Novigan

Novigan is a combined preparation with analgesic, antispasmodic and anti-inflammatory action.

Included in the ibuprofen has several properties - it anesthetizes, relieves inflammation and fever. In gynecology is used to reduce pressure inside the uterus and reduce the number of cuts.

Positive action is exerted by the active substance pitofenone hydrochloride, which relaxes smooth muscles, like fenpiverinia bromide, which is also an active component of Nogravana.

Clinical and pharmacological group

Spasmoanalgesic.

Conditions of leave from pharmacies

Released without a doctor's prescription.

Price list

How much does Novigan cost in pharmacies? The average price is at the level of120 rubles.

Form of issue and composition

Dosage form - tablets covered with a film sheath: round, convex on both sides, white, on one side stamping "NOVIGAN" (10 pcs. in a blister, 1 or 2 blisters in a cardboard bundle).

Active substances in the tablet:

Ibuprofen 400 mg;
Pitophenone hydrochloride - 5 mg;
Fentiveriinia bromide - 0.1 mg.

instagram viewer

Additional substances: glycerol, microcrystalline cellulose, magnesium stearate, corn starch, talc and silicon dioxide colloid.

The composition of the film shell: macrogol 6000, hypromellose 6 cps, polysorbate 80, titanium dioxide, sorbic acid, dimethicone, talc.

Pharmacological effect

The drug is a complex tool that can remove inflammation, provide analgesic, spasmolytic effects. It suppresses the production of prostaglandin. Among the components are fenpiverinium bromide, which acts as an m-holin-blocking substance, pithophenone hydrochloride, which provides myotropic spasmolytic effect, ibuprofen, which is a non-steroidal anti-inflammatory drug.

Bromide fenpiverinia relaxes smooth muscles due to anticholinergic properties. Pitophenone hydrochloride has a myotropic effect on the muscles of the internal organs, relaxing it, relieving spasms. Ibuprofen, which is a derivative of phenylpropionic acid, removes heat, inflammation, inhibits production prostaglandins, which are responsible for thermoregulation, inflammation, pain. The drug has an effect on the central nervous system, peripheral tissues.

With primary dysmenorrhea in women, the content of prostaglandins in myometrium decreases, intrauterine pressure decreases, and the heart rate decreases. Together, the components of the drug strengthen each other. They are easily absorbed by the intestines, reaching a maximum content in the blood after a lapse of 1-2 hours. Almost all ibuprofen comes in conjunction with blood plasma proteins, is processed by the liver, leaves with urine. The drug goes along with the bile.

Indications for use

What helps? Novigan is used to relieve weak or moderate pain with spasms of smooth muscles of internal organs. It is recommended to be used for biliary, renal colic, dyskinesia of the bile ducts, as well as for severe menstrual pain. In addition, it is effective in myalgia, radiculitis, neuralgia, moderate, or severe joint pain, bursitis, tendonitis. The drug quickly removes toothache, headache (this list includes migraines).

Positive feedback Novigan received in the treatment of colds, infectious and inflammatory diseases. This product reduces temperature and reduces heat.

Contraindications

Contraindications to the use of Nogravin are children under 16, pregnancy and lactation, as well as individual intolerance to any component that is part of the drug. When prescribing the drug should also take into account information about attacks of intolerance to acetylsalicylic acid in the anamnesis.

Also, the use of Novurane is contraindicated in the following diseases, disorders and conditions:

granulocytopenia;
tachyarrhythmia;
acute intermittent porphyria;
deficiency of glucose-6-phosphate dehydrogenase;
angle-closure glaucoma;
hyperplasia of the prostate;
intestinal obstruction, gastrointestinal bleeding, erosive and ulcerative lesions of the gastric mucosa and duodenum intestines, ulcerative colitis and other inflammatory bowel diseases that occur in the acute stage;
hepatic and / or renal failure, as well as progressive kidney disease;
violations of hematopoiesis system, hemophilia and other disorders of blood coagulability, hemorrhagic diathesis;
confirmed hyperkalemia;
diseases of the optic nerve.

The drug should be cautiously assigned to the following categories of patients:

elderly patients;
patients with diabetes mellitus, dyslipidemia or hyperlipidemia, nephrotic syndrome, severe somatic diseases;
patients with blood diseases;
patients suffering from congestive heart failure, arterial hypertension, cerebrovascular diseases, coronary heart disease, peripheral arterial disease;
patients with Helicobacter pylori infection, gastritis, colitis, enteritis, peptic ulcer and duodenal ulcer;
patients with hyperbilirubinemia and Cl creatinine level from 30 to 60.

The use of Novurane should be limited in dosage and frequency of administration in the treatment of patients suffering from nicotine and alcohol dependence, as well as taking antiplatelet agents, anticoagulants, SSRIs and oral GCS.

Use in pregnancy and lactation

During pregnancy, the drug is contraindicated (especially should be avoided in the first trimester and in the last six weeks of pregnancy), and it is not recommended to take Novigan during breastfeeding.

Dosage and route of administration

The instructions for use indicate that Novigan is taken orally, 1 hour before or 3 hours after a meal. To avoid irritating effects on the stomach, you can take the drug immediately after eating or drink milk.

In the absence of special doctor's instructions, it is recommended to take 1 tab. up to 3 times / day. The maximum daily dose is 3 tablets. Do not exceed the indicated dose!

The course of treatment with Novigan, without consulting a doctor, should not exceed 5 days. Longer use is possible under the supervision of a physician with control of peripheral blood and functional state of the liver.

Side effects

In case of taking the drug at recommended dosages, side effects should not be manifested.

