Neuromidine injections and pills: instructions for use

Neuromidine injections: instructions for use

Neuromidine is a synthetic medication and is used for diseases of the nervous system.

Composition, form of release

The medicament is produced in the form of a transparent liquid that does not have a color.

Each ampoule contains 1 ml of solution, this volume contains 5 or 15 mg of active compound in the form of ipidacrin.

Pharmacological properties

Neuromidine refers to anticholinesterase drugs that exhibit an activating effect on the transfer of impulse over neuromuscular fibers.

Also, the drug helps to increase the tone of smooth muscles, activates the salivary glands, reduces the risk of dementia due to memory improvement.

Metabolism of the main component of the drug occurs in the liver. Isolated from the body medication with kidneys and intestines.

Indications for use

Medication is prescribed for the following diseases:

• Diseases of the peripheral nervous system: poly- and mononeuropathy, myasthenic syndrome of various origin, polyradiculopathy, myasthenia gravis;
• Diseases of the central nervous system: the recovery time of damage to the central nervous system of organic nature, which have cognitive or motor negative changes; bulbar paresis and paralysis;
• Complex treatment of demyelinating diseases.

Dosing regimen

The drug is intended for subcutaneous or intramuscular injections. Duration of treatment and dosage should be determined only by a specialist, taking into account the complexity of the course of the disease.

For the treatment of polyradiculopathy and (poly-) mononeuropathy, a dosage of 5-15 mg is recommended 1 or 2 times per day. The therapy lasts about 2 weeks. Then appoint the pill of the same medication.

For the treatment of myasthenic and myasthenia gravis, a dosage of 15-30 mg is recommended 1 or 3 times a day. The therapy lasts 1-2 months. Next, prescribe the pill of the same drug. In some cases, you may need to repeat the course at intervals of 1-2 months.

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When treating bulbar paresis and paralysis, a dosage of 5-15 mg is recommended 1 or 2 times a day for about 2 weeks.

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To restore the damage to the central nervous system of the nature of the recommended dosage of 10-15 mg 1 or 2 times a day. Treatment takes 2 weeks. Further therapy is continued with the appointment of tablets of the same drug.

Overdose

If the drug is used in a dosage exceeding the therapeutic norm, the following symptoms may appear: drowsiness, coma, ataxia, agitation, anxiety, arrhythmia, bradycardia, vomiting, increase of peristalsis of the digestive tract, narrowing of the pupil, lacrimation, deterioration of appetite, weakness, negative changes in speech, seizures, a sense of fear, anxiety, lowering blood pressure, jaundice, urinary incontinence and defecation, nystagmus, increased sweating, bronchospasm.

In the case of an overdose, treatment aimed at suppressing undesirable symptoms is administered, m-holinoblockers are prescribed.

Drug Interactions

Parallel intake of drugs that depress the central nervous system, increases the sedative effect of Neuromidine.

The joint administration of m-cholinomimetic drugs and cholinesterase inhibitors leads to an increase in the effectiveness of the drug and its adverse reactions.

In patients with myasthenia gravis, there is an increased likelihood of a cholinergic crisis with concurrent administration of Neuromidine and other cholinergic medications.

Medication can be combined with nootropic drugs.

Adverse reactions of the drug are enhanced by joint intake of alcohol.

Lactation, pregnancy

Despite the fact that the medication does not show embryotoxic and teratogenic effects, it can not be administered to patients during lactation and pregnancy.

Side effects

The use of a medicament may provoke the following undesirable manifestations:

• Reactions associated with the activation of m-cholinergic receptors: increased secretion of bronchial secretion, bradycardia, diarrhea, palpitation, salivation, cramps, pain in the abdomen, jaundice, nausea, increased sweating;
• When using medicament in high dosage: drowsiness, vomiting, headache, allergic manifestations on the skin, weakness, painful sensations behind the sternum, dizziness.

Contraindications

Medication can not be administered in the following situations:

• High sensitivity to any component of the drug;
• Lactation;
• Acute phase of peptic ulcer disease of the duodenum and stomach;
• Asthma is bronchial;
• Angina pectoris;
• Disorders of the vestibular;
• The age is under 18 years;
• Pregnancy;
• Obstruction of urinary tract or intestines of a mechanical nature;
• Bradycardia in a marked degree;
• Extrapyramidal diseases with the presence of hyperkinesia;
• Epilepsy.

