Actovegin in ampoules: instructions for use

Actovegin refers to a well-known drug with a wide range of consumption.

A drug is used to treat changes in the brain metabolic and vascular nature, burns, bedsores, with chronically increased sugar in adults, children, during childbearing and lactation. The price of this medicine is high enough and is inaccessible to most categories of people, therefore they produce analogues of Actovegin, much cheaper than the official product.

On this page you will find all information about Actovegin: full instructions for use with this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Actovegin in the form of injections. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

A drug that activates the metabolism in tissues, improves trophic and stimulates the regeneration process.

Conditions of leave from pharmacies

Injections and pills are releasedon prescription.Ointment, cream, gel -without recipe.

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Price list

How much are the vials of Actovegin? The average price in pharmacies is at the level of650 rubles.

Form of release, composition and packaging

There are the following forms of the drug:

Tablets of Actovegin have a round biconvex form, covered with a yellow-green membrane. Packed in bottles of dark glass of 50 pieces.
Solution for injection 2 ml, , №5, 10 ml №10. It is placed in ampoules of colorless glass, which have a fracture point. Packed in a contour mesh package of 5 pieces.
Solution for infusions (Actovegin intravenously) is accommodated in 250 ml vials, which are clogged with a stopper and placed in a box of cardboard.
Cream Actovegin is packaged in tubes of 20 g.
Gel Actovegin 20% is packaged in tubes of 5 g.
Gel Actovegin ophthalmic 20% is packaged in tubes of 5 g.
Ointment 5% is packaged in tubes of 20 g.

The composition of this agent is included as an active substancede-proteinized gemoderivat from calf blood. The drug for injection also contains sodium chloride and water as additional substances. The code of the OKPD is 24.42.13.815.

pharmachologic effect

Actovegin is a universal stimulant of metabolism, which leads to a significant improvement in tissue nutrition and the utilization of glucose from the blood for the needs of cells of all organs. In addition, Actovegin increases the resistance of cells of all organs and tissues to hypoxia, resulting in minimal damage to cellular structures even in conditions of oxygen starvation. The total, total effect of Actovegin is to enhance the production of energy molecules (ATP), necessary for the flow of all vital processes in the cells of any organ.

The general effect of Actovegin, which consists in improving energy metabolism and increasing resistance to hypoxia, at the level of various organs and tissues is manifested by the following therapeutic effects:

Improves the synthesis of collagen fibers.
Stimulation of the process of cell division with their subsequent migration to areas where restoration of tissue integrity is necessary.
Stimulation of the growth of blood vessels, which leads to improved blood supply to tissues.
Accelerates the healing of any tissue damage (wounds, cuts, cuts, abrasions, burns, ulcers, etc.) and the restoration of their normal structure. That is, under the action of Actovegin, any wounds heal easier and faster, and the scar is formed small and unobtrusive.
The process of tissue respiration is activated, which leads to a more complete and rational use of oxygen, delivered with blood to the cells of all organs and tissues. Due to the more complete use of oxygen, the negative consequences of insufficient blood supply to tissues decrease.
The process of using glucose is stimulated by cells that are in the state of oxygen starvation or metabolic depletion. This means that, on the one hand, blood glucose is reduced in the blood, and on the other hand, tissue hypoxia is reduced due to the active use of glucose for tissue respiration.

The effect of Actovegin on increasing the utilization of glucose is very important for the brain, as its structures need this substance more than all other organs and tissues of the human body. After all, the brain uses mainly glucose for energy production. Actovegin also contains inositol phosphate-oligosaccharides, the effect of which is similar to that of insulin. And this means that under the action of Actovegin, the transport of glucose to brain tissue and other organs is improved, and further this substance is quickly captured by cells and utilized for energy production. Thus, Actovegin improves energy metabolism in the structures of the brain and provides its needs for glucose, the most normalizing the work of all departments of the central nervous system and reducing the severity of the syndrome of cerebral insufficiency (dementia).

In addition, improved energy exchange and increased utilization of glucose leads to a decrease in the severity of symptoms of circulatory disorders in any other tissues and organs.

What helps Actovegin?

Actovegin can be prescribed in many painful conditions. Its use is justified for such diseases:

radiation, thermal, solar, chemical burns up to 3 degrees;
polyneuropathy diabetic peripheral;
trophic damage;
Wounds of different genesis that are difficult to treat;
ulcerative skin lesions;
therapy of hemorrhagic stroke and residual phenomena after it;
encephalopathies of different origins;
failures observed in the work of venous, peripheral or arterial blood;
ischemic stroke;
various craniocerebral injuries;
angiopathy, especially of diabetic origin;
emerging bedsores;
damage to the mucous membranes and skin, provoked by radiation damage;
radiation neuropathies.

Contraindications

Contraindications to the use of the drug are the following conditions:

pulmonary edema;
oliguria, anuria;
fluid retention in the body;
children and adolescents under 18;
hypersensitivity to the drug Actovegin, similar to drugs or excipients;
decompensated heart failure.

