liver, kidneys and nervous system of a person, and when combined with tablets additionally increases the likelihood of negative symptoms.

The arterial pressure may drop, a slowing of consciousness may appear, and the overwhelming effect of alcohol may increase.

Drug Interactions

The instructions for the use of medication indicated its interaction with other medicines:

• cytochrome inhibitors increase the concentration of tizanidine, leading to overdose symptoms;
• inducers of enzymes lower the level of tizanidine in the blood, which reduces the therapeutic effect;
• it is contraindicated to combine Sirdalud with Fluvoxamine, Ciprofloxacin - leads to collapse;
• it is not recommended to simultaneously use tizanidine with antiarrhythmic drugs, fluoroquinolones, oral contraceptives;
• caution should be exercised when combining Sirdalud with cisapride, amitriptyline, Azithromycin;
• taking antihypertensive drugs, diuretic diuretics causes a marked decrease in pressure, bradycardia;
• long-term use of rifampicin and tizanidine is not recommended;
• sedative, antihistamines and hypnotics increase the sedative effect of the drug, adrenoreceptor antagonists increase the hypotensive effect;
• according to reviews, smoking requires an increase in the dosage of the drug.

Side effects of the drug

According to the instructions for the use of Sirdalud, the following side effects are possible:

• drowsiness, insomnia, dizziness;
• bradycardia, lowering of blood pressure;
• dry mouth, nausea, upset stomach;
• muscle weakness, fatigue;
• hallucinations, hepatitis;
• acute violation of the blood circulation of the brain with a sharp abolition of Sirdalud;
• vertigo, blurred vision, asthenia.

Overdose - slight deviations

There are several cases of drug overdose at a dose of 400 mg, which resulted in successful recovery.

Symptoms were nausea, vomiting, lowering of blood pressure, dizziness, drowsiness, anxiety, respiratory failure.

Treatment consists in repeated reception of the activated coal carrying out the forced diuresis and symptomatic therapy.

Contraindications for use

According to the instructions for use, the drug Sirdalud has the following contraindications, in which it can not be used for its intended purpose:

• severe liver disorders;
• hypersensitivity to components;
• age younger than 18 years;
• pregnancy, breast-feeding;
• with caution at the age of over 65, with impaired renal function.

Terms of Sale and Storage

In pharmacies, the drug is on list B, which means that it can not be sold without a prescription. The medicine is kept away from children at a temperature of 25 degrees, the shelf life is five years.

Analogues

By the combination of active substances and pharmacological action on the body, the following known analogues of Sirdalud, produced in the form of tablets by domestic and foreign manufacturers:

• Tizanidine-Teva;
• Tisaloud;
• Tizanil;
• Tizanidine;
• Baclofen;
• Miaxil;
• Midokalm;
• Midostad;
• Tolperil;
• Mioryx;
• Myoflex;
• Muscomed.

Mydocalm or Sirdalud

A known analogue of the drug is Midokalm, also referred to as muscle relaxants of the central action, relieves muscle spasms. The means differ by active substances - in the analogue contains tolperisone.

Tablets Midokalm are available with a dosage of 5 or, 5 g of the active ingredient. Tizanidine refers to alpha-adrenomimetics, similar in effect to clonidine, causes drowsiness.

Tolmperzone is a beta-aminoketone, similar in effect to novocaine, does not differ sedative effect. At a cost Sirdalud is cheaper by 40%.

Price Sirdaluda

You can buy the drug Sirdalud in online pharmacies or in the usual departments, presenting a prescription to the pharmacist. The cost depends on the selected concentration of tizanidine in tablets and the accepted mark-up level in the trading enterprise. Approximate prices are indicated below:

Name	Price when you buy through the online pharmacy, rubles	Price when you buy through a regular pharmacy, rubles
Tablets 2 mg 30 pcs.	223	250
4 mg 30 pcs.	324	349

Reviews

A source: http://vrachmedik.ru/582-sirdalud-instrukciya-po-primeneniyu.html

What helps with Sirdalud tablets? Instructions for use

The central muscle relaxant is Sirdalud tablets. From what do they help? The drug has an antispasmodic effect. Sirdalud instruction for use recommends taking with muscle spasms.

Form of issue

Produced in tablets of 2 and 4 mg. Tablets Sirdalud, from which they help with spasms, contain the active substance tizanidine and auxiliary components.

Tablets of 2 mg: white, flat, round, on one side of the line, on the other - the code "OZ".

Tablets of 4 mg: white, flat, round, on one side the inscription "RL on the other - crossing lines.

Pharmacological properties

The action is based on the ability of its main active substance to influence certain receptors, resulting in the suppression of spinal cord neurons, which are responsible for the muscular tone.

As a result of the use of Sirdalud, a pronounced myorelaxing effect is provided, which allows eliminating painful muscle spasms. Reviews of Sirdalud indicate that this drug is an effective remedy for chronic spasms of spinal and cerebral genesis.

It significantly reduces clonic convulsions and spasticity, thereby increasing the volume of active movements and decreasing resistance to passive movements.

Medicine Sirdalud: what helps

Indications for use are as follows:

• spasticity of skeletal muscles in the manifestation of neurological diseases (multiple sclerosis, chronic myelopathy, cerebral palsy, degenerative diseases of the spinal cord);
• muscle spasm, which is associated with diseases of the spine (these include lumbar and cervical syndromes), or which appeared after the intervention of the surgeon.

Contraindications by age

Sirdalud tablets can not be taken under instructions in the following cases:

• children and adolescents under 18 years of age (due to the limited experience of using this age category);
• simultaneous administration with ciprofloxacin or fluvoxamine;
• hypersensitivity to the main or auxiliary components of Sirdalud tablets, from which they can cause allregia;
• severe violations of the hepatic function.

With caution take the remedy with moderately severe violations of the liver, violations of kidney function, elderly over 65 years of age.

Sirdalud preparation: instructions for use

The medicine is taken orally, the dose is determined based on the individual characteristics of the human body. To minimize the risk of side effects, you should start with a dose of 1 tablet (2 mg) or half a tablet (4 mg) 3 times a day.

In severe muscle spasm, tablets of 2 mg or 4 mg are prescribed 3 times a day. In especially severe cases, you can take an additional 2 mg or 4 mg dose before bed.

When spasticity of skeletal muscles is manifested, which can be caused by neurological diseases, the initial dose is 6 mg per day, taken in 3 divided doses.

Do not take a dose above 36 mg per day.

People over the age of 65 are advised to start taking the drug with a minimal dose, incrementally increasing it to an optimal size, which will achieve effective therapy and minimal side effects. effects.

Patients with impaired renal function should begin treatment with a dose of 2 mg per day at a time. Dose is increased gradually, in small steps, taking into account the effectiveness and tolerability of the drug.

Instructions for use of Sirdalud MR

The preparation is a capsule containing 6 mg of tizanidine. The initial dose of Sirdalud is 1 capsule per day.

Gradually, the dose can be increased by 6 mg at intervals of 3 to 7 days. For the majority of patients, the optimal dose is 12 mg per day.

In rare cases, the dose can be increased to 24 mg (4 capsules) per day.

The injections of this drug can be prescribed exclusively by a doctor.

Side effects - overdose

• gastrointestinal disorders, a feeling of dryness in the oral cavity;
• nausea;
• lowering of blood pressure;
• dizziness, drowsiness;
• sleep disorders, insomnia;
• myasthenia gravis;
• increased activity of liver enzymes;
• increased fatigue.

When Sirdalud is used in small doses (with painful muscle spasms), the listed side effects are moderately expressed and pass independently.

Admission of higher doses of the drug, recommended for spasticity, leads to an increase in the incidence of and increase in the severity of adverse reactions, however, really serious cases requiring the discontinuation of the drug occur rarely.

Special instructions and recommendations

The drug is not recommended for patients who are intolerant to galactose, as well as suffering from severe form of lactase deficiency or glucose / galactose malabsorption, due to the presence of lactose.

Since one of the side effects of the drug is drowsiness, it is highly recommended to refrain from driving a car or performing work related to machinery or machines.

Drug interaction in the application

Sirdalud should not be used concurrently with cimetidine, rofecoxib, ticlopidine, antiarrhythmics (propafenone, mexiletine, amiodarone), oral contraceptives and certain fluoroquinolones (pefloxacin, enoxacin, norfloxacin),

Such combinations can lead to an increase in the plasma concentration of tizanidine and, as a result, an extension of the QTc interval. The drug is administered with caution at the same time as the drugs that extend the QT interval (azithromycin, amitriptyline, cisapride).

When combined with hypotensive drugs, there may be a marked decrease in blood pressure and bradycardia; from rifampicin - a decrease in the concentration of tizanidine in plasma by 50%, which leads to a decrease in the therapeutic effect Sirdaluda.

In smoking patients (when smoking more than 10 cigarettes a day), the systemic bioavailability of tizanidine is reduced by almost 30%, so prolonged treatment may require an increase in the dose of the drug. Alcohol can increase the risk of side effects of the drug.

Sirdalud, in turn, is able to enhance the inhibitory effect of alcohol on the central nervous system.

Antihistamines, hypnotics and sedatives can increase the sedative effect of tizanidine.

Other α2-adrenoreceptor agonists, when used concomitantly with Sirdalud, potentially increase the hypotensive effect.

Drug analogues

According to the form of output and composition, analogues are:

Midokalm or Sirdalud: what is better?

Sirdalud is more of a modern drug, with a dosage form that allows take it once a day, while Midokalm is more studied by doctors, has wider testimony to application. The side effects of both drugs are similar.

Price

In Moscow, Sirdalud tablets can be bought at a price of 218 rubles. In Kiev, the medicine costs 200 hryvnia. In Minsk, the drug is sold 8-30 bel. rubles. The price in Kazakhstan reaches 4718 tenge. Recipe in Latin - Rp.: Tab. Sirdalud.

Reviews

Many patients note the occurrence of such side effects as drowsiness and fatigue. There are also reports of the effect of the drug on the liver.

Reviews of doctors about Sirdalud: the drug is used for symptomatic treatment, it helps to reduce spasms of the muscles of the skeleton.

If there is a strong manifestation of side effects or a lack of results for 3 days of taking the medication, you should contact your doctor to adjust the therapy.

"The neurologist prescribed this medication for the symptom of a pear-shaped muscle. Not correct, sharp movement led to burning pains from the buttock to the calves. A dose of 4 mg at night. I drink a pill at night. The action comes in 30 minutes and, covers me.

Noise in my ears, I can hardly stand on my feet and there is no way to open my eyes (matches will not exactly help). You fall asleep on the go. The action takes an hour after 4, wake up and 2 hours just do not fall asleep. Plus probably in this whole story, it helps.

Removes this pain syndrome and weakens the muscle. "

"An indispensable medicine for me. Often the nerve constricts and the head starts to hurt, so I'm glad that it exists. I would not like to sleep so badly from him, in general, the weight of gold would be the tablet. "

"As a person, with constant low blood pressure, I had to take the drug with caution, because it can cause an even greater pressure decrease.

"Now about a month has passed since the onset of acute muscular pain. While taking the drug was still limited in motion, the pain was completely gone.

But all gradually, this was not to drink a pill and passed.

Sirdalud is stronger than midolkalma, I drank midodalam up to a month, sirdaluda was enough for one package. "

A source: http://remedy.ucoz.ru/index/sirdalud_ot_chego_pomogaet_instrukcija_po_primeneniju_analogi_otzyvy_cena/0-403