Amelotex: instructions for use, tablets, injections

Amelotex injections: instructions for use

The drug Amelotex as a solution for intramuscular injection refers to the pharmacological group of non-steroidal anti-inflammatory drugs.

The active substance of this drug, meloxicam, is a selective inhibitor of the COX-2 enzyme, the production of prostaglandins (mediators of the inflammatory reaction) decreases, the intensity of inflammation and intensity pain.

Amelotex in injections is used mainly in the complex therapy of various inflammatory diseases of the musculoskeletal system.

Form of issue and composition

Solution for intramuscular injections Amelotex is available in transparent ampoules, ml, in several kinds of packaging:

• 3 ampoules - contained in 1 contour mesh package.
• 5 ampoules in 1 contour squamous packaging.
• 6 ampoules - 2 contour packs with 3 ampoules each.
• 10 ampoules - 2 contour packs with 5 ampoules each.
• 20 ampoules - 4 contour cell packs of 5 ampoules each.

In 1 ml of solution for intramuscular injection contains 10 mg meloxicam, respectively in 1 ampoule - 15 mg. Also in 1 ampoule contains auxiliary substances:

• Meglumine - 9.375 mg.
• Glycofurfural 150 mg.
• Poloxamer 75 mg.
• Sodium chloride is 4.5 mg.
• Glycerol 7.5 mg.
• Sodium hydroxide solution 1M - up to pH 8.2-8.9.
• Water for injection - up to a volume of 1.5 ml.

Packing with a different number of ampoules in the package makes it possible to conveniently choose a package for the course of treatment.

Pharmacological properties

The main active substance of the solution for intramuscular injections is meloxicam, which belongs to the pharmacological group of non-steroidal anti-inflammatory drugs.

This substance is active against the enzyme cycloxygenase 2 (COX-2), which catalyzes the synthesis of prostaglandins.

Prostaglandins are biologically active compounds that are formed in tissues during an inflammatory reaction. They have a number of effects:

• Irritated sensory nerve endings - the emergence of a feeling of pain in the area of ​​the inflammatory process.
• Increase the permeability of the walls of the vessels of the microcirculatory bed - while the intercellular substance of the tissues leaves the liquid part of the blood (plasma) with the development of edema.
• Reduce the intensity of outflow of blood with its stagnation in the inflammatory process due to narrowing of venous vessels (hyperemia).

In the body, there are several subspecies of prostaglandins.

Some of them do not take part in the process of inflammation, they are localized to the stomach and perform a protective function in relation to the mucous membrane - prevent the development of erosions and ulcers under the action of hydrochloric acid gastric juice.

The production of such physiologically necessary prostaglandins catalyzes the enzyme cycloxygenase 1 (COX-1). Prostaglandins, which are mediators of inflammation, are synthesized with the help of COX-2.

Due to its selectivity, meloxicam only blocks COX-2, due to which it exerts a pronounced Anti-inflammatory effect and has a minimal damaging effect on the gastric mucosa and duodenum. The anti-inflammatory effect of the active substance of the solution for injection is manifested in a decrease in the intensity of pain, the severity of edema of the tissues and their hyperemia.

The therapeutic concentration in the blood of meloxicam is reached after 15-20 minutes after intramuscular injection of Amelotex injection solution.

It practically all (99%) binds to the proteins of the blood plasma and spreads through the body. The greatest amount is stored in the connective tissue.

Meloksikam penetrates the blood-brain barrier (from the blood, it can enter the tissues of the brain, spinal cord and spinal fluid).

Also, the active substance of the drug freely flows through the placenta into the fetus during pregnancy and into breast milk during lactation.

Half-life (the time during which 50% of the active substance of the drug is excreted from the body) for meloxicam is 10-12 hours. Meloksikam is processed in the liver to intermediate decay products, which are excreted mostly by the kidneys. Partly they can be excreted through the intestine, where I come from the liver with bile.

Indications for use

Since meloxicam is well accumulated in a therapeutic dose in the tissues of the organs of the musculoskeletal system, the solution for intramuscular injection Amelotex is indicated for various pathology of motor structures that are accompanied by inflammatory process. These include:

• Rheumatoid arthritis - inflammation of the joints due to a malfunction of the immune system, which produces autoantibodies that affect the tissues of the joints.
• Osteoarthrosis is a degenerative-dystrophic pathology of the joints with the destruction of their cartilaginous tissue and the development of an inflammatory reaction.
• Ankylosing spondylitis (Bechterew's disease) is an autoimmune pathology, accompanied by inflammation of the entire spine with a significant decrease in its mobility and pain.
• Arthritis - inflammation of joint tissues of various etiologies (bacterial infection, local hypothermia).