Also, care should be taken for patients suffering from thyrotoxicosis, obstructive respiratory diseases, acute respiratory illnesses.

special instructions

There is no systematic data on the use of injection forms of ipidacrin in pediatrics.

During the period of therapy it is not recommended to drive and engage in hazardous activities that require high attention and quick reactions.

Pediatric Use

Neuromidine should not be administered to children and adolescents under 18 years of age.

Conditions of leave from pharmacies

The medication is allowed to be released from pharmacies only if a prescription is available.

Neuromidine injections price

The average cost of Neuromidine in injections in Moscow is 971 rubles.

Analogues of injections Neuromidin

Analogues of the drug Neuromidine for pharmacological properties are: Ipidacrine, Amiridin solution, Aksamon.

Terms and conditions of storage

The medicament is stored at a temperature of not more than 25 gr C in a dark place, remote from small children. The medicine is allowed to be used within 2 years from the moment of its release.

A source: http://bezboleznej.ru/neyromidin-ukoly

Neuromidine

Composition

One tablet containsipidacrine hydrochloride+ excipients (starch, calcium stearate, lactose monohydrate).

In one ampoule contains the active substance (ipidacrine hydrochloride), 5 or, 5 + excipients (water for injection).

Form of issue

• In tablets of white color, round form, packing of 10 pieces.
• In ampoules, the liquid is clear and colorless, 1 ml each.

pharmachologic effect

Drugs that affect the central nervous system,anticholinesterase agents.

Pharmacodynamics and pharmacokinetics

Neuromidine is a blockercalcium channelsand reduces the contentpotassium, respectively, increases the concentration of calcium in nerve cells.

Also, the drug preventscholinesterasein the nerve and muscle fibers.

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Thanks to these two processes, the number ofmediators, such asserotonin, epinephrine,oxytocin, histaminein the cells.

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Activitypostsynapticcells is amplified, the mediators can easily pass through the semi-impermeablemembranecells. The medicine normalizes the processes of transmission of nerve impulses along the muscle tissue.

In the person taking the drug, the tone risessmooth musculature, are restoredsynoptic connectionsin nerve fibers, the process of memorizing is facilitated.

After taking the medicine, it isproteinsin the blood and quickly penetrates intotarget organs.

It is excreted from the body with the help of excretory system - through the kidneys with urine and through the digestive tract.

Indications for use Neuromidine

• polyneuropathyandmononeuropathydifferent degrees of gravity;
• multiple sclerosis;
• diseases of the central nervous system,paralysis;
• impaired motor activity after injuries or organic lesions;
• indications for the use of the drug in tablets can serveinadequate toneintestines.

Contraindications

Do not administer Neuromidin tablets and injections to children under the age of 14 years.

The tableted form is contraindicated:

Side effects

The medicine strengthenssalivation, may causenauseaandvomit, skin rashes, bronchospasmanddiarrhea.

Instructions for use Neuromidine (Method and dosage)

The drug is given in tablets orparenterallyin injections, depending on the disease and the degree of its severity. The maximum amount per day is, g.

According to the instructions for Neuromedin:

• atpoly-andmononeuropathythe drug is given either intravenously or intravenously at 30 mg per day for 2 times, 10-15 days. Then 3 tablets per day (for 3 doses) for 30-60 days;
• atimpaired motor activityAfter injuries or organic lesions, 15 ml of the drug are injected intramuscularly 2 times a day, 15 days;
• complex treatmentMultiple Sclerosis- 1 tablet 4 times a day, 60 days, the course is repeated several times a year;
• intestinal atony- 20 mg 3 times a day, for 7-14 days;
• variousdiseases of the central nervous system- 5-15 mg 2 times a day, 10-15 days or 1 tablet 3 times / day for 3-6 months.

Overdose

When an overdose is observed, a decrease in appetite,Vomiting, nausea, diarrhea, bronchospasm, violation of cardiac activity (tachycardia, bradycardia), decreasedHELL, feeling of fear,convulsions,jaundice, general weakness. Treatment is symptomatic, applyAtropineorCyclodol.

Interaction

The effect of CNS depression is increased when appliedsedatives.

