Vesicar

Vesicare - designed to reduce the tension of the muscles of the bladder.

In its composition, there is a compound called solifenacin. It actively relaxes the spasms of the smooth muscles of the urinary tract. Most noticeable is the result of the use of this medication after the first month of its use.

On this page you will find all information about Vesicare: the full instruction on the application for this medicine medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Vesicar. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antispasmodic.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much is Vesicar? The average price in pharmacies is at the level of1 000 rubles.

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Form of issue and composition

The medication is issued in the form of round, convex tablets with the logo of the issuing company on one side, coated a coating of light yellow color in Vesicare 5 mg and light pink in Vesicare 10 mg (depending on the concentration of the active substance). In cardboard packs there are from 1 to 3 blisters for 10 pieces of tablets in each.

• The main active ingredient is solifenacin succinate.
• Auxiliary components: lactose monohydrate, corn starch, hypromellose, magnesium stearate.

Pharmacological effect

Solifenacin - an active substance Vesicara - is an M-holinolitik, providing a blocking action, respectively, on the M-holinoretseptory located in the endings of parasympathetic nerves fibers.

As a result of this effect, glandular secretion decreases, pupils dilate, peristalsis weakens intestines, there is paralysis of accommodation, and the tone of smooth muscles, including urinary tract, ways. In this case, soliphenacin does not enter into interaction with ion channels and other receptors.

With the syndrome of the hyperactive bladder, Vesicar's effectiveness, the reviews confirm this, notes a few days after the start of treatment and stabilized over the next 12 weeks therapy. The maximum effect of solifenacin is observed after 4 weeks, and the effectiveness remains with long-term use of the drug (at least one year).

Indications for use

The drug is prescribed for the treatment of urgent (mandatory) urinary incontinence, frequent urination and urgent (imperative) urge to urinate accompanied by a syndrome of hyperactive urinary the bubble.

Contraindications

According to the instructions, Vesicare is contraindicated:

• In glaucoma of the closed type;
• During the procedure of hemodialysis;
• With increased sensitivity to one or more of the components of the drug;
• In conditions characterized by a delay in urination;
• In severe hepatic or renal insufficiency;
• In pathologies of the gastrointestinal tract, taking place in severe form (in particular, in the toxic megacolon);
• In myasthenia, an autoimmune disease affecting the nerves and muscles and characterized by the pathologically fast fatigue of the striated muscles;
• With moderate renal failure, which is accompanied by simultaneous treatment with cytochrome P450 3A4 inhibitors (ketoconazole, for example).

Since to date, the data on the onset of pregnancy against the background of taking Vesicare tablets, as well as information about his influence on an organism of the woman and its or her future child, are insufficient, during pregnancy a preparation appoint or nominate with limiting caution.

Application in pregnancy and lactation

Clinical data on the safety and efficacy of Vesicare in pregnant women are not available, so caution should be given during pregnancy.

There is no data on the penetration of solifenacin into breast milk. The drug is not recommended for use during breastfeeding.

Instructions for use

The instructions for use indicate that the recommended dosage of Vesicare for adults (over 18 years) and the elderly is 5 mg per day.

If necessary, the dose rises to 10 mg per day. Tablets are taken orally, whole, daily (at the same time), regardless of the time of eating. Wash down with a sufficient amount of liquid.

Side effects

Vesicare may cause side effects associated with the anticholinergic effect of solifenacin, usually of mild or moderate severity.

The frequency of these undesirable effects depends on the dose. The most frequently reported side effect of Vesicare is dry mouth. It was observed in 11% of patients receiving a dose of 5 mg per day, in 22% of patients receiving a dose of 10 mg per day, and in 4% receiving a placebo. The severity of dryness in the mouth was usually weak and only rarely resulted in interruption of treatment. In general, adherence to treatment (compliance) was very high.

Allergic reactions during clinical trials were not noted. However, the possibility of allergic reactions should not be ruled out.

Overdose

Symptoms of drug overdose are mild headache, mild dry mouth, slight dizziness, mild drowsiness and blurred vision. There were no cases of acute overdose.

In case of exceeding the dose, activated charcoal is prescribed, the stomach is washed. It is not recommended to induce vomiting. If necessary, perform symptomatic therapy.

special instructions

Before prescribing a drug, it should be established that there are other possible causes of the disorder urination (infection of the genitourinary system, kidney and ureter, cardiac failure).

If an infection of the genitourinary system is detected, antimicrobial treatment should be performed before taking this medication. It should be taken with care when working with vehicles and when dealing with hazardous activities.

Drug Interactions

The simultaneous use of Vesicar with:

• Ketoconazole or Itraconazole leads to increased concentrations;
• Ritonavir or Nelfinavir leads to a delay in excretion;
• Metoclopramide or Cisapride reduces their effectiveness;
• preparations of the group of m-holinoblokatorov leads to the development of undesirable effects;
• preparations of the m-cholinomimetic group leads to a mutual weakening of efficacy;
• Verapamil leads to complications in patients with liver failure.

Reviews

We picked up some feedback from people about the Vesicare drug:

1. Catherine. A few years after the birth, I was diagnosed with a hyperactive bladder syndrome. And my doctor advised me to drink Vesikar's course. Who appointed him? So I do not want to take dasg medicines, so I want to know the effectiveness of this drug.
2. Elena. "Vesicare" is a strong enough tool for the treatment of urinary incontinence. My grandmother suffers from such a disease, just suffers. How many tried the drugs, and the result is either weak, or none at all. Then the doctor prescribed Vesicare. Of course, I was alerted by a list of contraindications, but we tried. It helped, of course, not like a girl, but now she controls the process of urination and does not run to the toilet often. Grandmother drinks his courses on prescription of the doctor almost constantly.
3. Anya. I took Vesicare for 10 months a month. Terribly dried in the mouth, eyesight deteriorated and esophagitis reflux escalated. The effect seems to be while there, the second month lasts. The urologist said that if the medication does not help, then only surgery is necessary. I really do not want to.

Analogues

Structural analogues have not been developed. Medications with a similar mechanism of action:

• Driptane
• Spazmex
• Uro-Wax
• Urotol

Before using analogues, consult your doctor.

Storage conditions and shelf life

The drug is stored in a place protected from moisture and sunlight, inaccessible to children, at a temperature of no higher than 25 ° C. Shelf life is 3 years. Do not take the pill after the expiry date indicated on the package.

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