The use of a solution for intramuscular injection of Amelotex in these diseases is a component symptomatic therapy, which allows to reduce the intensity of pain syndrome and other inflammatory manifestations. The preparation does not influence the elimination of the cause of inflammation.

Contraindications for use

Meloksikam in the solution for intramuscular injections Amelotex can have a negative effect on organism under various pathological and physiological conditions, which are a contraindication to application:

• Individual hypersensitivity to meloxicam or other components of the drug.
• Bronchial asthma - meloxicam (like all other drugs of this pharmacological group) can provoke a severe attack of the disease until the development of asthmatic status.
• The combination of bronchial asthma, recurrent (with frequent exacerbations), polyposis of the nasal cavity, paranasal sinuses and intolerance to acetylsalicylic acid (as well as other representatives of the group of non-steroidal anti-inflammatory drugs) in past.
• Allergic reactions to meloxicam or excipients - they can manifest themselves skin changes (rash, itching, urticaria), angioneurotic edema (angioedema) and anaphylactic shock (an extremely severe allergic reaction with the development of a multi-organ insufficiency).
• Decompensated acute or chronic heart failure with severe circulatory disorders.
• Bleeding from the gastrointestinal tract (complication of peptic ulcer of the stomach or duodenum), bleeding of any other localization.
• Insufficient functional activity of the liver.
• Acute or chronic renal failure.
• Inflammatory nonspecific pathology of the intestine (nonspecific ulcerative colitis, Crohn's disease).
• Pregnancy at any time, the period of breastfeeding and children under 15 years.

Before the first use of the drug, it is necessary to pay attention to possible contraindications. In case the doctor prescribes the Amelotex administration, he first ascertains the absence of contraindications to its use.

Dosing and Administration

The drug Amelotex is administered intramuscularly. Its dosage is determined by the type of inflammatory pathology and the severity of its course, which is manifested by a different intensity of pain.

Usually the initial dosage is, mg per day (1/2 ampoules), if necessary, increase it to 15 mg per day.

Do not administer the drug into the hematoma, subcutaneous hemorrhage. The average course of treatment is 5 days, if necessary, the doctor can extend it up to 10 days.

Side effects

The use of Amelotex can lead to a number of negative side effects from various body systems:

• The digestive system - nausea, sometimes vomiting, belching of the air, abdominal pain, unstable stool (constipation or diarrhea), bloating or gastrointestinal bleeding. Possible esophagitis, gastritis or enteritis.
• Liver and bile ducts - increase of enzymes (ALT, AST), indicating damage to liver cells, increased bilirubin level, hepatitis.
• Central nervous system - headache, dizziness, tinnitus, drowsiness, disorientation in time or space, emotional instability.
• Respiratory organs - bronchospasm (narrowing of the lumen of the bronchi).
• Hemopoiesis is anemia (decrease in the number of erythrocytes and hemoglobin level), thrombocytopenia (decrease in the number of platelets), leukopenia (decrease in the number of leukocytes).
• Cardiovascular system - development of peripheral edema, palpitation, blood flow to the upper half of the trunk and face, increasing systemic blood pressure.
• Urinary system - increased levels of uric acid, urea, creatine in the blood, swelling of the tissues, there can rarely be a development of acute renal failure.
• Skin - the appearance of rash and itching, increased reaction to light (photosensitization), allergic urticaria.
• Eyes - reduction of visual acuity, conjunctivitis.
• Allergic reactions - depending on the severity of the sensitization of the body, they can vary from skin rash and itching to the development of anaphylactic shock.

Typically, these side effects can develop with prolonged use of the drug, more than 5 days. In the place of intramuscular injection of Amelotex, reactions in the form of burning and redness of the skin are possible. In case of side effects, the drug is stopped.

special instructions

Before starting the solution for intramuscular injections of Amelotex, you should carefully study the instructions and make sure there are no contraindications. It is worth paying attention to special instructions:

• Excluded the introduction of the drug to pregnant women, nursing women and children under 15 years.
• Elderly, the dose of the drug is reduced.
• With special care and constant clinical and laboratory control, the drug is prescribed for people with pathology of liver, kidney and peptic ulcer of the stomach or duodenum.
• Simultaneous use of Amelotex with other drugs may increase their activity (other representatives of non-steroidal anti-inflammatory drugs) or reduce it (antihypertensive drugs). Therefore, it is absolutely necessary to consult a doctor.
• In view of the possible development of drowsiness, the drug is undesirable to use for people whose activities are associated with increased concentration of attention and require a rapid psychomotor reaction.

If you have any doubts or questions, you should consult your doctor. In pharmacies, the solution for intramuscular injection Amelotex is dispensed by prescription.

