Solution Angioflux

Angioflux is an anticoagulant drug, has an angioprotective, fibrinolytic and antithrombotic effect.

If there are clots inside the blood vessels, venous insufficiency occurs, cerebral circulation is disturbed, then you need to urgently go to the hospital. Otherwise, the patient may become disabled in the future. Save an expensive person from such problems will help the tool "Angioflux". This drug is prescribed only by the treating doctor, it is impossible to use it independently.

On this page you will find all information about Angioflux: the full instructions for use on this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Angioflux. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

The drug with antithrombotic and angioprotective action.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Angio Flux cost? The average price in pharmacies is at the level of1 600 rubles.

Form of issue and composition

The solution is intended for intramuscular or intravenous administration.

The solution contains 600 LE (lipoproteinipase unit) of sulodexide. 1 ml of the drug includes 300EU, respectively.

Also the preparation is offered in the form of capsules of 250 LE of active substance.

The number of capsules in the package is 50 pieces: 5 blisters for 10 capsules or 2 blisters for 25.

Pharmacological effect

Active active substance of the drug Angioflux - sulodexide - a natural product, a natural mixture of glucosaminoglycans, consisting of a high-speed heparin-like fraction (80%) and dermatan sulfate (20%), obtained by enzymatic extraction from the mucosa of the small intestine of pigs.

The mechanism of action of sulodexide is due to the interaction of both fractions:

• a high-speed heparin-like fraction has an affinity for antithrombin III (ATIII);
• Dermatan sulfate has an affinity for the cofactor of heparin II (CG II).

Angioflux has antithrombotic, profibrinolytic, angioprotective and anticoagulant effects.

1. The prophyllinolytic effect of the drug is due to the increase in the blood concentration of the tissue plasminogen activator (TAP) in the lumen of blood vessels and a decrease in the content of the inhibitor of the tissue plasminogen activator (ITAP) in the blood.
2. The mechanism of angioprotective action is associated with the restoration of the structural and functional integrity of endothelial cells vessels, restoration of the normal density of negative electrical charge of the pores of the basal membrane of the vessels.
3. The mechanism of antithrombotic action is associated with the suppression of the activated Xa and Pa coagulation factor blood, increased synthesis and secretion of prostacyclin, a decrease in the concentration of fibrinogen in the blood plasma.

The drug normalizes the rheological properties of blood by reducing the concentration of triglycerides, as it stimulates the lipolytic enzyme - lipoprotein lipase, hydrolysing triglycerides. The effectiveness of Angioflux in diabetic nephropathy is determined by its ability to reduce thickness basal membrane and the production of extracellular matrix by reducing the proliferation of mesangium cells.

Indications for use

Angioflux is indicated for use in the following cases:

• problems with blood vessels in diabetes mellitus, neuropathy, retinopathy;
• ischemic stroke;
• circulatory disorders of the brain;
• phlebopathy, thrombosis;
• risk of increased thrombosis after a stroke;
• thrombotic conditions.

Contraindications

• hemorrhagic diathesis and other diseases accompanied by hypocoagulation;
• pregnancy I trimester;
• hypersensitivity to sulodexide or one of the auxiliary components of the drug.

You should not prescribe angiocyte to patients with hypersensitivity to heparin and preparations of a similar type, since the molecular structure of sulodexide is similar to that of heparin.

Carefully:patients on a salt-free diet (due to the presence of sodium).

Application in pregnancy and lactation

Contraindicated in the first trimester of pregnancy. In the II and III trimester of pregnancy and during the period of breastfeeding, the medicinal product can be used only in cases extreme necessity, if the benefit to the mother exceeds the potential risk to the fetus and the baby, and under the supervision of the doctor

Instructions for use Angiofluix

The instructions for use indicate that the solution Angioflux apply IV (bolus or drip) or IM, 2 ml (1 ampoule) per day.

Side effects

Most side effects are manifested in the form of a rash, little pain at the injection site. Disturbances of digestion, diarrhea, vomiting, a feeling of nausea, a slight weakness are also possible. As a result of the introduction of the drug, an allergy occurs, but it manifests itself primarily at the site of administration of the drug on the skin.

Overdose

When an overdose of the drug, there is a possibility of bleeding, in this case, taking the medicine must be immediately discontinued, medical treatment is indicated and symptomatic treatment is indicated.

special instructions

Angioflux does not affect the rate of psychophysical reactions and the ability to concentrate.

In case of need for combined use of antiplatelet agents or anticoagulants, blood coagulation indicators should be monitored periodically.

Drug Interactions

Angioflux enters into drug interactions very rarely, with simultaneous admission with antiplatelet agents or anticoagulants it is required to periodically check the coagulability of blood. Do not simultaneously drink angioflux and heparin, as the effect of heparin increases.

The attending physician should be informed of all diseases and other medications.

Reviews

In the Internet reviews about the preparation of Angiophlux is not very much, the information on the forums is practically absent. In available reports, people write about the effectiveness of the drug for pain in the legs, burning in the feet - pathologies, which are often accompanied by diabetes. Patients noted an improvement in blood circulation, a positive effect on the damaged nerves. The effect is observed already a week after the start of treatment, the state of the venous system begins to improve markedly

Analogues

The analogues of Angioflux are: Hemapaxan, Heparin Sandoz, Fraksiparin, Cibor, Wessel Douay F.

Before using analogues, consult your doctor.

Storage conditions and shelf life

The drug is stored in a dry room. It is necessary to take into account the humidity of the air and the temperature of the air in the place of storage. The temperature should not exceed 30 degrees. It is better if the air is not cooled where the drug is located, below the mark of 5 degrees.

You can store Angiophlux for three years. After this, the use of the drug is prohibited.

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