Nootropil

Nootropil (active substance - piracetam) - nootropic drug, which is a derivative of gamma-aminobutyric acid.

Nootropil can be called without exaggeration a reference nootropic. The mechanism of its action is associated with the influence on the flow of metabolic and bioenergetic processes in neurons, the acceleration of the turnover of information molecules and the stimulation of protein synthesis.

The effect of piracetam on oxygen utilization and glucose metabolism is determined by the conditions in which the drug acts - aerobic or anaerobic

Clinical and pharmacological group

Nootropic preparation.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Nootropized in pharmacies? The average price in 2018 is at the level of260 rubles.

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Form of issue and composition

The drug is produced in tablets, capsules, as well as a solution for ingestion and solutions for intravenous and intramuscular use.

A 1 coated tablet contains

• active substance: piracetam - 800 mg or 1200 mg;
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• auxiliary substances: silicon dioxide, magnesium stearate, macrogol 6000, sodium croscarmellose; opadray Y-1-7000 [titanium dioxide (E171), macrogol 400 giproxnose 2910 5cP (E464)], opadrai (DY-S-29019 [hypophyllose 2910 50 cP, macrogol 6000].

1 capsule contains:

• active substance: piracetam g;
• auxiliary components: lactose monohydrate, silicon dioxide colloid, macrogol 6000, magnesium stearate;
• capsule shell: titanium dioxide (E171), gelatin.

In 1 ml solution for oral administration contains:

• active substance: piracetam g;
• auxiliary components: propyl parahydroxybenzoate, glycerol 85%, methyl parahydroxybenzoate, sodium saccharinate, glacial acetic acid, apricot flavor, sodium acetate, caramel flavor, water purified.

In 1 ml of the solution for oral administration, 33% contain:

• active substance: piracetam 3 g;
• auxiliary components: sodium saccharin, glycerol, propylhydroxybenzoate, methylparahydroxybenzoate, caramel flavor, apricot flavor, sodium acetate, ice acetic acid, water.

Pharmacological effect

The drug Nootropil belongs to the group of nootropic drugs.

Under the influence of this tool, the work of the central nervous system improves, the mood is normalized, concentration of attention, working capacity, and craving for learning increase. Patients who are genetically predisposed to ischemic strokes, noted a significant improvement in the condition, and The survey showed a decrease in the foci of the brain, suffering from a lack of oxygen and nutrient substances.

The drug does not have a sedative effect, does not cause habituation with prolonged use and the development of the syndrome, cancellation with a sharp cessation of therapy.

Indications for use

The medicine is widely used in psychiatry, neurology and narcology. Let's consider in more detail, what at the medicine "Nootropilum" indications to use.

In neurological practice, it is advisable to apply the medicine when:

• cerebrovascular insufficiency (severe dizziness, headache, disturbance of attention, memory, speech);
• cardiovascular pathologies of the brain;
• comatose, subcomatose states;
• pathologies of the nervous system that violate the emotional-volitional sphere (Alzheimer's disease);
• reduction of intellectual-mnestic activity;
• intoxications, brain traumas;
• residual symptoms of impaired blood circulation of the brain by ischemic type.

In narcology, the medicine is used for:

• treatment of chronic alcoholism;
• relief of morphine withdrawal syndrome;
• withdrawal of alcohol withdrawal syndrome;
• getting rid of acute poisoning with phenamine, ethanol, barbiturates, morphine.

In psychiatry the drug is prescribed for:

• intolerance of antipsychotics, antipsychotic medications (for the removal of neurological, psychiatric, somatovegetative complications);
• asthenodepressive syndromes;
• vyaloapaticheskih defective conditions (schizophrenia, psycho-organic syndrome);
• Depressive states (which are resistant to the action of antidepressants);
• nephrotic syndromes;
• cortical myoclonic forms.

The medicine is used in pediatrics. The drug is administered under the following conditions:

• Cerebral palsy;
• consequences of perinatal damage to brain structures;
• a heavy learning process;
• mental retardation.

Contraindications

The drug "Nootropil" is prohibited for use under such conditions:

• hemorrhagic stroke;
• marked pathology of the renal system;
• intolerance to piracetam.

In the following cases, only a doctor, assessing possible risks, may prescribe this medicine:

• pregnancy;
• heavy bleeding;
• extensive surgical operations;
• pathology of hemostasis;
• breast-feeding.

Dosage and route of administration

The instructions for use indicate that Nootropil in the form of a solution for oral administration, tablets and capsules are taken orally, on an empty stomach or during meals, with a sufficient amount of liquid.