Overdose

Exceeding the permissible dose of the drug may lead to the development of any one or more side effects. There is no specific antidote, symptomatic therapy is used to improve the condition.

Terms and conditions of storage

Shelf life - 2 years. Keep out of reach of children and dark places at a temperature of +8 to +25 ° C.

Analogues of injections Amelotex

Analogues of the solution for injection Amelotex include Revmoxicam, Meloxicam, Movalis.

Prices for Amelotex

Amelotex solution for intramuscular injection 10 mg / ml, 3 pcs. - from 314 rubles.

A source: http://bezboleznej.ru/ameloteks-ukoly

Amelotex injections - instructions for use intramuscularly: the composition and action of the drug, the price, analogs and reviews of treatment

Often with diseases of the musculoskeletal system, a person experiences severe pain, discomfort, and swelling. To combat the symptoms of such a plan use non-steroidal anti-inflammatory drugs (NSAIDs).

These include Amelotex injections - instructions for use that are prescribed for certain indications, injected under the skin with inflammation in the spine, joints and other parts of the musculoskeletal apparatus.

Injections have an analgesic effect, restore physical activity, are more effective than tablets.

There are many non-steroidal anti-inflammatory drugs (NSAIDs) that are used for complex therapy of diseases of the musculoskeletal system. One of the most popular drugs in this group of drugs are injections Ameloteks.

According to the instructions, this medicine has antipyretic, analgesic effect, effectively removes inflammation.

To get the maximum effect from injecting therapy, you must clearly follow the instructions for use and be sure to consult with your doctor.

Name of component	Quantity in one ampoule (mg)
The main active substance is meloxicam (a selective inhibitor of the enzyme COX-2)	15
Sodium chloride	,
Water for injections	up to the volume,
Meglumine	, 75
Poloxamer	75
Glycofurfurol	150
Sodium hydroxide solution 1M	up to pH 8.2-8.9
Glycerol	,

Form of issue

Pharmacies offer Amelotex medication (intramuscular injections) in colorless glass ampoules. The liquid has a yellowish green tinge. The following forms of the drug are available:

• a contour bundle with cells containing three ampoules (you can buy a cardboard box with one or two packs);
• Packing with five ampoules of medicinal product (there are still large packs with one, two or four such packages).

Pharmacodynamics and pharmacokinetics

Solution for injections refers to the pharmacological group of non-steroidal anti-inflammatory drugs. When a drug enters the bloodstream through an intramuscular injection, it is sent to the diseased cells and tissues of the spine, as well as its structures.

There is a chain of chemical reactions that contribute to the inhibition of the enzyme cyclooxygenase-2, which provokes blocking of mediators of the inflammatory process (leukotrienes, prostaglandins). The whole chain of actions described leads to an anti-inflammatory effect.

The required concentration of meloxicam in the blood is reached 20 minutes after intramuscular injection. The active component is almost entirely bound by blood plasma proteins and diverges throughout the body. The injections have an anesthetic effect.

This is due to the function of the drug to "overlap" the painful brain center and to increase the pain threshold of the person's sensitivity.

The antipyretic effect of injections is also due to the blocking of inflammatory mediators, and also to a decrease in the sensitivity of the thermoregulatory center in the brain.

Amelotex - indications for use

Taking into account the fact that the active element of the preparation meloxicam excels in the tissues of the organs of the locomotor system apparatus, a drug for intramuscular injections Amelotex is prescribed for various pathological processes in the structure system. According to the instructions, the following indications are the main indications for the use of the medicament:

1. Arthritis is a joint disease, in which an inflammatory process that affects the joint tissues develops. It is often provoked by severe local hypothermia, bacterial infection.
2. Osteoarthritis is a degenerative-dystrophic joint disease, in which the disintegration of their cartilaginous tissue occurs, the formation of a focus of inflammation.
3. Rheumatoid arthritis - the development of inflammation of the human joints, caused by malfunctions in the functioning of the immune system. In the presence of this inflammatory disease, autoantibodies are produced that destroy the tissues of the joints.
4. Bechterew's disease or ankylosing spondylitis is a pathological process of the autoimmune type, which is characterized by the development of inflammation of vertebral structures. The mobility of the spine is greatly reduced, the person experiences regular back pain.

Amelotex injections - instruction

The solution is used for intramuscular (parenteral) injections.It is recommended to inject it deeply into the muscle, making sure before that that the needle has not entered the cavity of the vessel.

Instruction for use has information that the dosage of a medical preparation depends on the specific disease, the severity of its course and the intensity of the symptoms.

The initial dose of meloxicam in injections, which the doctor prescribes, is ½ (, mg) of the ampoule once a day. If necessary, the dosage is increased to 15 mg per day maximum.