Side effects increaseethanoland othersanticholinesterasemeans.

Weakened actionanesthetics. The drug can be used withnootropics.

Terms of sale

On prescription.

Storage conditions

In a dark, sheltered from children, a cool place, the temperature is not above 25 degrees.

Shelf life

• Tablet form: 18 months.
• Solution for injection: 12 months.

Neurromidine analogues

Matches by ATC code of 4th level:

The same active substance (a complete substitute for the drug) containsaksamon, ipepryx and amiridin 20 mg.

The analogues of the drug are:TOalimine 60 N and proserin. The price for analogs is lower than the original.

In pregnancy and lactation

The drug should not be taken during pregnancy due to the fact that it enhances the tone of the uterus. When lactation, the drug is excreted with milk.

Reviews about Neuromidine

Feedback on the reception of tablets are good. In the first days of the drug, memory is improved, the ability to think and analyze soberly, consistently expound information.

They write that the drug strongly affects the heart, so it is worthwhile to monitor your health in the process of taking the medicine.

Reviews about injections are positive, especially in patients with gastrointestinal problems.

Reviews about the reception of children are practically absent. Many are slow to take the drug, due to the age limitations described in the instructions. Those who decided to take such a serious medicine, as part of complex therapy, are generally happy.

Price for Neuromidine, where to buy

The price of Neuromidine tablets is about 600 rubles for 50 pieces (20 mg).

The price of ampoules of 15 mg (in 1 ml) - 10 pieces of 1009 rubles, you can buy a solution for injections of 5 mg (per 1 ml) for 629 rubles.

• Online pharmacies in RussiaRussia
• Internet pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

WER.RU

• Neuromidine tablets 20 mg 50 pcs. Olainfarm
• Neuromidine solution 15 mg / ml 1 ml 10 pcs. Olainfarm
• Neuromidine solution 5 mg / ml 1 ml 10 pcs.

ZdravZona

• Neuromidine 15mg / ml solution for injection 1ml # 10 ampoulesOlainfarm AO / Sopharma JSC (LATVIA)
• Neuromidine 5mg / ml solution for injection 1ml # 10 ampoulesOlainfarm AO / Sopharma JSC (LATVIA)
• Neuromidine 20mg # 50 tabletsOlainfarm AO

IFK Pharmacy

• Neuromidine OlainFarm, Latvia
• Neuromidine OlainFarm, Latvia
• Neuromidine OlainFarm, Latvia

Pharmacy24

• Neuromidine injection for 0.5% 1 ml №10Olainsky HFZ (Latvia)
• Neuromidine tablets 20mg # 50Olainsky HFZ (Latvia)
• Neuromidine injection for 1.5% 1 ml №10Olaynsky HFZ (Latvia)

PaniApoteka

• Neuromidine r / d 0.5% 1 ml №10Olaynsky HFZ
• Neuromidine r / d 0.5% 1 ml №10Olaynsky HFZ
• Neuromidine r / d 0.5% 1 ml №10Olaynsky HFZ

BIOSPHERE

• Neuromidine 20 mg No. 50 tablets. Olainfarm (Latvia)
• Neuromidine 15 mg / ml №10 r-r d / in. Amp. Софарма АО, owner reg.уд. Olainfarm AO, Latvia (Bulgaria)
• Neuromidine 5 mg / ml №10 r-r d / in.amp. Софарма АО, owner reg.уд. Olainfarm AO, Latvia (Bulgaria)

NOTE! Information about medicines on the site is a reference-generalizing, collected from public sources and can not serve as a basis for making a decision about the use of medications in the course of treatment. Before using the drug Neuromidine necessarily consult with your doctor.

A source: http://medside.ru/neyromidin

Neuromidine for Injection

Neuromidine belongs to the group of parasympathetic agents and anticholinesterase drugs. The main constituent of this drug is ipidakrin hydrochloride.

Form of release Neuromidine: injections and pills. Each ampoule contains 5 or 15 milligrams of the main component, and in each tablet - 20 milligrams.

Pharmacological properties

Neuromidine

The drug has the properties to provoke a stimulation of the impulse along the nerves, interneuronal and neuromuscular synapses, which are in the peripheral and central nervous systems.