For the hepabolitic system: hepatitis.
For the respiratory system: bronchospasm, dyspnea.
For the cardiovascular system: tachycardia, increased blood pressure, heart failure.
For the peripheral and central nervous system: anxiety, dizziness, confusion, insomnia, irritability and nervousness, depression, hallucinations, psychomotor excitement, headache, drowsiness, as well as aseptic meningitis, which is most often observed in patients suffering from autoimmune diseases.
For the gastrointestinal tract: pain in the mouth, aphthous stomatitis, ulceration of the gastrointestinal mucosa, sometimes complicated by bleeding and perforation, ulceration of the mucous membrane of the gums, NSAID-gastropathy (nausea, heartburn, vomiting, loss of appetite, abdominal pain, flatulence, diarrhea, constipation), dryness and irritation of the mucous membrane, pancreatitis may appear in the oral cavity.
For sense organs: visual impairment - fuzzy visual perception, irritation and dry eyes, scotoma, swelling eyelids and conjunctiva, paresis of accommodation, as well as hearing impairment - its deterioration, as well as ringing or noise in the ears.

Overdose

If the recommended therapeutic dose of Novigan tablets is significantly exceeded, abdominal pain develops, nausea, vomiting, heartburn, flatulence, retardation, drowsiness, headache, metabolic acidosis (displacement of the reaction of the blood environment in the acidic side), acute renal failure, impaired consciousness up to development of coma, a decrease in the level of systemic arterial pressure, violation of the rhythm and frequency of contractions of the heart, violation of breathing until its absence.

Treatment of Novigan tablets with an overdose consists of washing the stomach, intestines, and taking intestinal sorbents (activated charcoal), as well as symptomatic therapy in a medical hospital.

special instructions

Before you start using the drug, read the special instructions:

During treatment should refrain from drinking alcohol.
If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the test.
With long-term use, control of the peripheral blood picture and the functional state of the liver and kidneys is necessary.
To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose should be used. When symptoms of gastropathy appear, careful monitoring, including esophagogastroduodenoscopy, the analysis of a blood with definition of a hemoglobin and a hematocrit, the analysis of a feces on the latent blood.

During the treatment period, the patient should refrain from engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

Enhances the hypoglycemic effect of sulfonylurea derivatives.
Antacids and colestyramine reduce the absorption of ibuprofen.
The drug increases the concentration of digoxin, lithium preparations, methotrexate in the blood.
Strengthens the effect of m-holinoblokatorov, blockers of histamine H1-receptors, butirofenonov, phenothiazines, amantadine and quinidine.
Simultaneous administration of other NSAIDs increases the incidence of side effects.
Caffeine increases the analgesic effect.
In therapeutic doses Novigan does not enter into significant interactions with widely used drugs.
Inhibitors of microsomal oxidation reduce the risk of hepatotoxic action.
The drug reduces the hypotensive activity of vasodilators and natriuretic effect of furosemide and hydrochlorothiazide.
Cefamandol, cefoperazone, cefotetan, valproic acid, plikamycin increase the frequency of hypoprothrombinemia with simultaneous administration.
Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.
Cyclosporine and gold preparations increase the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by increased nephrotoxicity.
Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of its hepatotoxic effects.
Inducers of microsomal oxidation enzymes in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe intoxication.
Reduces the effectiveness of uricosuric drugs.
Strengthens the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics (which increases the risk of bleeding).
Increases the side effects of mineralocorticoids, glucocorticoids (increases the risk of gastrointestinal bleeding), estrogens, ethanol.
With simultaneous administration reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (possibly increasing the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent after the Novigan drug was started).
Drugs that block tubular secretion, reduce excretion and increase the plasma concentration of ibuprofen.

Reviews

We picked up some reviews of people using Novigan:

Irina. Excruciating wild pains with menstruation. As those times have advised these tablets. Now I'm saving myself only for them. I drank it earlier. I sit and rejoice. The third hour has gone... still working.
Marina. Saw Novigan from a toothache, could safely live up to reception of the stomatologist. Another medicine well helps me with exacerbation of migraine. For a day I drink 2 tablets, the next day the headache does not bother. Side effects from the drug I did not arise, and ibuprofen has already established itself as a strong analgesic component.
Oleg. Once I was given Novigan as an anesthetic. He, of course, helped, but I then suffered with a side effect for a long time with my stomach. It is better to find a means that is suitable for the body and less harmful, otherwise it is possible to get rid of one and get another problem.

Analogues

Structural analogs for the active substance:

Novospaz.

Analogues on the curative effect (funds for the treatment of migraine):

Amigrenin;
Amitriptyline;
Analgin;
Anaprilin;
Andipal;
Ascofen;
Betalk;
Vazobral;
Voltaren;
Diclofenac;
Dimephosphone;
Zomig;
Ibufen;
Inderal;
Ipronal;
Caffetin;
Ketonal;
Contamnol;
Korgard;
Xantinol nicotinate;
Kudevita;
Lexotan;
Metovit;
Metoprolol;
MIG 200;
Naisylate;
Naklofen;
Nalgezin;
Next;
Nilogrin;
Noblessite;
NovoPassit;
Nomigren;
Nurofen;
Nurofen for children;
Obsidan;
Omaron;
Ormidol;
Panadine;
Panadol;
Paracetamol;
Pentalgin;
Peritol;
Pikamilon;
Pliwalgin;
Propranolol;
Revalgine;
Redergin;
Rudotel;
Solpadein;
Stugeron;
Sumygamren;
Topamax;
Upsarin of the UPSA;
A sedative (sedative) collection;
Faspik;
Febricet;
Fezam;
Flamax;
Hyrumat;
Cefekon D;
Cinnarizine;
Citrapac;
Egilok;
Estecor;
Efkamon.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Shelf life of the tablets is 5 years from the date of their manufacture. The preparation should be stored in the original factory packaging, dark, dry, inaccessible to children at an air temperature of no higher than 25 ° C.