Cetrin

Cetrin is an antihistamine drug that eliminates allergic symptoms, both in adults and in children.

Refers to a group of electoral means or gistaminoblokatorov. The active component, cetirizine, has a blocking effect on histamine, thus preventing its effect on the receptors. Also reduces the amount of histamine and prevents its migration to the focus of an already existing allergy, relieves inflammation. When applied, there is no pronounced sedative effect, the drug does not inhibit the central nervous system.

In 50% of patients after taking 10 mg of Cetirizine, the effect is manifested after 20 minutes, 95% of patients feel better 1 hour after taking the tablet / syrup. The duration of the blockade of the histamine receptors is more than 24 hours. In children under 2 years (including newborns) - approximately 12 hours.

Clinical and pharmacological group

The blocker of histamine H1 receptors. Anti-allergic drug.

Terms of sale from pharmacies

Can buywithout a doctor's prescription.

Price

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How much does Tsetrin cost in pharmacies? The average price is at the level of185 rubles.

Composition and form of release

The manufacturer produces the medicine in the form of:

film-coated tablets 10 mg (package No. 20 or No. 30);
syrup 1 mg / ml (bottles 30 and 60 ml).

Cetrin tablets contain 10 mg of cetirizine hydrochloride, as well as corn starch, lactose, povidone K30, magnesium stearate.

In Cetrin syrup, the active substance is contained in a concentration of 1 mg / ml. As auxiliary components in the preparation include: benzoic acid, sucrose, glycerin, disodium edetate, sorbitol solution, sodium citrate, a mixture of fruit flavors ID20181PH, purified water.

Pharmacological effect

The drug has the following effects on the body:

elimination of itching;
removal and prevention of edema;
decrease in permeability of capillaries and vessels;
decrease in the yield of fluid in the tissue;
removal of spasm of smooth muscles.

Cetirizine clears histamine receptors. Due to the therapeutic effect, the secreted histamine is unable to contact the receptors and can not have an irritant effect. Histamine is responsible for the development of allergic reactions. Cetrin blocks the development of allergic reactions in the cells of the body, which in turn helps reduce external manifestations of allergies - pain, itching, swelling, redness of the skin, etc.

The drug is able to reduce the secretion of histamine and reduce the concentration of eosinophils in the foci of allergic reactions that leads to a decrease in the number of eosinophils and significantly reduces the development of late stages of allergic reactions. Cetrine is recommended to be used as an anti-inflammatory drug, which adversely affects the production of cytokines, supporting their inflammatory process in the body.

In the treatment and prophylactic administration of the drug, its ability to reduce the development of allergic reactions in bronchial cells is noted, which reduces the number of asthma attacks. Cetrin is able to actively suppress the allergic reaction in people who suffer from dermographism and hives.

The effect of the drug is noted 20 minutes after its administration. The effect lasts for 24 hours. After 3 days after the termination of the use of Cetrin, readiness for new manifestations of allergic reactions is restored.

Indications for use

What helps? Cetrin should be used to relieve allergy symptoms in the following conditions:

seasonal or persistent colds;
allergic conjunctivitis;
manifestations of any type of hives;
Pollinosis;
strongly pronounced itching dermatoses: neurodermatitis, anatomical dermatitis, etc .;
angioedema;
skin itching (except for the instance).

Contraindications

The drug should not be used in patients with a known hypersensitivity to cetirizine, hydroxyzine or ancillary syrup / tablets components, in pregnant women and in lactating women.

In pediatrics, syrup is prescribed from a two-year old, and pills from the age of six.

Relative contraindications are advanced age and chronic renal failure. Patients with CRF and elderly people dosage of the drug is selected individually depending on the functional state of the kidneys.

Intended use for pregnancy and lactation

Contraindicated in pregnancy. In case of application in the lactation period, the child should be transferred to the formula for artificial feeding.

Use in Pediatrics

In view of the potential inhibitory effect on the central nervous system, caution should be exercised in prescribing cetirizine in drops to children aged up to 1 year if there are the following risk factors for the occurrence of sudden infant death syndrome (but not limited to this list):

sleep apnea syndrome or sudden infant death syndrome in infants from a brother or sister;
abuse of the mother of drugs or tobacco during pregnancy;
young age of mother (19 years and younger);
the abuse of tobacco by a nanny caring for a child (1 pack of cigarettes a day or more);
children who fall asleep face down on a regular basis, who are not laid on their backs;
premature (less than 37 weeks of gestation) or those born with insufficient body weight (below the 10th percentile of gestational age);
joint use of drugs that exert a depressing effect on the central nervous system.

Dosage and route of administration

As indicated in the instructions for the use of the pill and drop, the Cetrinum should be taken, regardless of the meal, with 200 ml of water.

