Phosphogliv

Phosphogliv - a combined drug that has a membrane-stabilizing, antiviral and hepatoprotective effect.

The drug promotes the restoration of cell membranes of liver cells, improves the natural current of substances through them. Helps reduce the symptoms of inflammation and focal edema, inhibits the formation of negative metabolites. It is used to treat acute and chronic liver diseases that occur with the defeat of hepatocytes.

Phosphogliv is processed in the liver and is excreted with fecal masses with bile. It is used mainly in adults. Does not cause side effects with prolonged admission.

Clinical and pharmacological group

Hepatoprotector with immunomodulating and antiviral action.

Terms of sale from pharmacies

Can buywithout a doctor's prescription.

Price

How much does Phosphogliv cost in pharmacies? The average price is at the level of550 rubles.

Composition and form of release

The drug is available in two forms:

Capsules. The capsule case is orange, and the lid is black. Inside there is a light powder with a weak yellow tint. There is a weak specific smell. Capsules are placed on 10 pieces in blisters. Blisters are laid out on 5 in cardboard packs.
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Liofizilat for IV introduction. It looks like white or light yellow mass. It is placed in vials of 2.5 g. Vials of 5 or 10 pieces are laid out in cardboard packs.

The composition of 1 capsule includes active substances:

Phospholipids (Lipoid C 80) (the main component - phosphatidylcholine 73-79% (in terms of 100% substance)) - 65 mg;
Glycyrrhizinate sodium (trisodium salt glycyrrhizic acid) - 35 mg.

The composition of 1 bottle with lyophilizate for the preparation of the injection solution includes active substances:

Phospholipids (Lipoid C 100) - 500 mg;
Sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid) is 200 mg.

Phosphogliv or Phosphogliv Forte - what is better?

Often one can come across a question: what is the difference between Phosphogliv and Fosfoglve Forte? In fact, the composition of the drugs is identical, if you look at the ingredients, the difference is only in the dosage of these substances.

It is impossible to say which of these medicines is better, since the dosage should be selected taking into account weight, age, diagnosis. Buy exactly the drug that was prescribed to you by a doctor.

Pharmacological effect

Phosphogliv - a combined drug that has a membrane-stabilizing, hepatoprotective and antiviral effect.

Phosphatidylcholine - the main structural element of cellular and intracellular membranes, is able to restore their structure and functions in damage, providing a cytoprotective effect. Normalizes protein and lipid metabolism, prevents the loss of hepatocytes of enzymes, restores detoxifying liver function, inhibits the formation of connective tissue, reduces the risk of fibrosis and cirrhosis of the liver.

Glycyrate has an anti-inflammatory property, suppresses the reproduction of viruses in the liver and other organs due to stimulation of interferon production, enhancement of phagocytosis, increased activity of natural killer cells. Has a hepatoprotective effect. Potentiates the effects of endogenous glucocorticosteroids, anti-inflammatory and anti-allergic effects in non-infectious liver lesions.

With skin lesions due to membrane stabilizing and anti-inflammatory properties, it limits the spread of the process and promotes regression of the disease.

Indications for use

What helps Phosphogliv? The preparation of Phosphogliv is used to treat the majority of pathological violations of the liver function both infectious and non-infectious.

Indications for the use of Phosphogliv are such diseases as:

viral hepatitis A, B, C, D in acute and chronic forms;
steatohepatosis,
steatohepatitis,
cirrhosis of the liver,
damage to the liver as a result of the use of narcotic drugs;
hepatic insufficiency in acute and chronic forms,
intoxication of the body,
liver damage on the background of chronic diseases of the cardiovascular system, respiratory organs, diabetes, tuberculosis;
fatty hepatosis (fatty liver degeneration),
alcoholic liver damage caused by alcoholism,
medicinal liver damage,
psoriasis.

Liofizilat and capsules significantly improve the synthetic function of the liver and qualitatively reduce the symptoms of liver failure. In this case, the drug has good tolerability and a favorable safety profile.

Contraindications

Contraindications to the prescription of a medicinal product are:

Antiphospholipid syndrome.
Children under 12 years of age (safety and efficacy data are not enough).
Pregnancy and lactation.
Increased individual sensitivity to phosphatidylcholine, glycyrrhizic acid or other auxiliary components of the drug.