Injection is injected once at the same time, intramuscularly. The injection should be performed with mandatory observance of the rules of antiseptics, asepsis, which will help to avoid infection in the human body.

It is forbidden to introduce a non-steroidal anti-inflammatory drug into the area of ​​subcutaneous hemorrhage, hematomas.

According to the instructions, the average duration of therapy is 5 days, sometimes the doctor recommends a course of 8-10 days.

special instructions

Before starting treatment with the solution intramuscularly, it is worth familiarizing with the features of the drug:

1. It is forbidden to administer the drug to pregnant and lactating women, children under 15 years of age.
2. Dosage is adjusted, and injections are prescribed very cautiously with liver diseases, impaired renal function, ulcerative lesions of the gastrointestinal tract (gastrointestinal tract), erosive changes in the gastric mucosa and duodenum guts. Such patients should be under the supervision of the doctor the entire course of therapy.
3. The dose of medication for elderly patients decreases.
4. If we talk about the interaction of a solution for injecting Amelotex, then according to the instruction, its use with other medical products should be as sharp as possible. Intramuscular injections reduce the effectiveness of intrauterine contraceptives, antihypertensive drugs, increase the level of lithium concentration in the blood plasma. Increased risk of bleeding increases thrombolytics, heparin, anticoagulant therapy, drugs lithium, the use of diuretics can lead to kidney disease, colestyramin accelerates excretion meloxicam.
5. Given the fact that after the use of the drug may show drowsiness, it is not recommended to prick people whose activity requires constant high concentration and instant psychomotor reaction.
6. The intake of alcohol does not affect the effect of injections Ameloteks.

Side effects and overdose

If the dose of Amelotex medication permitted by the instructions or by the doctor is exceeded, this can lead to serious side effects. In this case, the patient will be prescribed additional treatment depending on the symptomatology. The main side effects:

1. An allergic reaction that manifests itself in different ways (depends on the individual characteristics of the patient).There may be a rash on the skin, itching, photophobia, urticaria, in some cases there is a risk of anaphylactic shock.
2. According to the patients, dizziness, drowsiness, loss of orientation in space, headache are observed.
3. Anemia, leukopenia, thrombocytopenia.
4. Attacks of nausea and vomiting, abdominal pain, diarrhea / constipation, gastrointestinal bleeding. Sometimes develops gastritis, esophagitis, enteritis.
5. According to patients, bronchial spasms may occur.
6. Increased palpitations, the appearance of peripheral edema, increased blood pressure, a rush of blood to the face and upper body.
7. Increase in the level of enzymes (AST, ALT), which signals violations of the liver, hepatitis, increased levels of bilirubin.
8. There may be a violation of visual function, conjunctivitis.
9. Increased levels of urea, uric acid, creatine in the blood, rarely develops acute renal failure.

Contraindications

Depending on different pathological and physiological conditions of a person, under which intramuscular Amelotex injections can adversely affect the body, instructions for use are as follows Contraindications:

1. Personal intolerance of the active ingredient - meloxicam and additional elements of the drug.
2. Chronic or acute form of heart failure with severe impairment of blood circulation.
3. Injections of Amelotex are contraindicated in the presence of bronchial asthma in the patient. The introduction of the drug can cause a severe attack of the disease, in some cases develops asthmatic status.
4. Development of bleeding of any location (eg, caused by a stomach ulcer or duodenal ulcer).
5. Symbiosis of asthma of bronchial, nasal chronic polyposis and intolerance of acetylsalicylic acid.
6. Chronic or acute type of kidney failure (especially if the patient is on hemodialysis).
7. Serious violations of the functional activity of the liver.
8. An allergy to meloxicam or ancillary components of the drug. Often it is manifested by rashes on the skin, itching, angioedema edema (Quincke's edema), anaphylactic shock (a very serious and dangerous form of allergic reaction with the presence of a multi-organ insufficiency).
9. Diseases of the intestines, accompanied by inflammatory process (Crohn's disease, ulcerative colitis).

Terms of Sale and Storage

Drug in the form of a solution for injection Amelotex according to the instructions should be stored at a temperature of no more than 25 degrees above zero. It should not be frozen, it is necessary to hide away from children. Shelf life of the drug is 2 years. In the pharmacy, the product is sold without a prescription.

Analogues

The list of the main analogues of Amelotex is as follows:

• Tenoktil;
• Zornika;
• Midokalm;
• The Texman;
• Piroxicam;
• Diclofenac;
• Piroximeter;
• Xefokam.

The price of Amelotex shots

You can buy a non-steroidal anti-inflammatory drug in any pharmacy kiosk or order online at a reasonable price.

The medicine is dispensed without a prescription, so it's very easy to buy it. The cost of the medication depends on the specific form of release and the place of sale of the product.

