Aerosol and inhalation solution Berotek: instructions for use

Berotek belongs to the group of inhaled bronchodilators.

It is used for relief of attacks with bronchial asthma, obstructive bronchitis and other pulmonolo- gic diseases accompanied by spasm of the bronchi. In some cases, it is prescribed for diagnostic tests when examining the ability of the bronchi to expand.

On this page you will find all information about Berotek: the full instruction on the application for this medicine medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Berotek. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Broncholytic drug - beta2-adrenomimetic.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Berotek cost? The average price in pharmacies is at the level of400 rubles.

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Form of issue and composition

Berotek is available as a clear, colorless solution for inhalation, free from particles and with an almost imperceptible odor.

• The main active substance of the drug is fenoterol hydrobromide. In 1 ml (20 drops) Berotek contains 1 mg of the active ingredient. Auxiliary substances of the solution: sodium chloride, benzalkonium chloride, hydrochloric acid 1 N, disodium edetate dihydrate and purified water.

Berotek is packed in vials of amber glass for 20, 40 and 100 ml. In a cardboard bundle 1 bottle.

Pharmacological effect

The active ingredient Beroteka has a bronchodilator effect, and also inhibits the release of inflammatory mediators from obese cells, thus providing a protective effect from the influence of such bronchoconstrictors as metacholine, histamine, allergens and cold air.

The medicine is used to stop and prevent bronchospasm attacks with bronchial asthma and other conditions that accompanied by reversible obstruction of the airways, for example, with chronic obstructive bronchitis with or without emphysema lungs.

Inhalation Berotekom prevent and effectively stop bronchospasm of various genesis in a short time - five minutes after inhalation.

Indications for use

Berotek, according to the instructions, is prescribed for the treatment of attacks of bronchial asthma or other conditions with reversible airway obstruction, including chronic obstructive pulmonary disease and chronic bronchitis.

Also inhalation Berotek apply:

• When conducting bronchodilator tests performed to study the function of external respiration;
• To prevent attacks of bronchial asthma, which arose because of physical stress;
• As a bronchodilator before inhalation with other drugs - mucolytics, antibiotics, glucocorticoids.

Contraindications

According to the instructions, Berotek is not assigned when:

• The perverse heart;
• Thyrotoxicosis;
• Decompensated diabetes mellitus;
• Glaucoma;
• Increased sensitivity of the patient to the components of the drug;
• Tachyarrhythmias;
• Hypertrophic obstructive cardiomyopathy;
• Aortic stenosis;
• Threatening miscarriage, as well as in the first trimester of pregnancy.

According to the instructions, Berotek should be carefully appointed when:

• Severe diseases of the cardiovascular system;
• Diabetes mellitus;
• Hyperthyroidism;
• Pheochromocytoma;
• Recently suffered myocardial infarction.

Application in pregnancy and lactation

When Berotek was used in pregnant women, the effect of this bronchodilator on the course of pregnancy was not revealed. However, the effect of the drug (especially in the first trimester) does not exclude the influence on the musculature of the uterus.

In this regard, he is prescribed to pregnant women only in those cases when the expected benefit during therapy exceeds the risk for pregnancy and fetal development.

Instructions for use

Treatment at home can be recommended to patients after consulting a doctor in cases where the use of dosed aerosol low doses of a high-speed bronchodilator - a beta-agonist (such as Berotek H) was not sufficient to alleviate state. It can also be recommended for patients who need nebulized therapy for other reasons, for example, in the case of problems with the use of metered aerosols or, if necessary, high doses.

The instructions for use indicate that treatment with Berotek should be started with the minimum recommended dose. It should be selected individually depending on the needs of the patient and adjusted depending on the severity of the acute episode. The drug should be discontinued when sufficient relief of symptoms is achieved.

Children under the age of 6 years (with a body weight of less than 22 kg):

• Due to the limited information on this age group, treatment is carried out only under medical supervision, prescribing the drug in the next dose: inhalation of about 50 μg / kg per administration (= 0.05 ml or 1 drop) / kg body weight, but not more than 0.5 ml (10 drops) per dose up to 3 once / day.

Children aged 6 to 12 years (with a body weight of about 22-36 kg)

Attacks of bronchial asthma and other conditions with reversible airway obstruction:

• Assign inhalation 0.25-0.5 ml (5-10 drops = 250-500 μg fenoterol hydrobromide), which in most cases is enough for immediate relief of symptoms; if it is necessary to re-administer the drug up to 4 times / day, the possibility of reducing the individual dose depending on the effectiveness nebulizer.
• ATsevere cases(for example, in most cases of inpatient treatment), higher doses of 1 ml (20 drops = 1000 μg fenoterol hydrobromide) may be required.
• ATexceptionally severe casesunder the supervision of a doctor, the drug can be administered at a dose of up to 1.5 ml (30 drops = 1500 μg fenoterol hydrobromide).

Preventing attacks of bronchial asthma due to physical stress:

• Assign an inhalation of 0.5 ml (10 drops = 500 μg fenoterol hydrobromide) to physical activity.

Adults (including patients older than 75 years) and adolescents over 12 years of age

Attacks of bronchial asthma and other conditions, accompanied by reversible airway obstruction:

• Assign inhalation 0.5 ml (10 drops = 500 μg fenoterol hydrobromide), which in most cases is sufficient for immediate arrest of the attack; at the need to re-prescribe the drug up to 4 times / day should consider the possibility of reducing the individual dose depending on the effectiveness nebulizer.
• ATsevere cases(for example, for most patients entering the ICU) higher doses of 1-1.25 ml (20-25 drops = 1000-1250 μg fenoterol hydrobromide) may be required.
• ATexceptionally heavycasesunder the supervision of a physician, doses up to 2 ml (40 drops = 2000 μg fenoterol hydrobromide) can be administered.

