Vilprafen tablets

Vilprafen is widely used for the treatment of bacterial and fungal diseases.

The drug belongs to the group of macrolides - antibiotics, similar in action to penicillins. Has a bacteriostatic, and in large doses, bactericidal action. Almost completely metabolized in the body, and its residues and metabolites are excreted in the urine.

On this page you will find all information about Vilprafen: the full instruction on the application for this medicine, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Vilprafen. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antibiotic group macrolides.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Wilprafen? The average price in pharmacies is at the level of600 rubles.

Form of issue and composition

The drug Vilprafen is available in the form of tablets for oral administration in a cardboard package in blisters for 10 pieces. Each tablet is covered with a film shell of white color and has a horizontal notch on one side.

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active substance: josamycin - 500 mg,
auxiliary substances: microcrystalline cellulose, polysorbate 80, silicon colloidal oxide, sodium carboxymethylcellulose, magnesium stearate, hydroxypropylmethylcellulose, Macrogol 6000, talc, titanium dioxide, aluminum hydroxide, methacrylic acid copolymer and its esters.

Pharmacological effect

The bactericidal effect of the active substance of the preparation is due to the fact that josamycin is able to bind to a large subunit of the ribosomal membrane (50S), does not allow transport RNA to be fixed, and also blocks the translocation of A-center peptides (a kind of mutation that accompanies chromosome rearrangement, affecting the properties of the cell) and suppresses intracellular production of proteins from amino acids.

The range of action of josamycin, which is part of Vilprrafen, is quite wide.

The substance has activity against Gram-positive aerobic microorganisms, including:

Isolated by the body in inflammatory processes of peptococci;
Peptostreptococci, which provoke the development of mixed infections;
Staphylococci;
The causative agent of anthrax is the anthrax bacilli;
Bacteria of the genus Corynebacterium, which are the causative agents of diphtheria;
Clostridium of perfringence - causative agents of gas gangrene and human toxicogenesis;
Streptococcus.

Wilprafen is also active against gram-negative microorganisms, including:

Hemophilus, which is the cause of hemophilic infections, including purulent meningitis, acute pneumonia, pericarditis, septicemia, etc .;
Neisseria, which are the causative agents of diseases such as gonorrhea and meningitis;
Some varieties of shigella provoking the development of dysentery;
Bacteroid fragilis, which are the causative agents of purulent-infectious diseases, developing after the traumas, surgical interventions, with immunodeficiency, etc .;

Also, josamycin has activity against various intracellular parasites: chlamydia, legionella, mycoplasmas, ureaplasmas.

Indications for use

According to the instructions, Vilprafen is prescribed for the treatment of the following infectious-inflammatory diseases caused by microorganisms sensitive to dzhozamycin:

Psittacosis;
Whooping cough;
Infections in ophthalmology (dacryocystitis, blepharitis);
Infections in dentistry (pericoronitis, alveolitis, gingivitis, periodontitis and alveolar abscess);
Burn and wound (including postoperative) infections;
Gonorrhea, venereal lymphogranuloma, syphilis (with increased sensitivity to penicillin);
Infections of ENT organs and upper respiratory tract, including pharyngitis, sinusitis, tonsillitis, laryngitis, paratonzillitis and otitis media;
Infections of the lower respiratory tract, including community-acquired pneumonia, acute and chronic bronchitis (exacerbations);
Scarlatina (Wilprafen is prescribed in case of hypersensitivity to antibiotics of the penicillin series);
Diphtheria (in complex therapy together with diphtheria antitoxin);
Infections of the genital tract and urinary tract (cervicitis, prostatitis, urethritis and epididymitis caused by mycoplasmas and / or chlamydia);
Infections of soft tissues and skin (furunculosis, furuncle, anthrax, acne, abscess, folliculitis, erysipelas, lymphadenitis, panaritium, lymphangitis and phlegmon);
Diseases of the gastrointestinal tract caused by Helicobacter pylori, including chronic gastritis and peptic ulcer of the stomach and duodenum.

Contraindications

The drug is contraindicated in severe violations of the liver or in the presence of hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug is not prescribed to pregnant women in the event that there are serious violations in the liver, sensitivity to the components.

Instructions for use

The instructions for use indicate that the recommended dose for adults and adolescents over 14 years is 1-2 g in 2-3 doses. The initial recommended dose is 1 g.

