Bicillin 5

Bacillin-5 - penicillin antibiotic - is active against various microorganisms.

Mostly those that provoke the onset of gonorrhea, infections of staphylococcus, meningitis, streptococcus, diphtheria, and other anaerobic infections.

Impotent against the effects of microorganisms that produce penicillinase. Many gram-negative bacteria, viruses and fungi are resistant to the influence of the agent.

On this page you will find all information about Bicillin 5: the full instructions for use for this medicine medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Bicillin 5. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antibiotic group of penicillins, destroyed penicillinase.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Bicillin 5 cost? The average price in pharmacies is at the level of700 rubles.

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Form of issue and composition

Powder for the preparation of suspension for intramuscular injection 1200000 ED + 300000 units. One bottle contains

• active substances:Benzathine benzylpenicillin - 1200000 units.
• Benzylpenicillin novocaine salt - 30, 00 units.

White or white with a slightly yellowish tint powder, prone to clumping, forming a stable suspension with the addition of water.

Pharmacological effect

Bicillin-5 is a combined bactericidal antibiotic, consisting of two salts of benzylpenicillin, which have a long-lasting effect. The drug inhibits the synthesis of the bacterial cell wall.

It is active against the following microorganisms: Gram-positive bacteria (Streptococcus spp., Including Streptococcus pneumoniae, Staphylococcus spp., Not producing penicillinase), Gram-negative bacteria (Neisseria meningitidis, Neisseria gonorrhoeae, Treponema spp.), anaerobic spore-forming rods (Clostridium spp., Bacillus anthracis, Actinomyces israelii).

Staphylococcus spp., Which produce penicillinase, is resistant to its action.

Indications for use

The main indications for Bicillin are the treatment of various infectious diseases that cause microorganisms that are sensitive to the drug.

Therefore, the drug is prescribed for:

• erysipelas inflammation;
• rheumatism;
• acute tonsillitis;
• scarlet fever;
• wound infections;
• syphilis, yaws, leishmaniasis and so on.

Contraindications

There are contraindications to the drug:

• lactation period;
• hypersensitivity to the components of the drug, as well as to other beta-lactam antibacterial drugs.

Caution should be used Bicillin-5 with the following conditions / diseases:

• weighed allergic anamnesis;
• pseudomembranous colitis;
• kidney failure;
• bronchial asthma;
• pregnancy.

Application in pregnancy and lactation

It was found that Bicillin-5 penetrates into the mother's milk and through the placental barrier. In pregnancy, the drug can be used only if the expected benefit of treatment for the mother clearly exceeds the possible risk to the fetus.

If the use of the drug is necessary during lactation, breastfeeding should be discontinued.

Instructions for use

The instructions for use indicate that Bicillin 5 is administered intramuscularly.

• Adults for 1.2 million. ED + 300 thousand. ED once every 4 weeks.
• Pre-school children - 480 thousand. ED + 120 thousand. ED once every 3 weeks, children older than 8 years - 960 thousand. ED + 240 thousand. ED once every 4 weeks.

To prepare the suspension use sterile water d /, isotonic sodium chloride solution or 0.25-0.5% solution of procaine (novocain).

Suspension of Bicillin-5 is prepared aseptically, just before use (ex tempore): 5-6 ml of solvent are slowly injected into the vial with the drug under pressure slowly (at a rate of 5 ml in 20-25 sec). The contents of the vial are mixed and shaken along the longitudinal axis of the vial to form a homogeneous suspension. Bubbles are allowed on the surface of the suspension near the walls of the vial. Suspension of Bicillin-5 immediately after preparation is injected deeply intramuscularly into the upper outer quadrant of the gluteus muscle.

Rubbing the gluteus muscle after injection is not recommended. When the administration is delayed, the physical and colloidal properties of the suspension change immediately after preparation, as a result of which the movement of the suspension through the syringe needle may be impeded.

