How to take Vasilip for lowering cholesterol

Vasilip is a drug used to reduce the total cholesterol and low-density lipoprotein (LDL) cholesterol in the blood plasma.

The active substance of the drug reduces the concentration of total Xc, Xc-LDL and triglycerides (TG). The Xc content of very low density lipoproteins (Xc-VLDL) also decreases, while the high-density lipoprotein (Xc-HDL) cholesterol content moderately increases.

On this page you will find all information about the Wazilip: full instructions for use on this medicated medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Vasilip. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Lipid-lowering drug.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Vazilip cost? The average price in pharmacies is at the level of250 rubles.

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Form of issue and composition

They are released in the form of tablets coated with a film membrane (round, slightly biconvex with chamfered edges, white or almost white), 7 pieces in blisters, 2 or 4 blisters in cardboard packs.

• The composition of 1 tablet includes 10 mg, 20 mg or 40 mg of active substance - simvastatin.
• Auxiliary components included in the preparation: butylhydroxyanisole, lactose monohydrate, microcrystalline cellulose, pregelatinized starch, anhydrous citric acid, ascorbic acid, corn starch, magnesium stearate.

Pharmacological effect

The active ingredient of Vasilip has a hypolipidemic effect and lowers the cholesterol content in the blood plasma. The drug is effective in coronary heart disease, as it reduces the risk of myocardial infarction. The therapeutic effect of the use of Wazilip develops for two weeks, and the maximum comes in a month of daily intake.

In addition, Vazilip has an anti-atherosclerotic effect on the components of blood and vessel walls.

Indications for use

What helps? Vasilip is prescribed to patients for the treatment and prevention of the following conditions:

1. Increased cholesterol in the blood.
2. Atherosclerosis of large arteries, as a result of which blood supply to vital organs and systems worsens.
3. Prevention of repeated infarctions and ischemic strokes in patients with severe atherosclerosis or diabetes mellitus.
4. Preventing the development of heart attacks and strokes in people at risk - overweight patients, people with prevalence in the diet of carbohydrates and overly fatty foods, patients with a genetic predisposition to hypercholesterolemia.

Contraindications

Application in pregnancy and lactation

The components of Wazilip have a negative effect on the development of the fetus, so exclude the medicine for the treatment of pregnant women. If in the process of therapy by Vasilip a pregnancy occurs, then the drug is stopped.

Instructions for use

In the instructions for use, it is indicated that Vasilip is taken orally, once in the evening.

• The recommended dose of simvastatin varies from 5 mg to 80 mg once a day in the evening. Most often, the initial dose of the drug is 10 mg. Changes (selection) of the dose should be carried out at intervals of not less than 4 weeks. The maximum daily dose is 80 mg. The maximum daily dose is recommended only for patients with severe hypercholesterolemia or a high risk of cardiovascular complications. Duration of the drug is determined individually by the attending physician.

Prevention of cardiovascular diseases:

• With a high risk of developing coronary heart disease (with or without hyperlipidemia), 20-40 mg of Wazilip per day is prescribed. The initial dose is 20 mg, the dose should be increased with an interval of at least 4 weeks. The maximum daily dose is 40 mg. With an LDL content of less than 75 mg / dl (4 mmol / L), a total Xc content of less than 140 mg / dL (mmol / L), the dosage of the drug should be reduced.

Hypercholesterolemia:

• The patient should observe a standard hypocholesterol diet throughout the entire period of treatment with Vasilip. The recommended initial dose of the drug for patients with hypercholesterolemia is 10 mg. With the aim of a more pronounced decrease in the level of X-LDL (more than 45%), treatment can be started from 20-40 mg / day (once in the evening). In patients with homozygous hereditary hypercholesterolemia, the recommended daily dose of Vasilip is 40 mg in the evening or 80 mg in 3 divided doses (20 mg in the morning, 20 mg in the afternoon and 40 mg in the evening); these patients should be used in combination with other lipid-lowering therapy (for example, apheresis LDL).

Concomitant therapy:

• The drug is effective in monotherapy or simultaneously with bile acid sequestrants (eg, colestipol and colestyramine). In patients receiving treatment with gemfibrozil, cyclosporine, other fibrates or nicotine acid (more than 1 g per day), therapy is recommended to start with 5 mg per day, the maximum daily dose - 10 mg. In such situations, further increase in dose is not recommended.

In patients who are simultaneously receiving amiodarone or verapamil, daily doses of Vasilip should not exceed 20 mg.

