Nimesulide: tablets, ointment, gel - instructions for use

Nimesulide - instruction on the use of an anti-inflammatory drug for children and adults

If you need a product that has an anti-inflammatory effect that will help reduce pain, heat, then pay attention to a non-steroid substance such as nimesulide. It is produced in different pharmacological forms. Detailed instructions for nimesulide for proper use are given below.

Application of Nimesulide tablets

Nimesulide is part of many medications, as it has an instant anti-inflammatory and analgesic effect.

In pharmacies, it can be found in the form of powders and ointments that are inexpensive, but the most popular are tablets.

The use of nimesulide is only after consultation with the doctor and the instructions, because if used improperly, serious side effects are possible. A suitable dosage will help to get rid of unpleasant symptoms.

It is important to understand that a medicine with nimesulide will relieve you of the symptoms of the disease, but it will not eliminate the ailment itself.

According to the instructions for use, the substance has three main areas of work:

• elimination of heat;
• anti-inflammatory effect;
• anesthesia.

The medicine received a large number of positive reviews and is actively used in medicine. If you do not know what helps nimesulid, check out this list:

• rheumatism;
• problems of the musculoskeletal system;
• osteochondrosis;
• inflammation of the tendons;
• pain in the muscles.

Today, a large number of medicines are on the market, including nimesulide.

They differ not only in the mark of production and in price. The form of release plays a big role in the effectiveness of the action.

To choose the right one for your case, you need to familiarize yourself with their full list:

• pills;
• powder;
• gel;
• ointment;
• syrup;
• ampoules (solutions for injections).

Composition of Nimesulide

Specialists refer the substance to the group of sulfonamides. Nonsteroidal anti-inflammatory drug quickly removes heat, prevents the formation of edema.

The composition of the preparation allows a short time to eliminate the disorder in the tissues, while not having a harmful effect on the human body. Gels and ointments are based on thimerosal and alcohols.

As for the dragees, corn starch and aspartame predominate there.

Nimesulide preparation - instructions for use

According to the observations of doctors, the substance, like its analogs, always gives a tangible effect, but it is better to keep it in the extreme case.

A large number of contraindications suggests that the instruction of nimesulide is very important for familiarization.

There are certain rules of use, which can not be forgotten:

• Pills. Take inside 1 piece 2 times a day. Dragee should be washed down with plenty of clean water. The maximum daily dose should not exceed 400 mg.
• Powder. It is accepted as a dragee, but its price is slightly more expensive. The daily dose should not exceed 400 mg.
• Creams and gels. Apply a small amount of ointment to the affected area 3-4 times. Use on top of the patch is not recommended.

Nimesulide tablets

The most widespread form of release. Nimesulide in tablets can be found in pharmacies under different names. Depending on the country of the manufacturer, the price may vary considerably.

The most popular commercial names are Nimesulide, Floelide, Ameolin. Dragee can dissolve with water. A day allowed to take 2 or a maximum of 4 pills. The total amount of the drug per day should not exceed 400 mg.

Tablets are consumed 2 times a day after meals.

Nimesulide powder - instructions for use

This form of release of the drug, like powder, perfectly replaces the pellet. Helps to blunt toothache, aching sensations in the lower abdomen during menstruation, fever during colds.

An adult patient needs to consume 100 mg of powder 2 times a day after eating. Dilute the granules in warm water. If this dose does not give a result, it can be doubled.

The course of treatment lasts no more than 15 days.

The most famous powders of this category are Nimesil and Nemuxle.

They can be prescribed for gynecological diseases, dental, headaches and other ailments that require immediate elimination of unpleasant sensations, inflammations.

With prolonged admission, it is better to act according to the doctor's prescription. If the patient has hepatic insufficiency, then Nimesulide powder is allowed only in the amount of 100 mg.

Nimesulide Gel - instructions

Gel is prescribed in the presence of problems with the musculoskeletal system. If the patient feels pain in the joints, then squeeze out a small amount of creamy substance and apply massage movements on the affected area.

To rub the Nimesulide Gel it takes a few minutes. To get a quick result, the procedure should be repeated 3-4 times a day.

Please note that the gel can not be applied to open wounds and can not be affected by various dermatological problems.

Nimesulide Ointment - instructions for use

Here the situation is almost the same as with gels. Apply Nimesulide ointment is necessary for pain sensations in the joints according to the instructions.

Regular rubbing of a creamy substance will allow you to get rid of an unpleasant feeling in a few days. The procedure should be 3-4 times a day.