Side effects

Before diluting the therapeutic powder, it is important to get acquainted with the negative consequences of its presence in the complex treatment regimen. Side effects of Bicillin-5 occur after only one dose, causing instability of the central nervous system and general malaise. After the introduction of the first injection, the body's reaction may turn out to be the most unpredictable.

Here are the potential side effects from the instructions for use:

• violation of laboratory indicators: anemia, leukopenia, hypocoagulation, thrombocytopenia;
• from the skin: anaphylactic shock, fever, urticaria;
• others: glossitis, stomatitis.

Overdose

In case of non-compliance with the norms of use in ED and the dose, allergic reactions and other side effects can be manifested with the injection.

special instructions

The drug is prohibited to be administered intravenously, subcutaneously, in the body cavity and endolumbally (into the spinal canal).

When prescribing the drug, patients with syphilis should undergo serological and microscopic examinations before starting treatment and then within 4 months. It is advisable simultaneous administration of vitamin C and vitamins of group B, as well as systemic antifungal agents (as possible the appearance of fungal infections). It should be borne in mind that when using inadequate dosages of Bicillin-5 or too early discontinuation of therapy, resistant strains of pathogens may appear.

With the accidental introduction of Bicillin-5 inside the vessel, visual impairment, the appearance of feelings of anxiety and depression (Ouenier syndrome) are possible. To avoid accidental intravascular injection of the suspension, it is recommended to perform aspiration before the injection so as to detect a possible syringe needle drop into the vessel.

Drug Interactions

The simultaneous use of this drug with bactericidal antibiotics, for example: cephalosporins, cycloserine, vancomycin, rifampicin, aminoglycosides may cause a synergistic effect. The combination with bacteriostatic agents: macrolides, chloramphenicol, lincosamides and tetracyclines causes antagonistic effect.

In addition, there was a decrease in the effectiveness of oral contraceptives or ethinylestradiol. Decrease tubular secretion or increase the concentration of the drug can diuretics, phenylbutazone, allopurinol and NSAIDs. Combination with allopurinol often causes allergic reactions, mainly in the form of skin manifestations.

Reviews

We picked up some feedback from people about the Bicillin 5 drug:

1. Liuba. I inject once a month for 6 months. That there was no erysipelas of inflammation, only by this I am saved.
2. Kate. At a daughter from the very early childhood chronic tonsillitis, a sore throat with a sore throat, cones began to appear in a throat. Constantly at the LOR and she, after all, said to put this shot with a prophylactic goal - from complications that can go to the heart and to the joints. We initially refused, but after reading the annotation, we decided - it is still possible for the children, so the drug is not so terrible. Now kolem every six months and live without angina at all!
3. Nina. In 1 year for 4 and then 5-6 times lay in the ENT compartment with angina and constantly cut a swelling in the throat. It is good that I had in 1995. was the attending physician I do not remember what his name is. But he prescribed this drug because I was not helped by anything. I am grateful to my doctor. I forgot about angina for 15 years, if not more. And at the moment I have angina again and I again put this drug and I'm sure that for a few more years I will forget about angina.

Usually, positive feedback about Bicillin-5 is most often said about its high efficiency at a relatively low cost. The antibiotic is characterized as being of low toxicity, noting the extremely long-acting effect. Those who received injections of Bicillin-5 warn that the procedure should be performed with caution, having certain skills.

Sometimes they note such negative effects as the pain of injections and the depressing effect of therapy on the intestinal microflora.

Analogues

If the patient was able to dissolve and use the drug according to the instructions for use, but the effect of zero or side effects appeared, it is necessary to introduce a replacement. Analogues of Bicillin-5 are no less effective, while reducing the list of potential side effects. If to speak about cost representatives of penicillin series approximately stay in one price range.

Conditionally they can be classified into two categories. It:

1. Similarity in chemical composition: Bicillin-3, Benzicillin-3.
2. Similarity in the mechanism of action in the body: Amoxiclav, Augmentin, Ampiox, Oxamp-sodium.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Shelf life of antibiotic is 3 years. The storage location must be dry and out of reach of children, the temperature should not exceed 15 degrees. Application after the expiry date is prohibited.

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