Phosphogliv is prescribed with extreme caution to patients with portal and arterial hypertension.

Intended use for pregnancy and lactation

The experience of using the drug Phosphogliv among pregnant women is absent or limited. Studies on the safety of the drug for the fetus have not been carried out, so capsules are not recommended for women during pregnancy.

It is not known whether the substance of the drug Phosphogliv is excreted in breast milk, and how it can affect the baby's body. Given the lack of information about the safety of the drug, take it inside the capsule. Phosphoglyv to women during breastfeeding is not recommended. If it is necessary to use the drug, it is necessary to solve the problem of stopping lactation and transferring the child to artificial feeding.

Dosage and route of administration

As indicated in the instructions for use Phosphoglivin are taken orally during meals. Capsules should be swallowed, not liquid, squeezed with a small amount of liquid.

Adults and children over 12 years of age are prescribed 2 caps. 3 times / day.

Duration of use can be up to 6 months, on average - 3 months.

Adverse Reactions

The use of a solution for injection can cause the following side effects:

Allergic reactions: hypersensitivity - skin rash (usually without additional measures after the abolition of therapy);
Other (with the administration of the drug in excess of the recommended daily doses): increased blood pressure (BP), edema, hypokalemia, fluid retention and sodium. If such violations occur, it is recommended to reduce the daily dose of the drug and / or apply potassium-sparing diuretic - spironolactone 50-100 mg per day (determined by the severity of side effects).

In the form of capsules, Phosphogliv, as a rule, is tolerated by patients well, disorders develop in very rare cases, according to the results of post-registration observations - <1/10 000. During treatment, the following side effects may develop:

Cardiovascular system: transient increase in blood pressure, peripheral edema;
Gastrointestinal tract: discomfort in the abdomen, dyspepsia in the form of belching, nausea, bloating;
Allergic reactions: conjunctivitis, cough, skin rash, difficulty in nasal breathing.

In case of occurrence of these violations, discontinue treatment and consult with a specialist.

Overdose

Cases of overdose with Phosphogliv were not registered, but do not intentionally increase the dose specified in the instructions to avoid the development of side effects.

When accidentally ingesting a large number of capsules (more than 6 pieces at a time), you should induce vomiting and take the tablets of Activated Carbon.

special instructions

In the event of an increase in blood pressure should stop taking the drug and see a doctor.

Compatibility with other drugs

The drug interaction of Phosphogliv is not described.

Reviews

We offer you to familiarize yourself with the reviews of people who used Phosphogliv:

Tatyana. Hepatitis A has recovered. the recovery period was long and painful - it just made me sick. I generally suffer from nausea very badly and heavily. some days could not even look at food. Seriously lost weight during the recovery. Phosphogliv took several months, finally the symptoms passed near the end of the second month of admission. drank the drug already for the therapeutic effect. In fact, nothing bothered.
Vera. After a course of antibiotics and a month in the hospital, she finally left for home. But it was probably early to rejoice. I started to put a lot of pressure on the liver. Literally the next day I went to the doctor. She explained that because of antibiotics the liver was damaged, the hepatoprotector prescribed. She bought Phosphogliv from the pharmacy, because it is inexpensive and, according to the pharmacist, should help well, because they take it perfectly. Has bought or purchased, has spent on drink a course. Indeed, it became easier. Control tests confirmed this.
Nastya. She took Phosphogliv. Has helped. The gastroenterologist wrote out, to it the therapist has sent me after complaints about unpleasant sensations from the right party or side in a side. Initially, did not attach much importance to this, but they did not pass and sometimes intensified. Has handed over analyzes, have made KT - have diagnosed fatty dystrophy. I was treated with a diet, Phosphogliv, I entered the pool. I lost weight very well in three months. 🙂 A checkup was carried out two weeks ago - liver enzymes almost returned to normal, a second CT scan also showed that the liver is recovering. In a few months I'll repeat the course, and diet and sport with me now for a long time.