The therapeutic effect of ipidacrine is based on the mechanism of action, which is as follows:

• blocked the channel of potassium transfer in the muscle cell and neuronal membrane;
• there is reversible inhibition of cholinesterase.

The drug in injections and pills helps to strengthen the effect on the smooth muscle fibers of various neurotransmitters.

The pharmacological properties of neuromidine are:

• improved stimulation of impulse and neuromuscular transmission;
• strengthening the contractility of all organs, the basis of which is smooth muscle;
• improvement of memory, inhibition of the progradient development of senile dementia;
• the resumption of impulses disturbed due to various factors, including trauma, inflammation, the influence of anesthetic, antibiotic, and even toxin;
• moderate stimulation of the central nervous system with some manifestation of sedative effect;
• manifestation of analgesic and antiarrhythmic properties.

The peculiarity of this drug is the absence of such effects:

• teratogenic;
• embryotoxic;
• mutagenic;
• carcinogenic;
• allergic;
• immunotoxic.

The endocrine system during treatment with Neuromidine does not suffer.

Pharmacokinetic properties

After introduction into the muscle or under the skin, the main component quickly enters the bloodstream and reaches its maximal concentration in half an hour. The metabolism processes occur in the liver, and metabolites are excreted in the urine and feces.

Indications

Neuromidine is recommended for patients with PNS diseases, which are manifested by mono- and polyneuropathy, polyradiculopathy, myasthenia and myasthenic syndrome of different origin.

Also, doctors often use this drug when:

• bulbar paralysis and paresis;
• during recovery from pathological processes that were accompanied by movement disorders.

Contraindications

To contraindications, in which it is forbidden to inject Neuromidine into the muscle, under the skin or take pills, include:

• allergy to the main or auxiliary components of the drug;
• the presence of epilepsy;
• hyperkinesis;
• angina pectoris;
• marked decrease in heart rate;
• bronchial asthma;
• pathology of the vestibular apparatus;
• obstruction of intestines and ureters of mechanical origin;
• gastric ulcer during an exacerbation.

Interaction

Clinical studies that were conducted in the study of the drug, found the following:

1. With the combination of Neurromidine with CNS suppressant drugs, the sedative properties increase.
2. The negative effect of ipidacrine is intensified when combined with m-cholinomimetics and cholinesterase agents.
3. With simultaneous administration with cholinergic drugs, patients with myasthenia reported that the risk of a cholinergic-type crisis is significantly increased.
4. If before the use of Neuromidine, the patient underwent a course of treatment with beta-blockers, then the chance of bradycardia is very high.
5. Nootropic drugs in combination with Neuromidine have no negative effects.
6. Alcoholic beverages have the properties to enhance the negative effects of ipidacrine hydrochloride on the patient.

special instructions

Patients who have a stomach ulcer, respiratory system diseases, SSS disease, must use the drug with extreme caution.

Pregnancy and lactemia

Neuromidine can increase the uterine tone and cause premature delivery. This does not entitle doctors to prescribe this medicine during the period of gestation by the woman of the fetus. It is also not recommended to use the drug during the feeding of the baby with breast milk.

Speed ​​and response

During therapy with Neuromidine, you need to give up driving and controlling other mechanisms that require increased attention and concentration.

In Pediatrics

Clinical studies on the effect of ipidacrine hydrochloride on children's body have not been conducted. For this reason, until the patient reaches 18 years of age, neuromidine is prohibited.

Selection of doses

Neuromidine in injections is intended for insertion into the muscle or under the skin. The dose is selected individually and depends on the severity of the pathological process.

Pathology of PNS

In the presence of mono- and polyneuropathies, 1 to 3 ampoules of ipidacrine are recommended up to two days. The course of such treatment is no more than 2 weeks, and later the patient passes to the reception of the tablet form of release.

The myasthenic syndrome must be treated by injecting under the skin or into the muscle from 1 to 6 Neuromide ampoules no more than three times a day. The duration of such treatment should not exceed two months. If the doctor considers it necessary, then after a certain period the course of therapy can be repeated.

CNS disease

With bulbar paralysis and paresis use 1-3 ampoules of Neuromidine once or twice a day for two weeks. After this period, you can switch to the use of tablets.

Dosage of tablets

To select a dose of tableted neuromidine, you must consult your doctor. In most cases, use from, up to 3 tablets per day, divided into 3 doses. The duration of therapy is 60 days. Only after 2 months you can spend another course of treatment.