The price of ointments is slightly lower than the cost of gels, especially when it comes to the domestic manufacturer.

Nimesulide suspension for children

The use of substances by children under 12 years is prohibited, but in practice, not one case is known when the medicine has negative consequences. The child should be given a suspension or syrup.

Such a pharmacological form of release is considered safe for children's health. The main indication for small patients is high fever in ARVI.

It should be remembered that such a suspension for children is given in cases where simple paracetamol does not give the desired effect.

.

Calculation of the dose for the child should be done very carefully, because the medicine is strong. The standard formula for determining the amount of the drug is as follows -3 mg per 1 kg of the weight of the baby.

.

Given the activity of the substance, the dose obtained should be divided by 2. The volume found is the daily amount of the drug, which is taken in 2-3 approaches.

If this dose of suspension or syrup per day does not give an effect to the baby, it can be increased by 1/3.

Contraindications nimesulide

The drug has a pronounced effect, so you need to be extra careful during the application.

If you want to take nimesulide, it is worth knowing the instructions and the fact that it is forbidden to those who suffer hypersensitivity, bronchial asthma, as well as intolerance to non-steroidal anti-inflammatory medicines.

Do not use it and those who are addicted to drugs, drink alcohol, have flu symptoms. In addition to the above, there are such contraindications to the use of nimesulide, indicated in the instructions:

• stomach ulcers and other gastrointestinal problems;
• hemophilia;
• heart, liver or kidney failure;
• pregnancy;
• lactation;
• children under 12 years.

Non-categorical contraindications are heart failure, diabetes, smoking cigarettes. It is worth paying attention to the compatibility of the drug with antiplatelet agents.

With caution, the use of non-steroidal agents in elderly people is recommended.

If there are relative contraindications, a specialist's consultation is mandatory, otherwise serious side effects may occur: nausea, vomiting, bleeding in the stomach.

The price of nimesulide

Nonsteroidal drug has a very strong effect, so you must choose only the original drug. Buy it best in a simple pharmacy. So you can be sure that you will not fall for a fake.

If you want to save money and buy a medicine inexpensively, you can always order it in an online pharmacy with delivery. The price of a nimesulide there will be a little cheaper, but you will have to wait. It is worth remembering that the cost of the drug depends on the form of release.

The table provides more detailed information.

Form of issue	Price of the facility
Pills	From 40 rubles
Powder	From 120 rubles
Ointment	From 75 rubles
Gel	From 110 rubles

: Analogues of nimesulide

Reviews

A source: http://sovets.net/8087-nimesulid-instrukciya-po-primeneniyu.html

Tablets, gel and powder Nimesulide: instructions for use, indications, price and reviews

Nimesulide is a substance that acts as the main active ingredient in preparations with different names depending on the manufacturer.

Pharmacological group

The drugs belong to the group of non-steroidal anti-inflammatory drugs.

NSAIDs block the action of the COX substance, which is produced under certain circumstances from arachidonic acid (located in the cell membrane). The cyclooxygenase enzyme can be of two types: COX-1 and COX-2.

Preparations of a new generation stop the effect of COX-2, and only to a small extent affect COX-1.

The first isoenzyme is responsible for the regulation of certain processes in the body, including those affecting the healthy state of the gastric mucosa.

The weakening of its action leads to a number of undesirable effects.

Blocking COX-2 quickly relieves pain and inflammation, although the cause of these phenomena remains.

In a comprehensive program, these actions prepare the patient for the opportunity to move to another stage of recovery.

Such NSAIDs are classified as a selective class.Nimesulide is one of the first representatives of a new generation of non-steroidal drugs.

Form of issue

Producers offer medicine in four forms:

The form	Name of the facility	Manufacturer
pills	Nimesulide-MaxPharma NimesulideNimulide	Inta Pharmaceuticals ZAO Lekhim-Kharkiv Panacea Biotec
suspension	Nize
powder	nemeleksNimesil	Ромфарм КомпаниЛаборатории Menarini
gel	Nimoolidnise	Panacea Biotech Radish

Composition

The form	The main component	amount	Additional substances
pills	nimesulide	100 mg in tablet	hydroxypropylcellulose, sodium lauryl sulfate, calcium, magnesium stearate, lactose monohydrate, croscarmellose, talc, cellulose, aerosil,
powder	nimesulide	100 mg per 2 g of granules in a sachet	citric acid, ketomacrog, pelstic flavor, aldodextrin, sucrose,
gel	nimesulide	1%	ethyl alcohol, carbomer, dimexide, macrogol.