Pregnancy

During pregnancy and during lactation, Actovegin should be used only in cases where therapeutic benefit exceeds the potential risk to the fetus or child.

Instructions for use Actovegin

The instructions for use indicate that Actovegin is used in / a, in / in (including in the form of infusion) and / m.

Depending on the severity of the clinical picture, you should first inject 10-20 ml of the drug iv or d / a daily; then - 5 ml IV or IM slowly, daily or several times a week.

For infusion of 10 to 50 ml of the drug should be added to 200-300 ml of the basic solution (isotonic sodium chloride solution or 5% glucose solution). The infusion rate is about 2 ml / min.

For intravenous injections use no more than 5 ml of the drug, which should be administered slowly, since the solution is hypertonic.

In the acute period of ischemic stroke (starting from 5-7 days) - 2000 mg / day IV drip up to 20 infusions with transition to the tablet form of 2 tablets. 3 times / day (1200 mg / day). The total duration of treatment is 6 months.
At a dementia - on 2000 mg / sut with / in a drip. Duration of treatment - up to 4 weeks.
In the peripheral circulation disorders and their consequences - 800-2000 mg / day in / a or / in drip. Duration of treatment - up to 4 weeks.
With diabetic polyneuropathy - 2000 mg / day iv drip 20 infusions with the transition to the tablet form of 3 tab. 3 times / day (1800 mg / day). Duration of treatment - from 4 to 5 months.

Instructions for the use of ampoules with a break point

Place the tip of the ampoule point to the top.
Gently tapping your finger and shaking the ampoule, letting the solution from the tip of the ampoule drain down.
Holding the ampoule in one hand with the tip up, with the other hand, break off the tip of the ampoule at the point of the fault.

Side effects

Fortunately, if the recommended dose of the drug is exceeded, then the patient does not face a similar oversight, since it is impossible to harm the body with the physiological components present in Actovegin.

As practice shows, the drug is well perceived by patients and does not cause side effects. However, in rare cases, anaphylactic and allergic reactions associated with individual intolerance of the drug may occur. In addition, sometimes the following side effects occur when taking Actovegin:

slight redness of the skin or rash on the body;
general malaise;
nausea and vomiting;
headache and loss of consciousness;
disruption in the work of the gastrointestinal tract;
joint pain;
shortness of breath, sometimes suffocation caused by stiffness of the respiratory tract;
increased sweating;
stagnation of water in the body;
because of the tightness of the airways, the patient may even have problems with swallowing water, food and saliva;
excessive excited state and activity.

special instructions

Solution for injection and infusion solutions have a slightly yellowish tinge. The intensity of coloration can vary from one batch to another, which does not affect the effectiveness of the drug. Do not use an opaque solution or solution containing particles.
With intramuscular administration, Actovegin should be administered slowly no more than 5 ml.
In connection with the likelihood of developing an anaphylactic reaction, a trial injection (intramuscularly 2 ml) is recommended.
The solution of Actovegin in the opened package is not subject to storage.
With multiple injections, it is necessary to monitor the water-electrolyte balance of the blood plasma.

Reviews

To a greater extent, the reviews of doctors and patients about Actovegin are positive. They write that the pressure goes down after 7-15 minutes. Actovegin it is quite possible to bring it back to normal. But more effective will be injections and droppers. At the same time, memory improves, and neurological disorders pass. Specialists do not recommend using it for type 1 diabetes.

Analogues

Actovegin does not have structural analogs for the active substance. Analogues for the pharmacological group (antihypoxants and antioxidants):

Actovegin granules;
Actovegin concentrate;
Antisthenes;
Astrox;
Vixipine;
Vitanam;
Hypoxen;
Glathion;
Deprenorm;
Dihydroquercetin;
Dimephosphone;
Cardiocipine;
Carditrim;
Carnitine;
Carniffite;
Kudevita;
Qudesan;
Kudesan for children;
Kudesan Forte;
Levocarnitine;
Limonar;
Mexidant;
Mexidol;
Mexidol injection 5%;
Mexicor;
Mexipridol;
Mexiprim;
Mexicin;
Methyl ethylpyridinol;
Metostabil;
Sodium oxybutyrate;
Neurox;
Neurolephone;
Octolipen;
Oliphen;
Predizin;
Preductal;
Rexod;
Romekor;
Solcoseryl;
Tiogamma;
Tiotriazolin;
Trekrezan;
Tridoukard;
Trimectal;
Trimetazidine;
Phenosanic acid;
Cerekard;
Cytochrome C;
Eltacin;
Emoxibel;
Emoxipine;
Energet;
Yantavit.

Before using analogues, consult your doctor.

Terms and conditions of storage

The drug should be stored out of reach of children, protected from light at a temperature of no higher than 25 ° C. Shelf life - 3 years. Do not use after expiry date.