Recommended dosing:

1. Dizziness and associated imbalance g per day, divided into 2-3 doses;
2. Psycho-organic syndrome (symptomatic therapy) g per day, divided into 2-3 doses;
3. Dyslexia (as part of complex therapy): daily dose for children older than 8 years g, divided into 2 doses.
4. Prevention of sickle cell vasocclusive crisis: daily dose - based on 6 g per 1 kg of body weight of the patient, divided into 4 divided doses;
5. Cortical myoclonia: initial daily dose g; every 3-4 days it is increased by, g until a maximum daily dose of 24 g is obtained, which is divided into 2-3 doses. Treatment should continue throughout the entire period of the disease, attempting to reduce the dose or cancel Nootropil every 180 days. Dose reduction should be made by gradually (1 every 2 days) a decrease in the daily dose of, g;

In the absence of renal failure in elderly patients, dose adjustment is not required.

If the kidney function is disturbed, the dose is adjusted taking into account the QC index.

If the liver function is not corrected dose Nootropil does not produce.

Side effects

There are the following side effects on the background of treatment: vomiting, nausea, impaired concentration, imbalance, motor disinhibition, mental agitation, gastralgia, sleep disorders, anxiety, eating disorders, stool disorders, increased sexual activity, convulsive syndrome, extrapyramidal disorders, headache, dizziness, tremor extremities.

With diagnosed angina, there is a worsening of the course of the disease. Most often, side effects are recorded when exceeding the recommended dose of 5 grams per day.

Overdose

When the drug is used in large doses, the patient gradually develops signs of an overdose that manifest themselves in the form of an increase in the side effects described above, as well as pronounced dyspepsia phenomena.

When taking a large number of tablets Nootropil inside the patient should as soon as possible to induce vomiting, rinse the stomach and enter inside activated carbon or other enterosorbents. If necessary, symptomatic therapy is performed, there is no antidote. You can conduct hemodialysis, but its effectiveness will be about 50%.

special instructions

It should be remembered that taking Nootropil can cause side effects. Therefore, when driving a car and controlling the mechanisms you need to be careful.

This drug is prescribed with extreme caution to people with hemostasis disorder, if necessary, surgical intervention, and patients with bleeding. These limitations are related to the effect of the active substance, i.e., piracetam, on the aggregation of platelets.

Patients with cortical myoclonia should not stop taking the medicine drastically, as this can trigger new attacks.

In elderly patients with prolonged intake of the drug it is important to monitor the indicators of kidney function. In case of abnormalities, the dosage is adjusted.

Drug Interactions

Nootropil reduces the risk of developing extrapyramidal disorders with simultaneous therapy with neuroleptics. Description of the drug Nootropil indicates its ability to improve the effectiveness of indirect anticoagulants, antipsychotics, psychostimulating drugs and thyroid hormones.

Reviews

We picked up some reviews of people who used the drug Nootropil:

1. Sergei. A year ago I received a brain concussion during a game of football. In the local clinic the doctor prescribed "Nootropil" along with other medications. I took them strictly according to the instructions. After about a week I began to feel better, the headaches began to disappear. Side effects from the drugs were not observed. Now with a head all right, violations and deviations did not notice. All this thanks to a good doctor and the execution of all instructions during treatment on my part.
2. Svetlana. Very good drug. Saw before the exams, passed perfectly. And do not give a damn if it's artificial memory or not, the main result is: without nerves and problems passed exam. This is not constant, but in exceptional cases.
3. Alexey. After a serious accident later, my head began to ache and vomit. The doctor prescribed nootropil and nicotinic acid. The treatment quickly helped in the first days of the course, the state of health became normal, the pain stopped. When a couple of years had to repeat the course, then instead of nootropil bought piracetam - a domestic drug, which is more than ten times cheaper. The effect was one-on-one, there was no difference between the drugs - no side effects, nothing.

Analogues

Structural analogs for the active substance:

• Lucetsam;
• Memotropized;
• Nootebril;
• Noocetam;
• Piraben;
• Pyramids;
• Pyramidal;
• Piracetam;
• Stamine;
• Cerebrial;
• The escotrope.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Keep away from children.

Store at temperature: IV solution and / m administration - up to 30 ° C; tablets, capsules, solution for oral administration - up to 25 ° C, in a place protected from moisture.

Shelf life: solution for intravenous and / or injection - 5 years; tablets, capsules, solution for oral administration - 4 years.

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