Therapeutic effect of the drug

• It is an excellent analgesic, relieves fever and inflammation.
• It shows antioxidant properties, protects cells from oxidation.
• Liquefies blood, reduces thrombosis.
• The effect of the drug reduces the possibility of bronchial spasm.
• Creates resistance to the destruction of cartilaginous tissue, its collagen fibers.

Indications for use

Nimesulid is appointed by a doctor, self-medication is unacceptable.

The drug is recommended for use in case of such symptoms and diseases:

• osteoporosis,
• painful consequences of trauma,
• rheumatoid arthritis,
• inflammation of tendons,
• arthralgia,
• arthritis of different nature,
• pain in the muscles,
• Bechterew's disease,
• osteochondrosis,
• sciatica,
• lumbago,
• radiculitis,
• rheumatism,
• headache
• acute pain in ARI, sore throat,
• increased temperature in inflammatory processes,
• pain in joints with gout,
• attacks of acute pain in the joints, muscles, ligaments,
• algodismenorea,
• postoperative period.

Contraindications

It:

• intolerance of the components of the agent,
• children can be taken after 12 years,
• categorically it is impossible to apply at pregnancy,
• ulcer pathologies in the digestive organs,
• period of lactation,
• hypertension,
• heart failure,
• internal bleeding,
• renal and hepatic insufficiency.

Side effects

During treatment with the drug, undesirable effects are rare.If there are any side effects of the remedy, it should be canceled.

Possible manifestations:

• drowsiness,
• rashes on the skin,
• itching,
• nausea,
• palpitation,
• dizziness,
• anxiety,
• fluctuations in pressure,
• asthma attacks.

Nimesulide: instructions for use and dosage regimen

Determine how much the patient should consume and the length of the course should the specialist. He will be able to take into account the age, the depth of the problem, the personal characteristics of the user and the compatibility with the medicines already in use.

The photo depicts the non-steroidal anti-inflammatory drug Nimesulide

Usually the drug is prescribed according to the instructions.

• Nimesulide TabletsThe maximum allowable dose of nimesulide per day is -400 mg, the usual intake is 200 mg. Tablets are recommended to be used one at a time two times a day and, if necessary, can be increased to the maximum number per day - four tablets. Take the remedy before meals, if discomfort in the digestive organs occurs, postpone the reception at the time after eating, you can eat while eating. If the tablets are soluble, the content in one active substance is half that (50 mg). Therefore, they are recommended to use the same scheme as insoluble, but increase the dose by half. Two tablets twice a day, if this is not enough to bring to the maximum rate - eight tablets. Soluble tablets are always consumed at the end of eating or after it.
• Powder of NimesulideThe contents of the sachet are dissolved in water. Powder is poured into half a cup of liquid and a suspension is obtained. Take the solution after eating. Norm for a day - two sachets.
• Gel (ointment) NimesulideExternal means used to relieve pain and inflammation with the delivery of the substance directly to the location of the problem. The drug is applied to the skin, the projection site of the pain signal. Use ointment or gel not more than four times a day, rubbing with light movements. At once apply three centimeters of the drug. On the irritated skin or open wounds the drug can not be used.

Overdose

If for the patient the dose of reception turned out to be large, then his body can signal by reactions similar to the side effects:

• drowsiness,
• nausea,
• dizziness,
• vomiting,
• pressure drops,
• stomach ache,
• anaphylactic reactions.

In these cases, the use of nimesulide is canceled. You should see a doctor for symptomatic treatment.

In pregnancy

During pregnancy, nimesulide preparations are prohibited. This is due to the fact that the substance acts on the synthesis of prostaglandins. They have the function of participating in labor.

It is possible to overdo the child or other violations. In the world practice, these funds are not prescribed for pregnant women.

Compatibility with alcohol

It is inadmissible to use drugs nemesila and alcohol intake. The consequences can be the most difficult. The liver gets a devastating blow of great strength.

It should be strongly discarded during treatment for alcoholic beverages.

Meloxicam or Nimesulide?

Preparations of similar action. Both belong to the NSAID group, selective.

You can do the same if you take a load on the liver when you take nimesulide.

Price

The cost of the product may differ in different pharmacies, the average price is indicated:

Form of preparation	The cost of the river.	Amount in a package
powder	65022	30 bags of 100 mg1 sachet
pills	130	tablets 10 pieces of 100 mg
gel	216	tube 30 g, 1%

Analgesic Pain Medications

Means containing nimesulide, which are analogues:

• mesulide,
• prolid,
• floid,
• nyz,
• amoeoline,
• nimulex,
• kokstral,
• neolide,
• nimesulide,
• nimika.

