Cortexin in ampoules: instructions for use

width = Cortexin is a nootropic preparation from a group of protein bioregulators.

The action of the drug is based on its ability to normalize metabolic processes in the brain, as a result of which it is observed antioxidant, anticonvulsant, nootropic, and therapeutic effect on the central nervous system.

As an active ingredient, complexes of low molecular weight water-soluble peptides, called cortexin, are used.

Clinical and pharmacological group

Nootropic preparation.

Conditions of leave from pharmacies

It is released on prescription.

Price list

How much does Cortexin cost? The average price in pharmacies is at the level of1 200 rubles.

Form of issue and composition

Cortexin is available in the form of lyophysiata for the preparation of a solution for further injection into the muscle. The preparation is produced in 5 ml vials of 10 pieces in a cardboard box with the attached detailed description. The contents of the vial is a porous white powdery mass with a slight yellowish tinge.

The composition of the lyophilized powder contained in one bottle for the preparation of the injection solution includes 5 or 10 mg complex of water-soluble polypeptide fractions (cortexin) as an active substance and 6 or 12 mg of glycine as stabilizer.
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Pharmacological effect

Pharmacological activity of the drug Cortexin is due to the effectiveness of the active substances - small in weight proteins, which after intramuscular infusion penetrate into the brain and contribute to the following positive impacts:

Antioxidant. The drug slows the oxidation of lipids, prevents the negative impact of free radicals on brain cells. Under the action of the drug, an increase in cell survival is observed in conditions of oxygen starvation (hypoxia).
Nootropic. Active components improve memory and learning process, contribute to increased concentration of attention, and resistance to psycho-emotional overstresses, stressful situations.
Neuroprotective effects. Active substances contribute to reducing the toxic effects of psychotropic components, as well as protecting neurons from a number of neurotoxic factors: calcium ions, free radicals.
Anticonvulsant. The drug helps suppress the activity of pathological foci in the brain.

Cortexin also activates metabolic processes, improves the functional state of the central nervous system and improves the tone. The drug prevents the formation of free radicals, optimizes the balance of metabolism of excitatory and inhibitory amino acids.

Indications for use

The instructions for the use of the drug Cortexin nyxes indicate that this remedy is indicated in the presence or development of such diseases:

Asthenia and encephalitis.
Vegetosovascular dystonia.
Cerebral palsy in children.
Malfunction of cerebral circulation.
Present craniocerebral trauma, as well as the resulting consequences.
The epileptic state of the patient.
Perinatal CNS damage in children.
Cognitive impairment, through which a person suffers from a memory disorder, attention and thinking.
Decrease the ability to learn and learn new knowledge.
Problems with the development of speech in childhood.

The use of the drug positively affects the development of the child, as well as improving the condition in people in old age.

Contraindications

Like many drugs, has the use of Cortexin - contraindications:

pregnancy;
individual intolerance;
lactation period;
hypersensitivity to the components of the drug.

Use in pregnancy and lactation

The drug is contraindicated for use in pregnancy (due to lack of data from clinical studies).

If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped (due to the lack of data from clinical trials).

Dosage and route of administration

The instructions for use indicate: Cortexin in the ampoules are injected in / m.

The contents of the vial before injection are dissolved in 1-2 ml of 0.5% solution of procaine (novocaine), water for injection or 0.9% sodium chloride solution, directing the needle to the wall vial to avoid foaming, and administered once daily: for children weighing up to 20 kg at a dose of 0.5 mg / kg, with a body weight of more than 20 kg - at a dose of 10 mg for 10 days.

If necessary, repeat the course in 3-6 months.

How to Breed Cortexin

The drug itself is available in powder form. For intramuscular injections, a special solution should be used. Than to dilute a cortexin? Do not use lidocaine. Only such liquids can be used:

,% procaine;
,% novocaine;
injection water;
,% physiological or sodium chloride solution.

Novocaine is an anesthetic, because it reduces the soreness of the injection, although the risk of developing allergies increases. It is better to use water for injection or solution. For one vial of the drug, you need 1 or, ml of liquid. This solution should be taken for the treatment of an adult. For the child, use 2 ml of solvent. Although the exact proportion can be chosen only by a doctor.