Below is a table with an approximate average price for Amelotex in various pharmacies of the capital and the region.

Name of the drug	Pharmacy	Price in rubles
Amelotex solution 10 mg (3 ampoules) Amelotex injections 10 mg (5 ampoules)	Neo-Pharm	350-355380-390
Injections into 3 ampoulesOn 5 ampoulesAmelotex №10	Nova Vita	270-280370-380510-520
Solution in-m №3 School № 5Injection №10	Laboratory of Beauty	280-285360-370500-510
Amelotex in-m solution for injections №3	City Pharmacy	350-360

A source: http://sovets.net/13378-ameloteks-ukoly-instrukciya-po-primeneniyu.html

What helps Amelotex? Instructions for use

A non-steroidal anti-inflammatory agent is Amelotex. What helps with this drug? The medicine has antipyretic and analgesic effect. Amelotex tablets instructions for use prescribe to take with arthritis and other joint diseases.

Composition and form of release

Produced in injections and pills. Injections are intended for intramuscular injection. In solution Amelotex, which helps with osteoarthritis, contains 15 mg of meloxicam - the active ingredient. Excipients are:

• glycofurfurol;
• meglumine;
• glycerol;
• poloxamer;
• sodium chloride;
• sodium hydroxide solution;
• water.

One Amelotex tablet contains:

• active substance - meloxicam mg or 15 mg depending on the dosage;
• auxiliary substances - MCC - 5, / 5, mg;
• lactose monohydrate 7, 2/7, 2 mg;
• sodium citrate -18 mg;
• crospovidone -1, mg;
• povidone mg;
• colloidal silicon dioxide, 4 mg;
• magnesium stearate, 4 mg.

Also, a gel is produced for external use.

Pharmacological properties

Injections, Amelotex tablets, which helps the medicine with pain, has analgesic, antipyretic and anti-inflammatory action. The mechanism of action is the inhibition of Pg synthesis as a result of selective suppression of the enzymatic activity of COX2.

With the appointment in high doses, long-term use and individual features of the organism, COX2, the selectivity decreases.

Suppresses the synthesis of Pg in the inflammatory region to a greater extent than in the gastric mucosa or kidneys, which is due to the relatively selective inhibition of COX2.

Less often causes erosive and ulcerative diseases of the digestive tract.

Amelotex: what helps

Indications for use Amelotex are as follows:

• rheumatoid arthritis;
• osteoarthritis;
• ankylosing spondylitis;
• degenerative and inflammatory diseases of the joints, with concomitant pain syndrome (solution for intramuscular injection).

Amelotex is intended for symptomatic treatment, easing of pain and inflammation during use, it does not influence the development of the disease.

Contraindications

Medication Amelotex instructions for use prohibit taking when:

• Hypersensitivity (including to NSAIDs al. groups);
• combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance of ASA and LS of pyrazolone series;
• stomach ulcer and duodenal ulcer (in the phase of exacerbation);
• severe hepatic insufficiency;
• CRF in patients not undergoing dialysis (QC less than 30 ml / min), active gastrointestinal bleeding;
• progressive kidney disease;
• severe hepatic insufficiency or active liver disease;
• after coronary artery bypass grafting;
• confirmed hyperkalemia;
• inflammatory bowel disease;
• children (up to 12 years);
• pregnancy, lactation.

Amelotex: instructions for use

Solution for intramuscular injection

In the form of a solution, Amelotex is administered intramuscularly, -15 mg once a day. The highest permissible daily dose is 15 mg. Patients with severe renal failure who is on hemodialysis should not exceed the daily dose, mg.

Pills

In the form of tablets, the drug should be taken orally once a day. Recommended daily doses:

• Rheumatoid arthritis - 15 mg, if necessary, reduce the dose to, mg.
• Osteoarthritis mg, if necessary, increase the dose to 15 mg.
• Ankylosing spondylitis - 15 mg.
• The highest permissible daily dose is 15 mg. Patients with severe renal failure who is on hemodialysis should not exceed the daily dose, mg.

Gel for external use

In this dosage form, Amelotex should be applied to clean, dry skin over the lesion and rubbed gently for 2-3 minutes. A single dose is - 2 g of gel (a strip about 4 cm in length).

Multiplicity of application - 2 times a day.

Duration of treatment is determined individually depending on the indications, the severity of the disease, the site of the lesion and the therapeutic effect of the drug, but should not exceed 4 weeks.

