Fliksonase

Fliksonaze ​​is a glucocorticosteroid drug used intranasally.

It has an overwhelming effect on the production of proinflammatory mediators, shows depressing qualities in relation to eosinophils, lymphocytes, macrophages, neutrophils and mast cells. It has a pronounced antihistamine, anti-inflammatory and anti-edematous effect. The antiallergic effect lasts for 2-3 hours from the first application.

The spray helps to cope with most of the symptoms of respiratory allergy, such as sneezing, itching, nasal congestion, discomfort in the paranasal sinuses and pressure sensations. In addition, Fliksonase removes allergic manifestations in the eye area.

Clinical and pharmacological group

GCS for intranasal administration.

Terms of sale from pharmacies

Can buyby prescription.

Price

How much does Fliksonase cost in pharmacies? The average price is at the level of500 rubles.

Composition and form of release

Fliksonase is released in the form of a spray nasal dosed: an opaque white suspension, free from the presence of foreign particles (60 or 120 doses each in dark glass bottles, 1 bottle per carton bundled with adapter and dosing device).

The composition of 1 dose of the spray is:

• Active substance: fluticasone propionate (micronized) - 0.05 mg;
• Auxiliary components: anhydrous dextrose, microcrystalline cellulose, microcrystalline carboxymethylcellulose, phenylethyl alcohol, benzalkonium chloride solution, polysorbate 80, dilute hydrochloric acid, purified water.

Pharmacological effect

Fliksonase is a well-known glucocorticosteroid agent that inhibits the production of biologically active substances and anti-inflammatory mediators. This drug has anti-allergic, anti-edematous and anti-inflammatory effect on the nasal mucosa. It lowers the proliferation of neutrophils, macrophages, eosinophils, lymphocytes and mast cells.

The anti-inflammatory effect of Fliksonase is due to the interaction of the drug with the glucocorticosteroid receptors. The drug has a pronounced and rapid anti-inflammatory effect. Antiallergic results appear after two to four hours after the first application. Fliksonase cures the symptoms of allergy in the nasal cavity - nasal congestion, rhinorrhea, sneezing, itching, a feeling of pressure, uncomfortable sensations and the like.

The drug removes allergic symptoms in the eye area. Reduction of symptoms or its elimination after a single application lasts about 24 hours. When used correctly, the medication does not inhibit the adrenal system and does not have systemic effects.

Indications for use

Fliksonaze ​​prescribe for year-round or seasonal allergic rhinitis (for treatment and prevention).

Contraindications

Do not prescribe the drug when:

• hypersensitivity to it;
• children under 4 years.

Intended use for pregnancy and lactation

In pregnancy, do not use Fliksonase. Its use is possible only if the expected benefit for the mother exceeds the risk of developing the fetus.

In the period of breastfeeding, use of the drug is also not recommended. If you can not do without it, you need to temporarily interrupt the lactation and resume it after the treatment is completed.

Dosage and route of administration

As indicated in the instructions for use, Fliksonase is intended for intranasal use only. To achieve full therapeutic effect the drug should be used regularly. The maximum therapeutic effect is manifested after 3-4 days of therapy.

Children between the ages of 4 and 12

For 1 injection into each nostril 1 time / day (100 mcg / day). Do not exceed the recommended dose (100 μg / day). In children from 4 to 12 years of age, the drug should be used within the shortest period of time necessary to control the symptoms of the disease. It is necessary to consult a doctor if the child needs to use the drug for a period longer than 2 months per year.

The maximum daily dose is 100 μg (not more than 1 injection and each nostril).

In the absence of effect from the use of the drug in all age groups of patients it is necessary to consult a doctor.

Adults and children over 12 years of age

Week 1: 2 injections per each nostril 1 time / day (200 μg / day);

from the 2nd week to 3 months: 1 or 2 injections in each nostril 1 time / day (100-200 μg / day).

The maximum daily dose is 200 mcg / day (no more than 2 injections in each nostril).

To patients of advanced ageprescribe in a usual dose intended for adults.

Terms of use

Before use, you should gently shake the bottle, take it by placing the index and middle fingers on either side of the tip, and the thumb under the bottom.

At the first use of the drug or a break in its use for more than 1 week, it is necessary to check the serviceability of the nebulizer: point the tip away from yourself, make a few taps, until a small cloud appears from the tip. Next, you need to clean your nose (blow your nose). Close one nostril and insert the tip into the other nostril. Tilt your head slightly forward, continuing to hold the bottle upright. Then you should start breathing in through your nose and, continuing to inhale, press once with your fingers to spray the drug. Exhale through the mouth. Repeat the procedure for the second spray in the same nostril if necessary. Then repeat the above procedure completely by inserting the tip into the other nostril. After use, the tip should be soaked with a clean cloth or a handkerchief and cover it with a cap.

The spray should be washed at least once a week. To do this, carefully remove the tip and rinse it in warm water. Shake off excess water and leave to dry in a warm place. Avoid overheating. Then gently place the tip on the same place in the top of the vial. Put the protective cap on.

If the tip of the tip is clogged, the tip should be removed as described above and left for some time in warm water. Then rinse under a stream of cold water, dry and re-put on the bottle. Do not clean the tip of the tip with a pin or other sharp objects.

Adverse Reactions

Usually, the spray is very well tolerated by patients, but individuals with increased individual sensitivity to Fliksonase components may develop side effects:

• bleeding from the nose;
• burning and itching in the nose;
• dryness of the mucous membranes of the nose;
• sneezing;
• perforation of the nasal septum;
• bronchospasm;
• headache;
• violation of the sense of smell.