Preventing attacks of bronchial asthma due to physical stress:

• Assign an inhalation of 0.5 ml (10 drops = 500 μg fenoterol hydrobromide) to physical activity.

Treatment with Berotek is carried out by inhalation using commercially available nebulizers. Pulmonary deposition and systemic bioavailability of the drug depend on the nebulizer used.

It should be taken into account that 20 drops = 1 ml, 1 drop contains 50 μg of fenoterol hydrobromide. The recommended dose of Berotek is diluted in a nebulizer chamber with 0.9% sodium chloride solution to a final volume of 3-4 ml and inhaled until a sufficient relief of symptoms is achieved. Berotek can not be distilled with distilled water. The solution is diluted every time immediately before use; the remaining solutions are poured.

Instruction for aerosol

Dosage of Aerosol Berotek:

• With an acute attack of bronchial asthma - 1 dose; Inhalation can be repeated after 5 minutes. The next application of Berotek is possible only after 3 hours.
• In order to prevent asthma physical effort and as a symptomatic therapy of conditions that are accompanied by a reversible narrowing of the respiratory tract-1-2 doses per dose (no more than 8 doses per day).

Side effects

When using the drug, including the use of high doses of the drug, it is possible to develop such side effects:

1. From the gastrointestinal tract: nausea, vomiting.
2. From the central and peripheral nervous system: headache, dizziness, nervousness, increased excitability, weakness, convulsions. In isolated cases, mainly with prolonged use of the drug, the development of changes in the psyche is possible.
3. From the side of the cardiovascular system: tachycardia, palpitations, increased systolic blood pressure, decreased diastolic blood pressure, angina attacks, heart rhythm disturbances.
4. Allergic reactions: skin rash, itching, urticaria, local inflammatory reactions, anaphylactic shock, Quincke's edema.
5. From the respiratory system: cough, local irritation of the mucous membranes, paradoxical bronchospastic reactions.
6. Other reactions: increased sweating, myalgia, increased blood glucose levels.

In addition, the use of the drug may cause the development of severe hypokalemia, especially the risk of developing hypokalemia in patients with severe bronchial asthma who receive glucocorticosteroids, diuretics and derivatives xanthine. With prolonged therapy with the drug, as well as in patients receiving therapy with other drugs, regular monitoring of the level of potassium in the blood plasma should be carried out.

If side effects develop, you should consult your doctor.

Overdose

When an overdose of a pharmaceutical product, the following symptoms are observed

• arterial hyper- or hypotension (depending on the patient's predisposition);
• increased pulse pressure;
• intensive hyperemia of the skin of the face and upper body;
• tachycardia;
• anginal pain;
• palpitation;
• arrhythmias;
• attacks of angina pectoris;
• intentional tremor.

special instructions

The cylinder is designed for 200 inhalations. After that it needs to be replaced.

The tip should be kept clean. If necessary, it can be washed in warm water. After using detergent or soap, rinse thoroughly with clean water.

The contents of the cylinder are under pressure. The cylinder should not be opened and subjected to heating above 50 ° C.

During the treatment, dizziness may develop. Therefore, care should be taken when driving vehicles or using mechanisms.

Drug Interactions

At appointment it is necessary to consider medicinal interaction with other preparations:

1. The combination of Berotek with β-adrenoreceptor blockers leads to a marked decrease in bronchodilation (enlarged bronchial lumen);
2. Simultaneous application of Berotek with β-adrenomimetics, anticholinergics, xanthine derivatives (including theophylline) stimulates the development of side effects;
3. Simultaneous reception with halogenated hydrocarbon antiseptics (enflurane, halothane, etc.) enhances the effect of the active components of Berotek on the cardiovascular system;
4. The general therapeutic effect of Beroteka increases with simultaneous use with anticholinergic substances, tricyclic antidepressants, β-adrenoreceptor agonists, enzyme inhibitors monoamine oxidase (MAO).

Therapeutic effect of conservative treatment of bronchial asthma and chronic obstructive pulmonary disease Berotekom increases with its combined use with anti-inflammatory drugs (inhalation glucocorticosteroids). However, such treatment is recommended to be performed in a hospital for continuous monitoring of the patient's condition.

Reviews

Reviews about Berotek indicate that the drug effectively removes bronchospasm as in asthma attacks, and in other diseases of the bronchopulmonary system. Patients note the long-term effect of this drug and its good tolerability.

In rare cases, there are side effects, the severity of which largely depends on the patient's health and the adequacy of the prescribed dose. Irritation of the oral mucosa, cough and perspiration with this drug For the first time, as a rule, they did not demand the cancellation of Berotek and passed independently for a short period time. Allergic reactions to the constituent components of this bronchodilator were rarely detected.

Most patients estimate Berotek's price as "affordable" and "acceptable."

Analogues

The structural analogue of the drug is Berotek H, available as an aerosol for inhalation, as well as preparations of Fenoterol, Aerum, Dosberotec, Segamol and Arutherol.

Before using analogues, consult your doctor.

Storage conditions and shelf life

The solution for inhalation Berotek is stored at a temperature of up to 30 ° C, in a dry place, protected from sunlight and inaccessible to children. Keep the drug away from open flame, do not freeze. Shelf life is 5 years.

Do not use the medicinal product after the expiration date indicated on the package.

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