Dipyridamole

Dipyridamole refers to immunomodulators that have an angioprotective and antiaggregant pharmacological effect.

The basis of this drug is a chemical substance derived from pyrimidine. At its core - it is an interferon inducer, which increases the body's resistance to viral diseases. It improves the functioning of the microcirculatory bed, and the inhibition of the formation of thrombi is facilitated by inhibition of platelet aggregation.

On this page you will find all information about Dipiridamole: the full instruction on the application to this medicinal medium, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already applied Dipyridamole. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antiaggregant, angioprotector, immunomodulator.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does dipyridamole cost? The average price in pharmacies is at the level of420 rubles.

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Form of issue and composition

Dipyridamole is available in the form of tablets and suspensions for oral administration.

• The tablets covered with a cover, are packed on 40 and 120 pieces. Each tablet contains, 25 or, 75 g of dipyridamole.
• Suspension of the drug is produced in bottles of dark glass with a volume of 150 ml in a cardboard bundle. In 5 ml of the suspension contains 50 mg of the active ingredient of the drug - dipyridamole, as well as a number of auxiliary components.

Each drug form of the drug is accompanied by detailed instructions.

Pharmacological effect

Dipyridamole is a drug that has a vasodilator, arteriodilating, antiaggregational and anti-adhesion action. Its use promotes inhibition of the adhesion of platelets, increased blood flow velocity, expansion of coronary vessels and development of collateral circulation in cardiac vessels.

This drug normalizes venous outflow, thereby reducing the risk of blood clots, and oxygenates the venous blood. It lowers the brain tone, and also improves placental circulation.

Indications for use

The medicine can be taken systemically or comprehensively for various diseases. It is forbidden to prescribe medication independently. Vascular diseases should be treated exclusively by a doctor.

Scope of the drug:

• the initial stages of myocardial infarction;
• signs of angina pectoris;
• treatment of ARVI, influenza;
• complex stimulation of the immune system, the establishment of the proper operation of all organs;
• ischemic heart disease;
• prevention of blood clots after heart surgery;
• vascular, vein or arterial thrombus involvement;
• problems with the placenta in pregnant women. Such a state can be detrimental to the child. Therefore, prescribe drugs that help improve the supply of the placenta.

Contraindications

Absolute contraindications:

• acute myocardial infarction;
• decompensated CHF;
• severe arrhythmias;
• unstable angina;
• arterial hypotension;
• hypersensitivity;
• hemorrhagic diathesis;
• liver failure;
• Stomach ulcer with a tendency to bleeding.

It is used with caution in the lactation period and in children under 12 years old. Do not use intravenously in case of collapse.

Application in pregnancy and lactation

The use of dipyridamole during pregnancy and during breastfeeding is possible only if the intended benefit to the mother exceeds the possible risk to the fetus and the baby.

The duration of the course of treatment is determined by the doctor.

Instructions for use

The instructions for use indicate that dipyridamole is taken orally as an antithrombotic (anti-clotting) agent, 25 g (25 mg) 3 times a day.

As an agent for the treatment of angina pectoris is taken orally (on an empty stomach 1 hour before eating), 25 5 g (1-2 drops, 25 g) 3 times a day.

In more severe cases, 25 g (225 mg - 3 dragees, 75 g) per day in 3 divided doses. The course of treatment lasts from several weeks to several months.

Side effects

As a rule, the drug is well tolerated by patients. In some cases, the use of dipyridamole may provoke the development of the following unwanted reactions of the body.

Dipyridamole suspension can cause:

1. From the digestive system: infrequently - pain in the epigastric region, diarrhea, nausea, vomiting.
2. From the side of blood and the system of homeostasis: infrequently - thrombocytopenia, a violation of the functional properties of thrombocytes; rarely bleeding; very rarely - increased bleeding.
3. Different: noise in the ears, weakness, hyperemia of the skin of the face, dizziness, headache, feeling of stuffiness ear, rhinitis, arthritis, allergic reactions (hives, rashes, angioedema, strong bronchospasm).
4. From the side of the cardiovascular system: infrequently - tides of blood to the face, a feeling of palpitations, aetiology, tachycardia, lowering blood pressure, coronary steal syndrome (at a dose of more than 225 mg in day).

Unwanted effects of taking tablets can be:

1. Digestive system: nausea, vomiting, diarrhea.
2. Nervous system: headache, dizziness.
3. Allergic reactions: urticaria, skin rash.
4. Cardiovascular system: when taking high doses - tides, arterial hypotension, tachycardia, more often when combined with vasodilators.

Usually, the use of suspension in therapeutic doses does not cause significant side effects, as a rule, they are temporary.

Overdose

Symptoms: marked reduction in blood pressure, development or exacerbation of angina attacks, tachycardia, a feeling of heat, "tides" of blood to the face, increased sweating, anxiety, weakness and dizziness.

Treatment: induction of vomiting, gastric lavage, the use of adsorbents to reduce absorption (activated charcoal, etc.). The undesirable vasodilating effect of the drug can be suppressed with a slow (50-100 mg / min) intravenous injection of aminophylline. In case of symptoms of angina pectoris, sublingual application of nitroglycerin is indicated.

special instructions

Use with caution in patients with arterial hypotension, recent myocardial infarction, heart failure.

There is evidence that with IV injection of dipyridamole, a possible uneven redistribution of blood flow in the coronary vessels and development of the syndrome of stealing, accompanied by aggravation of symptoms of angina (including depression of the ST segment on the ECG). In this regard, is not recommended iv introduction of dipyridamole.

Drug Interactions

Antiaggregant effect of this drug is enhanced with simultaneous reception with acetylsalicylic acid, tetracycline, penicillin, cephalosporin, indirect anticoagulants and nicotine acid.

It should also be noted that indirect anticoagulants, thrombolytics and heparin may increase the likelihood of hemorrhagic complications. One can not help saying that caffeine-containing drugs and xanthines reduce vasodilator and antithrombotic effects of the agent in question, and antacids reduce its absorption and reduce concentration in the blood.

As for the drug itself, it enhances the effect of antihypertensive drugs.

Reviews

We picked up some of the people's comments about the dipyridamole drug:

1. Anna. When I became pregnant, I had to take all the tests. They found hyperaggregation of platelets. The doctor immediately appointed a quarantine, but immediately made a reservation that he had a cheaper Russian analogue of "Dipiridamol". I did not hesitate to buy it. I was prescribed a continuous intake of 75 ml once a day. And what can I say, the drug helped me, all the indicators have decreased and are now within normal limits. Pregnancy proceeds well, the viscosity of the blood decreases, there is no edema. After childbirth, I will also continue taking it as indicated by the testimony.

Most of the reviews about Dipiridamole were left by the patients who were assigned to it during pregnancy. Almost all of them praise this drug for its effectiveness, and only a few note the manifestation of such side effects as a sharp drop in blood pressure and dizziness.

Individuals who were prescribed this medicine for coronary heart disease and atherosclerosis also argue that dipyridamole helped them to significantly alleviate the condition.

Analogues

Structural analogs for the active substance:

• Courantil;
• Parsedil;
• Persantin;
• Sanomil Sanovel.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Store at temperatures up to 25 ° C, tablets - in a dry place. Keep away from children.

Shelf life: tablets - 5 years, suspension - 2 years.

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