To treat rosacea - 500 mg 2 times / day for 10-15 days.
For the treatment of pyoderma - 500 mg 2 times / day for 10 days.
For the treatment of urogenital chlamydia - 500 mg 2 times / day for 12-14 days.
For the treatment of chronic periodontitis, with abscessing of periodontal bone - 500 mg 2 times / day for 12-14 days.
At ordinary and globular (conglobate) eels appoint 500 mg 2 times / day for the first 2-4 weeks, then 500 mg 1 time / day as maintenance therapy for 8 weeks.

Tablets should be swallowed, not liquid, with a small amount of liquid, between meals. Usually the duration of treatment is determined by the doctor. In accordance with the recommendations of the WHO on the use of antibiotics, the duration of treatment for streptococcal infections should be at least 10 days.

It is preferable to prescribe the drug in the form of a suspension for breast children and children under the age of 14 years. The daily dose is 30-50 mg / kg of body weight, divided into 3 doses. In newborns and children under 3 months of age, the dose should be selected according to the exact weight of the child's body.

Before use, the vial with suspension should be shaken.

Side effects

If the drug is used correctly and the dose of Wilprafen is accurately observed, the patient is well tolerated, but in some cases, the following side effects may occur:

Allergic Skin Reactions: urticaria, rashes, Quincke's edema, in very rare cases anaphylactic shock.
GIT: nausea, abdominal pain, excessive salivation, heartburn, vomiting, indomitable diarrhea, the development of the inflammatory process in the intestine in rare cases.
From the liver and biliary tract: an increase in the activity of liver transaminases, rarely a violation of outflow of bile and gallbladder functioning due to which the patients developed jaundice.

Overdose

With regard to the means to date, cases of overdose have not been recorded. In case of an overdose after taking the remedy, it is necessary to assume an increase in side effects, to carry out symptomatic therapy.

special instructions

In patients with renal insufficiency, correction of the dosing regimen is required in accordance with the values of CK.
Jozamycin is not prescribed for premature infants. When used in newborns, it is necessary to monitor liver function.
If pseudomembranous colitis develops, josamycin should be discontinued and appropriate therapy prescribed. Drugs that reduce intestinal motility are contraindicated.

Consider the possibility of cross-resistance to various antibiotics of the macrolide group (eg, microorganisms, resistant to treatment related to the chemical structure of antibiotics, can also be resistant to dzhozamycin).

Drug Interactions

Vilprafen inhibits the elimination of xanthines, which can trigger the development of intoxication.
It is advisable to avoid simultaneous application of Vilprafen with other antibiotics. This can lead to a decrease in their effectiveness.
The simultaneous use of an antibiotic with cyclosporine can lead to an increase in the concentration of the latter, so you should monitor its level throughout the treatment.
Taking Vilprrafen may reduce the effectiveness of hormonal contraceptives, so to avoid unwanted pregnancy is recommended to additionally use non-hormonal contraceptives.
The complex application of Vilprafen with antihistamines including astemizole and terfenadine increases the concentration of the latter, which can lead to the development of serious cardiac arrhythmias that threaten life.

Reviews

We picked up some feedback from people about the preparation of Wilprafen:

Masha. Passed inspection during pregnancy, passed the tests and it turned out that I have ureaplasmosis. The doctor has written out to me "Vilprafen" + preparations from a dysbacteriosis. I was very worried if they were possible during pregnancy, but she convinced me that they are fairly sparing, but at the same time effective. I completed the full course, no side effects were observed. But the most important thing that helped! I took these pills myself for a note, since I read that they are quite a wide range of activities and at an affordable price.
Artem. I used this antibiotic for the first time this year, when I fell ill. It hurt greatly in the throat and the rhinitis troubled me. My mother recommended the medicine. She prescribed this medicine in the year when she had a severe sore throat, more than two months she treated her. What can I say about the medicine? Yes I do not know, it helped me, or another set of medicines that I used. But I cured my illness in ten days, as I began to take this antibiotic. No allergies or disorders in the intestines, I did not have rashes. The device is transferred well. Not happy with the price of the medicine, in our city is about four hundred rubles!

According to feedback, Wilprafen is an effective drug, but the risk of developing adverse reactions during treatment is high. Patients diagnosed with chlamydia and ureaplasmosis report that within a few days after the start of the drug, the symptoms of the disease disappear completely. There are reports of such side effects of Wilprafen, as a violation of the gastrointestinal tract and allergic rashes, which are relatively common.