The tablet is important to take after eating and drink a sufficient amount of liquid (preferably water).

Very often, the use of tablets begins after the patient has been treated with Neuromidine in the form of injections, since This dosage form helps to cope with the acute course of the pathological process, and the tablets are used for the supporting therapy.

Overdose

If you accidentally or purposefully enter a large dose of Neuromidine, then the development of such symptoms:

• spasm of bronchi;
• copious lacrimation;
• increased sweating;
• nystagmus;
• increased peristalsis of the digestive tract;
• there is a feeling of fear;
• develops ataxia;
• the patient's body cramps;
• the patient can fall into a coma;
• speech is broken;
• I really want to sleep;
• the patient complains of the appearance of general weakness.

Therapy consists in the elimination of symptoms and the use of m-holinoblokatorov.

Adverse Reactions

In clinical trials, it was found that ipidakrine hydrochloride has the properties to cause the development of negative effects, which include:

• increased heart rate;
• reduction in the number of heartbeats per minute;
• headache;
• the appearance of seizures;
• dizziness;
• increased bronchial secretion;
• development of bronchospasm;
• the appearance of a large amount of saliva;
• a feeling of nausea;
• vomiting;
• diarrhea;
• pain in the area behind the sternum;
• an allergy, which is manifested by a rash, itching, angioedema;
• increased uterine tone.

If there are side effects, you should reduce the dosage or interrupt therapy for a few days. Reduce the separation of saliva and increase the heart rate can be using atropine.

Storage

The expiry date is indicated on each package and duplicated on each ampule of the drug. Basically it is 24 months. After the expiration of this period, neuromidine should not be used, and the drug itself must be disposed of.

To avoid losing its therapeutic properties, it is necessary to store Neuromidine in a room with a temperature that does not exceed 25 degrees and away from children's access.

Acquisition of

To buy Neuromidine in injections and ampoules, you need to contact your doctor for a prescription. The pharmacist at the pharmacy will release the drug only upon presentation of the prescription, indicating the dose, the frequency of administration and the necessary course of therapy.

Price

At pharmacies in the city, the cost of injections and Neuromidine tablets may vary significantly. The average price of this drug is at the level of:

• tablets of 20 mg № 50 - 550-650 rubles;
• nyxes 1 ml № 10 - 600-650 rubles per packing.

Reviews

On the Internet, you can find a large number of reviews that indicate that Neuromidine helps to achieve positive dynamics.

Already in the first days of treatment, patients notice improvement in memory, sober thinking and analysis. There is also a negative effect on the heart.

For this reason it is important to monitor your health and tell your doctor about everything.

There is not enough information about the use of this drug in children's practice. The instructions have significant limitations for this, and parents are looking for alternative therapies for their kids, which are allowed and approved.

Analogues

Instructions for the use of injections Neuromidine describes that the following medicines are analogues of this drug:

• Ubretid;
• Amiridin;
• Aksamon;
• Ipigrix;

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Neuromedin - instruction for adults and children in tablets or ampoules, price and analogy

If you have been prescribed Neuromedin, the instructions for use will help you understand the treatment regimens and the formulations of the drug. Learn from the annotation below, from what unpleasant symptoms and painful conditions you can get rid of by taking this medicine.

Neuromidine - indications for use

Indications for the use of Neuromidine in the form of tablets are such diseases or pathological conditions:

• diseases of the peripheral nervous system;
• polyneuropathy and polyradiculopathy;
• myasthenia gravis and myasthenic syndrome;
• bulbar paralysis and paresis;
• vestibular disorders;
• cognitive impairment;
• the recovery period after organic lesions of the CNS in the presence of motor disorders;
• intestinal atony of different etiology;
• lag in the child's physical and mental development.

In addition to the above indications, the drug in the form of injections (injections) is used for such violations:

• mononeuropathy;
• diseases of the CNS (central nervous system);
• weak labor activity.

The composition of Neurromidine includes the substance - ipidacrine hydrochloride. In the therapeutic dosage it has a stimulating effect on the transmission of a nerve impulse.

The agent with such a composition is prescribed for the treatment of pathologies of the nervous system. You can take the medicine for the prevention of sclerosis or during periods of increased mental stress.