Side effects

Medication Amelotex causes the following reactions of the body:

• From the digestive system: often - dyspepsia, incl. nausea, vomiting, abdominal pain, constipation, flatulence, diarrhea; infrequently - a transient increase in activity "Hepatic" transaminases, hyperbilirubinemia, belching, esophagitis, gastroduodenal ulcer, bleeding from the gastrointestinal tract (including latent), stomatitis; rarely - perforation of the gastrointestinal tract, colitis, hepatitis, gastritis.
• On the part of the organs of hematopoiesis: often - anemia; infrequently - a change in the blood formula, incl. leukopenia, tamocytopenia.
• From the skin: often - itching, skin rash; infrequently - hives; rarely sensitization, Bullous eruptions, erythema multiforme, incl. Stevens-Johnson syndrome, toxic epidermal necrolysis.
• From the respiratory system: rarely - bronchospasm.
• From the nervous system: often - dizziness, headache; infrequently - vertigo, noise in the ears, drowsiness; rarely confusion, disorientation, emotional lability.
• From the CCC: often - peripheral edema; infrequently - increased blood pressure, palpitations, "hot flashes" of blood to the skin of the face.
• From the side of the urinary system: infrequently - hypercreatininaemia and / or increased urea concentration in the blood serum; rarely acute renal failure; connection with the reception of meloxicam is not established - interstitial nephritis, albuminuria, hematuria.
• From the sense organs: rarely - conjunctivitis, visual impairment, incl. blurred vision.
• Allergic reactions: rarely - angioedema, anaphylactoid / anaphylactic reactions.

Interaction

With simultaneous reception:

• with Abciximab, Aspirin, Warfarin, Heparin, Dalteporin nartium increases the risk of bleeding;
• with Acebutolol, hydrochlorothiazide, captopril, lisinopril, moexipril, Perindopril, Timolol, the hypotensive effect is weakened;
• with other non-steroidal anti-inflammatory drugs, the risk of serious adverse events increases dramatically.

special instructions

Under the constant supervision and monitoring of indicators of kidney function during treatment should be elderly people, patients with chronic cardiac insufficiency and the phenomena of circulatory insufficiency, patients with cirrhosis of the liver, patients with hypovolemia as a result of surgical interference.

With the simultaneous use of various dosage forms of Amelotex (for example, tablets and gel for external application), it should be borne in mind that the total daily dose of meloxicam should not exceed 15 mg.

Analogues

The following analogues of Amelotex are widely distributed and known:

• Arthrosan.
• Matarin.
• Meloksikam.
• Movalis.
• Movasin.
• Oxycamox.

Children and pregnancy and lactation

The drug is banned for use by persons under 15 years of age. The medicine can not be taken by pregnant women who breastfeed women.

Price

Amelotex tablets in Russia cost 106 rubles. You can buy medicine in Kiev for 150 UAH. In Belarus and Kazakhstan, it is difficult to buy the drug.

Opinions of patients and doctors

Reviews about Amelotex in tablets, as well as reviews about Amelotex injections are extremely ambiguous.

Along with reports of an excellent analgesic effect, negative evaluations of the drug occur because of side effects or lack of effect.

"When my joints get inflamed such pains are strong, that I get a shot - for happiness.

To me in this regard, Amelotex came up perfectly, because the first appointment of a doctor was not very effective, the pain passed slowly, and not for long.

"I have arthrosis of the knee joint, Amelotex takes a pill a day, it removes the pain syndrome quickly and effectively, does not allow inflammatory processes to develop. One Amelotex certainly does not manage, even fiz. exercise, massage and other honey. preparations. All in a complex and gives a positive result. "

"The drug is serious, and of course you should not prescribe it yourself, only on the prescription of the doctor, so that there will be no problems later, with side effects.

Personally, my therapist, he was appointed at the knee arthrosis, joints hurt, especially at night.

I did 6 injections of Amelothex, after the first, the pain decreased significantly, after the 6th it all passed, I forgot in general what problems with knees, pobochek did not notice either. "

A source: http://remedy.ucoz.ru/index/ameloteks_ot_chego_pomogaet_instrukcija_po_primeneniju/0-339

Amelotex - instructions for use, indications, form of release, side effects, analogues and price

Nonsteroidal anti-inflammatory drugs are often prescribed for the treatment of joint diseases. One such remedy is Amelotex.

This drug has a pronounced analgesic and antipyretic effect, anti-inflammatory properties.

If the patient complains of muscle pain, inflammation or arthrosis was diagnosed, the doctor often prescribes Amelotex - the instruction for use is mandatory for study.

The drug Amelotex

The medicine is used for symptomatic treatment of various diseases of the musculoskeletal system, helps to remove inflammation, calm pain and reduce body temperature.

To obtain the maximum effect from the use of the product, it is necessary to adhere strictly to the dosages indicated in the instructions for use and to consult with your doctor.

The medicine is not as harmless as it looks.

Amelotex is produced on the basis of a single active ingredient - meloxicam. In the pharmacy you can buy several forms of the drug: tablets, solution for injections, local action gel and rectal suppositories.