Adults and children over 6 years of age the drug is prescribed in the form of tablets of 10 mg (1 tab.) 1 time / day or 5 mg (1/2 tab.) 2 times / day, or in the form drops - the initial dose is 5 mg 1 time / day (10 drops), if necessary, the dose can be increased to 10 mg (20 drops) 1 time / day. Sometimes an initial dose of 5 mg (10 drops) may be sufficient to achieve a therapeutic effect.
Children aged 6 months to 12 months are prescribed 2.5 mg (5 drops) 1 time / day; children aged 1 to 2 years - 2.5 mg (5 drops) up to 2 times / day; children aged 2 to 6 years - 2.5 mg (5 drops) 2 times / day or 5 mg (10 drops) 1 time / day.

Because cetirizine is excreted mainly by the kidneys, when the drug is prescribed for patients with renal insufficiency and elderly patients, the dose should be adjusted depending on the magnitude of the CC.

With CC> 80 ml / min (normal) or 50-79 ml / min (mild renal failure), the drug is prescribed in the usual dosing regimen - 10 mg (1 table. or 20 drops) / day. With SC from 30 to 49 ml / min (average degree of renal failure), the drug is prescribed at 5 mg (1/2 table. or 10 drops) of the drug 1 time / day. With SC from 10 to 29 ml / min (severe stage of kidney failure) of 5 mg (1/2 table. or 10 drops) every other day. With CC less than 10 ml / min (terminal stage of renal failure), the use of the drug is contraindicated.

CK for men can be calculated based on the serum creatinine concentration, according to the following formula:

CK (ml / min) = [140 - age (years)] × body weight (kg) / 72 × KCvary (mg / dl).

KK for women can be calculated by multiplying the obtained value by a factor of 0.85.

When combined renal and hepatic insufficiency, the drug is also prescribed in the above mode.

Patients with a dysfunction of the liver with normal kidney function correction dosage is not required.

Older patients with normal renal function are not required to adjust the dose.

Adverse Reactions

The drug has minimal side effects and in most cases is easily tolerated by patients. In rare cases, the following side effects are possible:

From the gastrointestinal tract: dry mouth, flatulence, indigestion, abdominal pain, discomfort in the process of digestion.
From the side of the central nervous system: psychomotor agitation, dizziness, drowsiness, weakness, migraine, in rare cases - headache.
Other: in exceptional cases - allergic reactions: Quincke's edema, rash, itching, urticaria.

Overdose Symptoms

With a single admission of the drug at a dose of 50 mg, the following symptoms were observed: confusion, diarrhea, dizziness, fatigue, headache, malaise, mydriasis, itching, weakness, anxiety, sedation, drowsiness, stupor, tachycardia, tremor, urinary retention.

Treatment: immediately after taking the drug - gastric lavage or stimulation of vomiting. It is recommended to take activated charcoal, conduct symptomatic and maintenance therapy. There is no specific antidote. Hemodialysis is ineffective.

special instructions

Before you start using the drug, read the special instructions:

When the dose is exceeded 10 mg / day, the speed of psychomotor reactions can be slowed down.
In patients with spinal cord injury, prostatic hyperplasia, and in the presence of other predisposing factors to urinary retention; Cetirizine may increase the risk of urinary retention.
Methyl parahydroxybenzoate and propyl parahydroxybenzoate, which are part of the drug in the form of drops, can cause allergic reactions, including. delayed type.
Drops do not contain sugar, as a sweetener used sucralose, which does not affect the glucose in the blood serum, so Tetrin in the drops can be prescribed to patients with diabetes mellitus.
Prior to the appointment of allergological samples, a three-day wash-out period is recommended because inhibitors histamine H1 receptors (including cetirizine) inhibit the development of skin allergic reactions.

With an objective assessment of the ability to drive vehicles and manage mechanisms, there were no significant adverse events when taking the drug at the recommended dose, but during the period it is advisable to refrain from driving motor vehicles and other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Compatibility with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

With concomitant use with ritonavir, AUC of cetirizine increased by 40%, while that of ritonavir slightly changed (-11%).
The simultaneous use with the antibiotics of macrolides (azithromycin, erythromycin) and ketoconazole does not lead to changes in the ECG of patients.
In therapeutic doses, cetirizine did not demonstrate a clinically significant interaction with ethanol (at an ethanol concentration of 0.5 g / l in the blood). Nevertheless, one should refrain from drinking alcohol.
When studying the pharmacokinetic interaction of cetirizine with pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin, glipizide, diazepam and antipyrin, there was no clinically significant adverse interaction.
With simultaneous application with theophylline (400 mg / day), the total clearance of cetirizine is reduced by 16% (theophylline kinetics does not change).
Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.

