Sermion

Sermion is a vasodilator that improves cerebral and peripheral circulation. Effective in metabolic, chronic and acute cerebral vascular insufficiency.

With regular administration of the drug (8-24 weeks), improvement in cognitive (mental) functions of the brain and a decrease in the manifestations of dementia were noted.

In the role of the active substance of the agent acts nicergoline (derivative of ergot alkaloid) - an analog of ergoline with a nicotinic acid site. This compound has both α - adrenoblocking action and spasmolytic activity, and also improves the metabolic processes and hemodynamics of the brain. In addition, the substance exhibits antiplatelet properties.

Clinical and pharmacological group

Alpha-blocker. A drug that improves cerebral and peripheral circulation.

Terms of sale from pharmacies

It is possible to buy under the prescription of the doctor.

Price

How much does Sermion cost in pharmacies? The average price is at the level of450 rubles.

Composition and form of release

Sermion comes in the following forms:

• The tablets covered with a cover: round, biconcave, orange (Sermion 5 mg), white (Sermion 10 mg) or yellow (Sermion 30 mg) colors (5 mg and 30 mg - 15 pieces in blisters, in a cardboard bundle 2 blisters, 10 mg - 25 pieces in blisters, in a cardboard bundle 2 blisters);

• Lyophilizate for solution for injection: powder or porous mass of white; solvent - colorless transparent liquid (4 mg each lyophilizate in vials of colorless glass, 4 ml of solvent in ampoules, 1 set of 4 vials and 4 ampoules; in a cardboard bundle 1 set).

Composition of 1 tablet:

• Active substance: nicergoline - 5 mg, 10 mg or 30 mg;
• Auxiliary components: microcrystalline cellulose, sodium carboxymethylcellulose, calcium hydrophosphate dihydrate, magnesium stearate;
• Sheath composition: Sermion 5 mg - talc, titanium dioxide, acacia gum, sucrose, rosin, sandaraka resin, carnauba wax, magnesium carbonate, yellow sanset; Sermion 10 mg - talc, titanium dioxide, tar of acacia, sucrose, rosin, sandaraka resin, carnauba wax, magnesium carbonate; Sermion 30 mg - titanium dioxide, hypromellose, silicone, iron oxide yellow, polyethylene glycol 6000.

Composition of 1 bottle of lyophilizate:

• Active substance: nicergoline - 4 mg;
• Auxiliary components: tartaric acid, lactose monohydrate;
• The composition of the solvent: sodium chloride, water for injection, benzalkonium chloride.

pharmachologic effect

The active substance of Sermion, nicergoline, has a pronounced alpha-1-adrenergic blocking effect, improving cerebral and peripheral blood circulation. The drug lowers the vascular resistance, increases arterial blood flow, as well as the intake of glucose and oxygen by brain tissues.

The use of Sermion helps to reduce platelet aggregation, improve hemodynamic and metabolic processes in the brain, and also increase the blood flow velocity in the lower and upper extremities.

Indications for use

The drug is effective in chronic and acute cerebral metabolic and vascular disorders that have arisen as a result of arterial hypertension, atherosclerosis, embolism or thrombosis of cerebral vessels.

According to the testimony, Sermion is prescribed for the treatment of the following ailments:

1. Headaches caused by vasospasm.
2. Functional and organic arteriopathy of the extremities.
3. Raynaud's disease.
4. Acute transient impairment of cerebral circulation.
5. Syndromes caused by impaired peripheral blood flow.
6. Vascular dementia.

In some cases, it is administered parenterally as an additional means to relieve the hypertensive crisis.

Contraindications

• age under 18 years (for oral administration);
• pregnancy and the period of breastfeeding (safety profile for this group of patients has not been studied, during pregnancy, parenteral administration of the solution is possible only under the direct supervision of a specialist and in the presence of strict indications);
• individual intolerance to the components of the drug;
• isomaltase / sucrose deficiency, fructose intolerance, glucose-galactose malabsorption (for oral administration);
• severe bradycardia;
• bleeding in acute flow;
• orthostatic hypotension;
• acute myocardial infarction.

Sermion in all dosage forms is administered with caution in the presence of the following diseases / conditions (relative contraindications):

• weighed down anamnesis for gout or hyperuricemia;
• combined use with drugs that can affect uric acid (disrupt metabolism and / or excretion).

Intended use for pregnancy and lactation

Studies of the drug Sermion during pregnancy have not been conducted, so it should only be taken under the supervision of the doctor for strict indications for use.

At the time of taking this medicine, you should refrain from breastfeeding, as nicergoline and the products that are formed as a result of metabolism are excreted together with breast milk.

Dosage and route of administration

As indicated in the instructions for use, Sermion is administered orally 5-10 mg 3 times / day or 30 mg 2 times / day, at regular intervals, for a long time.