Reviews

Users respond about the ability of the drug to quickly help with pain and inflammation.Especially note the effective action of powders.

Taken to the doctor's prescription for various types of pain, including intercostal neuralgia, pain in the spine with osteochondrosis, viral respiratory diseases, joint pain and describe that the negative symptoms were gone fast.

Patients who drank tablets received good results for colds, discomfort in the back and joints. The use of the gel brings relief in the place of application, absorbs well, relieves inflammation.

A source: http://OsteoHondroza.net/medikamenty/preparaty/nimesulid.html

Nimesulide

Composition

Nimesulide tablets contain 100 mg of active ingredientnimesulide, as well as auxiliary substances.

Form of issue

Produced in the form of tablets.

The active substance in the form of a powder (granules for the preparation of a suspension) is contained in preparationsNyz, Nimesil, Nemux.

In the form of a gel (ointment), the active substance is contained in preparationsNyzandNimoolid.

pharmachologic effect

Nimesulid - what is it?

Nonsteroid, inflammatory agent. The drug has antiplatelet, antipyretic, analgesic and anti-inflammatory effects.

Pharmacodynamics and pharmacokinetics

The principle of action is aimed at inhibiting the synthesis processprostaglandinsin an inflammatory focus, to selectively inhibit cyclooxygenase-2.

Indications for use of Nimesulide

From what tablets?

Indications for the use of Nimesulide are: osteoarthritis, rheumatoid arthritis, bursitis, tendonitis, arthritis of various genesis.

The drug is prescribed for relief of acute pain syndrome with myalgia,algodismenorea, toothache,arthralgia, headache, in the postoperative period.

The drug does not affect the progression of the disease, it is effectively used for reduce the severity of the inflammatory process, to reduce pain, and as a symptomatic therapy.

Contraindications

Nimesulide is not prescribed for erosive and ulcerative diseases of the digestive tract, for bronchial asthma, for intolerance to drugs of the NSAID group, for cerebrovascular and other bleeding, withulcerative colitis, inflammatory bowel disease,hemophilia, Crohn's disease, a recurring form of polyposis of the paranasal sinuses and nose, with active bleeding in the gastrointestinal tract, with a violation of blood clotting.

The drug is not used in the progressive pathology of the renal system, with a pronounced form of renal failure, with hepatotoxic reactions against the background of nimesulide in history, with active diseases of the hepatic system, with a decompensated form chronicheart failure, when pregnant, withhyperkalemia, children up to the age of 12, with simultaneous use of other hapatotoxic drugs, in the period afteraortocoronary shunting.

Side effects

Use of the drug Nimesulide can cause a number of side effects.

Central nervous system:Reye syndrome, headache, "nightmarish" dreams, fear, anxiety, dizziness, nervousness.

Skin: increased sweating, itching, rashes, dermatitis, erythema,angioedema, toxic epidermal necrolysis, multiform erythema exudative,hives, Stevens-Johnson syndrome.

Urinary system:interstitial nephritis, renal failure, hematuria, dysuria, urinary retention,oliguria.

.

The digestive tract: cholestasis, gastritis, flatulence, constipation, increased level of liver enzymes, bleeding from the gastrointestinal tract, vomiting, nausea, diarrhea syndrome, jaundice, fulminant hepatitis, epigastric pain, perforation and ulcerative wall lesions stomach.

.

Organs of hematopoiesis: increased bleeding time,hemorrhages, purpura, pancytopenia, thrombocytopenia, anemia.

Respiratory system:bronchospasm, shortness of breath, possibly exacerbation of an existing bronchial asthma.

Organs of Senses: Visual impairment in the form of blurred vision.

Cardiovascular system: "tides" of blood flow to the skin of the face, drop in blood pressure, rapid heart rate. Also observed is hypothermia, general weakness, increased levels of potassium ions.

Instructions for use Nimesulide (Method and dosage)

Nimesulide tablets, instructions for use

The drug is taken twice a day for 50-100 mg, preferably after eating. With a pronounced pathology of the renal system, the daily dosage is 100 mg. It is recommended to use the drug as minimally as possible in minimal, but effective doses.

Instructions for use Nimesulide Maxpharma is similar.

Powder with nimesulide

This form of release is used in other drugs. How to use, read the appropriate instructions for the drug Nemuxle.

Overdose

May be manifested by nausea, vomiting, increased drowsiness. There may also be signs of apathy, bleeding in the stomach and intestinal tract, increased blood pressure, respiratory depression.