Doctors-hepatologists and infectious disease specialists in general are positive about Phosphogliv. Especially often it is prescribed in the complex therapy of hepatitis C, since the drug has a pronounced positive effect on the liver and significantly inhibits the activity of virus multiplication. Japanese doctors prescribe Phosphogliv to all patients with hepatitis C, before antiviral therapy, in some cases, even completely cures the disease and stops the reproduction of the virus. That is why hepatologic doctors respond about Phosphoglive with respect to hepatitis positively.

Also, doctors respond positively to Phosphogliva, as a hepatoprotector, which is used in any liver lesions of toxic, medicinal or alcoholic origin, and in hepatoses. Under these conditions, the drug normalizes biochemical analyzes, liver condition, and also significantly improves the overall well-being of a person. Doctors say that the complex therapy of various liver diseases with the use of Phosphogliva normalizes the condition of the organ more quickly than without the use of this hepatoprotector.

Physicians-dermatologists, who use the medicinal preparation in the therapy of various skin diseases, including psoriasis, speak positively about Phosphogliv. For many girls and women, Phosphogliv helped get rid of pimples and acne, normalizing the liver and increasing its ability to neutralize toxic substances.

Analogues

Phosphogliv does not have structural analogs for the active substance.

Analogues on the therapeutic effect (hepatoprotectors):

L-Methionine;
S-Adenosylmethionine;
Alpha-lipoic acid;
Antraliv;
Berlition 300;
Berlition 600;
Betaine citrate;
Brentzialle forte;
Vitanorm;
Hepa-Mertz;
Hepatosan;
Hepatofalk the plant;
Heptor;
Heptral;
Heptrog;
Glutargin;
Covechol;
Karsil;
Karsil Forte;
Cryomelt;
Legalon;
Livedoksa;
Livolife Forte;
Lipoic acid;
Lipoid PPL 400;
Lipoid C 100;
Maxar;
Methionine;
Milife;
Moliksan;
Octolipen;
Ornitsetil;
Resalute Pro;
Silegon;
Silibinin;
Sylimar;
Silymarin;
Sirepard;
Thiolipone;
Tiotriazolin;
Tyqveol;
Urdoks;
Urso 100;
Ursodez;
Ursodeoxycholic acid;
Ursodex;
Ursuliv;
Ursor;
Ursosan;
Ursofalk;
Phosphogliv Forte;
Phosphontsiale;
Hepabos;
Holudexan;
Exxhol;
Erbisol;
Essentiale N;
Essentiale forte N;
Essential phospholipids;
The Essler.

Before buying an analogue, consult your doctor.

Heptral or Phosphogliv?

According to the latest orders of the Ministry of Health of the Russian Federation, Phosphogliv is one of the standard drugs for specialized medical care for acute hepatitis C of severe and moderate severity, as well as for chronic hepatitis C. In turn, Heptral is not included in this list of drugs. Thus, it can be concluded that in chronic hepatitis C, as well as with severe and moderate severity of acute hepatitis C, Phosphogliv should be preferred.

At the same time, heptral is a more effective drug for treating ABP and toxic hepatitis. Therefore, with these diseases, Heptral should be preferred.

In other respects, the preparations of Heptral and Phosphogliv are comparable in effectiveness of the therapeutic effect. Therefore, you can use any drug, which for some subjective reasons more like a person. However, do not forget that the body of each person is individual, so one patient may well approach Heptral, and the other - on the contrary, Phosphogliv.

Phosphogliv or Essentiale?

Both Essentiale and Phosphogliv are hepatoprotectors, and contain phospholipids as active components. In this Essential contains exclusively phospholipids, and Phosphoglivus also contains glycyrrhizic acid. This acid is in its chemical structure a steroid saponin, that is close in structure to the hormones of the adrenal cortex of a person.

However, this difference in the composition of drugs is not always a criterion for choosing one of them. The organism of each person is unique, and one patient is better suited to Phosphogliv, and to another - Essential. Therefore, before choosing a hepatoprotector and its dosage, you should consult your doctor.

It should also be noted that the Essentiale product contains products of lipid peroxidation, while Phosphogliv does not contain these compounds.

Shelf life and storage conditions

Keep out of the reach of children, out of the reach of children.

Shelf life:

Capsules - 3 years at a temperature of up to 25 ° C;
Lyophilizate for the preparation of injection solution - 2 years at a temperature of up to 20 ° C.