Patient Reviews

We offer you to read reviews of people who used Tsetrin:

Anastasia. The child had an allergic reaction to the pet's hair, suffered from severe itching. After using Cetrin syrup, allergy symptoms disappeared. Now the drug has become indispensable in the home medicine cabinet
Tatyana. Awfully want to sleep from the cetrine, despite the fact that you drink it at night, at work you feel weakness and weakness.... Come home (if the legs are carried) and sleep..... A terrible drug, from this drug until the itch does not stop ....
Snow-covered. From pollinosis I am saved only by Cetrin. In this case, I prefer to take it in the morning, not at night. After reception in the morning, there is minimal drowsiness, but after an evening intake of the drug - it is very difficult to get up. For me, one meal is enough for three days. With the signs of an allergy cope perfectly

Analogues

Instead of Cetrin, the following drugs can be used:

Zirtek is an original medication that contains cetirizine as an active ingredient. The medicine is released in drops and tablets. Antihistamine can be prescribed to children older than 6 months and breast-feeding patients. During pregnancy, it is worth to abstain from taking a medication.
Erius refers to the substitutes for Cetrin on the therapeutic group. It is produced in syrup, usual and absorbable tablets. Antiallergic can be used in children older than 6 months. It is contraindicated in pregnant and lactating women.
Suprastin is a substitute for Cetrin on the pharmacological group. The medication is sold in injections and pills. Suprastin is banned in the newborn period, pregnant and lactating.
Claritin is an antihistamine, the therapeutic effect of which is explained by loratadine. It is produced in tablets and syrup. The drug can be prescribed to children older than 2 years and women in the situation. Claritin is incompatible with breastfeeding.

Before buying an analogue, consult your doctor.

Suprastin or Tsetrin - which is better?

Cetrin belongs to antihistamine drugs of the second generation, and Suprastin represents the first generation. This means that when Cetrin is used, side effects develop much less frequently and are less pronounced than Suprastin. However, Suprastin has a stronger antiallergic effect.

For today doctors consider, that for independent application it is necessary to choose Zetrin. Suprastin can be used only in the conditions of a medical institution under the supervision of doctors to remove an acute allergic reaction, which can not be stopped by other means. In developed countries it is forbidden to use it in children under 12 years old.

Suprastin dries the mucous membranes of the respiratory tract, which leads to a high risk of infection. As a result, in 70% of cases, the suprapubic allergy suppression ends with bronchitis, angina or other similar disease. In addition, this drug has a negative impact on the central nervous system, causing severe drowsiness, reducing the ability to learn and adequately perceive information. Cetrin does not cause such side effects. Therefore, despite the weaker antiallergic effect, it should be preferred instead of Suprastin.

Which is better - Cetrin or Tavegil?

The drug Tavegil is manufactured by the Austrian company Nycomed Austria GmbH. As an active substance, it contains klemastin, one of the most common histaminoblockers of the first generation.

Has a high cholinolytic activity, but through the BBB penetrates in smaller quantities than the earlier histaminoblockers. In this regard, the sedative effect in patients on the background of its use develops infrequently - in less than 10% of cases. In this case, the likelihood of a sedative effect increases with parenteral administration of the drug

Tavegil is available in tablet form and in injection form. The latter is used for the prevention and treatment of pseudoallergic and allergic reactions, and also as an additional remedy for angioedema and anaphylactic shock.

Clemastin cleavage ranges from 2 to 4 hours, cetirizine to 1 hour. Anti-histamine activity of Clemastin reaches a maximum on average after 6 hours, the effect persists to 12 hours (sometimes - within 24 hours). Cetirizine also lasts more than 24 hours.

Thus, the advantages of Tavegil are good knowledge and long experience of use, as well as the presence of an injection form and low cost of treatment.

The advantages of Cetrin are a higher affinity for the H1-type histamine receptors, longer duration of action, low permeability through the BBB, absence of tachyphylaxis, absence of inactivation of the active substance by food.

Cetirizine does not cause addiction and sedation and, in addition, is not practically metabolized in the body, whereas klemastine biotransformirouetsya almost completely (in pure form, the substance is determined in the urine in very small concentrations).

Zirtek or Tzetrin - what to choose?

They are synonymous drugs, because they contain the same active substance - cetirizine. That is why there is no fundamental difference between Zirtek and Zetrin. You can choose any drug that you like more. If the decisive factor in the choice of a medicine is the price, then choose Cetrin, which is significantly cheaper than Zirtek.

Pharmacists believe that Zirtek contains cetirizine with a higher degree of purification, so it rarely causes side effects. However, the practice of their use has shown that the incidence of side effects in both drugs is exactly the same.

Cetrin or Erius?

The basis of the drug Erius is the substance desloratadine - an active metabolite loratadine, H1-blocker III generation. Possessing all the advantages of loratadine, it exhibits the highest selectivity for histamine receptors and very rarely provokes the development of undesirable reactions.

The use of Eryus is preferred for long-term therapy of allergic diseases such as chronic urticaria or all-the-year-round rhinitis.

The affinity of desloratadine for H1 receptors is 50 times greater than that of cetirizine, which is why Erius is proven in the medical practice, and in clinical studies - is a stronger histaminoblocker than its analogue.

Shelf life and storage conditions

Store the drug in a place inaccessible to children, at a temperature of not more than 25 degrees. The shelf life of tablets from the date of manufacture is 2 years, not taken orally after the expiration date.