Gastric lavage, the use of activated charcoal, treatment for symptoms are used.

Interaction

Riskhepatotoxic effectssignificantly increases with the simultaneous use of hepatotoxic drugs. The drug improves the effectiveness of anticoagulants. When taking furosemide, there is a decrease in the severity of its diuretic effect.

Nimesulide supplantssalicylic acid, fenofibrate and furosemide from bonds with proteins. The drug raises the level of concentration of lithium ions in the blood plasma.

The drug can increase the toxicity of methotrexate, enhance the nephrotoxic effect of cyclosporine. The risk of gastrointestinal bleeding increases with simultaneous therapy with selective serotonin reuptake inhibitors, glucocorticosteroids.

Terms of sale

A recipe is required.

Storage conditions

In a dark place inaccessible to children at a temperature of no more than 25 degrees Celsius.

Shelf life

Not more than 3 years.

special instructions

Patients in the period of treatment with Nimesulide are encouraged to monitor the liver system twice a month. With increasing levels of liver enzymes, the appearance of itching, rashes, pain in the epigastric region, jaundice, with darkening of urine treatment is discontinued.

Reviews of the Nimesulide drug indicate a visual impairment in patients who have been taking the drug for a long time.

When registering any changes on the part of the eye, the therapy is stopped, the mandatory completeophthalmological examination.

The drug can not replace the preventive effectantiplatelet agents, despite a marked decrease in the rate of platelet aggregation. The drug is not prescribed to women planning a pregnancy due to a negative effect onfertility. Nimesulide may affect the management of motor vehicles.

Analogues of Nimesulid

Analogues of Nimesulide are drugs:Amoeolin, Aponil, Mesulide, Nyz, Nygan, Nimegesic, Nimesil, Nimesin, Nimid, Nimujet, Nimoolid, Nimuspaz, Remesulid, Remisid, Sulidine.

Reviews of Nimesulide

The vast majority of reviews about Nimesulide are positive color. The medicine is very effective for relieving pain symptoms, temperature, various kinds of inflammation. The drug helps quickly and its effect is long-lasting.

A source: http://medside.ru/nimesulid

Nimesulide: instruction, description, contraindications to the use of tablets and gel (ointments)

Nyz is a preparation of a group of non-steroidal drugs, which removes the inflammatory process. The main active substance of the drug is nimesulide. It contains 100 mg per 1 tablet. The auxiliary components of the drug include lactose, povidone, castor oil and microcrystalline cellulose.

Features of the drug and indications for use

Nays from the Teva brand has anti-inflammatory, analgesic and antipyretic effects.

Its active component is able to penetrate into the focus of pathology and synovial fluid.

The drug is indicated for use as one of the auxiliary means of getting rid of joint diseases.

Nimesulide can be presented in the following dosage form:

• pills;
• suspension;
• gel for external use;
• lozenges;
• granules for solution preparation.

In each case, the doctor will select a form of the drug for the patient that can be as effective for him as possible. The instruction for use states that Nyz is shown when:

1. bursitis;
2. complex treatment of psoriatic, rheumatoid arthritis, osteochondrosis, osteoarthritis, spondyloarthritis;
3. acute manifestation of gout and to eliminate joint syndrome;
4. inflammatory process in the ligaments and tendons.

In addition, the drug is recommended for pain relief after surgical intervention, with injuries of varying intensity, dental, headache, algodismenorea and arthralgia. It is good to use it in the development of fever, which occurs after infection with infectious and inflammatory diseases.

Nyz gel and ointment is used to get rid of the pain syndrome caused by joint problems, myalgia and various limb injuries.

It is indicated for complex therapy with the aim of eliminating the symptoms of the disease, but it can not affect its progression.

Who is contraindicated?

The drug can not be used for individual intolerance of its main active substance and additional components. Also it is impossible to take Naise from Teva in case of diseases:

• erosive and ulcerative;
• gastric bleeding;
• acute rhinitis;
• hepatic and renal insufficiency;
• disorders of blood clotting;
• bronchospasm;
• urticaria;
• severe heart failure;
• lesions of the gastrointestinal tract.

Contraindicated in pregnancy and lactation. It can cause serious violations in the fetus. In addition, to abstain from nimesulide follows those patients who have recently undergone aortocoronary bypass surgery.

Children up to the age of 12 years can not be prescribed a drug in tablets. In pediatric practice, it is customary to use a suspension.

.

Nase gel is forbidden to use when intolerance of its active or additional substances. Do not apply to open wounds, mucous membranes and damaged skin.