The drug has a positive effect on the functioning of the entire nervous system.

Neuromedin - Instruction

You can see the annotation to the medicine online. Neuromidine - instructions for use give an exhaustive description of the drug.

The drug has good compatibility with nootropic medicines. It can be used in complex therapy for strokes and heart attacks.

It is planned to release a drug of enhanced action - Neuromidine forte.

General information:

• trade name - Neuromidin (Neiromidini);
• INN - Ipidacrin;
• form of release - tablets, solution for intramuscular and subcutaneous injection.

The drug may cause side effects. Especially they are amplified when the patient simultaneously takes alcohol and medication.

Perhaps the manifestation of such symptoms as: bradycardia, bronchospasm, dizziness, headache, dyspepsia, heartburn, disorders of the digestive tract (gastrointestinal tract), allergic reactions of the skin, general weakness and convulsions.

Depending on the type of illness, the doctor prescribes the individual dosage, schedule and duration of treatment. The positive effect of the drug is achieved by combining injections and tablets.

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It is preferable to begin treatment with the injection form, and then continue with the pills.

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With caution take the drug patients with acute gastrointestinal disorders and disorders of the functioning of the thyroid gland.

Round, white Neuromidine tablets contain 20 milligrams of active substance - ipidacrine hydrochloride (form of monohydrate).

The composition contains lactose, which should be taken into account when used in patients with lactose insufficiency. The packet contains one blister - 10 tablets.

Disease	Number of tablets at one time	Number of receptions (24 hours)	The course of treatment days
Neuritis	1	2 - 3	11 - 15 (acute phase) 20 - 30 (chronic form)
With myasthenia gravis	12	2 - 3	15
Strokes and heart attacks	1	3	30
Atony of the intestine	13	3	15 - 25
Mental disorders in adults	2	2	30

Neuromidine - injections

The manufacturer produces Neuromidine in ampoules in the form of a colorless solution in packs of 10 pieces. Dosage is 5 mg / ml and 15 mg / ml.

The injection form is designed to inject the drug under the skin or the gluteus muscle of the patient.

The action of the drug with this method of reception develops faster than when administered orally. Treatment regimens for parenteral administration:

Disease	Number of mg of the drug at one time	Number of receptions per 24 hours	The course of treatment days
The defeat of nerves in the periphery	5 - 15	2	15
Diseases of the central nervous system	5 - 30	13	30 - 60
With the weakness of labor	10 - 15	13	1

Neuromidine contraindications

Sometimes it is not possible to carry out treatment with the help of the drug. Contraindications Neuromidine will be such diseases or conditions of the body:

• pregnancy;
• lactation (breast-feeding);
• the presence of gastric ulcer in the acute phase;
• duodenal ulcer;
• intestinal obstruction of any etiology;
• bronchial asthma in the acute stage;
• angina pectoris and heart failure;
• extrapyramidal diseases with hyperkinesis;
• epilepsy.

Neuromidine analogues

The original preparation is produced in Latvia. Its price corresponds to the quality. Treatment is long-term and requires the purchase of several packages, sometimes it is more appropriate to purchase an analogue of Neuromidine.

You can replace the drug with home-made medicines. They are always available and are inexpensive, they have the same effect on the body as the original medicine.

Analogues are: Amiridin (trade name Amiridinum), Axamon and Neuromed.

Price for Neuromedin

Now there is an opportunity to find out how much Neurromidine costs without leaving home. The drug can be bought at online stores relatively inexpensively.

In the catalog you have the opportunity to order the form you need, read the description of the medicine you are purchasing.

The price of a medicine can vary, so purchase immediately all the necessary quantities of packages for a course of treatment. According to the Moscow region, its approximate cost varies in such limits:

• 10 tablets - 605 - 1125 rubles;
• packing of ampoules (5 mg / ml) - 1155 - 1355 rubles;
• packing of ampoules (15 mg / ml) - 1453 - 2030 rubles.

: drug Neuromidine

Reviews

A source: http://sovets.net/9348-neyromidin-instruktsiya-po-primeneniyu.html

What helps Neurromidine? Instructions for use

The anticholinesterase drug used to treat pathologies of the central and peripheral nervous system is Neuromidine. What helps the medicine, explains the instructions for use.