• With chronic disorders of cerebral circulation, vascular cognitive impairment, post-stroke states Sermion appoint 10 mg 3 times / day. The therapeutic effect of the drug develops gradually, and the course of treatment should be at least 3 months.
• In vascular dementia appoint 30 mg 2 times / day. In this case, the patient is advised to consult with the doctor every 6 months about the advisability of continuing therapy.
• In acute disorders of cerebral circulation, ischemic stroke due to atherosclerosis, thrombosis and embolism of cerebral vessels, transient disorders of cerebral circulation (transient ischemic attacks, hypertensive cerebral crises) it is preferable to begin treatment with parenteral administration of nicergoline, then continue taking the drug inside.
• In the peripheral circulation disorders, Sermion is prescribed 10 mg 3 times a day for a long time (up to several months).

In patients with impaired renal function (serum creatinine ≥2 mg / dl), Sermion is recommended for use in lower therapeutic doses.

Injection

Possible way of introducing Sermion: intramuscular, intravenous, intraarterial.

The doctor determines the scheme of application individually, depending on the nature of the disease. To start a course in some cases is preferable with an injection, after which for carrying out maintenance therapy the patient is transferred to Sermion's intake inside.

Depending on the mode of administration, Sermion is prescribed in the following doses:

• intramuscularly: 2 times a day for 2-4 mg;
• intravenously: infusion solution - 4-8 mg of Sermion in a 0.9% solution of sodium chloride or 5-10% solution of dextrose volume of 100 ml (in the form of a slow infusion); if necessary, this dose is administered several times a day;
• intraarterially: solution - 4 mg in a 0.9% solution of sodium chloride with a volume of 10 ml; the time of administration is 2 minutes.

Sermion solution recommended to enter immediately after recovery.

In lower doses, the drug in all dosage forms is administered to patients with functional renal impairment (with serum creatinine ≥2 mg / dL).

Side effect

During the start of Sermion tablets, it is possible to develop negative pathological reactions from various organs and systems:

1. Allergic reactions - the appearance of skin rashes.
2. Nervous system - periodic dizziness, insomnia or drowsiness, confusion.
3. Metabolism is an increase in the level of uric acid in the blood, which does not depend on the dosage and duration of the drug.
4. The digestive system - nausea, periodic vomiting, dyspeptic phenomena with bloating (flatulence), diarrhea or constipation.
5. The cardiovascular system is a marked decrease in the level of arterial pressure (arterial hypotension), the appearance of a sensation of fever in the face.

When there are signs of negative side reactions, the doctor decides to cancel the drug individually, which depends on their nature and severity.

Overdose

If there is a significant deviation from the recommended dosages, a significant decrease in blood pressure values ​​is not excluded. Often, such a violation does not require special correction, normal values ​​are restored independently.

special instructions

Before you start using the drug, read the special instructions:

1. In therapeutic doses, Sermion, as a rule, does not affect BP, but in patients with hypertension it can cause a gradual decrease in blood pressure.
2. The drug acts gradually, so it should be taken for a long time, while the doctor should periodically (at least every 6 months) evaluate the effect of treatment and the appropriateness of its continuation.

Despite the fact that Sermion helps to improve the concentration, the effect of the drug on the ability to drive vehicles and work with mechanisms has not been specifically studied. Given the nature of the underlying disease, patients should be cautious in potentially hazardous activities.

Interaction with other drugs

With the simultaneous use of Sermion can enhance the effect of antihypertensive drugs.

With the simultaneous use of nicergoline with acetylsalicylic acid, an increase in bleeding time is possible.

Nicergoline is metabolized under the action of the isoenzyme CYP2D6, so it is impossible to exclude the possibility of Sirmione's interaction with drugs that are metabolized with the participation of this enzyme.

Reviews

We offer you to read reviews of people who used the drug Sermion:

1. Margarita. Mom drank as prescribed by the doctor sermion from the headache of the month four, and before that, injections of nicergoline, i.e. the same composition. Unfortunately, the treatment did not help.
2. Lydia. I was prescribed a drug for dizziness, weakness, trembling in the hands, legs and chest. And from him, too, the head is spinning, the pressure is reduced, and I often have 90 to 60 or even 50 without it. Absolutely no forces left.
3. Inna. My mother began to deteriorate memory, and she refused to go to doctors. Having read reviews about Sermion and consulted with the doctor remotely, bought her several packages - forced to drink. After half a year of use, there was noticeable enlightenment of thoughts, anxiety and panic. The only negative is the high price of the drug.

Analogues

There are several similar in therapeutic effect and composition, but different in the price of drugs. However, you should not buy other medicines yourself without consulting a doctor, even if they are similar in effect.

The main analogs of Sermion:

• Nicergoline;
• Nilogrin;
• Cavinton;
• Mildronate;
• Nootrop;
• Adalate;
• Rhythmocor;
• Nitselin;
• Ehrgotp.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

The shelf life of Sermion tablets is 3 years from the date of their manufacture. The drug should be stored in intact original packaging, dark, dry, inaccessible to children at an air temperature of no more than + 25 ° C.

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