.

Instruction for use warns that with special care tablets are prescribed under such conditions:

• ischemic heart disease and congestive heart failure;
• diabetes mellitus of any degree;
• diseases of peripheral arteries;
• in old age;
• smoking and regular consumption of alcoholic beverages;
• prolonged use of other non-steroidal anti-inflammatory drugs;
• severe somatic disorders;
• combined therapy with the use of anticoagulants, selective serotonin reuptake inhibitors, antiaggregants, oral glucocorticosteroids.

Method of application and dosage

The appointment of Nyz from Teva should be done by a doctor.

Drug use can be carried out up to 2 times a day immediately after ingestion or during it. The tablets are washed down with a large volume of water.

If the patient suffers from kidney failure, the maximum daily dose should be reduced.

The gel is applied to the affected areas with a thin layer and is not rubbed. Multiplicity of application - 3-4 times a day. Avoid getting the drug on the mucous membranes and eyes. After using the medicine, you should wash your hands thoroughly.

Side effects and cases of overdose

When using the Nyz (gel, tablets), side effects from the side can be noted:

1. the digestive tract. Dyspeptic disorders are possible: diarrhea, nausea, vomiting, gastritis, flatulence, abdominal pain, stomach ulcer and duodenal ulcer, stomatitis, gastrointestinal bleeding;
2. central nervous system. There is a development of feelings of fear, headache, drowsiness, nervousness, nightmarish dreams, dizziness;
3. development of allergies: anaphylactic reactions, hypersensitivity;
4. sense organs. Possible impaired vision;
5. skin integument. There is a rash, itching, redness, excessive sweating, swelling, dermatitis, exudative erythema;
6. urinary system. There may be a delay in urine, hematuria, swelling;
7. organs of hematopoiesis. It is rare enough to develop anemia, an increase in the duration of bleeding, thrombocytopenia.

If the patient has had at least one of the considered undesirable effects after he used the gel and other forms of the drug, then a change in the approach to its use is provided. You should consult your doctor for advice.

In case of an overdose by Nyz from Teva, the patient may experience attacks of nausea, vomiting, drowsiness and apathy. Such reactions are completely reversible and can be eliminated in the provision of medical care.

When there was a use of high doses of the drug (tablets, gel) for the last 4 hours, then you can do a lavage of the stomach, take activated charcoal (or any other sorbent) and laxative a drug.

Specific guidance and interaction with other drugs

Nays from Teva should be taken in consideration of its possible interaction with other medications. Provided simultaneous use with funds that contribute to reduce blood clotting, there is a high probability of increasing their pharmacological effect on the body.

When used in parallel with Furosemide and antihypertensive drugs, their therapeutic effect may be reduced. The drug may increase the risk of gastric bleeding when used concomitantly with drugs:

• group of glucocorticosteroids;
• non-steroidal anti-inflammatory;
• inhibitors of serotonin reuptake.

It is possible to increase the concentration of lithium in blood plasma under the condition of use with those drugs that contain this substance. With the use of nimesulide with cyclosporine, a detrimental effect on the kidneys can be exacerbated.

With extreme caution, the drug should be used by patients who have a predisposition to develop bleeding.

The use of Naise (tablets, gel) can also cause delays in the body fluid.

This should always be taken into account by patients with high blood pressure and impaired proper functioning of the heart and blood vessels.

.

People whose professional activity requires increased concentration of attention must take into account that Naise can influence psychomotor reactions.

.

In other words, the drug becomes a constant cause of drowsiness and development of dizziness. Instruction for use draws special attention to this.

How much is and what to replace

The cost of Naise from Teve depends on many factors, however, the average price will be:

• tablets of 100 mg (20 pieces) - from 50 to 70 rubles;
• tablets of 100 mg (120 pieces) - within 2500 rubles.

Analogues of the drug are medicines: Nimid, Nimesil, Nimegesik, Nimulid. Each tool is accompanied by an instruction for use.

A source: http://sustav.info/lechim/medikamenty/nimesulid.html

Nimesulide

This anti-inflammatory non-steroidal agent has an antioxidant, analgesic and antipyretic effect on the human body.

Nimesulide is produced in various forms: tablets, soluble tablets, suspension, powder for its preparation and gel.

Assign them for arthritis, osteoarthritis, gout, bursitis, tendinitis, tendovaginitis, to eliminate pain after operations, injuries, with gynecological diseases, for removing heat in infectious-inflammatory diseases.