Composition and form of release

The main active ingredient of the drug is the active substance ipidacrine hydrochloride. The drug is produced in several dosage forms:

In the form of round, flat-cylindrical Neuromidine tablets of white color with a fracture risk on one side.

One tablet Neuromidine, which helps with nervous diseases, contains 20 mg of ipidacrine hydrochloride, as well as various additional components: lactose monohydrate, potato starch and calcium stearate.

As a clear, colorless solution for intramuscular and subcutaneous injections. The solution is available in 1 ml ampoules. In one ampoule contains 5 or 15 mg of the active ingredient.

Pharmacological properties

Neuromidine is a blocker of calcium channels and reduces the potassium content, respectively, increases the concentration of calcium in nerve cells. Also, the drug prevents cholinesterase in the nerve and muscle fibers.

Due to these two processes, the number of mediators such as serotonin, adrenaline, oxytocin, histamine in cells increases. The activity of the postsynaptic cell is enhanced, the mediators can easily pass through the semi-impermeable membrane of the cell.

Medication Neuromidine, instructions for use informs about this, it normalizes the processes of transmission of nerve impulses along muscle tissue.

.

In the person taking the drug, the tone of smooth muscles rises, synoptic connections in nerve fibers are restored, the memorization process is facilitated.

.

After taking the drug, it binds to proteins in the blood and quickly penetrates the target organs. The drug is metabolized in the liver. The maximum concentration in the blood - after 30 minutes. It is excreted from the body with the help of excretory system - through the kidneys with urine and through the digestive tract.

Injections, tablets Neuromidine: what helps the medicine

Indications for the use of the drug are as follows:

• treatment and prevention of intestinal atony;
• diseases of the peripheral nervous system: mono- and polyneuropathy, polyradiculopathy, myasthenia gravis, myasthenic syndrome of various etiologies;
• diseases of the central nervous system: bulbar paralysis and paresis; the recovery period of organic CNS lesions, accompanied by motor and / or cognitive impairment.

Contraindications

Instruction for use prohibits the administration of tablets and injections of Neuromidine to children under the age of 14 years.

The medicine is contraindicated:

• patients with arrhythmia and bradycardia;
• patients with epilepsy;
• with gastric ulcer;
• with asthma and allergies to certain substances that are part of the drug Neuromidine, from which tablets and solution can cause deterioration of the patient;
• pregnant and lactating women.

Neuromedin: instructions for use

Neuromidine is used orally, intramuscularly or subcutaneously. The duration of therapy and dose are determined by the doctor individually based on the severity of the disease.

Injection solution

• Mono and polyneuropathy of various etiologies: 1-2 times a day for 5-15 mg subcutaneously or intramuscularly, the duration of the course is 10-15 days (with severe course - up to 30 days).

  Later on they switch to Neuromidine intake;

• Myasthenia gravis and myasthenic syndrome: 1-3 times a day for 15-30 mg subcutaneously or intramuscularly. Later they switch to Neuromidine intake inside. The total duration of treatment is 1-2 months.

  According to the indications, it is possible to conduct several courses with a break of 1-2 months;

• Bulbar paresis and paralysis: 1-2 times a day for 5-15 mg subcutaneously or intramuscularly for 10-15 days.

  If possible, proceed to the tablet form of Neuromidine;

• Rehabilitation with organic lesions of the central nervous system: 1-2 times a day for 10-15 mg intramuscularly for 15 days, in the future it is recommended to switch to tablets.

If you miss a single dose, you should not double the next. The maximum daily dose is 200 mg.

Pills

• Polyradiculopathy, mono- and polyneuropathy, myasthenic syndrome of various etiology and myasthenia gravis: 1-3 times a day for 1 / 2-1 tablets (10-20 mg). The duration of the course is 1-2 months.

  According to the indications it is possible to conduct several medical courses at intervals of 1-2 months;

• Severe disorders of neuromuscular conduction, as well as prevention of myasthenic crises: briefly parenterally inject 1-2 ml (15-30 mg),% injection solution Neuromidine, and then switch to the reception preparation inside. Daily dose, if necessary, increase to 5-10 tablets (1-2 tablets 5 times a day);
• Diseases of the central nervous system, including bulbar paresis and paralysis, recovery period after organic lesions of the central nervous system (vascular, traumatic and other genesis) that occur with cognitive and / or motor impairment: 2-3 times a day for 1 / 2-1 tablets, the duration of the course is 2-6 months. If necessary, repeat therapy;
• Atony of the intestine (therapy and prophylaxis): 2-3 times a day for 1 tablet for 1-2 weeks.