Overdose

There have been no cases of overdose in the treatment of Fliksonase. With prolonged use of high doses, oppression of the adrenal glands is possible. Their workability is restored within a few days after the drug is discontinued.

special instructions

For adults and children from the age of 12: Fliksonase Nasal Spray should not be used for more than 3 months. If it is necessary to use the drug for more than 3 months, it is necessary to consult a doctor.

For children from 4 to 12 years old: Fliksonase nasal spray should not be used for more than 2 months. If you need to use the drug for more than 2 months, you need to consult a doctor. With prolonged use, regular monitoring of the function of the adrenal cortex is necessary.

1. Infections of the nasal cavity or paranasal sinuses require appropriate treatment, but are not a contraindication to the use of the nasal spray Fliksonase.
2. In most patients, nasal spray fluticasone propionate eliminates the symptoms of seasonal allergic rhinitis, but in some cases, with a very high concentration of allergens in the air, additional therapy may be necessary.
3. To relieve the symptoms from the eyes on the background of the successful therapy of seasonal allergic rhinitis, additional therapy may be required.
4. To achieve the maximum therapeutic effect, you must adhere to a regular scheme of application.
5. Care should be taken when transferring patients from systemic GCS therapy to fluticasone propionate treatment in the form of a nasal spray, especially if there is a violation of adrenal function against a background of regular monitoring.
6. Fliksonase, spray nasal aqueous contains benzalkonium chloride, which can cause bronchospasm.
7. In case of contact with patients with chickenpox, measles and in case of changes in vision, it is recommended to stop treatment and consult a doctor.
8. There are reports of systemic effects when using nasal GCS, especially at high doses for a long time. These effects are much less likely than with oral administration. Systemic effects when using nasal corticosteroids can occur, in particular, when used in high doses for a long time. The likelihood of these effects is much lower than when taking corticosteroids by mouth, and they can vary in individual patients and between different corticosteroid drugs.
9. Possible systemic effects may include Itenko-Cushing syndrome, characteristic signs of cushingoid, suppression of adrenal function, growth retardation in children and adolescents, cataracts, glaucoma and less often a number of psychological or behavioral effects, including psychomotor hyperactivity, sleep disorders, anxiety, depression, or aggression (especially in children).
10. In children receiving therapy with some intranasal GCS in the allowed doses, growth was slowed. It is recommended to regularly monitor the growth of children receiving long-term treatment with intranasal GCS. If the growth is slowed, treatment should be revised to reduce the intranasal SCS dose, if possible, to a minimum dose that ensures the maintenance of effective control over the symptoms and contact the pediatrician.
11. The simultaneous use of ritonavir and fluticasone propionate should be avoided except in cases where the potential The benefit to the patient will exceed the possible risk of developing systemic side effects of corticosteroids.
12. It is recommended to stop taking the drug and consult a doctor if there is no improvement within 4 days. Consultation with a doctor is also necessary if the patient has new symptoms, such as pronounced facial pain, thick discharge from the nose, which may indicate infection and are not associated with allergies.
13. Infections of the nasal cavity or paranasal sinuses require appropriate treatment, but are not a contraindication to the use of the nasal spray Fliksonase.

Compatibility with other drugs

The plasma concentration of fluticasone propionate in the blood after application of Fliksonase is insignificant, so the development of clinically significant interaction with other drugs / substances is unlikely.

When combined with ritonavir, the plasma concentration of the active substance in blood, which can cause the development of adverse reactions due to the systemic action of corticosteroids, including. Cushing's syndrome and suppression of the function of the adrenal cortex.

Reviews

We offer to read reviews of people who used Fliksonaze:

1. Julia. And at me about 8 years ago doctors diagnosed - a chronic rhinitis, and wanted lor already moxibles everyones to do or make. But one remarkable doctor advised to undergo a course of treatment - the first 2 weeks 2 times a day for 2 injections in each nostril 2 times a day, 2 more weeks for 1 injection once a day. And with each use of the drug, take a pill of Claritin. Afterwards, use within 5 days in case of illness. Everything has passed.
2. Margarita. My husband has a spring hay fever for several years. So that in May he did not strongly suffer, we conduct preparatory work in March on the scheme of an allergist. The main preparation of this preparation is Fıxonase. The husband does not always take pills, so spray care is obvious. Her husband is losing itch in the nose, reducing the swelling of the face and mucous membranes, stop watering his eyes. We have been conducting prevention for 5 years already. Every year the manifestations of allergy are becoming weaker.
3. Svetlana. During the flowering of various herbs, a runny nose and a stuffy nose just do not let me breathe. I spent a long time looking for a drug that will really help me to alleviate my suffering, so to speak. I found a fliksonase, my nose cracked with cheers. The drug is worth its money. With an exacerbation of allergies I spray 2 times, and then I switch to one injection. It helps me so much. The doctor lor wrote it out to me. Lauries now generally have a lot of work, due to the fact that allergies are very widespread among our population. It's a pity that only drugs against allergies do not get cheaper.

Analogues

Structural analogs for the active substance:

• Kutiweit;
• Nazarel;
• Fliksotid;
• Fluticasone propionate.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Keep the vial of the drug in a place inaccessible to children, in a dark place, at room temperature. The shelf life of the spray is 2 years from the date of its production, provided that the storage rules are observed.

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