Powder of Nimesulide

Nimesulide powder is intended for oral administration. It is bred in drinking water to produce a suspension. The contents of the sachet must be dissolved in half a glass of water and drink after eating. Do this procedure no more than 2 times a day.

Children under 12 years of age are not eligible for the drug, and for patients with renal insufficiency the dosage is 1 packet per day. Nimesulide can be taken continuously for 2 weeks.

Nimesulide in the form of a powder is a medication Nimesil, Nyz, Mesulid, Aulin, Nemux, Flolid.

Suspension of Nimesulide

A syrup or suspension of Nimesulide is available under the names Nimulid and Naise. They are designed for children under 12 years. 1 ml of the suspension contains 10 mg of the active ingredient.

Dosage is calculated from the body weight: for each kilogram of body weight you need -3 mg per day. The daily dose should be divided into 2-3 doses. The maximum dosage per day is 5 mg per 1 kg of body weight.

The package contains a measuring syringe for convenient measurement of the required dose. More than 2 weeks to give the drug can not be, otherwise side reactions may develop.

Gel Nimesulide

Gel Nimesulide is intended for external use and is prescribed to eliminate soreness in soft tissues and joints, with injuries of ligaments and muscles, with stretching.

Apply the gel on a dry and clean skin with light massage movements in a thin layer. Do not rub the gel, it is also not recommended to apply an airtight bandage.

.

Use the drug should not be more than 4 times a day, and after use, you should thoroughly wash your hands with soap.

.

If you follow the correct treatment regimen, then no adverse reactions are observed, but local skin reactions in the form of itching, flaking and redness are possible.

Nimesulid children

In Ukraine and Russia Nimesulide is banned for use in children because of the risk of developing hepatitis (as indicated by manufacturers).

But in fact, no cases of hepatitis due to the use of this drug have been identified, so it is often prescribed to children as an effective anti-fever drug.

Dosage is calculated as follows: for each kilogram of body weight should be -3 mg per day, dividing the dose into 2-3 doses. 1 ml of the suspension contains 10 mg of the active ingredient.

Analogues of Nimesulid

Nimesulid has many analogues according to the ATS code, the composition of the active substance and the form of release. These are Ameolin, Aponil, Nise, Nimesin, Nimid, Nimulid and Remesulid. All of them have an active component of nimesulide in their composition.

Ameolin, Aponil, Nimesin, Naise, Remesulid and Nimulid are used for acute pain, primary dysmenorrhea and osteoarthritis for the removal of pain syndrome.

Nimide is available in the form of a gel for external use and is used for rheumatic diseases of joints and soft tissues (bursitis, spondylitis, osteoarthritis, tendinitis), postoperative pain syndromes, painful muscle spasms, gynecological diseases, manifested by pain syndrome and inflammation, adnexitis.

Content of the site: Dmitry N.

Name:

Nimesulide

Pharmacological
act:

Nimesulide -nonsteroidal anti-inflammatory drug; belongs to the class of sulfonanilides.

Selectively inhibits cyclooxygenase-2 (COX-2), which promotes the synthesis of prostaglandins (PG), which are direct mediators (factors) of inflammation, pain and edema.

The drug has an inhibitory effect both directly on prostaglandins E2 (and in the centers of inflammation, and on the way of impulses from the spinal cord), and on their predecessors - short-lived prostaglandins H2, which is why Nimesulide has a pronounced anti-inflammatory, analgesic and antipyretic Effect.

Activates glucocorticoid receptors, which leads to an increase in the anti-inflammatory activity of the drug.

The drug has very little effect on cyclooxygenase-1 and the mechanism of the formation of PG E2 from arachidonic acid, which reduces the side effects of Nimesulide compared with other non-steroids.

.

Suppresses the synthesis of urokinase, interleukin-6 metalloproteases (collagenase, elastase) and therefore prevents the destruction and decay of cartilaginous tissue.

.

The drug affects the aggregation of platelets, suppressing it by inhibiting the synthesis of thromboxane A2, endoperoxides and aggregation factor.

Nimesulide dramatically reduces the release of histamine and cytokines, the latter affecting by inhibiting the release of tumor necrosis factor-b. Does not affect the activity of phagocytosis and hemostasis. Detects antioxidant properties.

By reducing the activity of myeloperoxidase,reduces the formation of toxic free radical decomposition products of oxygen, which leads to inhibition of lipid peroxidation.

Indications for
application:

Osteoarthritis; - extra-articular rheumatic diseases; - pain and inflammation after surgical intervention; - pain and fever in acute inflammatory processes in the upper respiratory tract;

Pain associated with dysmenorrhea.