In what form it is better to use the remedy, the doctor decides, based on the testimony of laboratory tests and the general condition of the patient. The concentration of active substances and the composition of auxiliary components varies depending on the form of release.

The detailed information is presented in the table:

Form of release Ameloteks	Concentration of meloxicam	Auxiliary components	Total volume of the dosage form
Gel	1 mg	water, trometamol, ethanol 95%, carbomer, orange and lavender oil, methylpyrrolidone	50 ml
Pills	, / 15 mg	silicon dioxide, MCC, glucose monohydrate, povidone, magnesium citrate and stearate, crospovidone	packs of 20 tablets 075 mg or in packs of 10 tablets 15 mg
Candles	, / 15 mg	solid fat, macrogol glyceryl hydroxy stearate	6 candles with the concentration of the active substance, 15 or, 075 mg
Solution	15 mg	water, glycerol, meglumine, sodium hydroxide in solution, sodium chloride, poloxamer, glycofurfurol	1 ampoule volume, ml

Pharmacodynamics and pharmacokinetics

The drug has a pronounced anti-inflammatory, easy analgesic and antipyretic effect.

In this case, Amelotex does not affect the cartilaginous tissue of the joints and does not suppress the synthesis of proteoglycan.

The effect of meloxicam is based on the inhibition of the activity of the enzymes COX-2, which take part in the biosynthesis of prostaglandins in the inflammatory region.

With the simultaneous administration of the drug with food, its absorption does not change. Meloksikam and auxiliary components almost completely break up into components in the liver.

Bioavailability of the medicine is 89%. In the form of metabolites, the drug is excreted by the kidneys, in the unchanged state - with feces. The average half-life is 15-20 hours.

Indications for use

Amelotex in the form of a gel is prescribed for symptomatic therapy of osteoarthritis, if the disease is accompanied by a severe pain syndrome.

It helps to reduce the area of ​​inflammation, remove pain, but does not affect the progression of the disease.

Indications for the use of suppositories, tablets and solution are degenerative or inflammatory joint diseases:

• ankylosing spondylitis;
• osteoarthritis;
• rheumatoid arthritis.

Overdosing with the drug can lead to many negative consequences and worsening of the patient's condition.

To prevent this from happening, doctors are strongly advised to adhere to the dosages prescribed in the dosage instructions.

With the simultaneous use of different dosage forms Amelotex should be counted daily dosages.It is important that the dose of meloxicam does not exceed 15 mg.

Gel

It is produced in a metal tube and is used only as a local therapy for pain syndrome. Transparent, sometimes with a yellow or green tinge, the gel is almost odorless and does not stain the skin.

Use Amelotex in this form can only be externally, applying a remedy to the focus of inflammation in two layers, with light rubbing movements. The recommended dosage of the gel is a 4-centimeter strip.

Duration of treatment - no more than four weeks in a row.

Injections

The solution for intramuscular injections is supplied in transparent ampoules in packages of 5 pieces. The liquid has a light yellow-green hue.

The dosage of the drug depends on the severity of the course of the disease and the intensity of the symptoms. To prevent the occurrence of side effects, it is recommended to start treatment with minimal doses mg per day.

If necessary, you can enter up to 15 mg meloxicam. The average duration of treatment, according to the instructions - 5-10 days.

Candles

Rectal suppositories are torpedo-shaped, they are green or greenish-yellow in color.

Candles Amelotex appointed only if the reception of other forms of the drug for some reason is impossible. To introduce suppositories should be deep into the anus, previously emptying the intestine.

The recommended dosage is 1 candle in the morning or in the evening. The minimum course of treatment is two weeks, the maximum - 30 days.

Tablets

They have a round biconvex shape, a pale yellow color, sometimes the presence of marble color and slight roughness.

On one side of the pills is a risk.Tablets are taken orally during meals.

Dosage, according to the instructions, is determined depending on the diagnosis:

• With rheumatoid arthritis 15 mg / day. If the desired therapeutic effect was achieved, the dose is reduced to, mg / day.
• With Bekhterov's disease - 15 mg / day.
• With deforming arthrosis - 7.5 mg / day. If the tablets were ineffective, the dosage is increased to 15 mg.

special instructions

With special care, the medication is prescribed if there is a history of peptic ulcer of the stomach or duodenum.

Because of the high risk of ulcerative erosive processes in the digestive tract, Amelotex therapy can only be performed under medical supervision when performing anticoagulant therapy.

For patients on hemodialysis, the daily dose of the drug should not exceed, mg.

Like other anti-inflammatory non-steroid drugs, Amelotex erases the symptoms of infectious diseases.

