Pylobact

Pylobakt is a combined set of drugs used in the treatment and prevention of gastric and duodenal ulcers, gastritis caused by the action of Helicobacter pylori.

Each Pylobacte strip contains two capsules of omeprazole (20 mg each), two clarithromycin tablets (250 mg each) and two 500 mg tablets of tinidazole.

The average duration of treatment with the drug is 7 days.

Clinical and pharmacological group

An anti-ulcer drug that has a bactericidal effect on Helicobacter pylori.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Pylobact in pharmacies cost? The average price is at the level of1 300 rubles.

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Form of issue and composition

Pylobact is available in the form of capsules and tablets, packaged in strips, containing a daily dose for admission. Packing includes 7 blisters. Each strip, calculated for the day of treatment, contains:

• Omeprazole (20 mg) - 2 capsules;
• Clarithromycin (250 mg) - 2 tablets;
• Tinidazole (500 mg) - 2 tablets.

Pharmacological effect

Pharmacological group - combined medical preparations for excretion of the causative agent of Helicobacter pylori by the triple scheme of treatment (includes three medicinal preparations).

Pharmacological action of the drug:

• decrease in secretory activity of the stomach;
• normalization of the mucous membrane of the stomach, intestines;
• antimicrobial action, including with respect to Helicobacter pylori infection;
• inhibition of RNA synthesis of bacteria, including Helicobacter pylori infection.

The joint action of the following drugs included in its composition, guarantee a high eradication of Helicobacter pylori:

1. Clarithromycin is an antibiotic that belongs to the macrolide group and is active against Helicobacter pylori. Suppresses the synthesis of protein in the microorganism.
2. Omeprazole - reduces the production of gastric acid, regardless of the nature of the stimulus. After its reception, the substance begins to act in an hour.
3. Tinidazole - is capable of damaging the DNA of a pathogenic microorganism and suppressing its synthesis. It is characterized by high activity to anaerobes, amoebas, trichomonads, lamblia, and Helicobacter pylori.

In the preparation "Pylobakt Neo" and "Pylobact AM"replace "Tinidazol" with "Amoxicillin" - a semisynthetic antibiotic that damages and destroys bacteria at the cellular level during their active reproduction. The greatest concentration of the drug is achieved in an hour, after which a partial excretion of the body begins. The medication is assimilated by 75 - 90%. The tablet has an oval and convex shape on both sides with a dividing strip.

Indications for use

Pylobact is used for eradication therapy of Helicobacter pylori in the presence of peptic ulcer of the stomach and duodenum.

The drug has proven itself in the treatment of active chronic gastritis.

Contraindications

Contraindications to the use of the Pilobakt, which are approved in the official annotation to the drug, are such states:

• deficiency of kidneys, liver;
• pregnancy;
• blood diseases of various etiologies;
• allergy;
• lactation;
• children's age (not used in children under 16 years of age).

Use in pregnancy and lactation

The drug Pylobactum is not prescribed for the treatment of pregnant women, since the safety of drugs regarding the fetal development of the fetus is not established and there is no experience of application.

This drug is not prescribed for the treatment of peptic ulcer in nursing mothers, since the active ingredients are excreted in breast milk and may adversely affect the babe. If therapy is necessary for a woman, it is recommended to stop lactation.

Dosage and route of administration

In the instructions for use, it is indicated that the Pylobacter must take inwards one capsule of omeprazole, one tablet of clarithromycin and one tablet of tinidazole 2 times a day during or after meals in the morning and in the evening. Tablets and capsules can not be broken and chewed, they should be swallowed whole.

• Each Pylobacte strip contains two capsules of omeprazole (20 mg each), two clarithromycin tablets (250 mg each) and two tablets of tinidazole (500 mg each), and are calculated for 1 day of treatment.

Duration of treatment is 7 days.

Side effects

Pylobact rarely causes adverse reactions. When using the drug and analogs, the following side effects may appear:

1. Allergic reactions: bronchospasm, angioedema, hives, anaphylactic shock;
2. From the musculoskeletal system: arthralgia, myalgia, muscle weakness;
3. From the hemopoietic system: thrombocytopenic purpura, thrombocytopenia, anemia, neutropenia, leukopenia;
4. From the skin: itching; rarely a rash on the skin; in individual cases - alopecia, multiforme exudative erythema, photosensitivity;
5. From the side of the central nervous system: tinnitus, disorientation, increased fatigue, dizziness, drowsiness / insomnia, agitation, confusion, ataxia, headache, hallucinations, nightmares, fear, psychosis, paresthesia, weakness, depersonalization, epileptic reactions, convulsions, peripheral neuropathy, depression;
6. On the part of the digestive system: a metallic taste in the mouth, a taste disorder, dry mouth, stomatitis, diarrhea / constipation, flatulence, nausea, vomiting, decreased appetite, abdominal pain, dysbiosis, impaired liver function, transient increase in hepatic activity transaminases, hepatitis (including jaundice); rarely - pseudomembranous enterocolitis, in patients with a previous liver disease - encephalopathy;
7. Other: fever, visual impairment, tachycardia, increased sweating, interstitial nephritis, gynecomastia, peripheral edema.