Mode of application:

Inside for 100 mg of the drug (1 tab. or an appropriate amount of suspension) twice a day, with the aim of leveling possible complications, preferably after eating.

The drug should be washed down with a sufficient amount of water. The maximum daily dose of Nimesulide is 400 mg. The duration of treatment is selected individually.

Long-term use of the drug is performed under mandatory systematic monitoring of kidney and liver function of the patient.

Gel. Approximately 3 cm of gel (1%) is applied externally to the affected area and is easily rubbed, applied no more than four times a day. Do not use under a bandage.

Side effects:

Nimesulide is well tolerated by patients, but in very rare casespossible adverse reactionsdrowsiness; - dizziness and headache; - nausea and vomiting; - gastralgia and heartburn; - ulceration of mucous membranes and melena; - oliguria and hematuria; - exanthema and urticaria;

- anaphylactic shock.

It is possible to change the blood picture: anemia, leukopenia, agranulocytosis, thrombocytopenia, prolongation of bleeding time.

With external application possible:erythema, local irritation, rash, itching, and discoloration of the skin, peeling of the skin at the site of application of the gel.

Occurrence of any adverse reactions is a reason for stopping the drug and following a doctor's advice.

Contraindications:

Absolute contraindications: - pregnancy; - Children's age (up to 12 years); - the presence of ulcerative pathologies and bleeding, diagnosed in the gastrointestinal tract; - "aspirin" asthma;

- hepatic and renal insufficiency.

Relative contraindications: - gastric ulcer changes; - heart failure; - arterial hypertension; - lactation period; - hypersensitivity to other anti-inflammatory non-steroids in the anamnesis.

In allergic reactions to other NSAIDs, Nimesulide is administered with caution, although it has already been shown that it can be safely used in these cases.

Carefullyshould be used orally in patients with impaired renal function, with hypertension, with cardiac disorders, and visual impairment. In case of external application, the doctor needs to monitor the condition of elderly patients with impaired renal function, liver function, and congestive heart failure.

When used in pediatrics, dosage forms intended for children should be used.

Impact on the ability to drive vehicles and manage mechanisms
Because nimesulide may cause dizziness and drowsiness when administered orally, caution should be exercised with it patients involved in potentially hazardous activities requiring increased concentration of attention and rapid psychomotor reactions.

Interaction with other medicines

means:

.

By displacing certain drugs from places where they are linked to plasma proteins, Nimesulide can significantly increase both their effectiveness and the toxicity of these drugs.

.

Simultaneous administration of Nimesulide and other drugssignificantly enhances the effects of cyclosporine, methotrexate, digoxin, phenytoin and lithium preparations, diuretics, antidiabetic and antihypertensive agents, as well as other NSAIDs.

There was no clinically significant effect on nimesulide and furosemide, warfarin, glibenclamide, theophylline, cimetidine, antacids.

Pregnancy:

Nimesulid is absolutelycontraindicatedduring pregnancy. The most dangerous is its use in the last trimester of pregnancy because of the possible provocation of atony of the uterus in the mother, and premature closure of the ductal fistula in the fetus.

During the lactation period, the drug can be prescribed only if breastfeeding is stopped for the period of treatment.

Overdose:

Symptoms: overdose may include nausea and vomiting, epigastric pain and gastrointestinal bleeding, drowsiness and lethargy, arterial hypertension and acute renal failure, respiratory depression and anaphylactic reactions up to shock and coma.

Treatment: there is no specific antidote. In case of an overdose of Nimesulide, the victims are prescribed only symptomatic treatment: gastric lavage and taking activated charcoal or other adsorbents during the first four hours.

Hemodialysis is not performed because it is not effective.

Form of issue:

Granules for the manufacture of suspension100 mg (, 0 packs per pack),oral suspension(60 ml),pillson 100 mg (10, 20, 30 pieces in the package),gel,% (30 g in a tube).

Storage conditions:

At room temperature, protect from light.

Composition:

1 tablet of Nimesulidecontains active substance: nimesulide g;

- auxiliary substances: lactose monohydrate, calcium hydrophosphate dihydrate, aerosil, cellulose microcrystalline, croscarmellose sodium, hydroxypropyl cellulose, talc, magnesium stearate, sodium lauryl sulfate.

1 g of Nimesulide gelcontains active substance: nimesulide 1 g;

- auxiliary substances: carbomer, macrogol 40, ethyl alcohol, propylene glycol, dimexide.

A source: http://MedHall.ru/nimesulid/