In patients with severe renal failure (CC less than 30 ml / min), the recommended dose of the drug should not exceed 10 mg / day. If it is necessary to increase the dose, careful monitoring of such patients is necessary.

Side effects

In general, the medication is well tolerated by patients. Side effects and allergic reactions are not so common, in a mild form, and quickly pass.

Nevertheless, such manifestations are possible:

1. From the viewpoint: clouding of the lens.
2. From the genitourinary system: a violation of potency, a violation of kidney function.
3. From the gastrointestinal tract: increased activity of hepatic transaminases, dyspepsia, pancreatitis, nausea and vomiting, constipation.
4. From the central nervous system: increased fatigue, peripheral neuropathies, depression, sleep disorders, headache.
5. From the side of the muscles: dermatomyositis, muscle weakness, rhabdomyolysis with subsequent renal failure. This side effect is extremely rare, mainly in patients who take cyclosporine or other drugs in the group of statins in parallel.
6. Other possible side effects: photosensitization, alopecia.

In some cases, the intake of this drug is characterized by such manifestations of allergies as hives, fever, eczema and redness of the skin. In these cases, it is necessary to inform the doctor about such an organism reaction to taking the medicine. A blood test can also show changes such as an increased content of eosinophils and ESR.

Overdose

There are cases of excess dose of Vasilip, but they did not cause serious consequences and serious violations. Despite this, in case of drug overdose it is necessary to take enterosorbents and rinse stomach, and recommended monitoring of the body's systems, especially for the kidneys and liver.

special instructions

1. It is recommended to avoid joint intake of simvastatin and grapefruit juice.
2. Before and during the course of therapy, the patient should be on a hypocholesterol diet.
3. With unexplained pain in the muscles, the patient is advised to consult a doctor urgently.
4. The drug may cause a slight and clinically insignificant increase in the activity of hepatic enzymes in the blood serum. Usually after the cancellation of the Wazilip, transaminase levels slowly decrease to the initial value. However, before the start of treatment and in the future it is necessary to conduct a study of liver function.
5. It is not recommended to take if there is a risk of rhabdomyolysis or renal insufficiency (due to arterial hypotension, severe acute infection, severe metabolic disorders, trauma).

The adverse effect of the drug on the ability to drive and work with machinery has not been reported. However, it should be borne in mind that cases of dizziness are noted in the post-marketing application of simvastatin.

Drug Interactions

Vasilip (and analogs of this drug) can not be taken in combination with amiodarone, diltiazem, gemfibrosin, verapamil, cyclosporine, fenofibrate, nicotinic acid.

Reviews

We picked up some of the people's reviews about the drug Vazilip:

1. Nina. My drug was prescribed by my therapist after she was diagnosed with high cholesterol. The price of the drug was acceptable, in comparison with other funds for a price over 1000 rubles. The medicine mum drank month, after repeatedly has handed over analyzes. Cholesterol returned to normal.
2. Mark. Vazilip is prescribed for life. Alcohol and vasilip (statin, imvastatin, ozostatin) are not compatible. with unauthorized cancellation or dose changes. Basically get problems. You can lower the dose if you stick to the anti-cholesterol diet.
3. Marina. I was always inclined to hypolipodemia, but I tried to stop the disease with diets and sports. Has handed over the analysis because of bad state of health - the cholesterol was 12. Have appointed or nominated vasilip. Took a month, after this time he fell to 3. Prior to this, took simvastatin, he did not give such success. As I understand it, vasilip is a very serious drug, because I was prescribed it only in case of a strong deviation from the norm.
4. Inga. My family doctor prescribed this drug, she had high cholesterol. Have told or said to spend on drink a monthly course, and then again to hand over analyzes. The price of the drug is very acceptable, because in the pharmacy, we saw the funds even for 1000 rubles and more... A month later, my mother again passed the tests and the level of cholesterol came back to normal.

Analogues

Vazilip has many analogues, among which:

• Atoris, Rosukard, Roksera, Rosuvastatin, Mertenil, Atomax, Lipitor, Pravastatin, Simvastol, Simgal, Lovastatin, Tulip, Ovenkor, Rosulip, Zokor, Rosart, Tevastor, Liprimar. The most popular among them are Tulip, Livostor, Vazoklin and Atorvakor.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Keep out of the reach of children at temperatures up to 30 ° C.

Shelf life - 3 years.

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