To dilute an adult or children's lyophilizate, 1 to 2 ml of any of these solutions is necessary. The dilution is carried out as follows:

Take a sterile syringe of the correct volume and place the needle on the needle holder.
Open the ampoule with the solvent.
Lower the needle into the vial or ampoule and dial the desired amount of solution (1 - 2 ml).
Remove aluminum foil from the stopper on the vial with Cortexin lyophilizate (if any).
Pierce the rubber stopper on a vial of lyophilisate with a needle of the syringe in which the solvent is located.
Lower the needle approximately to the middle of the vial with lyophilizate.
Slowly pressing the plunger of the syringe, release the solvent into the lyophilizate. To prevent foaming of the lyophilizate, it is recommended to direct the needle from the syringe to the wall of the vial, since in this case the liquid will flow evenly over the glass and enter the powder without blowing him.

When the entire volume of the solvent is released into the lyophilizate, it is necessary, without removing the needle of the syringe, to gently shake the bottle from side to side in order to achieve complete dissolution of the powder. When there is a homogeneous solution in the vial without flakes, this means that the lyophilizate is completely dissolved and can be used for injection.

After completely dissolving the lyophilizate, it is injected into the syringe. Liofilizate can be typed with the same needle that was used to dissolve the drug, provided it was not removed from the plug for a period of stirring the solution. If the needle was removed from the stopper vial with lyophilizate, then to set the finished solution in a syringe another sterile needle should be taken, since it will be used for the subsequent injections.

Side effects

Cortexin is well tolerated, but in rare cases, after its administration, allergic reactions may occur in the form of skin rash, itching. As practice shows, adverse reactions appear only when during the use of the drug the lyophilizate is diluted with novocaine. The minimal risk of side effects is present when the powder is diluted with 9% sodium chloride.

Overdose

If the recommended dose of the drug is not observed, there is a risk of overdose, but in the annotation to the drug such information is not available. To reduce the risk, in the treatment process, you must strictly observe the prescribed dose of the drug and in no case without consulting a doctor not to adjust the dose.

special instructions

For the correct administration of the medicine and the maximum therapeutic effect, certain rules must be followed in the treatment of Cortexin.

To introduce lyophilizate solution should be slow, because with rapid administration there will be soreness.
Dilute the medicine right before it is injected.
If the solution remains in the vial, it is prohibited to use it again.
When a Cortexin shot is missed for some reason, you do not need to enter a double dose.
During the injection you must strictly adhere to the rules of antiseptics.
The drug does not affect driving or work with complicated equipment.
During the treatment, you must strictly follow the dosage, duration of treatment.
Use the drug with other nootropics can only be recommended by a doctor.

Observing the elementary rules, treatment with Cortexin will be effective and completely safe for the health of the patient.

Drug Interactions

The drug Cortexin does not interact with drugs, so it can be used in complex therapy with other medications. Exceptions are preparations in which an active substance having a peptide structure is contained.

Reviews

We picked up some reviews of people taking the drug Cortexin:

Nat. Cortexin helped me during the delivery of the Unified State Examination, then I thought about this day and night, could not get together, I did not know what kind of thing to grab. Stress was creepy, but Cortexin helped to get ready and put everything on the shelves. Calms the nerves, increases efficiency, organization. I strongly advise in periods of congestion at work and school.
Veronica. My baby was born with 2-sided hematomas on his head. In the maternity hospital they said: "It's nothing to worry about - it will resolve," the district pediatrician is the same. We came to the neurologist a month, it turned out that we urgently need to take measures, that cysts can be formed in the head, etc. Has appointed or nominated as a part of complex treatment of an injection of a cortexin. It was very scary to watch how the injections are done in the ass, which is still not there properly, but we withstand the baby. By the 7th month, ultrasound showed that everything was fine and we had time to eliminate all the consequences of birth trauma, the cysts dissolved, the blood circulation of the brain was good. Now to the child year, develops on age, all is good, fie-fie.
Oksana. My daughter recently went to the second grade. Her school program was given to her with difficulty. The neurologist prescribed a nootropic drug. I read reviews about the medicine, instruction and decided to try, and the price is small at the expense. Treatment began to help in a few days, the effect was noticed by the teacher. In addition, my daughter became calmer.

Analogues

In the domestic pharmaceutical market, Cortexin has only analog preparations that contain other active substances, but have a similar spectrum of therapeutic activity.

So, the analogues of Cortexin are the following drugs: