Indomethacin Ointment: Instructions for Use

Ointment Indomethacin is an analgesic, anti-inflammatory and decongestant drug for external use.

The mechanism of action of the drug is associated with inhibition of biosynthesis of prostaglandins. With articular syndrome, the medication weakens the pain, and pain occurs both in rest and motion. The use of ointment reduces the morning stiffness and swelling of the joints, contributing to an increase in the volume of movements.

On this page you will find all information about Indomethacin: the full instructions for use on this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used the ointment Indomethacin. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

NSAIDs for external use, an indoleacetic acid derivative.

Conditions of leave from pharmacies

Released without a doctor's prescription.

Price list

How much is indomethacin ointment? The average price in pharmacies is at the level of50 rubles.

Form of issue and composition

Ointment for external use 10%: from dark yellow to light yellow with a greenish tinge and specific odor (15, 30 or 40 g in aluminum tubes, or 30 grams in a polymer tube, in a cardboard bundle 1 tube; 10, 15, 20, 25, 30 or 40 g in glass jars, in a cardboard bundle of 1 can).

Active substance - indomethacin:

• 1 g of ointment - 100 mg;

Auxiliary components:

• Macrogol 1500, dimethylsulfoxide, glycerol, macrogol 400;

Pharmacological effect

The drug group of NSAIDs, that is - non-steroidal anti-inflammatory drugs, respectively, has the properties of inhibiting the enzyme cyclooxygenase (COX) in the body. The drug has an effect by inhibiting the production of prostaglandins (mediators of inflammation) from arachidonic acid and inhibits the aggregation of platelets in the blood. As a result of taking the medication, the intensity of the inflammatory process decreases, the manifestations of pain and heat stop.

The use of indomethacin in inflammatory-degenerative lesions of the musculoskeletal system contributes increased mobility of joints, reduction of puffiness and morning stiffness, helps to eliminate pain syndrome. The drug is intended for systemic and external use, a pronounced anti-inflammatory effect is observed after a week of treatment.

Indications for use

External forms of the drug (gel and ointment) are prescribed for the treatment of the following conditions:

• osteoarthrosis;
• radiculitis;
• neuralgia and myalgia;
• rheumatoid arthritis;
• psoriatic arthritis;
• pains in the spine;
• exacerbation of gout and rheumatism;
• ankylosing spondylitis;
• articular syndrome on the background of inflammation of the joint tissue;
• osteochondrosis with pronounced radicular syndrome;
• inflammatory damage to the tissues of tendons or ligaments.

Indomethacin external forms are widely used for symptoms of sciatica, bursitis and lumbago, used in the therapy of post-traumatic inflammations in soft tissues and joints, as well as pain syndrome in muscles of rheumatic and other nature.

Contraindications

Contraindications to the use of the drug are:

1. Hypocoagulation;
2. Individual intolerance to non-steroidal anti-inflammatory drugs;
3. Hypersensitivity to the active substance or auxiliary components of the ointment;
4. Ulcerative lesion of the duodenum and stomach (in the phase of exacerbation);
5. Violation of the integrity of the skin in the area of ​​ointment application.

With special care, Indomethacin ointment is prescribed to patients who underwent an "aspirin" triad, with polyps of the nasal mucosa, coagulation pathologies blood, allergic rhinitis, bronchial asthma, and also with simultaneous use with other non-steroidal anti-inflammatory drugs.

Application in pregnancy and lactation

Indomethacin is contraindicated in the third trimester of pregnancy. In the I and II trimesters of pregnancy, as well as during lactation (breastfeeding), the use is not recommended.

Indomethacin in small amounts excreted in breast milk.

Instructions for use

In the instructions for use indicated that the ointment Indomethacin is applied externally 2 times a day.

The gel is applied a thin layer on the painful parts of the body, and lightly rubbed into the skin. A single dose for adults corresponds to a strip of gel 4-5 cm in length, for teenagers - 2-2.5 cm. The multiplicity of procedures for 5% of the gel is 3-4 times, for 10% - 2-3 times per day.

Do not exceed the recommended dose of the drug.

Side effects

In some cases, when applying indomethacin ointment, the following side effects are noted: reddening, itching, burning and flushing of the skin, rash, allergic reactions. With prolonged treatment, it is possible to develop systemic manifestations peculiar to indomethacin.

There are separate reports of cases of exacerbation of psoriasis.

special instructions

1. It is not recommended simultaneous use with acetylsalicylic acid and other NSAIDs, with diflunizole.
2. The drug should be used with caution if the patient has diarrheal symptoms.
3. The use of the drug should be accompanied by systematic monitoring of the peripheral blood picture, liver and kidney function.
4. Only in case of emergency, Indomethacin is used if there is a history of allergic reactions to NSAIDs.

Ointment and gel are applied only to areas with undisturbed integrity of the skin, do not allow them to enter the mucous membranes, including the eyes.

Drug Interactions

Possible adverse reactions of interaction with concomitant use with indomethacin:

1. Paracetamol - the risk of developing nephrotoxic effects;
2. Gold preparations and cyclosporine - an increase in the nephrotoxicity of indomethacin;
3. Valproic acid, cefoperazone and cefamandol - the risk of bleeding, the likelihood of developing hypoprothrombinemia;
4. Glucocorticosteroids, colchicine and ethanol - the risk of developing gastrointestinal complications, accompanied by bleeding.

It should also be borne in mind that indomethacin:

1. Potentiates the toxic effect of zidovudine;
2. Enhances the hypoglycemic effect of sulfonylurea derivatives;
3. Strengthens the effect of antiaggregants, indirect anticoagulants and fibrinolytics;
4. Increases the side effects of estrogens, mineralocorticosteroids, other NSAIDs;
5. Increases the concentration of penicillins, lithium, digoxin and methotrexate in the blood;
6. Reduces the effectiveness of diuretics (saluretics), uricosuric and hypotensive drugs.

Reviews

We picked up some of the people's reviews about indomethacin ointments:

1. Elvira. A cheap indomethacin ointment helps me well for pain in the joints. Particularly concerned about joints in cold and rainy weather, it happens that even from bed to get up difficult. In this case, I apply ointment and soon mobility returns, pain and discomfort recede, and during the day I can safely attend to the usual household chores. Constantly ointment I do not use, as in the annotation to the preparation it is painfully much indicated side effects, but so far, none of them have not felt on myself.
2. Elena. I consider indomethacin ointment one of the best ointments for the treatment of pain in the knee joints and lower back. I even used this tool to quench toothache, applying it on the cotton wool to a sick tooth. It is cheap, but there is a disadvantage too fat.
3. Pauline. At me after physical activities in sports. hall, apparently with unaccustomed, from the beginning of the beginning to hurt a loin. Has bought or purchased ointment Indometacin, have advised in a drugstore. Ointment is not expensive, it is pleased. I started to apply 3 times a day to the waist area and already literally in 2 days the pain passed. Then everything stabilized and she was not sick anymore. Now I keep it in the medicine cabinet at home just in case. After all, it can be used for bruises and stretch marks. And classes in the gym can be traumatic. Can still it is useful.

Analogues

The main active ingredient with indomethacin ointment is identical:

• Indocide;
• Indomethacin-Altpharm;
• Indovazin;
• Metindole;
• Indomethacin Sopharma;
• Indotard;
• Vero-Indomethacin;
• Indomethacin-Acry;
• Indowis EU;
• Indocollar;
• Biosynthesis-indomethacin;
• Indoene;
• Metindol-Retard.

Analogues on the principle of action, which contain other components in the composition:

• Ketonal;
• Nyz;
• Dolgit;
• Deep Relief;
• Butadione;
• Diclofenac;
• Bystrumgel;
• Pimafukort;
• Ibuprofen.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Keep out of the reach of light and keep away from children, at room temperature, not more than + 25 ° C.

Shelf life - 2 years.

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