During treatment, it is possible to reduce psychomotor reactions, so it is recommended to abandon the management of vehicles and complex mechanisms.

The use of meloxicam affects fertility, so the drug is contraindicated in the planning of pregnancy.

Drug Interactions

Simultaneous use of Amelotex with other drugs of the non-steroid group can provoke erosive-ulcerative processes and gastrointestinal bleeding. With other combinations of drugs with Amelotex, it is possible to:

• with lithium preparations - an increase in the concentration of normotimics;
• with drugs that lower blood pressure - a decrease in the effectiveness of these drugs;
• with Methotrexate - increased side effects due to negative effects on the hematopoietic system, possibly the development of anemia and leukopenia;
• with Warfarin, Heparin and other anticoagulants - the risk of bleeding;
• with carboplatin and other drugs that have a mielodepressivnoe effect - the mutual enhancement of toxic effects;
• with Cyclosporine and other diuretics - the development of renal failure;
• with selective serotonin inhibitors - the risk of bleeding.

Amelotex and alcohol

It is worth paying attention to the fact that the instructions for use do not indicate the interaction of Amelotex with alcohol.

Reception of alcoholic beverages does not interfere with the absorption of active substances, but negatively affects the liver and kidneys, creating an additional burden for the body.

For these reasons, use any form of the drug, especially the injection solution, for the duration of alcohol treatment is contraindicated.

Side effects

According to the patients' feedback, it is clear that fewer negative reactions appear when using a gel.

Due to local effects, the gel can provoke the appearance of dry skin at the site of application, small rashes and allergic reactions - burning, itching or urticaria. It is extremely rare to develop epidermal necrolysis of tissues.

Ampoules and tablets provoke more side effects from different organs and body systems:

• respiratory organs - bronchial spasms;
• CNS - dizziness, drowsiness, disorientation, headaches;
• hematopoiesis system - anemia, leukopenia, thrombocytopenia;
• cardiovascular system - peripheral edema, hypertension, heart palpitations, rush of blood to the face or chest;
• digestive organs - abdominal pain, exacerbation of gastritis, hepatitis, hyperbilirubinemia, bleeding, stool, colitis, nausea, or vomiting;
• urinary system - hematuria, albuminuria, development of renal failure, edema, interstitial nephritis;
• sight and hearing - the development of conjunctivitis, reduced visual acuity, tinnitus.

Overdose

There is no direct antidote for Amelotex. Overdosing with the drug only increases the manifestation of side effects.

If you accidentally took an extra dose of medication, it is recommended that you immediately consult a doctor.

To eliminate symptoms, the patient is rinsed and prescribed medications for symptomatic relief. In some cases, the doctor may prescribe hemodialysis.

Contraindications

Gel for joint diseases is not prescribed for children and people with sensitive skin or negative reaction of the organism to meloxicam.

In other cases, the product can be applied to undamaged skin areas according to the instructions for use.

All other forms of the drug are categorically prohibited if:

• allergic reactions;
• cardiovascular diseases;
• renal and hepatic insufficiency;
• ulcer of the stomach or duodenum;
• bronchial asthma;
• polyposis of the nose;
• active liver diseases;
• inflammatory bowel disease;
• kidney diseases;
• with lactase deficiency and lactose intolerance;
• children under 15;
• pregnant and lactating.

Terms of Sale and Storage

Tablets, injectable solutions and suppositories are dispensed from pharmacies only if a prescription is available from the doctor. The gel can be found on a free sale.

Store all forms of the drug, except for the solution, it is necessary in the refrigerator or at a temperature of no higher than 25 degrees. Ampoules are stored at 8-25 degrees Celsius.

Shelf life of the medication is 3 years.

Analogues - similar drugs

If there are contraindications to the patient or individual intolerance of one or more components of the drug, the doctor may replace Amelotex with an analogue. Similar drugs include:

• Arthrosan;
• Matarin;
• Meloksikam;
• Movalis;
• Oxycamox;
• Meloksikam Pfizer;
• Diclofenac;
• Xsefokam;
• Midokalm;
• Bee-ksikam;
• Lem pills;
• Melbeck.

Price Amelotex

You can buy a non-steroidal anti-inflammatory drug at any pharmacy in the country, order it from the official manufacturer's catalog or buy from the online store. The cost of a medicine depends on its form of release and volume.

Below is a table with approximate prices for Amelotex medicine in Moscow:

Form of issue, volume	Price, rubles
Solution 5 ampoules	350
Injections 5 ampoules	390
Tablets, mg 20 pcs.	64
Tablets 15 mg 10 pcs.	127
Suppositories 6 pcs.	133
Gel 50g	343

A source: http://vrachmedik.ru/661-ameloteks-instrukciya-po-primeneniyu.html