Overdose

Overdose of Clarithromycin causes nausea. vomiting, diarrhea, headache, confusion. Gastric lavage and symptomatic treatment are required.

Overdose of Tinidazole requires symptomatic treatment and hemodialysis.

special instructions

Before you start using the drug, read the special instructions:

1. Tinidazole causes dark staining of urine.
2. With heart disease in the anamnesis, simultaneous administration with terfenadine, cisapride, astemizole is not recommended.
3. Before the beginning of therapy it is necessary to exclude the presence of malignant process, t. treatment, masking the symptoms, can delay the setting of the correct diagnosis.
4. Caution is prescribed against the background of taking medicines metabolized by the liver. In the case of co-administration with warfarin or other indirect anticoagulants, prothrombin time should be monitored.

During the treatment period, care must be taken when driving vehicles and occupying others Potentially hazardous activities requiring increased concentration and attrition psychomotor reactions.

Drug Interactions

When using the drug, it is necessary to take into account the interaction with other drugs:

1. Simultaneous administration of clarithromycin with indirect anticoagulants can potentiate the effect of the latter.
2. Simultaneous administration of clarithromycin with terfinadine increases the concentration of the latter and may lead to an elongation of the QT interval.
3. Omeprazole can slow the elimination of phenytoin, diazepam, warfarin, and also affect the absorption of ketoconazole, ampicillin and iron salts by inhibiting the secretion of acid in the stomach. Increases the inhibitory effect on the hemopoietic system and other medicines.
4. Tinidazole enhances the effect of indirect anticoagulants and the action of ethanol - disulfiram-like reactions are possible. It is not recommended to administer with ethionamide. Phenobarbital accelerates the metabolism of tinidazole.
5. At simultaneous appointment with clarithromycin levels of carbamazepine, cyclosporine, phenytoin, disopyramide, lovastatin, valproate, cisapride, pimozide, astemizole, digoxin can be increased.
6. Simultaneous appointment of theophylline and clarithromycin is accompanied by an increase in the concentration of theophylline. Clarithromycin decreases the absorption of zidovudine (between the use of drugs should be an interval of at least 4 hours). It is possible to develop cross-resistance between clarithromycin, lincomycin and clindamycin.

Reviews

We picked up some reviews of people who used the drug Pylobact:

1. Nadia. I suffer from diseases of the gastrointestinal tract for 2 years. The following diagnoses were made: gastritis, pancreatitis, dysbacteriosis, etc. I was diagnosed, treated with pills and decoctions. For 2 years, it became even worse, I went to a doctor, found a Helicobacter pylori infection, I was assigned a "Pylobact". Stops constipation and insomnia, there was an unpleasant sensation in the mouth. While I'm flying and waiting for improvements.
2. Olga. Has handed over the analysis of a blood on Helik and have found out this bacterium. I have been taking Pylobact for 5 days already. My intestines exploded, all the guts rumbled, sulked, such gases gurgled, that horror. But as all the bowels were ill, and most importantly near the navel and in the stomach it hurts. But I want to drink 7 days. I do not know what to do next. She began to drink coal a little more lightly.
3. Catherine. Two years ago I was diagnosed with a peptic ulcer of 12 duodenum. Long treated and observed a strict diet. After 4 months, I began to add a little sweet, salty and fat to my diet. After 2 - 3 months, the ulcer manifested itself. A friend told me about her treatment with Pylobacter, I did not want to go to the doctor and went straight to the pharmacy, but the pharmacist refused because of the lack of a prescription. I had to go to a specialist, after which I was sent for examination and appointed this drug for the intended purpose. All the symptoms have passed, the ulcer has healed. A year later for the prevention of propyl is still a course of medicine, more illness does not bother.

Analogues

There are no structural analogues, since the preparation consists of components of different active substances. It is possible to select specific preparations containing this or that active component, after consulting a doctor:

• Omeprazole and amoxicillin;
• Fromromide;
• Peptipack;
• Pylobakt Neo;
• Clatinol;
• Peptic kobipek;
• Ezoxium combi;
• Helicocin;
• B-Clathinol.

Before using analogues, consult your doctor.

Storage conditions and shelf life

Pylobact is stored at a temperature below 26 ° C, in a dry place out of the reach of children. The storage period from the date of issue is 36 months.

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