Adverse Events

Reviews of Neuromidine report that this drug is normally tolerated by most patients. However, in some cases against the background of the drug can occur various side effects:

• palpitation;
• salivation;
• drowsiness;
• nausea, vomiting;
• skin allergic reactions (itching, rash);
• increase in the tone of the uterus;
• increased sweating;
• pain in epigastrium;
• increased secretion of bronchial secretions;
• convulsions;
• dizziness;
• headache;
• diarrhea;
• general weakness;
• bradycardia.

In addition, when Neuromidine is used in higher dosages, the following side effects may occur: dizziness, general weakness, vomiting, various manifestations of skin allergic reactions (itching, redness and rashes), drowsiness. When these adverse events appear, you should reduce the dosage of the drug or even discontinue Neuromidine for several days.

When passing the course of treatment, it should be borne in mind that the use of alcohol can increase the side effects of the drug.

When pregnant and lactating

The drug should not be taken during pregnancy due to the fact that it enhances the tone of the uterus. When lactation, the drug is excreted with milk.

Drug Interactions

Neuromidine enhances sedation in combination with CNS depressants. The effect of the drug and side effects are enhanced when combined with other cholinesterase inhibitors and m-cholinomimetic agents.

In patients with myasthenia gravis, the risk of developing a cholinergic crisis increases with the simultaneous use of Neuromidine with other cholinergic agents. The risk of bradycardia increases if beta-blockers were used before the start of treatment with Neuromidine.

The drug can be used in combination with nootropic drugs. Ethanol (alcohol) increases the side effects of the drug. Neuromidine weakens the depressing effect on neuromuscular transmission and conduction of excitation along the peripheral nerves of local anesthetics, aminoglycosides, potassium chloride.

Analogues of the drug Neuromidine

The same active substance contains analogues:

• Aksamon.
• Ipigrix.
• Amiridin 20 mg.

Analogues of the drug are: Kalimin 60 N and Proserin. The price for analogs is lower than the original.

Price

Various dosage forms of the drug are dispensed in the pharmacy only on prescription. The drug Neuromidin can be bought in Moscow for 1200 rubles.

The price in Kiev and Ukrainian cities is 350 hryvnia. In Minsk, pharmacies offer to buy a remedy for 11-27 Bel. rubles. In Kazakhstan, it costs , 85 tenge.

Reviews

About the reception of Neuromidine tablets reviews are good. In the first days of the drug, memory is improved, the ability to think and analyze soberly, consistently expound information.

They write that the drug strongly affects the heart, so it is worthwhile to monitor your health in the process of taking the medicine.

Reviews about injections are positive, especially in patients with gastrointestinal problems.

Reviews about the reception of children are practically absent. Many are slow to take the drug, due to the age limitations described in the instructions. Those who decided to take such a serious medicine, as part of complex therapy, are generally happy.

"I knew this drug as an effective medicine to improve the transmission of nerve impulses after strokes. But at that time, I did not realize that it was effective even with intestinal atony. "

"For the treatment of atony, I received a weekly course of therapy Neuromidine (in combination with other drugs).

I took one tablet three times a day, you can drink no matter what you eat, but I tried to keep the gap between meals at least an hour. After an hour or two after taking Neurromidine, I was sick with nausea.

On the second day, tachycardia was added (and I already had it congenital), my palpitation was terrible, sweat on my forehead, I was terribly pounding. "

"The drug has a light hypnotic, soothing effect. I get very sleepy after the injection. "

"I know what a heart palpitations at a reduced pressure. The negative consequences from this drug are many times greater than the help. "

"I get it appointed twice a year or with the first symptoms of muscle dying. The injection is pretty painless.

Neuromidine improves the impulse in the nervous system and neuromuscular transmission into the muscles. "

A source: http://remedy.ucoz.ru/index/nejromidin_ot_chego_pomogaet_instrukcija_po_primeneniju_analogi_cena_otzyvy_tabletki/0-529